scholarly journals Antimicrobial Activity of Essential Oils againstStreptococcus mutansand their Antiproliferative Effects

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Lívia Câmara de Carvalho Galvão ◽  
Vivian Fernandes Furletti ◽  
Salete Meyre Fernandes Bersan ◽  
Marcos Guilherme da Cunha ◽  
Ana Lúcia Tasca Góis Ruiz ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Tumor Cell ◽  
Essential Oils ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Human Tumor ◽  
Gas Chromatography Mass Spectrometry ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

This study aimed to evaluate the activity of essential oils (EOs) againstStreptococcus mutansbiofilm by chemically characterizing their fractions responsible for biological and antiproliferative activity. Twenty EO were obtained by hydrodistillation and submitted to the antimicrobial assay (minimum inhibitory (MIC) and bactericidal (MBC) concentrations) againstS. mutansUA159. Thin-layer chromatography and gas chromatography/mass spectrometry were used for phytochemical analyses. EOs were selected according to predetermined criteria and fractionated using dry column; the resulting fractions were assessed by MIC and MBC, selected as active fractions, and evaluated againstS. mutansbiofilm. Biofilms formed were examined using scanning electron microscopy. Selected EOs and their selected active fractions were evaluated for their antiproliferative activity against keratinocytes and seven human tumor cell lines. MIC and MBC values obtained for EO and their active fractions showed strong antimicrobial activity. Chemical analyses mainly showed the presence of terpenes. The selected active fractions inhibitedS. mutansbiofilm formation (P<0.05) did not affect glycolytic pH drop and were inactive against keratinocytes, normal cell line. In conclusion, EO showed activity at low concentrations, and their selected active fractions were also effective against biofilm formed byS. mutansand human tumor cell lines.

scholarly journals Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts ofLaurus nobilisL. from Different Origins

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Maria Inês Dias ◽  
João C. M. Barreira ◽  
Ricardo C. Calhelha ◽  
Maria-João R. P. Queiroz ◽  
M. Beatriz P. P. Oliveira ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Aqueous Extracts ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Methanolic Extracts

Natural matrices are important sources of new antitumor and antimicrobial compounds. Species such asLaurus nobilisL. (laurel) might be used for this purpose, considering its medicinal properties. Herein,in vitroactivity against human tumor cell lines, bacteria, and fungi was evaluated in enriched phenolic extracts. Specifically, methanol and aqueous extracts of wild and cultivated samples ofL. nobiliswere compared considering different phenolic groups. Principal component analysis (PCA) was applied to understand how each extract acts differentially against specific bacteria, fungi, and selected human tumor cell lines. In general, the extract type induced the highest differences in bioactivity of laurel samples. However, from the PCA biplot, it became clear that wild laurel samples were higher inhibitors of tumor cell lines (HeLa, MCF7, NCI-H460, and HCT15). HepG2 had the same response to laurel from wild and cultivated origin. It was also observed that methanolic extracts tended to have higher antimicrobial activity, except againstA. niger, A. fumigatus, andP. verrucosum. The differences in bioactivity might be related to the higher phenolic contents in methanolic extracts. These results allow selecting the extract type and/or origin with highest antibacterial, antifungal, and antitumor activity.

Antiproliferative Activity of Artemisia asiatica Extract and Its Constituents on Human Tumor Cell Lines

Planta Medica ◽  
2014 ◽  
Vol 80 (18) ◽  
pp. 1692-1697 ◽  
Author(s):  
Zsuzsanna Hajdú ◽  
Judit Hohmann ◽  
Peter Forgo ◽  
Imre Máthé ◽  
Judit Molnár ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Artemisia Asiatica

Antiproliferative Activity of Korean Wild Vegetables on Different Human Tumor Cell Lines

2009 ◽  
Vol 64 (4) ◽  
pp. 257-263 ◽  
Author(s):  
Buk-Gu Heo ◽  
Sang-Uk Chon ◽  
Yun-Jum Park ◽  
Jong-Hyang Bae ◽  
Su-Min Park ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Wild Vegetables

Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines

2008 ◽  
Vol 16 (2) ◽  
pp. 862-868 ◽  
Author(s):  
Julio Benites ◽  
Jaime A. Valderrama ◽  
Felipe Rivera ◽  
Leonel Rojo ◽  
Nair Campos ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

Antiproliferative activity against human tumor cell lines and toxicity test on Mediterranean dietary plants

2008 ◽  
Vol 46 (10) ◽  
pp. 3325-3332 ◽  
Author(s):  
F. Conforti ◽  
G. Ioele ◽  
G.A. Statti ◽  
M. Marrelli ◽  
G. Ragno ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Toxicity Test ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Dietary Plants
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