scholarly journals Clarithromycin-Induced Long QT Syndrome: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
Mecnun Cetin ◽  
Munevver Yıldırımer ◽  
Serkan Özen ◽  
Sema Tanrıverdi ◽  
Senol Coskun
Keyword(s):  
Long Qt Syndrome ◽  
Antiarrhythmic Drugs ◽  
Macrolide Antibiotic ◽  
Torsade De Pointes ◽  
Qt Prolongation ◽  
Atypical Pneumonia ◽  
Interval Prolongation ◽  
Long Qt ◽  
Qt Interval Prolongation ◽  
Qt Syndrome

Long QT syndrome develops for a number of reasons. The number of non-antiarrhythmic drugs reported to induce QT interval prolongation with or without torsade de pointes continues to increase. Clarithromycin is a macrolide antibiotic being increasingly used for the treatment of atypical pneumonia. In this paper, we describe a patient who developed long QT prolongation syndrome after receiving clarithromycin for the treatment of atypical pneumonia.

Predicting Torsade de Pointes in Acquired Long QT Syndrome: Optimal Identification of Critical QT Interval Prolongation

Cardiology ◽  
2012 ◽  
Vol 122 (1) ◽  
pp. 3-11 ◽  
Author(s):  
John Chiladakis ◽  
Andreas Kalogeropoulos ◽  
Fani Zagkli ◽  
Nikolaos Koutsogiannis ◽  
Konstantinos Chouchoulis ◽  
...  
Keyword(s):  
Long Qt Syndrome ◽  
Qt Interval ◽  
Torsade De Pointes ◽  
Interval Prolongation ◽  
Long Qt ◽  
Acquired Long Qt Syndrome ◽  
Qt Interval Prolongation ◽  
Qt Syndrome

scholarly journals Transient Long QT Development in a Patient with Takotsubo Cardiomyopathy

2016 ◽  
Vol 2 (2) ◽  
pp. 81-84
Author(s):  
Dániel Czuriga ◽  
Andrea Szegedi ◽  
Ferenc Győry ◽  
Attila Szilágyi ◽  
Sándor Sipka ◽  
...  
Keyword(s):  
Takotsubo Cardiomyopathy ◽  
Long Qt Syndrome ◽  
Qt Interval ◽  
Ventricular Arrhythmias ◽  
Interval Prolongation ◽  
Long Qt ◽  
Electrolyte Disturbances ◽  
Acquired Long Qt Syndrome ◽  
Qt Interval Prolongation ◽  
Qt Syndrome

Abstract QT interval prolongation on the electrocardiogram is considered a precursory sign for imminent, potentially lethal ventricular arrhythmias. Beside the inherited condition of long QT syndrome, numerous drugs, certain electrolyte disturbances and early transmural ischemia have been identified to induce reversible prolongation of the QT interval, collectively called as acquired long QT syndrome. Herein we describe a case of a patient with transient QT prolongation and Takotsubo cardiomyopathy, a rather infrequent cause of long QT development. Serial changes of the repolarization pattern were documented to demonstrate progression and resolution of the abnormal QT interval.

scholarly journals Long QT in stunned myocardium: unrecognised cause of acquired long QT syndrome

2014 ◽  
Vol 83 (3) ◽  
pp. 250-254
Author(s):  
Jerzy Sacha
Keyword(s):  
Long Qt Syndrome ◽  
Qt Interval ◽  
Ventricular Tachyarrhythmia ◽  
Torsade De Pointes ◽  
Stunned Myocardium ◽  
Long Qt ◽  
Wave Inversion ◽  
Qt Interval Prolongation ◽  
Evolutionary Changes ◽  
Qt Syndrome

Long QT syndrome (LQTS) is a heart disorder characterized by a prolongation of the QT interval on ECG and a predisposition to ventricular tachyarrhythmias, which may lead to syncope, cardiac arrest or sudden cardiac death. This condition may be inherited or induced by external factors such as drugs, electrolyte imbalances and some acquired cardiac diseases. The review addresses LQTS caused by acute cardiac illnesses which are associated with a large amount of stunned myocardium, i.e. the reperfused myocardial infarction and the group of stress-related cardiomyopathies. In these cases, specific ECG evolutionary changes may be observed, i.e. dynamic deep T-wave inversion and QT interval prolongation which predispose to fatal polymorphic ventricular tachyarrhythmia, i.e. torsade de pointes. However, lethal arrhythmias are relatively rare in these instances and probably concern patients with an underlying predisposition to LQTS. The pathological mechanisms of both repolarization abnormalities and ventricular arrhythmias as well as the practical approach how to interpret electrocardiographic changes and identify high risk patients are discussed in this review.

scholarly journals Acquired long QT syndrome caused by pseudohypoparathyroidism

2020 ◽  
Vol 5 (4) ◽  
pp. 235-238
Author(s):  
L. A. Balykova ◽  
E. S. Samoshkina ◽  
Yu. A. Petrushkina ◽  
T. M. Zolnikova ◽  
A. V. Krasnopolskaya ◽  
...  
Keyword(s):  
Long Qt Syndrome ◽  
Qt Interval ◽  
Review Of Literature ◽  
Interval Prolongation ◽  
Long Qt ◽  
Acquired Long Qt Syndrome ◽  
Qt Interval Prolongation ◽  
Qt Syndrome ◽  
Electrolyte Abnormalities

The article presents a review of literature data on the long QT syndrome (LQTS), focusing on the role of secondary factors in the development of this disorder. In particular, it describes in detail pseudohypoparathyroidism a rare genetically and clinically heterogeneous condition characterized by resistance to parathyroid hormone, often manifested by arrhythmogenic syncope and seizures. A specific clinical case illustrates the necessity to exclude the endocrine and electrolyte abnormalities in syncopal conditions associated with the QT interval prolongation.

Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG

2004 ◽  
Vol 107 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Kenshi HAYASHI ◽  
Masami SHIMIZU ◽  
Hidekazu INO ◽  
Masato YAMAGUCHI ◽  
Hidenobu TERAI ◽  
...  
Keyword(s):  
Missense Mutation ◽  
Long Qt Syndrome ◽  
Xenopus Oocytes ◽  
Torsade De Pointes ◽  
Qt Prolongation ◽  
Delayed Rectifier ◽  
Long Qt ◽  
N Terminus ◽  
Qt Syndrome ◽  
Herg Channels

Patients with LQTS (long QT syndrome) with a mutation in a cardiac ion channel gene, leading to mild-to-moderate channel dysfunction, may manifest marked QT prolongation or torsade de pointes only upon an additional stressor. A 59-year-old woman had marked QT prolongation and repeated torsade de pointes 3 months after initiation of probucol, a cholesterol-lowering drug. We identified a single base substitution in the HERG gene by genetic analysis. This novel missense mutation is predicted to cause an amino acid substitution of Met124→Thr (M124T) in the N-terminus. Three other relatives with this mutation also had QT prolongation and one of them had a prolonged QT interval and torsade de pointes accompanied by syncope after taking probucol. We expressed wild-type HERG and HERG with M124T in Xenopus oocytes and characterized the electrophysiological properties of these HERG channels and the action of probucol on the channels. Injection of the M124T mutant cRNA into Xenopus oocytes resulted in expression of functional channels with markedly smaller amplitude. In both HERG channels, probucol decreased the amplitude of the HERG tail current, decelerated the rate of channel activation, accelerated the rate of channel deactivation and shifted the reversal potential to a more positive value. The electrophysiological study indicated that QT lengthening and cardiac arrhythmia in the two present patients were due to inhibition of IKr (rapidly activating delayed rectifier K+ current) by probucol, in addition to the significant suppression of HERG current in HERG channels with the M124T mutation.

Epinephrine-Induced QT Interval Prolongation: A Gene-Specific Paradoxical Response in Congenital Long QT Syndrome

2002 ◽  
Vol 77 (5) ◽  
pp. 413-421 ◽  
Author(s):  
MICHAEL J. ACKERMAN ◽  
ANANT KHOSITSETH ◽  
DAVID J. TESTER ◽  
JOSEPH B. HEJLIK ◽  
WIN-KUANG SHEN ◽  
...  
Keyword(s):  
Long Qt Syndrome ◽  
Qt Interval ◽  
Interval Prolongation ◽  
Long Qt ◽  
Paradoxical Response ◽  
Qt Interval Prolongation ◽  
Qt Syndrome ◽  
Congenital Long Qt Syndrome

scholarly journals Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation

2021 ◽  
Vol 22 (15) ◽  
pp. 8090
Author(s):  
Daniela Baracaldo-Santamaría ◽  
Kevin Llinás-Caballero ◽  
Julián Miguel Corso-Ramirez ◽  
Carlos Martín Restrepo ◽  
Camilo Alberto Dominguez-Dominguez ◽  
...  
Keyword(s):  
Long Qt Syndrome ◽  
Qt Interval ◽  
Molecular Mechanisms ◽  
Torsade De Pointes ◽  
Individual Variability ◽  
Long Qt ◽  
Drug Induced ◽  
Qt Interval Prolongation ◽  
Qt Syndrome ◽  
The Many

Long QT syndromes can be either acquired or congenital. Drugs are one of the many etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used in the clinical setting are a known risk factor for a prolonged QT interval, thus increasing the chances of developing torsade de pointes. The molecular mechanisms involved in the prolongation of the QT interval are common to most medications. However, there is considerable inter-individual variability in drug response, thus making the application of personalized medicine a relevant aspect in long QT syndrome, in order to evaluate the risk of every individual from a pharmacogenetic standpoint.

scholarly journals Acquired long QT syndrome, manifesting in the first complex after a ventricular extrasystole

2021 ◽  
Vol 28 (2) ◽  
pp. 37-43
Author(s):  
O. V. Kononenko ◽  
S. A. Zenin ◽  
A. V. Fedoseenko ◽  
I. M. Felikov ◽  
O. V. Pyataeva ◽  
...  
Keyword(s):  
Case Report ◽  
Long Qt Syndrome ◽  
Qt Interval ◽  
Ventricular Premature Beat ◽  
Interval Prolongation ◽  
Ventricular Extrasystole ◽  
Long Qt ◽  
Acquired Long Qt Syndrome ◽  
Qt Interval Prolongation ◽  
Qt Syndrome

A case report of unusual QT interval prolongation after ventricular premature beat is presented.

Effect of atropine on QT prolongation and torsade de pointes induced by intracoronary acetylcholine in the long QT syndrome

1999 ◽  
Vol 83 (5) ◽  
pp. 714-718 ◽  
Author(s):  
Hiroshi Furushima ◽  
Shinichi Niwano ◽  
Masaomi Chinushi ◽  
Masayuki Yamaura ◽  
Koji Taneda ◽  
...  
Keyword(s):  
Long Qt Syndrome ◽  
Torsade De Pointes ◽  
Qt Prolongation ◽  
Long Qt ◽  
Qt Syndrome
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