scholarly journals Design and Synthesis of Crown Ether Functionalized Imidazoles as a New type of Building Blocks

2012 ◽  
Vol 9 (4) ◽  
pp. 2128-2133
Author(s):  
Sheng-Hui Li ◽  
Jing Xia
Keyword(s):  
Crown Ether ◽  
Elemental Analysis ◽  
Building Blocks ◽  
Efficient Synthesis ◽  
Esi Ms ◽  
Design And Synthesis ◽  
H Nmr ◽  
New Type

A simple, convenient and efficient synthesis for a series of crown ether functionalized imidazoles from benzo-15-crown-5 (B15C5), benzo-18-crown-6 (B18C6), imidazole (Im), 2-methylimidazole (mIm), benzimidazole (bIm) and 2-methyl benzimidazole (mbIm) is reported. All these compounds obtained were characterized by IR,1H NMR, ESI-MS and elemental analysis.

Synthesis and Characterization of Novel Roflumilast Analogues

2013 ◽  
Vol 781-784 ◽  
pp. 1190-1193
Author(s):  
Yu Hui Si ◽  
Gang Chun Sun ◽  
Ge Song ◽  
Wen Peng Mai ◽  
Zhi Cheng Li
Keyword(s):  
Crown Ether ◽  
Elemental Analysis ◽  
Synthesis And Characterization ◽  
Esi Ms ◽  
H Nmr

A series of new roflumilast analogues with Crown ether structures were designed and synthesized. Crown-ether-type benzaldehydes were first prepared from 3,4-dihydroxybenzaldehyde with 1-bromo-3-chloropropane and 1-chloro-2-(2-chloroethoxy) ethane respectively, then after oxidation, acylation and amidation as the last step with 3,5-dichloropyridin-4-amine the roflumilast analogues were obtained. These compounds were characterised by1H NMR, IR, ESI-MS and elemental analysis.

Design and Synthesis of Polypyrazolyl Compounds as a New Type of Versatile Building Blocks†

2006 ◽  
Vol 24 (9) ◽  
pp. 1225-1229 ◽  
Author(s):  
Sheng-Hui Li ◽  
Hai-Ping Huang ◽  
Shu-Yan Yu ◽  
Xian-Ping Li
Keyword(s):  
Building Blocks ◽  
Design And Synthesis ◽  
New Type

scholarly journals Synthesis of 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles

2010 ◽  
Vol 6 ◽  
pp. 966-972 ◽  
Author(s):  
Yang Li ◽  
Wentao Gao
Keyword(s):  
Elemental Analysis ◽  
Condensation Reaction ◽  
Sodium Ethoxide ◽  
Efficient Synthesis ◽  
H Nmr

A simple and efficient synthesis of novel 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles, utilizing sodium ethoxide as a catalyst via a Friedländer condensation reaction between 3-acetyl-9-ethyl-9H-carbazole or 3,6-diacetyl-9-ethyl-9H-carbazole and β-aminoaldehydes or β-aminoketones is described. All of the title compounds were obtained in good yields of 52–72% and their structures were confirmed by IR, 1H NMR, MS, and elemental analysis.

Synthesis, Characterization and Photophysicochemical Properties of Zinc(Ii) Phthalocyanine With New Benzenesulfonamide Derivative Substituents

2021 ◽  
Author(s):  
Gülen Atiye Öncül ◽  
Ömer Faruk Öztürk ◽  
Mehmet Pişkin
Keyword(s):  
Elemental Analysis ◽  
Mass Spectra ◽  
Spectroscopic Methods ◽  
H Nmr ◽  
Maldi Tof Mass Spectra ◽  
New Type ◽  
Ft Ir ◽  
Photochemical Properties ◽  
Photocatalytic Applications ◽  
C Nmr

Abstract Novel (E)-4-((5-bromo-2-hydroxy-3-methoxybenzylidene)amino)-N-(pyridin-2-yl)benzenesulfonamide 1, (E)-4-((5-bromo-2-(3,4-dicyanophenoxy)-3-methoxybenzylidene)amino)-N-(pyridin-2-yl)benzene sulfonamide 2 and 2(3),9(10),16(17),23(24)-tetra-[(E)-4-((5-bromo-3-methoxy-2-(λ1-oxidanyl)benzyl idene)amino)-N-(pyridine-2-yl)benzenesulfonamide]phthalocyaninato zinc(II) phthalocyanine 3 were synthesized. Their (1-3) structures were illuminated with spectroscopic methods such as FT-IR, 1H NMR,13C NMR, UV–vis, MALDI-TOF mass spectra and also elemental analysis. The spectroscopic, photophysical and photochemical properties of the zinc(II) phthalocyanine 3 were investigated in dimethyl sulfoxide and its effects on the above mentioned properties were reported as a result of containing new type benzenesulfonamide derivatives as substituents. In addition, its above-mentioned properties were reported by comparing different species with those of their substituted and/or unsubstituted counterparts. The zinc(II) phthalocyanine 3 has photosensitizing abilities suitable and sufficient especially for photocatalytic applications.

INTERACTIVE IIR SC MULTIRATE COMPILER APPLIED TO MULTISTAGE DECIMATOR DESIGN

2007 ◽  
Vol 16 (04) ◽  
pp. 517-525 ◽  
Author(s):  
PHILLIP N. CHEONG ◽  
R. P. MARTINS
Keyword(s):  
Building Block ◽  
Building Blocks ◽  
Automated Design ◽  
Operational Amplifiers ◽  
Efficient Synthesis ◽  
Design And Synthesis ◽  
Interactive Architecture ◽  
Specific Stage

This paper proposes an interactive architecture compiler for SC multirate circuits that allows the automated design from the frequency specifications to the building block implementation, applied to the design and synthesis of multistage SC decimators. The compiler provides a library of different topologies that comprises a few independent multi-decimation building blocks. New building blocks defined by the users are also available for the design of a specific stage. A design example of a 7th order SC decimator illustrates the efficient synthesis of the corresponding resulting circuits that achieve the required anti-aliasing amplitude responses with respect to the speed requirements of the operational amplifiers and also the minimum capacitance spread and total capacitor area.

Synthesis and Transport of K+ Ions of Mono-Substituted Calix[4]arenes

2012 ◽  
Vol 441 ◽  
pp. 392-397
Author(s):  
Xu Chen Tao ◽  
Lei Li
Keyword(s):  
Elemental Analysis ◽  
Esi Ms ◽  
Tert Butyl ◽  
H Nmr ◽  
Potential Possibility ◽  
Upper Rim

To yield a series of upper rim mono-substituted compounds with potential possibility to polymerize with other monomers, the p-tert-butyl groups were removed from the p-tert-butylcalix[arene, and acrylamido groups were incorporated. These target products were characterized by IR,1H NMR, elemental analysis and ESI-MS. The transport of K+ion was studied. Results indicate the substituting groups with the ability to withdraw electron are benefit to the net transport.

Effects of Saccharomyces Cerevisiae Strains on Chemical Profiles of Cabernet Sauvignon Wines: Based on the Combined Results of 1H NMR, HS-SPME/GC-MS and HPLC-DAD-ESI-MS/MS

2018 ◽  
Vol 18 (2) ◽  
pp. 115-131
Author(s):  
Liang Heng-Yu ◽  
Su Ning ◽  
Guo Kun ◽  
Wang Yuan ◽  
Yang De-Yu
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Principal Component ◽  
Grape Juice ◽  
Pilot Scale ◽  
Ethyl Esters ◽  
Cabernet Sauvignon ◽  
Esi Ms ◽  
H Nmr ◽  
Chemical Profiles ◽  
Indigenous Yeasts

Five Saccharomyces cerevisiae strains (Chinese indigenous yeasts SC5, WC5, SC8, CC17 and commercial starter F15) were inoculated into Cabernet sauvignon grape must and fermented at pilot scale. For the first time, combination of 1H NMR, HS-SPME/GC-MS and HPLC-DAD-ESI-MS/MS metabonomic profiling techniques was performed to analyze the global chemical fingerprints of sampled wines at the end of alcoholic and malolactic fermentation respectively, then 13 non-volatile flavor compounds, 52 volatile organic aromas and 43 polyphenolic molecules were identified and determined correspondently. All principal component analysis (PCA) of two fermentation stages based on the analytical results of 1H NMR, HS-SPME/GC-MS and HPLC-DAD-ESI-MS/MS divided these strains into three clusters: (1) SC5 and SC8, (2) WC5 and F15 and (3) CC17. The wine fermented by indigenous yeast, CC17, showed a very unique chemical profile, such as low pH and high color intensity, reduced amino acids (including proline) and the lowest total higher alcohols levels, most of the fixed acids, glycerol, ethyl esters and anthocyanins concentrations. The statistical results indicate that CC17 strain possesses very special anabolism and catabolism abilities on such substances in grape juice and has potentiality to produce characteristic wines with high qualities.

New type of addition to 5-substituted 4-arylidene-2-(4,5-dihydrofurfurylidene)-N,N-dimethyliminium bisperchlorates. Preparation of 4-substituted 5-(N,N-dimethylamino)-2-furancarbaldehydes

1986 ◽  
Vol 51 (3) ◽  
pp. 573-580 ◽  
Author(s):  
Tibor Gracza ◽  
Zdeněk Arnold ◽  
Jaroslav Kováč
Keyword(s):  
Nmr Spectra ◽  
Addition Reaction ◽  
H Nmr ◽  
Organic Bases ◽  
New Type

4-Arilidene-5-(N,N-dimethyliminium)-2-(4,5-dihydrofurfurylidene)-N,N-dimethyliminium bisperchlorate I undergoes a 1,4-addition reaction with organic bases under re-formation of the furan nucleus; this behaviour has been utilized in the preparation of new 4-substituted 5-(N,N-dimethylamino)-2-furancarbaldehydes II, III. The structure of the prepared compounds has been confirmed by 13C and 1H NMR spectra.

Synthesis and Antituberculotic Activity of Some Substituted 3-Arylamino-5-cyano-2-pyrazinecarboxamides

1995 ◽  
Vol 60 (7) ◽  
pp. 1236-1241 ◽  
Author(s):  
Martin Doležal ◽  
Jiří Hartl ◽  
Antonín Lyčka ◽  
Vladimír Buchta ◽  
Želmíra Odlerová
Keyword(s):  
Nucleophilic Substitution ◽  
Elemental Analysis ◽  
Nmr Spectra ◽  
Substituted Anilines ◽  
H Nmr

Nucleophilic substitution of 3-chloro-5-cyano-2-pyrazinecarboxamide by substituted anilines afforded substituted 3-arylamino-5-cyano-2-pyrazinecarboxamides I-X. The structures of compounds were confirmed by elemental analysis, UV, IR and 1H NMR spectra. The assessment of in vitro antimycotic and antimycobacterial activities of the compounds was carried out. The highest antituberculotic activity against M. tuberculosis in this series was shown by 3-anilino- 5-cyano-2-pyrazinecarboxamide (I), whose efficacy was the same as that of pyrazinecarboxamide.

scholarly journals 1,3-Diketone Calix[4]arene Derivatives—A New Type of Versatile Ligands for Metal Complexes and Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1214
Author(s):  
Sergey N. Podyachev ◽  
Rustem R. Zairov ◽  
Asiya R. Mustafina
Keyword(s):  
Structural Diversity ◽  
Building Blocks ◽  
Structural Features ◽  
Structure Property ◽  
One Pot ◽  
Arene Ligands ◽  
Structure Property Relationships ◽  
New Type ◽  
Synthetic Routes ◽  
Magnetic Resonance Imaging Mri

The present review is aimed at highlighting outlooks for cyclophanic 1,3-diketones as a new type of versatile ligands and building blocks of the nanomaterial for sensing and bioimaging. Thus, the main synthetic routes for achieving the structural diversity of cyclophanic 1,3-diketones are discussed. The structural diversity is demonstrated by variation of both cyclophanic backbones (calix[4]arene, calix[4]resorcinarene and thiacalix[4]arene) and embedding of different substituents onto lower or upper macrocyclic rims. The structural features of the cyclophanic 1,3-diketones are correlated with their ability to form lanthanide complexes exhibiting both lanthanide-centered luminescence and magnetic relaxivity parameters convenient for contrast effect in magnetic resonance imaging (MRI). The revealed structure–property relationships and the applicability of facile one-pot transformation of the complexes to hydrophilic nanoparticles demonstrates the advantages of 1,3-diketone calix[4]arene ligands and their complexes in developing of nanomaterials for sensing and bioimaging.

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