scholarly journals A Gastrointestinal Stromal Tumor of the Stomach Demonstrating a Stepwise Progression from Low- to High-Grade Malignancy

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Takahiko Nakajima ◽  
Tomonori Ushijima ◽  
Atsushi Kihara ◽  
Kenichiro Murata ◽  
Toshiro Sugiyama ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Clinical Course ◽  
Submucosal Tumor ◽  
Histological Finding ◽  
Stromal Tumor ◽  
Gastric Gist ◽  
High Grade ◽  
Grade Malignancy ◽  
Multiple Liver Metastases ◽  
High Grade Malignancy

We report a case of a gastrointestinal stromal tumor (GIST) of the stomach that demonstrated a stepwise progression from low- to high-grade malignancy. The patient had been followed for a small gastric submucosal tumor that had turned malignant after 8 years of indolence, manifested by tarry stools. The tumor was enucleated, and gastric GIST was diagnosed. The most significant histological finding was that the tumor comprised two clearly demarcated areas, one with less aggressive characteristics and the other with highly aggressive characteristics. The patient exhibited multiple liver metastases 24 months after surgery. Imatinib mesylate was not administered throughout the clinical course because it was not available for clinical use at that time. The patient followed an unfavorable clinical course and died of liver dysfunction 55 months after surgery. Autopsy was performed. By comparing the immunohistochemical profiles of primary and metastatic tumors, it was established that only the tumor cells with highly aggressive characteristics had metastasized.

scholarly journals RESECTION OF ESOPHAGEAL GASTROINTESTINAL STROMAL TUMOR WITH HIGH-GRADE MALIGNANCY-A CASE REPORT-

2006 ◽  
Vol 67 (7) ◽  
pp. 1541-1545 ◽  
Author(s):  
Hisashi ISHIKURA ◽  
Hiroshi OKITSU ◽  
Akihiro SAKATA ◽  
Masashi ISHIKAWA ◽  
Jyunnichi SEIKE ◽  
...  
Keyword(s):  
Case Report ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
High Grade ◽  
Grade Malignancy ◽  
High Grade Malignancy

scholarly journals Distinction of surgically resected gastrointestinal stromal tumor by near-infrared hyperspectral imaging

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Daiki Sato ◽  
Toshihiro Takamatsu ◽  
Masakazu Umezawa ◽  
Yuichi Kitagawa ◽  
Kosuke Maeda ◽  
...  
Keyword(s):  
Machine Learning ◽  
Gastrointestinal Stromal Tumor ◽  
Hyperspectral Imaging ◽  
Near Infrared ◽  
Submucosal Tumor ◽  
Stromal Tumor ◽  
Training Data ◽  
Support Vector ◽  
Gastric Gist ◽  
Mucosal Layer

AbstractThe diagnosis of gastrointestinal stromal tumor (GIST) using conventional endoscopy is difficult because submucosal tumor (SMT) lesions like GIST are covered by a mucosal layer. Near-infrared hyperspectral imaging (NIR-HSI) can obtain optical information from deep inside tissues. However, far less progress has been made in the development of techniques for distinguishing deep lesions like GIST. This study aimed to investigate whether NIR-HSI is suitable for distinguishing deep SMT lesions. In this study, 12 gastric GIST lesions were surgically resected and imaged with an NIR hyperspectral camera from the aspect of the mucosal surface. Thus, the images were obtained ex-vivo. The site of the GIST was defined by a pathologist using the NIR image to prepare training data for normal and GIST regions. A machine learning algorithm, support vector machine, was then used to predict normal and GIST regions. Results were displayed using color-coded regions. Although 7 specimens had a mucosal layer (thickness 0.4–2.5 mm) covering the GIST lesion, NIR-HSI analysis by machine learning showed normal and GIST regions as color-coded areas. The specificity, sensitivity, and accuracy of the results were 73.0%, 91.3%, and 86.1%, respectively. The study suggests that NIR-HSI analysis may potentially help distinguish deep lesions.

scholarly journals Uncommon Finding of a Gastrointestinal Stromal Tumor in a Patient with Hyperechoic Liver Lesions - Case Report

2018 ◽  
Vol 64 (4) ◽  
pp. 169-172
Author(s):  
Adina Maria Roman ◽  
Daniela Dobru ◽  
Crina Fofiu ◽  
Alina Boeriu
Keyword(s):  
Case Report ◽  
Gastrointestinal Stromal Tumor ◽  
Kinase Inhibitors ◽  
Narrow Band Imaging ◽  
Submucosal Tumor ◽  
Stromal Tumor ◽  
Arterial Phase ◽  
Gastric Gist ◽  
Liver Lesions ◽  
Diagnostic Challenge

AbstractIntroduction: Hyperechoic liver lesions identified by conventional ultrasonography are diverse in underlying pathology and most of the time require further investigations. Gastrointestinal stromal tumors (GIST) are rare neoplasms of the gastrointestinal tract which are uncommonly found in metastatic stages at first presentation.Case report: We present the case of a 51 years old woman with nonspecific symptoms in which conventional ultrasonography showed hyperechoic lesions in the right lobe of the liver with a diameter up to 40 mm. Esophagogastroduodenoscopy revealed a submucosal tumor on the small curvature of the stomach, on the anterior wall, with central ulceration, with normal narrow band imaging (NBI) mucosal pattern and negative gastric biopsy. Contrast enhanced ultrasonography was performed, describing multiple lesions with inhomogeneous enhancement in the arterial phase and rapid washout at the end of arterial phase. Endoscopic ultrasound with fine needle aspiration (EUS-FNA) biopsy examination was definitive for the final diagnosis of epithelioid gastric gastrointestinal stromal tumor. The patient was diagnosed with T2N0M1 epithelioid gastric GIST, stage IV, and is currently under treatment with tyrosine kinase inhibitors.Conclusions: GIST represent a diagnostic challenge in medical practice because of its size, unusual location in the submucosal layer and lack of symptoms. The role of EUS-FNA is of paramount importance in increasing the accuracy of diagnosis in the case of GIST. The particularity in our case consists of the unusual presentation with the lack of specific symptoms and signs associated with the presence of metastatic lesions at the moment of the diagnosis of GIST.

Salivary duct adenocarcinoma: a high grade malignancy

1986 ◽  
Vol 100 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Kathleen K. Hui ◽  
John G. Batsakis ◽  
Mario A. Luna ◽  
Bruce MacKay ◽  
Robert M. Byers
Keyword(s):  
Surgical Treatment ◽  
Lymph Nodes ◽  
Local Control ◽  
Clinical Course ◽  
High Grade ◽  
Salivary Duct ◽  
Regional Lymph Nodes ◽  
Grade Malignancy ◽  
Distinguishing Features ◽  
High Grade Malignancy

AbstractSalivary duct carcinomas of the major salivary glands have two major distinguishing features. They closely resemble ductal carcinomas of the breast and they are high-grade malignancies. In general, but particularly for carcinomas measuring three or more centimeters in size, the clinical course is one characterized by a resistance to local control, metastases to regional lymph nodes and distant sites, and death within a few years after primary surgical treatment.

scholarly journals Preoperatively diagnosed gastric collision tumor with mixed adenocarcinoma and gastrointestinal stromal tumor: a case report and literature review

2021 ◽  
Author(s):  
Kunihiko Matsuno ◽  
Yoshikazu Kanazawa ◽  
Daisuke Kakinuma ◽  
Nobutoshi Hagiwara ◽  
Fumihiko Ando ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Distal Gastrectomy ◽  
Submucosal Tumor ◽  
Smooth Muscle Actin ◽  
Collision Tumor ◽  
Stromal Tumor ◽  
Lower Body ◽  
Muscle Actin ◽  
First Case ◽  
S 100

AbstractReports of gastric collision tumors, comprising adenocarcinoma and gastrointestinal stromal tumor, are extremely rare. Here, we report the case of a 68-year-old male who was diagnosed with a lower-body, moderately differentiated, tubular-type adenocarcinoma and submucosal tumor and underwent an elective D2 distal gastrectomy. The tumor cells of the gastrointestinal stromal tumor were positive for H-caldesmon and CD117, weakly positive for smooth muscle actin and DOG-1, and negative for desmin, S-100 protein, CD31, and AE1/AE3. The tumor had grown into a mixed form of adenocarcinoma and gastrointestinal stromal tumor. Thus, we report the first case of a preoperatively diagnosed collision tumor in the stomach consisting of adenocarcinoma and gastrointestinal stromal tumor.

Low-grade malignant perineurioma of the paravertebral column, transforming into a high-grade malignancy

1999 ◽  
Vol 49 (9) ◽  
pp. 820-825 ◽  
Author(s):  
Shino Karaki ◽  
Joji Mochida ◽  
Yoon Hwan Lee ◽  
Kazuhiro Nishimura ◽  
Yutaka Tsutsumi
Keyword(s):  
Low Grade ◽  
High Grade ◽  
Grade Malignancy ◽  
High Grade Malignancy

Gastrointestinal stromal tumor arising in the rectovaginal septum

2004 ◽  
Vol 14 (2) ◽  
pp. 373-377 ◽  
Author(s):  
K. Nasu ◽  
T. Ueda ◽  
S. Kai ◽  
H. Anai ◽  
Y. Kimura ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Submucosal Tumor ◽  
Rectal Wall ◽  
Rectal Mucosa ◽  
Pelvic Lymphadenectomy ◽  
Japanese Woman ◽  
Stromal Tumor ◽  
Resected Specimen ◽  
Rectovaginal Septum ◽  
Tissue Mass

We report herein a rare case of malignant gastrointestinal stromal tumor (GIST) originated from the rectal wall, which presented as a tumor on the rectovaginal septum.A 54-year-old Japanese woman, gravida 4, para 3, was admitted complaining of anuresis and severe constipation. She had a history of hysterectomy and right salpingo-oophorectomy for uterine leiomyoma 11 years previously. Pelvic examination revealed an 8.5 × 7.5 × 7.5 cm hard mass in the rectovaginal space. The inferior border of the tumor was 2 cm from the vaginal introitus and 2 cm from the anus. Computed tomography and magnetic resonance imaging showed a well-circumscribed soft-tissue mass filling the rectovaginal space. Urinary bladder and rectum were markedly compressed and displaced. Colon fiberscopy revealed invasion of the tumor into the rectal mucosa. An abdominoperineal resection of the rectum with posterior vaginal wall resection and pelvic lymphadenectomy was performed. The resected specimen showed a rectal submucosal tumor that was 8 × 8 × 7 cm in size. The tumor was diagnosed as a malignant GIST. Immunohistochemical analysis confirmed this diagnosis. The patient is now healthy without evidence of recurrence at 13 months after surgery.Gynecologists should be aware of rectal GIST arising in the rectovaginal space as a differential diagnosis of vaginal submucosal tumor.

scholarly journals Musculoskeletal oncology: patient triage and management during the COVID-19 pandemic

2020 ◽  
Vol 27 (5) ◽  
Author(s):  
N. Olshinka ◽  
S. Mottard
Keyword(s):  
Surgical Oncology ◽  
Low Grade ◽  
High Grade ◽  
Oncology Patient ◽  
Exposure Risks ◽  
Grade Malignancy ◽  
Oncology Centre ◽  
Sarcoma Treatment ◽  
Musculoskeletal Oncology ◽  
High Grade Malignancy

Sarcoma treatment during the covid-19 pandemic is a new challenge. This patient population is often immunocom­promised and potentially more susceptible to viral complications.    Government guidelines highlight the need to minimize patient exposure to unnecessary hospital visits. However, those guidelines lack practical recommendations on ways to manage triage and diagnosis expressly for new cancer patients. Furthermore, there are no reports on the efficiency of the guidelines.    One of the main issues in treating musculoskeletal tumours is the complexity and variability of presentation. We offer a triage model, used in a quaternary-referral musculoskeletal oncology centre, that allows us to maintain an open pathway for referral of new patients while minimizing exposure risks. A multidisciplinary approach and analysis of existing investigations allow for a pre-clinic evaluation.    The model identifies 3 groups of patients: Patients with suspected high-grade malignancy, or benign cases with aggressive features, both in need of further evaluation in the clinic and prompt treatment Patients with low-grade malignancy, and benign cases whose treatment is not urgent, that are managed, during the pandemic by telemedicine, with reassurance and information about their illness Patients who can be managed by their local medical professionals    In comparison to a pre-pandemic period, that approach resulted in a higher ratio of malignant-to-benign con­ditions for new patients seen in the clinic (3:4 vs. 1:3 respectively), thus using available resources more efficiently and prioritizing patients with suspected high-grade malignancy.    We believe that this triage system could be applied in other surgical oncology fields during a pandemic.

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