scholarly journals Pretransplant Fasting Glucose Predicts New-Onset Diabetes after Liver Transplantation

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Elizabeth J. Carey ◽  
Bashar A. Aqel ◽  
Thomas J. Byrne ◽  
David D. Douglas ◽  
Jorge Rakela ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplant ◽  
Fasting Glucose ◽  
Meld Score ◽  
Transplant Recipients ◽  
Onset Diabetes ◽  
The Mean ◽  
One Year ◽  
Liver Transplant Recipients ◽  
New Onset

New-onset diabetes after transplantation (NODAT) is common after liver transplant and associated with poorer outcomes. The aim of this study was to identify risk factors for NODAT in liver transplant recipients off corticosteroids. In 225 adult nondiabetic liver transplant recipients, the mean age was 51.7 years, the majority were men (71%), and half had HCV (49%). The mean calculated MELD score at transplantation was 18.7, and 19% underwent living-donor transplant (LDLT). One year after transplantation, 17% developed NODAT, and an additional 16% had impaired fasting glucose. The incidence of NODAT in patients with HCV was 26%. In multivariate analysis, HCV, pretransplant FPG, and LDLT were significant. Each 10 mg/dL increase in pretransplant FPG was associated with a twofold increase in future development of NODAT. The incidence of NODAT after liver transplant in patients off corticosteroids is 17%. Risk factors for developing NODAT include HCV and pretransplant FPG; LDLT is protective.

Incidence and risk factors for new-onset diabetes in living-donor liver transplant recipients

2013 ◽  
Vol 27 (3) ◽  
pp. 426-435 ◽  
Author(s):  
Masaki Honda ◽  
Katsuhiro Asonuma ◽  
Shintaro Hayashida ◽  
Hiroko Suda ◽  
Yuki Ohya ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplant ◽  
Living Donor ◽  
Transplant Recipients ◽  
Donor Liver ◽  
Onset Diabetes ◽  
Living Donor Liver Transplant ◽  
Donor Liver Transplant ◽  
Liver Transplant Recipients ◽  
New Onset

scholarly journals Risk factors predicting Cytomegalovirus infection in post liver transplant recipients

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M G Abdelrahman ◽  
H A Mahmoud ◽  
M K Mohsen ◽  
M O Ali ◽  
A M N Mohamed
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Organ Transplantation ◽  
Chronic Rejection ◽  
Cytomegalovirus Infection ◽  
Transplant Recipients ◽  
Cmv Infection ◽  
Donor Liver Transplantation ◽  
Liver Transplant Recipients

Abstract Background Liver transplantation is considered to be the only curative treatment for patients with end stage liver disease. Postoperative infection remains to be one of the most common causes of morbidity and mortality throughout the past years. Cytomegalovirus (CMV) infection although considered to be a weak viral infection that usually passes asymptomatic in immunocompetent patients, however, it is considered one of the most common pathogens causing morbidities and mortality in liver transplant recipients. Multiple studies have been done to assess the risk factors for developing CMV infection. Objective Identification of risk factors predicting Cytomegalovirus infection in liver transplant recipients following transplantation. Methods This retrospective study was conducted on 194 patients and their donors who underwent living donor liver transplantation operation at Ain Shams centre for organ transplantation (ASCOT) at Ain Shams specialized hospital in the period between January 2010 and December 2016 with at least one year follow up period after operation for the recipient group. Results In our study, 194 patients undergoing liver transplantation at Ain shams centre for organ transplantation over seven years from January 2010 to December 2016 have been followed to assess risk factors affecting CMV infection development. Chronic rejection was found to be the most common factor associated with CMV infection followed by Cyclosporin (Neoral) as main postoperative immunosuppressant following liver transplantation. Other factors that were found to carry risk for CMV infection included younger age, advanced MELD score, positive CMV IgM status of the donors and recipients. Conclusion Differentiation of Cytomegalovirus disease from Cytomegalovirus infection isn’t always available as it requires tissue invasive techniques. Multiple risk factors have been attributed to cause Cytomegalovirus infection (viremia) . In our study, rejection (chronic rejection) was the factor that carries highest risk for Cytomegalovirus infection development followed by Cyclosporin .

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