scholarly journals Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Jaroslaw Dudka ◽  
Renata Gieroba ◽  
Agnieszka Korga ◽  
Franciszek Burdan ◽  
Wlodzimierz Matysiak ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Liver Toxicity ◽  
Morphological Changes ◽  
Cardiac Effect ◽  
Drug Dose ◽  
Superoxide Dismutase Activity ◽  
High Dose ◽  
Histological Changes ◽  
Heart Lipid

The aim of the study was to evaluate the effect of resveratrol in doxorubicin-induced cardiac and hepatic toxicity. Doxorubicin was administered once a week throughout the period of 7 weeks with 1.0 or 2.0 mg/kg body weight or concomitantly with resveratrol (20 mg/kg of feed). Heart and liver toxicity was histologically and biochemically evaluated. Resveratrol protected from the heart lipid peroxidation caused by 1 mg doxorubicin and it sharply diminished superoxide dismutase activity. An insignificant effect of resveratrol on the lipid peroxidation level and the superoxide dismutase activity was observed in the hearts of rats administered a higher dose of doxorubicin. However, resveratrol attenuate necrosis and other cardiac histopathological changes were induced by a high dose of doxorubicin. Interestingly, it slightly intensified adverse cardiac histological changes in rats receiving a lower dose of doxorubicin. Resveratrol did not have any protective effect on the hepatic oxidative stress, while exerting a mild beneficial effect on the morphological changes caused by doxorubicin. All in all, this study has shown different effects of resveratrol on dose-related doxorubicin-induced heart and liver toxicity. Resveratrol may modulate the hepatic and cardiac effect of doxorubicin, depending on the drug dose.

scholarly journals Lipid Peroxidation, Erythrocyte Superoxide-Dismutase Activity and Trace Metals in Young Male Footballers

2003 ◽  
Vol 44 (6) ◽  
pp. 979 ◽  
Author(s):  
Gökhan Metin ◽  
Pınar Atukeren ◽  
A. Ata Alturfan ◽  
Tevfik Gülyaşar ◽  
Mehmet Kaya ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Trace Metals ◽  
Young Male ◽  
Superoxide Dismutase Activity ◽  
Erythrocyte Superoxide Dismutase

ESSENTIAL OILS SUPEROXIDE DISMUTASE ACTIVITY AND LIPID PEROXIDATION IN OCIMUM BASILICUM L.

1993 ◽  
pp. 347-351
Author(s):  
D. Å tajner ◽  
O. GaÅ¡ic ◽  
E. Lemberkovics ◽  
I. Mathe ◽  
N. Mimica-Dukic
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Essential Oils ◽  
Ocimum Basilicum ◽  
Superoxide Dismutase Activity

Superoxide dismutase activity and the effects of NBQX and CPP on lipid peroxidation in experimental spinal cord injury

1999 ◽  
Vol 199 (5) ◽  
pp. 285-293 ◽  
Author(s):  
Aşkın Görgülü ◽  
Talat Kırış ◽  
Faruk Ünal ◽  
Ümit Turkoğlu ◽  
Mutlu Küçük ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Lipid Peroxidation ◽  
Spinal Cord Injury ◽  
Superoxide Dismutase ◽  
Superoxide Dismutase Activity ◽  
Experimental Spinal Cord Injury ◽  
Cord Injury

scholarly journals Prooxidant-Antioxidant Balance in the Heart of Rats with Different Behavioral Activities under the Conditions of Light Exposition

2021 ◽  
Vol 6 (3) ◽  
pp. 360-365
Author(s):  
L. D. Chebotar ◽  
◽  
E. N. Laricheva ◽  
M. Sh. Gilmutdinova
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Open Field ◽  
Emotional Stress ◽  
Light Exposure ◽  
Superoxide Dismutase Activity ◽  
Main Role ◽  
Experimental Animals ◽  
Behavioural Activity

The purpose of the article. The article shows that the effect of round-the-clock lighting causes changes in the processes of lipid peroxidation and antioxidant activity in rats, and depends on their behavioural activity. The effects of lighting on the processes of oxidative metabolism of varying degrees in the heart of resistant and unstable to emotional stress rats. Materials and methods. Investigations were carried out on 32 mature Wistar rats, divided into four groups: group 1 – animals resistant to emotional stress (intact); group 2 – intact animals unstable to emotional stress; group 3 – experimental animals resistant to emotional stress (30-day light exposure (1000 lux)); group 4 – experimental animals, unstable to emotional stress (30-day light exposure (1000 lux)). When assessing the effect of light on the state of the organism, the most important integral indicator is the behavior of animals. Therefore, during the experiment we used the observation of behavioral reactions in the test “open field”. Based on the characteristics of the behavior of animals in the “open field” rats were divided into groups resistant and unstable to emotional stress. To assess lipid peroxidation in the heart homogenate, the concentration of TBA-active products, the concentration of diene, oxidiene and triene conjugates were determined. Antioxidant processes were assessed by the increase in the concentration of TBA- active products during 1.5-hour incubation in an iron-ascorbate buffer solution, as well as by the activity of superoxide dismutase and catalase. Results and discussion. Prooxidant activity was characterized by an increase in the concentration of TBA-reactive substances in animals resistant to emotional stress. The concentration of TBA-reactive substances after 1.5-hour incubation increased in both experimental groups. Changes in the antioxidant status were illustrated by an increase in superoxide dismutase activity in the group of stress-unstable rats, whereas catalase activity increased in both experimental groups. In addition, in the group of animals resistant to emotional stress, a significant decrease in the resources of α-tocopherol and β-carotene was revealed. Conclusion. The long-term light exposure promotes the formation of end products of peroxidation in the heart of rats resistant to emotional stress and causes a decrease in antioxidant potential, regardless of behavioural activity. Antioxidant activity in the heart of emotionally stress-resistant rats is realized through both the enzyme and non-enzyme links of the antioxidant defence, while the main role in the heart of emotionally stress-resistant rats is played by superoxide dismutase activity

scholarly journals Palm oil extracts protected against cadmium chloride poisoning via inhibition of oxidative stress in rats

2022 ◽  
Vol 46 (1) ◽  
Author(s):  
Patrick Chukwuyenum Ichipi-Ifukor ◽  
Samuel Ogheneovo Asagba ◽  
Chibueze Nwose ◽  
Joseph Chukwufumnanya Mordi ◽  
John Chukwuma Oyem
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Palm Oil ◽  
Underlying Mechanism ◽  
Antioxidant Response ◽  
High Dose ◽  
Stress Indicators ◽  
Cadmium Poisoning ◽  
Oxidative Stress Indicators

Abstract Background The probable mechanism of an earlier reported capacity of palm oil extracts to confer protection against high dose cadmium poisoning in rats was reported in this study. Similar experimental design earlier reported by us was retained. Rats therefore were sacrificed at intervals of twelve; twenty four and forty eight hours post CdCl2 insult. Results Oxidative stress and antioxidant status (malondialdehyde, superoxide dismutase, catalase and glutathione) were assessed in tissues (liver, kidney, heart, brain, muscle) and serum. Oxidative stress indicators showed a significantly (p < 0.05) increased lipid peroxidation and alterations in antioxidant defence systems occasioned by drop in catalase and superoxide dismutase enzymes (serum, liver, heart, brain and kidneys) of the rats. Also observed were significant (p < 0.05) reduction in the non-enzymatic antioxidant reduced glutathione over time. Pre-administration of rats with the crude palm oil and its extracts modulated cadmium mediated depletion of the antioxidant capacities of rats acutely exposed to cadmium and rising lipid peroxidation profile. Conclusions Regulation of stress and antioxidant response was the underlying mechanism by which the extracts conferred protection against high dose cadmium insult thus suggesting its potential as a viable therapeutic target against its deleterious effects. Graphical Abstract

scholarly journals Evaluation of the effective dose of amygdalin for the improvement of antioxidant gene expression and suppression of oxidative damage in mice

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9232
Author(s):  
Sarah Albogami ◽  
Aziza Hassan ◽  
Nibal Ahmed ◽  
Alaa Alnefaie ◽  
Afnan Alattas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Body Weight ◽  
High Dose ◽  
Male Mice ◽  
Antioxidant Gene ◽  
Oxidative Balance ◽  
Antioxidant Gene Expression ◽  
Medium Dose

Background Little is known regarding the toxic and therapeutic doses of amygdalin. Treatment regimens and schedules can vary between humans and animal models, and there have been reports of cyanide toxicity due to amygdalin use. Objective The aim of this study was to evaluate the effect of different doses of amygdalin on antioxidant gene expression and suppression of oxidative damage in mice. Methods Forty adult male mice were divided randomly into four groups (n = 10) as follows and treated orally for two weeks: a control group treated with saline solution, a group treated with amygdalin at 200 mg/kg body weight, a group treated with amygdalin at 100 mg/kg body weight, and a group treated with amygdalin at 50 mg/kg body weight. Liver and testis samples were collected for gene expression, biochemical and histopathological analyses. Results The mice treated with medium-dose amygdalin (100 mg/kg) showed upregulated mRNA expression of glutathione peroxidase (P < 0.01) and superoxide dismutase (P < 0.05) and significantly decreased lipid peroxidation (P < 0.05) in hepatic and testicular tissues compared to those in the untreated groups (controls), with mild histopathological effects. The mice treated with high-dose of amygdalin (200 mg/kg) showed downregulated mRNA expression of glutathione peroxidase and superoxide dismutase (P < 0.01) and significantly increased lipid peroxidation (P < 0.05) in both hepatic and testicular tissues compared to those in the untreated groups (controls), with an apparent effect at the histopathological level. No effects were observed in the mice treated with low-dose amygdalin (50 mg/kg) at the gene, protein and histopathological level. Conclusion Low-and medium-dose amygdalin did not induce toxicity in the hepatic and testicular tissues of male mice, unlike high-dose amygdalin, which had a negative effect on oxidative balance in mice. Therefore, amygdalin at a moderate dose may improve oxidative balance in mice.

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