scholarly journals Fabrication of Highly Rough Ag Nanobud Substrates and Surface-Enhanced Raman Scattering ofλ-DNA Molecules

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Chuyun Deng ◽  
Wanyun Ma ◽  
Jia-Lin Sun
Keyword(s):  
Raman Scattering ◽  
Single Molecule ◽  
Surface Enhanced Raman Scattering ◽  
Silver Nanowire ◽  
Metal Nanostructures ◽  
Dna Molecules ◽  
Sers Substrates ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Raman scattering signals can be enhanced by several orders of magnitude on surface-enhanced Raman scattering (SERS) substrates made from noble metal nanostructures. Some SERS substrates are even able to detect single-molecule Raman signals. A novel silver nanobud (AgNB) substrate with superior SERS activity was fabricated with a solid-state ionics method. The AgNB substrate was formed by tightly collocated unidirectional 100 nm size silver buds, presenting a highly rough surface topography. Distinct SERS signals of singleλ-DNA molecules in water were detected on AgNB substrates. AgNB substrates were compared with disordered silver nanowire (AgNW) substrates manufactured by the same method through the SERS detection ofλ-DNA solutions. This original AgNB substrate provides a reliable approach towards trace analysis of biomacromolecules and promotes the utilization of the SERS technique in biomedical research.

scholarly journals Large-Scale Fabrication of Ultrasensitive and Uniform Surface-Enhanced Raman Scattering Substrates for the Trace Detection of Pesticides

Nanomaterials ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 520 ◽  
Author(s):  
Jia Zhu ◽  
Guanzhou Lin ◽  
Meizhang Wu ◽  
Zhuojie Chen ◽  
Peimin Lu ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Large Scale ◽  
Capillary Flow ◽  
Surface Enhanced Raman Scattering ◽  
Ag Nps ◽  
Uniform Size ◽  
Sers Substrates ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Technology transfer from laboratory into practical application needs to meet the demands of economic viability and operational simplicity. This paper reports a simple and convenient strategy to fabricate large-scale and ultrasensitive surface-enhanced Raman scattering (SERS) substrates. In this strategy, no toxic chemicals or sophisticated instruments are required to fabricate the SERS substrates. On one hand, Ag nanoparticles (NPs) with relatively uniform size were synthesized using the modified Tollens method, which employs an ultra-low concentration of Ag+ and excessive amounts of glucose as a reducing agent. On the other hand, when a drop of the colloidal Ag NPs dries on a horizontal solid surface, the droplet becomes ropy, turns into a layered structure under gravity, and hardens. During evaporation, capillary flow was burdened by viscidity resistance from the ropy glucose solution. Thus, the coffee-ring effect is eliminated, leading to a uniform deposition of Ag NPs. With this method, flat Ag NPs-based SERS active films were formed in array-well plates defined by hole-shaped polydimethylsiloxane (PDMS) structures bonded on glass substrates, which were made for convenient detection. The strong SERS activity of these substrates allowed us to reach detection limits down to 10−14 M of Rhodamine 6 G and 10−10 M of thiram (pesticide).

scholarly journals Multiplexed Liquid Biopsy and Tumor Imaging Using Surface-Enhanced Raman Scattering

Biosensors ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 449
Author(s):  
Francesco Dell’Olio
Keyword(s):  
Raman Scattering ◽  
Single Molecule ◽  
Liquid Biopsy ◽  
Tumor Imaging ◽  
Surface Enhanced Raman Scattering ◽  
Detection Sensitivity ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

The recent improvements in diagnosis enabled by advances in liquid biopsy and oncological imaging significantly better cancer care. Both these complementary approaches, which are used for early tumor detection, characterization, and monitoring, can benefit from applying techniques based on surface-enhanced Raman scattering (SERS). With a detection sensitivity at the single-molecule level, SERS spectroscopy is widely used in cell and molecular biology, and its capability for the in vitro detection of several types of cancer biomarkers is well established. In the last few years, several intriguing SERS applications have emerged, including in vivo imaging for tumor targeting and the monitoring of drug release. In this paper, selected recent developments and trends in SERS applications in the field of liquid biopsy and tumor imaging are critically reviewed, with a special emphasis on results that demonstrate the clinical utility of SERS.

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