Primary Clear Cell Chondrosarcoma of the Spine: A Case Report of a Rare Entity and a Review of the Literature

Case Reports in Oncological Medicine ◽

10.1155/2012/693137 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Nikolaos A. Paidakakos ◽

Aristides Rovlias ◽

Evaggelos Rokas ◽

Spyridon Theodoropoulos ◽

Patroklos Katafygiotis

Keyword(s):

Thoracic Spine ◽

Clear Cell ◽

Proximal Part ◽

Biological Behavior ◽

Spinal Tumors ◽

Subtotal Resection ◽

Recurrence Rates ◽

Adequate Treatment ◽

Clear Cell Chondrosarcoma ◽

Vertebral Involvement

Chondrosarcoma is the third most common primary malignant bone tumor after osteosarcoma and Ewing’s sarcoma. Clear cell chondrosarcoma is a rare subtype variant of chondrosarcoma, most commonly encountered in the proximal part of the femur or humerus. Vertebral involvement is exceedingly rare and shows a predilection for the thoracic spine. We report the case of a woman with clear cell chondrosarcoma of the thoracic spine, which has been surgically excised, and review the pertinent literature (PubMed). Although it has a reasonably benign biological behavior, clear cell chondrosarcoma needs to be treated as a malignancy. The best treatment for spinal chondrosarcoma is surgery. It should be promptly and adequately resected. Gross-total resection should be the ultimate surgical goal. Radiation therapy should also be considered, especially in the case of subtotal resection or inoperable lesions. In conclusion, it is important to keep in mind this entity in the differential diagnosis of spinal tumors, in order to optimize treatment planning. With adequate treatment, local recurrence rates as low as 20% can be achieved.

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P.107 Primary clear cell chondrosarcoma of the thoracic spine

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2016.208 ◽

2016 ◽

Vol 43 (S2) ◽

pp. S45-S45

Author(s):

S Mcgregor ◽

M Kurdi ◽

R Hammond ◽

F Siddiqi ◽

B Wehrli

Keyword(s):

Radiation Therapy ◽

Thoracic Spine ◽

Clear Cell ◽

Stable Condition ◽

Giant Cells ◽

En Bloc Resection ◽

Low Grade ◽

En Bloc ◽

Clear Cell Chondrosarcoma ◽

Bloc Spondylectomy

Background: Clear cell chondrosarcoma (CCC) is a rare, low-grade, subtype of chondrosarcoma. It arises most commonly in the epiphyses of the certain longbones. Spinal involvement is extremely rare, but when present it most frequently involves the thoracic spine. Complete surgical resection is the best curative treatment, with radiation therapy being a consideration for inoperable tumours. Methods: We report a case of a 70-year-old gentleman with CCC of the T7-8 thoracic spine. Gross en-bloc spondylectomy of the T6-8 vertebral bodies with expandable cage reconstruction and T3-11 instrumented fusion were performed. Results: Histological examination revealed a cellular neoplasm composed of well-defined, round to oval cells with abundant clear cytoplasm embedded in a loose cartilaginous matrix with large numbers of admixed osteoclast-type giant cells and scattered bone trabeculae between the lesional cells. The patient experienced significant improvement in neurological function and was discharged from hospital in stable condition seven days after surgery. Conclusions: CCC is a rare variant of chondrosarcoma that rarely involves the osseous spine. In this location, treatment may be challenging given the presence of spinal cord and nerve roots. Given the lack of effective chemotherapy and radiation therapy for CCC, en-bloc resection of CCC involving the spine should be considered.

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Primary Clear Cell Chondrosarcoma of Thoracic Spine

International Journal of Surgical Pathology ◽

10.1177/1066896916666317 ◽

2016 ◽

Vol 25 (2) ◽

pp. 181-184 ◽

Cited By ~ 5

Author(s):

Maher Kurdi ◽

Stuart McGregor ◽

Robert Hammond ◽

Fawaz Siddiqi ◽

Bret Wehrli

Keyword(s):

Thoracic Spine ◽

Clear Cell ◽

Clear Cell Chondrosarcoma

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Bifocal clear cell chondrosarcoma of femoral head.

American Journal of Roentgenology ◽

10.2214/ajr.170.3.9490982 ◽

1998 ◽

Vol 170 (3) ◽

pp. 802-803 ◽

Cited By ~ 3

Author(s):

G de Pinieux ◽

P Anract ◽

E Pessis

Keyword(s):

Femoral Head ◽

Clear Cell ◽

Clear Cell Chondrosarcoma

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RADT-37. THE IMPACT OF POSTOPERATIVE RADIATION THERAPY (PORT) AND EXTENT OF SURGERY ON CLINICAL OUTCOMES OF ATYPICAL MENINGIOMA (AM): A META-ANALYSIS

Neuro-Oncology ◽

10.1093/neuonc/noaa215.790 ◽

2020 ◽

Vol 22 (Supplement_2) ◽

pp. ii189-ii189

Author(s):

Philip Haddad ◽

Furqan Akhtar ◽

Kevin Gallagher

Keyword(s):

Clinical Outcomes ◽

Comparative Studies ◽

English Language ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Subtotal Resection ◽

Recurrence Rates ◽

Postoperative Radiation Therapy ◽

Extent Of Surgery ◽

The Impact

Abstract BACKGROUND Although meningiomas are among the most prevalent types of brain tumors, AMs account for around 4% of all meningiomas. AMs tend to be more aggressive with relatively higher rates of recurrence and mortality. Gross total resection (GTR) has been the standard of care when possible. However, GTR itself is not always enough to prevent the recurrence of AMs. The role of PORT remains controversial in AM as the comparative studies to support its use have provided conflicting RESULTS: The purpose of this meta-analysis is to evaluate the impact of PORT on clinical outcomes according to the extent of resection in AMs. METHODS A review of the medical literature was conducted using online databases. Inclusion criteria consisted of AM diagnosis, English language, Simpson graded resections, and comparative studies reporting recurrence rates (RcR), Progression-Free Survival (PFS), and Overall Survival (OS) with hazard ratios (HR) or Kaplan-Meier curves. A meta-analysis was conducted using an inverse variance method with a random-effects model. RESULTS Twenty-two comparative studies with a total of 5,129 patients were included and analyzed. When GTR was attained, PORT was associated with improved RcR (HR =0.72, 95%CI:0.59-0.86) and PFS (HR=0.77, 95%CI:0.65-0.90), but not OS (HR=0.93, 95%CI:0.83-1.04). When subtotal resection (STR) was attained, PORT was associated with improved PFS (HR=0.35, 95%CI:0.26-0.48) as well as OS (HR=0.70, 95%CI:0.54-0.89). The extent of surgery also impacted AM outcomes as GTR demonstrated superior PFS (HR=0.45, 95%CI:0.31-0.65) and OS (HR=0.30, 95%CI:0.13-0.72). CONCLUSIONS This is the first meta-analysis to show that PORT is associated with PFS benefit in AMs with GTR and STR. Moreover, PORT significantly improved OS of AMs that underwent STR but had no impact on OS when GTR was achieved. In the absence of randomized clinical trials, this meta-analysis represents the most compelling data supporting the use of PORT in this patient population.

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Fine needle aspiration biopsy diagnosis of primary clear cell chondrosarcoma: A case report

Diagnostic Cytopathology ◽

10.1002/dc.23808 ◽

2017 ◽

Vol 46 (2) ◽

pp. 165-169 ◽

Cited By ~ 4

Author(s):

Kelsey E. McHugh ◽

Cynthia L. Emory ◽

Graham E. Parks ◽

Scott E. Kilpatrick

Keyword(s):

Case Report ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Biopsy ◽

Clear Cell ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Clear Cell Chondrosarcoma ◽

Fine Needle ◽

Biopsy Diagnosis ◽

Needle Aspiration Biopsy

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Monostotic fibrous dysplasia of the thoracic spine: clinopathological description and follow up

Journal of Neurosurgery Spine ◽

10.3171/spi.2004.100.4.0378 ◽

2004 ◽

Vol 100 (4) ◽

pp. 378-381 ◽

Cited By ~ 3

Author(s):

Mehmet Arazi ◽

Onder Guney ◽

Mustafa Ozdemir ◽

Omer Uluoglu ◽

Nuket Uzum

Keyword(s):

Fibrous Dysplasia ◽

Thoracic Spine ◽

Histopathological Examination ◽

En Bloc Resection ◽

Spinal Tumors ◽

En Bloc ◽

Content Type ◽

Thoracic Spinal ◽

Fine Print

✓ The authors report the case of a 53-year-old woman with monostotic fibrous dysplasia of the thoracic spine. The patient presented with a 1-month history of pain in the thoracic spinal region. En bloc resection of the lesion was successfully performed via a transthoracic approach, and a histopathological examination confirmed the diagnosis of fibrous dysplasia. At 24-month follow-up examination, pain and vertebral instability were absent. The findings in this case illustrate that, although very rare, monostotic fibrous dysplasia of the thoracic spine should be considered in the differential diagnosis of spinal tumors. Although a consensus for management of this disease has not been achieved, the authors recommend radical removal of all involved bone as well as internal fixation or bone graft—assisted fusion to achieve long-term stabilization.

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Clear Cell Chondrosarcoma

Atlas of Musculoskeletal Tumors and Tumorlike Lesions ◽

10.1007/978-3-319-01748-8_30 ◽

2013 ◽

pp. 133-136

Author(s):

Nicola Fabbri ◽

Davide Donati

Keyword(s):

Clear Cell ◽

Clear Cell Chondrosarcoma

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A case of clear cell chondrosarcoma: Imprint cytology and cytologic differential diagnosis.

The Journal of the Japanese Society of Clinical Cytology ◽

10.5795/jjscc.34.103 ◽

1995 ◽

Vol 34 (1) ◽

pp. 103-109

Author(s):

Masami SUGISHITA ◽

Masaharu FUKUNAGA ◽

Shinichiro USHIGOME ◽

Kazuhito NAKAMORI ◽

Sachiko MIURA ◽

...

Keyword(s):

Differential Diagnosis ◽

Clear Cell ◽

Imprint Cytology ◽

Clear Cell Chondrosarcoma

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Histomorphological and Immunophenotypic Characterization of Feline Injection Site-Associated Sarcoma

Acta Scientiae Veterinariae ◽

10.22456/1679-9216.109525 ◽

2021 ◽

Vol 49 ◽

Author(s):

Sílvia Teixeira Pereira ◽

Conrado Oliveira Gamba ◽

Rodrigo Santos Horta ◽

Rúbia Monteiro de Castro Cunha ◽

Gleidice Eunice Lavalle ◽

...

Keyword(s):

Overall Survival ◽

Tumor Grade ◽

Histologic Grade ◽

Biological Behavior ◽

Histological Subtypes ◽

Recurrence Rates ◽

Ki 67 ◽

Nerve Sheath ◽

Cox 2 ◽

Grade Iii

Background: Feline Injection Site-Associated Sarcoma (FISS) is a mesenchymal neoplasia of aggressive behavior that develops in sites where vaccine or drugs were administered. FISS is clinically characterized by the appearance of a solitary firm nodule or a diffuse mass, adhered to tissues, in regions associated to vaccine or drug applications. Despite low prevalence, tumor recurrence rates can reach 80%. FISS present more aggressive histological characteristics when compared to sarcomas not associated to injection sites. The aim of this paper is to contribute towards the understanding of the biological behavior of FISS.Materials, Methods & Results: Sixteen samples of FISS were analyzed. Fibrosarcomas were the most frequent histological subtype (62.5%). Malignant peripheral nerve sheath tumor was diagnosed in 18.75% cases. Ten (62.5%) FISS were classified as grade II; 4/16 (25%) grade I, and 2/16 (12.5%) grade III. Cox-2 overexpression occurred in 3/16 (18.75%) samples, with positive correlation between Cox-2 expression and cellularity (r = 0.696, P = 0.003). Mitotic index lower than 9 events was found in 11/16 (68.7%) samples and between 10 and 19 mitotic events in 5/16 (31.3%) cases. Mean Ki-67 expression was 2.39 ± 2.48%. FISS characterized as fibrosarcomas presented longer overall survival (median 545 days) than other histological subtypes (median 130.5 days) [P = 0.01].Discussion: Patients with FISS generally present with larger nodules than those with sarcomas not associated to injections, suggesting a challenge for pet owners to note subcutaneous tumors in the interscapular region, in addition to the aggressive biological behavior of FISS. The influence of size on prognosis remains controversial. An association between histologic grade and the development of metastasis has been observed, with patients with grade III FISS associated with an increase in the metastatic rate. The present study did not find a correlation between overall survival and histologic grade. A positive correlation between the presence of giant multinucleated cells and tumor grade has been observed.Despite the absence of such correlation in the present study, possibly due to a small sample, a trend for higher frequency of giant cells in advanced histologic grade was observed. Cox-2 expression in 81.75% and overexpression in 18.75% of our samples contrasts with the 64% Cox-2 expression and the absence of Cox-2 expression found by other authors. A positive moderate correlation between cellularity and Cox-2 expression was also observed, while another study did not find a correlation of Cox-2 expression with tumor grade, recurrence rates or overall survival. Cox metabolites such as prostaglandins can enhance cellular proliferation, inhibit apoptosis, induce angiogenesis, alter cellular adherence to facilitate metastatic development and inhibit immune surveillance. In the present study, no correlation was found between Cox-2 and angiogenesis in FISS. Our findings demonstrated low immunolabeling for Ki-67. A previous study analyzed 52 samples of FISS, 51% of them considered grade III, with a mean Ki-67 labeling of 14%. The lower Ki-67 staining in the samples of the present study may be related to the lower number of samples of grade III FISS or to a difference in the studied population. Fibrosarcomas are associated with better prognosis than other histological subtypes. Furthermore, malignant peripheral nerve sheath tumors were diagnosed as a possible histological subtype of FISS.

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