scholarly journals Epigenetic Changes in Response to Tai Chi Practice: A Pilot Investigation of DNA Methylation Marks

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Hua Ren ◽  
Veronica Collins ◽  
Sandy J. Clarke ◽  
Jin-Song Han ◽  
Paul Lam ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Tai Chi ◽  
Well Being ◽  
Epigenetic Changes ◽  
Biological Mechanisms ◽  
Age Related ◽  
Significant Difference ◽  
Pilot Investigation ◽  
Tai Chi Exercise ◽  
Epigenetic Biomarker

Tai chi exercise has been shown to improve physiological and psychosocial functions, well-being, quality of life, and disease conditions. The biological mechanisms by which tai chi exerts its holistic effects remain unknown. We investigated whether tai chi practice results in positive epigenetic changes at the molecular level.Design. The DNA methylation profiles of sixty CpG-dinucleotide marks in female tai chi practitioners (N=237; 45–88 years old) who have been practising tai chi for three or more years were compared with those of age-matched control females (N=263) who have never practised tai chi.Results. Six CpG marks originating from three different chromosomes reveal a significant difference (P<0.05) between the two cohorts. Four marks show losses while two marks show gains in DNA methylation with age in the controls. In the tai chi cohort all six marks demonstrate significant slowing (by 5–70%) of the age-related methylation losses or gains observed in the controls, suggesting that tai chi practice may be associated with measurable beneficial epigenetic changes.Conclusions. The results implicate the potential use of DNA methylation as an epigenetic biomarker to better understand the biological mechanisms and the health and therapeutic efficacies of tai chi.

scholarly journals Effect of Twelve Sessions of Tai Chi Exercise on Static and Dynamic Balance in Young Girls

2020 ◽  
Vol 8 (1) ◽  
pp. 26
Author(s):  
Abdolhamid Daneshjoo ◽  
Aida Tavakol ◽  
Hassan Sadeghi
Keyword(s):  
Tai Chi ◽  
Dynamic Balance ◽  
Training Group ◽  
Repeated Measure ◽  
Control Group ◽  
Young Girls ◽  
Balance System ◽  
Significant Difference ◽  
Tai Chi Exercise ◽  
And Control

Background: Tai Chi is Chinese martial art strengthening the performance of individuals. Objectives: The purpose of present study is to determine the effect of a Tai Chi exercise period on static and dynamic balance of young girls. Methods: For the purpose of this research, 32 young girls were voluntarily selected and randomly divided into two groups: Tai Chi training group (21 subjects; mean ± SD; age 22.05±2.4 weight 53.67±6.3 kg, height 1.60±0.5 m) and control group (11 subjects; mean ± SD; age 23.37±0.9 weight 53.64±7.8 kg, height 1.62±0.4 m) players. Static and dynamic balance were measured using Biodex Balance System SD three days before and after a 12-session training period with similar conditions in terms of time and place (75 minutes each session). Results: Mixed repeated measure test showed a significant difference between pre and post-tests in open eye single-foot, closed eye single-foot, open eye two-foot, and closed eye two-foot stances (p=0.001). However, no significant difference was revealed in the control group (p>0.05). While there was better balance state in all stances of Tai Chi group, no significant difference was observed between the groups in this respect (p>0.05). Conclusions: The findings of this research indicated the effectiveness of Tai Chi exercises on static and dynamic balance of young girls. Although there was no significant difference in effect of exercise between training and control groups, mean percentage of changes in training group revealed the effectiveness of exercise in training group compared to control. Therefore, Tai Chi exercises can be recommended to treat and prevent injury due to poor balance. We suggested performing Tai Chi more than 12 session in order to enhance it influences.

scholarly journals DNA METHYLATION: CAUSE OR CONSEQUENCE OF AGING?

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S32-S33
Author(s):  
Morgan E Levine ◽  
Sara Hagg
Keyword(s):  
Dna Methylation ◽  
Biological Age ◽  
Causal Role ◽  
Epigenetic Mark ◽  
Epigenetic Changes ◽  
Recent Advances ◽  
Age Related

Abstract Epigenetic changes are one of the Hallmarks of Aging. DNA methylation is a key epigenetic mark that has been shown to change during aging. Several "clocks" have been developed whereby changes in DNA methylation can be used to predict chronological, and perhaps, biological age. This symposium will focus on recent advances in understanding how and why changes in DNA methylation occur during aging and whether these changes play a causal role in age-related functional declines and disease.

The Effect of Cyberspace-based Education on the Well-Being of Caregivers of Elderly People with Dementia

2021 ◽  
Vol 14 ◽  
Author(s):  
Yadollah Abolfathi Momtaz ◽  
Parisa Mollaei ◽  
Parisa Taheri-Tanjani
Keyword(s):  
Elderly People ◽  
Negative Impact ◽  
Intervention Group ◽  
Well Being ◽  
World Health ◽  
Control Group ◽  
People With Dementia ◽  
Age Related ◽  
Significant Difference ◽  
The Impact

Introduction: One of the consequences of aging is the prevalence of chronic and age-related diseases, such as dementia. Caring for patients with dementia has a negative impact on the caregiver's well-being. This study aimed to examine the impact of cyberspace-based education on the well-being of caregivers of demented elderly people. Methods: This experimental study was done on a sample of 86 caregivers of elderly with dementia in 2018. The study sample was selected from memory clinic of Taleghani Hospital and randomly assigned into groups (intervention n = 43, control n = 43 groups). The well-being was measured using the World Health Organization - Five Well-Being Index (WHO-5), before and two months after the intervention. Cyberspace-based educational intervention was conducted for one month. The SPSS software version 23 was employed in data analysis. Results: The mean age of the caregivers in the intervention and control groups were (M = 51.95, SD = 10.90) and (M = 51.36, SD = 15.12) respectively. No significant difference was found between two groups in terms of age, gender and level of education. The results of analysis showed that while the well-being of the intervention group was significantly increased (t (38) = -11.38, P<0.001) the well-being in the control group was significantly reduced ( t(36) =4.71 , P<0.001). Conclusion: The findings showed that cyberspace-based education can improve the well-being of caregivers of the elderly with dementia.

scholarly journals Feasibility of a Tai Chi with Thera-Band Training Program: A Pilot Study

2020 ◽  
Vol 17 (22) ◽  
pp. 8462
Author(s):  
Meiling Qi ◽  
Wendy Moyle ◽  
Cindy Jones ◽  
Benjamin Weeks
Keyword(s):  
Randomized Controlled Trial ◽  
Tai Chi ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Well Being ◽  
Office Workers ◽  
Learning Stage ◽  
Enrolment Rate ◽  
Randomized Controlled ◽  
Tai Chi Exercise

Tai Chi, combined with Thera-band (TCTB) exercise may be associated with an improvement in health where it increases physical fitness, improves psychological well-being, and decreases pain. This paper aimed to determine the feasibility of TCTB exercise in older sedentary office workers. Forty office workers aged over 55 years participated in a pilot randomized controlled trial (i.e., 12-week TCTB exercise or Tai Chi exercise only). Feasibility of the TCTB exercise approach was ascertained through the recruitment and enrolment rate, acceptability of the study intervention by participants including retention and adherence rates, participants’ learning process, the appropriateness of data collection as well as the participants’ evaluation of the intervention. Recruitment took longer than planned, with a low recruitment rate of 2.0% (42/2020), but a high enrolment rate of 95.2% (40/42). Thirty-one participants (i.e., 77.5%) completed the intervention. Of those who completed the trial, the overall average attendance was reported as 85.2%; 84.7% in the TCTB group and 85.7% in the Tai Chi only group. A total of 58.3% of participants (n = 21) could independently practice the TCTB or Tai Chi exercise motions at the end of the learning stage. There were no missing data except for the nine participants who withdrew during the intervention. No adverse events or effects were reported, and all participants were satisfied with the 12-week exercise intervention. Results support the feasibility of a large-scale randomized controlled trial to explore the efficacy of a TCTB program for improving health in older sedentary office workers.

scholarly journals Tai Chi exercise for psychological well-being among adults with cardiovascular disease: A systematic review and meta-analysis

2020 ◽  
Vol 19 (7) ◽  
pp. 580-591 ◽  
Author(s):  
Ruth E Taylor-Piliae ◽  
Brooke A Finley
Keyword(s):  
Cardiovascular Disease ◽  
Psychological Distress ◽  
Tai Chi ◽  
Meta Analysis ◽  
Well Being ◽  
Psychological Well Being ◽  
Random Effects Models ◽  
Rigorous Study ◽  
Tai Chi Exercise ◽  
Study Designs

Background: Regular exercise is beneficial for adults with cardiovascular disease to improve psychological well-being. Tai Chi is a mind–body exercise thought to promote psychological well-being. Aim: Examine the efficacy of Tai Chi in improving psychological well-being among persons with cardiovascular disease. Methods: An electronic literature search of 10 databases (AMED, CINAHL, Embase, OpenGrey, PsycARTICLES, PsycINFO, PubMed, Scopus, SPORTDiscus, and Web of Science) was conducted. Clinical trials that examined one or more aspect of psychological well-being, incorporated a Tai Chi intervention among cardiovascular disease participants, and were published in English or German languages were included. Comprehensive Meta-Analysis version 2.0 software (Biostat, Inc.) was used to calculate the effect sizes (i.e. Hedges’ g) and the 95% confidence intervals using random effects models. Results: A total of 15 studies met the inclusion criteria, enrolling 1853 participants (mean age = 66 years old, 44% women). Outcomes included: quality of life (QOL), stress, anxiety, depression, and psychological distress. When Tai Chi was compared with controls, significantly better general QOL (Hedges’ g 0.96; p=0.02, I2=94.99%), mental health QOL (Hedges’ g=0.20; p=0.01, I2=15.93) and physical health QOL (Hedges’ g=0.40; p=0.00, I2=0%); with less depression (Hedges’ g=0.69; p=0.00, I2=86.64%) and psychological distress (Hedges’ g=0.58; p=0.00, I2=0%) were found. Conclusions: Few Tai Chi studies have been conducted during the past decade examining psychological well-being among older adults with cardiovascular disease. Further research is needed with more rigorous study designs, adequate Tai Chi exercise doses, and carefully chosen outcome measures that assess the mechanisms as well as the effects of Tai Chi.

scholarly journals Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Sara Zocher ◽  
Rupert W. Overall ◽  
Mathias Lesche ◽  
Andreas Dahl ◽  
Gerd Kempermann
Keyword(s):  
Dna Methylation ◽  
Brain Function ◽  
Environmental Enrichment ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Aged Mouse ◽  
Lifestyle Interventions ◽  
Epigenetic Changes ◽  
Aging Effects ◽  
Age Related

AbstractThe decline of brain function during aging is associated with epigenetic changes, including DNA methylation. Lifestyle interventions can improve brain function during aging, but their influence on age-related epigenetic changes is unknown. Using genome-wide DNA methylation sequencing, we here show that experiencing a stimulus-rich environment counteracts age-related DNA methylation changes in the hippocampal dentate gyrus of mice. Specifically, environmental enrichment prevented the aging-induced CpG hypomethylation at target sites of the methyl-CpG-binding protein Mecp2, which is critical to neuronal function. The genes at which environmental enrichment counteracted aging effects have described roles in neuronal plasticity, neuronal cell communication and adult hippocampal neurogenesis and are dysregulated with age-related cognitive decline in the human brain. Our results highlight the stimulating effects of environmental enrichment on hippocampal plasticity at the level of DNA methylation and give molecular insights into the specific aspects of brain aging that can be counteracted by lifestyle interventions.

scholarly journals DNA methylation predicts age and provides insight into exceptional longevity of bats

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Gerald S. Wilkinson ◽  
Danielle M. Adams ◽  
Amin Haghani ◽  
Ake T. Lu ◽  
Joseph Zoller ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Immune Response ◽  
Chronological Age ◽  
Methylation Change ◽  
Epigenetic Changes ◽  
Promoter Regions ◽  
Age Related ◽  
Cancer Suppression ◽  
Insight Into ◽  
Species Longevity

AbstractExceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. We demonstrate that DNAm accurately predicts chronological age. Across species, longevity is negatively associated with the rate of DNAm change at age-associated sites. Furthermore, analysis of several bat genomes reveals that hypermethylated age- and longevity-associated sites are disproportionately located in promoter regions of key transcription factors (TF) and enriched for histone and chromatin features associated with transcriptional regulation. Predicted TF binding site motifs and enrichment analyses indicate that age-related methylation change is influenced by developmental processes, while longevity-related DNAm change is associated with innate immunity or tumorigenesis genes, suggesting that bat longevity results from augmented immune response and cancer suppression.

Abstract WP509: Stroke Survivors’ Perceptions of Well-Being and Recovery After a Tai Chi Exercise Intervention

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Ruth E Taylor-Piliae ◽  
Melinda A Zeimantz ◽  
Anne G Rosenfeld
Keyword(s):  
Tai Chi ◽  
Exercise Intervention ◽  
Well Being ◽  
Stroke Survivors ◽  
Tai Chi Exercise

scholarly journals The Influence of the Duration of Breastfeeding on the Infant’s Metabolic Epigenome

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1408 ◽  
Author(s):  
Sara Pauwels ◽  
Lin Symons ◽  
Eva-Lynn Vanautgaerden ◽  
Manosij Ghosh ◽  
Radu Corneliu Duca ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Maternal Nutrition ◽  
Positive Association ◽  
Postnatal Period ◽  
Infant Growth ◽  
Breastfeeding Duration ◽  
Epigenetic Changes ◽  
Significant Difference ◽  
Underlying Mechanisms ◽  
Duration Of Breastfeeding

Nutrition in the postnatal period is associated with metabolic programming. One of the presumed underlying mechanisms involves epigenetic modifications (e.g., DNA methylation). Breastfeeding has an unknown impact on DNA methylation at a young age. Within the Maternal Nutrition and Offspring’s Epigenome (MANOE) study, we assessed the effect of breastfeeding duration on infant growth and buccal methylation in obesity-related genes (n = 101). A significant difference was found between infant growth and buccal RXRA and LEP methylation at 12 months of breastfeeding. For RXRA CpG2 methylation, a positive association was found with duration of breastfeeding (slope = 0.217; 95% confidence interval (CI) 1.03, 0.330; p < 0.001). For RXRA CpG3 and CpG, mean methylation levels were significantly lower when children were breastfed for 4–6 months compared to non-breastfed children (only CpG3), and those breastfed for 7–9 months, 10–12 months, or 1–3 months. On the other hand, higher LEP CpG3 methylation was observed when mothers breastfed 7–9 months (6.1%) as compared to breastfeeding for 1–3 months (4.3%; p = 0.007) and 10–12 months (4.6%; p = 0.04). In addition, we observed that infant weight was significantly lower when children were breastfed for 10–12 months. Breastfeeding duration was associated with epigenetic variations in RXRA and LEP at 12 months and with infant biometry/growth. Our results support the hypothesis that breastfeeding could induce epigenetic changes in infants.

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