scholarly journals Methodology for Anti-Gene Anti-IGF-I Therapy of Malignant Tumours

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Jerzy Trojan ◽  
Yuexin X. Pan ◽  
Ming X. Wei ◽  
Adama Ly ◽  
Alexander Shevelev ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Triple Helix ◽  
Peripheral Blood Lymphocytes ◽  
Expression Vectors ◽  
Malignant Tumours ◽  
Mhc I ◽  
Primary Glioblastoma ◽  
Common Criteria ◽  
Igf I ◽  
The Common

The aim of this study was to establish the criteria for methodology of cellular “anti-IGF-I” therapy of malignant tumours and particularly for glioblastoma multiforme. The treatment of primary glioblastoma patients using surgery, radiotherapy, and chemotherapy was followed by subcutaneous injection of autologous cancer cells transfected by IGF-I antisense/triple helix expression vectors. The prepared cell “vaccines” should it be in the case of glioblastomas or other tumours, have shown a change of phenotype, the absence of IGF-I protein, and expression of MHC-I and B7. The peripheral blood lymphocytes, PBL cells, removed after each of two successive vaccinations, have demonstrated for all the types of tumour tested an increasing level of CD8+ and CD8+28+ molecules and a switch from CD8+11b+ to CD8+11. All cancer patients were supervised for up to 19 months, the period corresponding to minimum survival of glioblastoma patients. The obtained results have permitted to specify the common criteria for “anti-IGF-I” strategy: characteristics sine qua non of injected “vaccines” (cloned cells IGF-I(−) and MHC-I(+)) and of PBL cells (CD8+ increased level).

scholarly journals Anℋ∞Optimal Robust Pole Placement with Fixed Transparent Controller Structure on the Basis of Nonnegativity of Even Spectral Polynomials

2012 ◽  
Vol 2012 ◽  
pp. 1-25 ◽  
Author(s):  
Andrej Sarjaš ◽  
Rajko Svečko ◽  
Amor Chowdhury
Keyword(s):  
Controller Design ◽  
Polynomial Equation ◽  
Pole Placement ◽  
Robust Controller ◽  
Reference Tracking ◽  
Common Criteria ◽  
Sensitivity Problem ◽  
The Common ◽  
Partial Fraction Decomposition ◽  
Iterative Evolution

This paper presents the synthesis of an optimal robust controller with the use of pole placement technique. The presented method includes solving a polynomial equation on the basis of the chosen fixed characteristic polynomial and introduced parametric solutions with a known parametric structure of the controller. Robustness criteria in an unstructured uncertainty description with metrics of normℋ∞are for a more reliable and effective formulation of objective functions for optimization presented in the form of a spectral polynomial with positivity conditions. The method enables robust low-order controller design by using plant simplification with partial-fraction decomposition, where the simplification remainder is added to the performance weight. The controller structure is assembled of well-known parts such as disturbance rejection, and reference tracking. The approach also allows the possibility of multiobjective optimization of robust criteria, application of mixed sensitivity problem, and other closed-loop limitation criteria, where the common criteria function can be composed from different unrelated criteria. Optimization and controller design are performed with iterative evolution algorithm.

Herbal Medicine Isolation, Phaleria macrocarpa for primary glioblastoma multiforme cells

2008 ◽  
Vol 18 (9) ◽  
pp. 718
Author(s):  
Agung Budi Sutiono ◽  
A. Faried ◽  
M.Z. Arifin ◽  
K. Wiriadisastra ◽  
T. Ohta
Keyword(s):  
Glioblastoma Multiforme ◽  
Herbal Medicine ◽  
Primary Glioblastoma ◽  
Phaleria Macrocarpa

scholarly journals Transmission of murine viruses and mycoplasma in laboratory mouse colonies with respect to housing conditions

1994 ◽  
Vol 28 (2) ◽  
pp. 113-120 ◽  
Author(s):  
Felix R. Homberger ◽  
Peter E. Thomann
Keyword(s):  
Sendai Virus ◽  
Hepatitis Virus ◽  
Laboratory Mouse ◽  
Infectious Agents ◽  
Housing Conditions ◽  
Laboratory Mice ◽  
Mycoplasma Pulmonis ◽  
Common Criteria ◽  
Encephalomyelitis Virus ◽  
The Common

Pathogen-free sentinel mice were placed in 7 animal rooms with different housing conditions and were serologically screened for antibodies to mouse hepatitis virus (MHV), pneumonia virus of mice (PVM), Sendai virus, reovirus 3, Theiler's mouse encephalomyelitis virus (TMEV), ectromelia virus and Mycoplasma pulmonis by enzyme-linked immunosorbent assays, at intervals after introduction. The most commonly detected antibody was against MHV, which was found in mice from 4 rooms, followed by PVM antibody in mice from 3 rooms. Seroconversion to Sendai virus and TMEV was detected in mice from one room each. No seroconversion to any of the antigens was found in 2 rooms. The common criteria of these 2 rooms were that they housed pathogen-free animals from a single source and that the access to the rooms was, purposely or not, restricted to people who had no contact to other mice. The study demonstrated the importance of husbandry and hygienic regimen on the prevalence of infectious agents in laboratory mice.

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