scholarly journals Complete PSA Remission without Adjuvant Therapy after Secondary Lymph Node Surgery in Selected Patients with Biochemical Relapse after Radical Prostatectomy and Pelvic Lymph Node Dissection

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Alexander Winter ◽  
Jens Uphoff ◽  
Rolf-Peter Henke ◽  
Friedhelm Wawroschek
Keyword(s):  
Lymph Node ◽  
Radical Prostatectomy ◽  
Adjuvant Therapy ◽  
Therapeutic Benefit ◽  
Choline Pet ◽  
Psa Relapse ◽  
Secondary Resection ◽  
Pet Ct ◽  
Secondary Lymph Node ◽  
Psa Response

Introduction. To evaluate whether secondary resection of lymph node (LN) metastases (LNMs) can result in PSA remission, we analysed the PSA outcome after resection of LNM detected on PET/CT in patients with biochemical failure.Materials and Methods. 11 patients with PSA relapse (mean 3.02 ng/mL, range 0.5–9.55 ng/mL) after radical prostatectomy without adjuvant therapy were included. Suspicious LN (1–3) detected on choline PET/CT and nearby LN were openly dissected (09/04–02/11). The PSA development was examined. Histological and PET/CT findings were compared.Results. 9 of 10 patients with histologically confirmed LNM showed a PSA response. 4 of 9 patients with single LNM had a complete permanent PSA remission (mean followup 31.8, range 1–48 months). Of metastasis-suspicious LNs (14) 12 could be histologically confirmed. The additionally removed 25 LNs were all correctly negative.Conclusions. The complete PSA remissions after secondary resection of single LNM argue for a feasible therapeutic benefit without adjuvant therapy. For this purpose the choline PET/CT is in spite of its limitations currently the most reliable routinely available diagnostic tool.

scholarly journals The Role ofC11-Choline-PET/CT-Guided Secondary Lymphadenectomy in Patients with PSA Failure after Radical Prostatectomy: Lessons Learned from Eight Cases

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Thomas Martini ◽  
Roman Mayr ◽  
Emanuela Trenti ◽  
Salvatore Palermo ◽  
Evi Comploj ◽  
...  
Keyword(s):  
Lymph Node ◽  
Radical Prostatectomy ◽  
Lymph Node Metastases ◽  
Lessons Learned ◽  
Ct Guided ◽  
Curative Therapy ◽  
Choline Pet ◽  
Pet Ct ◽  
Psa Response ◽  
Node Metastases

Introduction.11C-choline-PET/CT is a promising technique for detection/restaging of patients with biochemical failure (BF) after curative therapy for prostate cancer (PCA). The aim of this paper was to evaluate the PSA response in patients with BF after radical prostatectomy (RP) who underwent secondary lymphadenectomy (LAD) due to11C-choline-PET/CT findings.Material and Methods. Eight patients with BF and positive lymph nodes in11C-choline-PET/CT after RP were retrospectively included in the study. Extended LAD until the common iliac arteries was performed in all patients.Results. Six of 8 patients had histologically proven lymph node metastases. Four patients showed an initial PSA reduction after LAD, and in 4 patients the PSA increased. Two of the latter had no histological lymph node metastases.Conclusions. Because 50% of our patients showed an initial PSA response, our data suggest that positive11C-choline-PET/CT after RP and BF could help to select patients that could benefit from secondary LAD.

scholarly journals Direct comparison of choline PET/CT and MRI in the diagnosis of lymph node metastases in patients with prostate cancer

Medicine ◽  
2018 ◽  
Vol 97 (50) ◽  
pp. e13344 ◽  
Author(s):  
Shi-ming Huang ◽  
Liang Yin ◽  
Jian-lan Yue ◽  
Yan-feng Li ◽  
Yang Yang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Choline Pet ◽  
Pet Ct ◽  
Node Metastases ◽  
Ct And Mri
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