scholarly journals Silicea Gastrointestinal Gel Improves Gastrointestinal Disorders: A Non-Controlled, Pilot Clinical Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
B. Uehleke ◽  
M. Ortiz ◽  
R. Stange
Keyword(s):  
Symptom Score ◽  
Responder Rate ◽  
Gastrointestinal Disorders ◽  
Pivotal Phase ◽  
Abdominal Symptoms ◽  
Pilot Clinical Study ◽  
Upper Abdominal Symptoms ◽  
Sum Scores ◽  
Upper Abdominal ◽  
Upper Abdomen

Aim. To investigate efficacy and tolerability of Silicea Gastrointestinal Gel in patients with gastrointestinal disorders.Methods. Open, prospective pivotal phase IV study with oral Silicea Gastrointestinal Gel over 6 weeks. Symptom score was part 1 of the Nepean Dyspepsia Index: 15 questions addressing intensity, frequency and impact of upper abdominal symptoms. 10 lower abdominal symptoms were asked analogously. A responder showed reduction of score of >50%.Results. 62 of 90 patients were evaluated per protocol. Upper and lower abdomen sum scores decreased already in the first three weeks (P<0.001), which continued the following three weeks (P<0.01). Mean symptom score for upper abdomen decreased from52.2±31.0to33.7±28.7(or by 35.4%; responder rate 37%); for lower from39.6±24.7to22.6±21.7(by 42.9%; responder rate 46%). Subgroups with diarrhea, IBS and GERD presented highest responder rates. 6% of patients reported adverse reactions with probable or possible relationship to the test product.Conclusions. Silicea Gastrointestinal Gel seems suitable beyond infectious acute gastrointestinal disorders. Responses are relevant for chronic functional disorders, but it remains unclear, how much of that might be placebo-effect. Controlled studies are recommended in gastrointestinal syndromes like IBS or GERD.

scholarly journals Prevalence of Upper Abdominal Complaints in Patients Who Have Undergone Partial Gastrectomy

2000 ◽  
Vol 14 (8) ◽  
pp. 681-684 ◽  
Author(s):  
RJLF Loffeld
Keyword(s):  
Symptom Score ◽  
Bile Reflux ◽  
Partial Gastrectomy ◽  
Upper Gastrointestinal Endoscopy ◽  
Billroth Ii ◽  
Billroth I ◽  
Abdominal Symptoms ◽  
Upper Abdominal Symptoms ◽  
Upper Abdominal

Little is known about the long term occurrence and prevalence of upper abdominal complaints after previous partial gastrectomy. Therefore, a retrospective, uncontrolled, cross-sectional, descriptive, clinical, endoscopic study was done. A questionnaire was mailed to patients who had undergone partial gastrectomy and been sent for upper gastrointestinal endoscopy. Eight questions were scored on a five-point Likert scale, and a symptom score was calculated. During the five-year study period, 189 patients (137 men, 52 women) were identified as having had a partial gastrectomy -- 143 (76%) received the Billroth II operation and 46 (24%) received the Billroth I operation. The questionnaire was mailed to 124 patients, of whom 79 (64%) responded. Eighty-eight per cent of patients had undergone surgery more than 15 years earlier. Fifty-nine patients (75%) suffered from upper abdominal symptoms. Regurgitation of food, retrosternal heartburn and bile reflux occurred significantly more often in patients who underwent the Billroth II operation. The mean symptom score of patients who underwent Billroth I resection was significantly lower (4.5 [SD 3.6]) than that of patients who underwent Billroth II resection (7.1 [SD 4.4])(P=0.04). One or more symptoms indicative of dumping were found in 70% of patients who underwent Billroth II resection and in 59% of patients who underwent Billroth I resection (not significant). Many patients who had undergone a partial gastrectomy developed upper abdominal symptoms during long term follow-up that were not specifically linked to dumping.

Prevalence of Unexplained Upper Abdominal Symptoms in Patients with Migraine

Cephalalgia ◽  
2006 ◽  
Vol 26 (5) ◽  
pp. 506-510 ◽  
Author(s):  
T Kurth ◽  
G Holtmann ◽  
J Neufang-Hüber ◽  
G Gerken ◽  
H-C Diener
Keyword(s):  
Confidence Interval ◽  
Odds Ratio ◽  
Blood Donors ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Healthy Controls ◽  
Abdominal Symptoms ◽  
Upper Abdominal Symptoms ◽  
Upper Abdominal ◽  
Disease Questionnaire

Patients with functional gastrointestinal disorders frequently report migraine. We aimed to determine the prevalence of idiopathic upper abdominal symptoms in patients with migraine and compare it with a control population of healthy blood donors. We assessed abdominal symptoms using the Bowel Disease Questionnaire in a series of 488 consecutive blood donors without migraine and 99 patients with migraine. Upper abdominal symptoms were reported by 38% [95% confidence interval (CI) 32, 44] of blood donors compared with 81% (67, 91, P < 0.001) of migraine patients. Of the blood donors, 23% (18, 28) reported frequent dyspepsia compared with 60% (44, 74, P < 0.001) of the migraine patients. Migraine was associated with frequent upper abdominal symptoms (odds ratio 2.7, 95% CI 1.2, 6.1) after adjusting for age, gender, smoking and consumption of analgesics and alcohol. Upper abdominal symptoms are significantly more frequent in patients with migraine compared with healthy controls. The association between migraine and idiopathic upper abdominal symptoms may suggest common pathophysio-logical mechanisms.

Comparison of the effects of omeprazole and famotidine in treatment of upper abdominal symptoms in patients with reflux esophagitis

2009 ◽  
Vol 44 (4) ◽  
pp. 261-270 ◽  
Author(s):  
Hiroaki Kusunoki ◽  
Masayasu Kusaka ◽  
Soichiro Kido ◽  
Ryo Yamauchi ◽  
Yoshinori Fujimura ◽  
...  
Keyword(s):  
Reflux Esophagitis ◽  
Abdominal Symptoms ◽  
Upper Abdominal Symptoms ◽  
Upper Abdominal

Upper abdominal symptoms in patients with Type 1 diabetes: unrelated to impairment in gastric emptying caused by autonomic neuropathy

2008 ◽  
Vol 25 (5) ◽  
pp. 570-577 ◽  
Author(s):  
J. Punkkinen ◽  
M. Färkkilä ◽  
S. Mätzke ◽  
T. Korppi-Tommola ◽  
T. Sane ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gastric Emptying ◽  
Autonomic Neuropathy ◽  
Abdominal Symptoms ◽  
Upper Abdominal Symptoms ◽  
Upper Abdominal

scholarly journals Gastroparesis as a significant gastrointestinal adverse event during intensive chemotherapy for solid cancer

2021 ◽  
Author(s):  
Tomohiro Nakayama ◽  
Koji Haratani ◽  
Takashi Kurosaki ◽  
Kaoru Tanaka ◽  
Kazuhiko Nakagawa
Keyword(s):  
Delayed Gastric Emptying ◽  
Late Onset ◽  
Solid Cancer ◽  
Gastrointestinal Adverse Event ◽  
Abdominal Symptoms ◽  
Solid Malignancies ◽  
Platinum Based Chemotherapy ◽  
Anticancer Treatment ◽  
Upper Abdominal Symptoms ◽  
Upper Abdominal

Abstract Proper management of chemotherapy-related gastrointestinal toxicities is essential to maximize therapeutic outcome for malignancies. Gastroparesis is characterized by delayed gastric emptying without gastrointestinal obstruction. Although it has not been well recognized as a complication of chemotherapy for solid malignancies, we here report a case of gastroparesis apparently due to neurotoxicity of high-intensity taxane- and platinum-based chemotherapy for a solid tumor. The patient experienced late-onset gastric dysmotility as evidenced by an abnormally dilated stomach even after cessation of feeding for several days. The gastroparesis was successfully controlled with a 5-HT4 receptor agonist, resulting in recovery of gastric motility and allowing completion of curative anticancer treatment. Despite its rarity in patients with solid cancers, gastroparesis should be recognized as a potential cause of persistent upper abdominal symptoms during neurotoxic chemotherapy in such individuals, given that a delay in its management may be detrimental to survival outcome.

Clinical significance of upper abdominal symptoms

1985 ◽  
Vol 20 (sup109) ◽  
pp. 19-22 ◽  
Author(s):  
Hermod Petersen ◽  
Ulf Fjøsne ◽  
Terje Johannessen ◽  
Pål Kristensen ◽  
Per Erik Haf-Stad ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Abdominal Symptoms ◽  
Upper Abdominal Symptoms ◽  
Upper Abdominal

A Study of the Efficacy of Proton Pump Inhibitors in Treating Upper Abdominal Symptoms

2011 ◽  
Vol 140 (5) ◽  
pp. S-79
Author(s):  
Tomoari Kamada ◽  
Yoshinori Fujimura ◽  
Kensuke Goto ◽  
Noriaki Manabe ◽  
Hiroshi Imamura ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Abdominal Symptoms ◽  
Upper Abdominal Symptoms ◽  
Upper Abdominal
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