scholarly journals Stem Cell Applications in Tendon Disorders: A Clinical Perspective

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Mark Young
Keyword(s):  
Surgical Repair ◽  
Scar Tissue ◽  
Lifestyle Changes ◽  
Dermal Fibroblasts ◽  
Tendon Tissue ◽  
Tendon Tear ◽  
Activity Restriction ◽  
Cell Therapies ◽  
Significant Health ◽  
The Ideal

Tendon injuries are a common cause of morbidity and a significant health burden on society. Tendons are structural tissues connecting muscle to bone and are prone to tearing and tendinopathy, an overuse or degenerative condition that is characterized by failed healing and cellular depletion. Current treatments, for tendon tear are conservative, surgical repair or surgical scaffold reconstruction. Tendinopathy is treated by exercises, injection therapies, shock wave treatments or surgical tendon debridement. However, tendons usually heal with fibrosis and scar tissue, which has suboptimal tensile strength and is prone to reinjury, resulting in lifestyle changes with activity restriction. Preclinical studies show that cell therapies have the potential to regenerate rather than repair tendon tissue, a process termed tenogenesis. A number of different cell lines, with varying degrees of differentiation, have being evaluated including stem cells, tendon derived cells and dermal fibroblasts. Even though cellular therapies offer some potential in treating tendon disorders, there have been few published clinical trials to determine the ideal cell source, the number of cells to administer, or the optimal bioscaffold for clinical use.

scholarly journals MR Imaging of the Achilles Tendon after Surgical Repair

2017 ◽  
Vol 11 (1) ◽  
pp. 697-703 ◽  
Author(s):  
Kwok Fai Tam ◽  
Tun Hing Lui
Keyword(s):  
Achilles Tendon ◽  
Surgical Repair ◽  
Healing Process ◽  
Scar Tissue ◽  
Tendon Tear ◽  
The Status ◽  
Healing Phase ◽  
Magnetic Resonance Imaging Mri ◽  
Tendon Remodeling ◽  
Early Healing

Achilles tendon tear is common and increasingly frequent. Magnetic resonance imaging (MRI) is the modality of choice for radiological evaluation. It is accurate to assess the status and integrity of the tendon with well documented features. In this article, the MR findings of a normal Achilles tendon as well as common diseases like insertional and noninsertional tendinosis, chronic tendinosis with marked lengthening, tendon rupture are illustrated. After a torn Achilles tendon receives surgical repair, it undergoes different stages of healing process including inflammatory, reparative and remodeling phases. Acute scar tissue in the surgical bed may share similar MR features of tendon re-rupture especially in the early healing phase because both are T2W hyperintense. The size of the gap may even appear larger than expected on T2W images possibly due to tendon remodeling. Understanding of the healing process in post-operative period may prevent overestimation of tendon gap and misdiagnosis of re-tear. We describe the MR features of the post-operative changes with serial studies in different months after surgery. The MR findings with the highlights of the expected sequential changes in normal healing process are illustrated in different cases. A case with surgical repair on a partial tear of Achilles tendon is also included.

Progress with stem cell therapies for tendon tissue regeneration

2020 ◽  
Vol 20 (11) ◽  
pp. 1373-1379 ◽  
Author(s):  
Filippo Migliorini ◽  
Markus Tingart ◽  
Nicola Maffulli
Keyword(s):  
Stem Cell ◽  
Tissue Regeneration ◽  
Tendon Tissue ◽  
Stem Cell Therapies ◽  
Cell Therapies

scholarly journals Rhinoplasty in the Cleft Lip Patient

1997 ◽  
Vol 34 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Gilbert J. Nolst Trenité ◽  
Richard H.L. Paping ◽  
Albert H. Trenning
Keyword(s):  
Cleft Lip ◽  
Surgical Repair ◽  
Operative Procedure ◽  
Scar Tissue ◽  
Graft Material ◽  
Nasal Vestibule ◽  
Secondary Rhinoplasty ◽  
Custom Made ◽  
Postoperative Problems ◽  
Cleft Lip Nose

Several important factors to consider in the surgical repair of the cleft lip nose are described: the importance of an adequate lip closure technique to ensure symmetry can prevent a more conspicuous deformity of the nose during growth, the consequences of secondary rhinoplasty in the growing nose in which the surgeon has to weigh the possible growth inhibition due to scar tissue against the possible functional and esthetic improvement, a systematic surgical approach in which the operative procedure is divided Into different steps, and the use of autogenous graft material. In the evaluation of 52 cleft lip patients (5 bilateral clefts, 47 complete unilateral clefts) who had undergone a secondary rhinoplasty, two specific postoperative problems were encountered: slight to moderate recurrence of the caudal septal deviation (in unilateral clefts) and restenosis of the nasal vestibule at the cleft side. Adjustment of the surgical technique and the use of a custom-made vestibulum device diminished these sequellae considerably.

scholarly journals Review of the History of Materials Used With Experience with Bone Cement Cranioplasty

2017 ◽  
Vol 14 (1) ◽  
pp. 7-13
Author(s):  
Yam Bahadur Roka
Keyword(s):  
Head Injury ◽  
Bone Cement ◽  
Traffic Accident ◽  
Surgical Repair ◽  
Road Traffic ◽  
Physical Assault ◽  
Cranial Defect ◽  
History Of ◽  
Materials Used ◽  
The Ideal

Cranioplasty is the surgical repair of cranial defect or deficiency of the skull with a aim for functional and cosmetic improvement. Inorganic and organic materials have both been used for cranioplasty with the ideal cranioplasty material is yet to be made or discovered with present focus of research on molecular biology. This article does a brief review of the history of materials used and discusses the results of the use of bone cement cranioplasty (BCC) in this centre. A total of 61 cases were included in the study with the majority being males (44 cases). Road traffic accident was the most common initial cause of injury (45 cases), followed by fall (10 cases) and physical assault in the rest. On admission and based on the GCS based head injury classification the majority were in the severe head injury type (GCS<8) in 44 cases followed by moderate head injury in the rest. The majority of the decompressive craniectomy was done on the left side (32 cases) followed by right (22 cases) and bilateral in 7 cases (including single fl apbifrontal in 5 cases). In our centre as for other centres in Nepal and developing countries, bone cement remains the best, safest, cheapest choice along with autologous graft for cranioplasty.Nepal Journal of Neuroscience, Volume 14, Number 1, 2017, Page: 7-13

scholarly journals Evaluation of Traumatic Injuries of Median and Ulnar Nerves at the Wrist after Surgical Repair: Ultrasound and Electrophysiological Correlation

2021 ◽  
pp. 123-131
Author(s):  
Omnia F. Saif ◽  
Radwa M. El-khouly ◽  
Hamdy A. Khallaf ◽  
Fahima S. Rihan ◽  
Salwa E. Abd El Ghany
Keyword(s):  
Clinical Assessment ◽  
Surgical Repair ◽  
Nerve Repair ◽  
Traumatic Injury ◽  
Scar Tissue ◽  
Motor Power ◽  
Severity Of Injury ◽  
Significant Difference ◽  
The Us ◽  
Good Agreement

Aims: To quantify the contribution of ultrasonography (US) as a complementary tool to electrodiagnostic evaluation of traumatic lesions of median and ulnar nerves after surgical repair"  Patients and Methods: The study included a total of 50 nerves from 40 patients with traumatic injury of wrist median and/ or ulnar nerves. Patients were evaluated at one and three months after primary nerve repair clinically, electrophysiological, and US examinations. Results: No significant difference (p = 0.125) was found between classification of injury by electrodiagnosis and by US. Good agreement between clinical assessment of the motor power and the severity of injury based on electrodiagnosis was found. Moderate agreement between clinical assessment of motor power and continuity of the repaired nerve based on US was noted. Good agreement between the severity of the injury by electrodiagnosis and the continuity of the repaired nerve by the US (p <0.001*) was detected. The sensitivity of US in detecting nerve continuity was 87.9% one month after repair and 80% after three months. Conclusion: As a supplement to electrodiagnostic testing, the US can offer a noninvasive and complementary tool for assessing post-operative repair of traumatic nerve lesions with respect to their exact location, course, continuity, extent, and neuroma formation and can be of value in the visualization of the morphological abnormalities associated with nerve injuries, including swelling and perilesional scar tissue formation.

scholarly journals Patch bulging after plaque incision and grafting procedure for Peyronie’s disease. Surgical repair with a collagen fleece

2015 ◽  
Vol 87 (2) ◽  
pp. 173 ◽  
Author(s):  
Andrea Fabiani ◽  
Fabrizio Fioretti ◽  
Alessandra Filosa ◽  
Lucilla Servi ◽  
Gabriele Mammana
Keyword(s):  
Clinical Practice ◽  
Surgical Therapy ◽  
Surgical Repair ◽  
Daily Clinical Practice ◽  
Peyronie’S Disease ◽  
Boston Scientific ◽  
Peyronie's Disease ◽  
Grafting Materials ◽  
Grafting Procedure ◽  
The Ideal

The incision/excision and grafting techniques (PIG) for surgical therapy of Peyronie’s disease (PD) have gained popularity in recent years. Several different graft materials have been used but the ideal graft has yet to be established. The use of grafting materials could cause complications. In the daily clinical practice it will always be more frequent to manage complications arising from their use. We present herein the case of a patch bulging repaired with a ready-to-use collagen fleece (Tachosil®, Takeda, Linz, Austria, Europe) in a 61 years old man subjected to intervention of geometric corporoplasty with Paulo Egydio technique using an acellular collagen material (Xenform® patch, Boston Scientific, Natick, MA, USA) as graft. We also discuss the possible implications of PIG procedure.

scholarly journals Physical activity and nutrition in older adults

1999 ◽  
Vol 2 (3a) ◽  
pp. 429-436 ◽  
Author(s):  
AS Dontas ◽  
J Moschandreas ◽  
A Kafatos
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Nutrient Intake ◽  
Structure And Function ◽  
Healthy Diet ◽  
Optimal Health ◽  
Physiological Structure ◽  
And Function ◽  
Significant Health ◽  
The Ideal

AbstractPhysical activity and nutrient intake are important determinants of health throughout life. Many of the alterations in physiological structure and function that occur with age may result from disuse and disability as well as from diets deficient in energy, protein or other specific nutrients. Although a healthy diet can provide significant health benefits, diet alone, is not sufficient to provide optimal health, nor protect us from the hazards of sedentary habits. Nor is physical activity alone. The ideal combines sufficient exercise and a healthy diet.

Engineering human neo-tendon tissue in vitro with human dermal fibroblasts under static mechanical strain

Biomaterials ◽  
2009 ◽  
Vol 30 (35) ◽  
pp. 6724-6730 ◽  
Author(s):  
Dan Deng ◽  
Wei Liu ◽  
Feng Xu ◽  
Yang Yang ◽  
Guangdong Zhou ◽  
...  
Keyword(s):  
Mechanical Strain ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Tendon Tissue ◽  
Static Mechanical
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