scholarly journals Hypolipidemic Activity ofEryngium carlinaeon Streptozotocin-Induced Diabetic Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Ruth Noriega-Cisneros ◽  
Omar Ortiz-Ávila ◽  
Edgar Esquivel-Gutiérrez ◽  
Mónica Clemente-Guerrero ◽  
Salvador Manzo-Avalos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Risk Factor ◽  
Total Cholesterol ◽  
Significant Risk ◽  
Ethanolic Extract ◽  
Chronic Administration ◽  
Significant Risk Factor ◽  
Cardiovascular Complications ◽  
Diabetic Rats

Diabetes mellitus (DM) is a significant risk factor for the development of cardiovascular complications. This study was undertaken to investigate the effect of chronic administration of ethanolic extract ofEryngium carlinaeon glucose, creatinine, uric acid, total cholesterol, and triglycerides levels in serum of streptozotocin- (STZ-) induced diabetic rats. Triglycerides, total cholesterol, and uric acid levels increased in serum from diabetic rats. The treatment withE. carlinaeprevented these changes. The administration ofE. carlinaeextract reduced the levels of creatinine, uric acid, total cholesterol, and triglycerides. Thus administration ofE. carlinaeis able to reduce hyperlipidemia related to the cardiovascular risk in diabetes mellitus.

scholarly journals Evaluation and Management of Patients with Diabetes and Hearing Loss

2019 ◽  
Vol 40 (04) ◽  
pp. 308-314 ◽  
Author(s):  
Christopher Spankovich ◽  
Krishna Yerraguntla
Keyword(s):  
Diabetes Mellitus ◽  
Hearing Loss ◽  
Risk Factor ◽  
Noise Exposure ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Patients With Diabetes ◽  
Acquired Hearing Loss ◽  
Ototoxic Drugs

AbstractDiabetes mellitus is a significant risk factor for acquired hearing loss and tinnitus. Persons with diabetes (PWD) may present with hearing loss symptoms earlier in life than those without diabetes. Furthermore, diabetes may exacerbate risk for hearing loss related to noise exposure and ototoxic drugs. The purpose of this article is to provide recommendations for the prevention, screening, evaluation, and management of hearing loss in PWD.

scholarly journals Gestational Diabetes Mellitus Is a Significant Risk Factor for Long-Term Maternal Renal Disease

2015 ◽  
Vol 100 (4) ◽  
pp. 1412-1416 ◽  
Author(s):  
Ofer Beharier ◽  
Ilana Shoham-Vardi ◽  
Gali Pariente ◽  
Ruslan Sergienko ◽  
Roy Kessous ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Gestational Diabetes ◽  
Renal Disease ◽  
Gestational Diabetes Mellitus ◽  
Significant Risk ◽  
Significant Risk Factor

scholarly journals Antidiabetic Activity of Extracts of Pithecellobium dulce Benth Leaves in Alloxan Induced Diabetic Rats

2016 ◽  
Vol 8 (05) ◽  
Author(s):  
V. S. Mul ◽  
N. Naikwade ◽  
C. Magdum ◽  
V. Jagtap
Keyword(s):  
Uric Acid ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Ethanolic Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Glycogen Level

The objective of the present study was to study effect of Pithecellobium dulce Benth (P. dulce) leaves in alloxan induced diabetic rats. The P. dulce leaves were extracted by maceration and soxhelation method by using water and ethanol as solvent. Acute toxicity study was performed according to OECD 425 guidelines for both aqueous and ethanolic extracts of P. dulce leaves. The dose of 200 mg/kg and 400 mg/kg was selected for further studies. Animals were rendered diabetic by administration of alloxan (130 mg/kg, i.p.). The albino rats were divided in to seven groups with five animals in each group. Diabetic animals were treated with aqueous and ethanolic extract for 20 days. Then blood glucose, triglyceride, total cholesterol, urea, uric acid, creatinine, aspartate aminotransferase (AST), alanine transaminase (ALT) and glycogen level in liver, muscle and kidney were estimated according to standard procedures. The result shows significant decrease in blood glucose, triglyceride, total cholesterol, urea, uric acid, creatinine, AST and ALT level when compared to diabetic group. The liver and muscle glycogen level was increased significantly in extract treated groups when compared to diabetic control group. Both extract of P. dulce posses antidiabetic and hypolipidemic potential.

Gestational diabetes mellitus is a significant risk factor for long-term ophthalmic morbidity

2017 ◽  
Vol 295 (6) ◽  
pp. 1477-1482 ◽  
Author(s):  
Ofer Beharier ◽  
Ruslan Sergienko ◽  
Roy Kessous ◽  
Irit Szaingurten-Solodkin ◽  
Asnat Walfisch ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Significant Risk ◽  
Significant Risk Factor

scholarly journals Urinary Tract Infection due to Extended-spectrum Beta-lactamase Producing Organisms is a Risk Factor for Bacteraemia Among Patients with Type 2 Diabetes Mellitus

2019 ◽  
Vol 31 (1) ◽  
pp. 9-12
Author(s):  
Muhammad Abdur Rahim ◽  
Shahana Zaman ◽  
Ishrat Jahan ◽  
Samira Humaira Habib ◽  
Tabassum Samad ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Urinary Tract Infection ◽  
Risk Factor ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Beta Lactamase ◽  
Extended Spectrum Beta Lactamase ◽  
Type 2 Diabetic

Introduction: Urinary tract infection (UTI) is common among patients with diabetes mellitus and the aetiological agents are often extended-spectrum beta-lactamase (ESBL) producing bacteria. Diabetic patients with UTI are sometimes complicated by bacteraemia. This study was designed to evaluate whether UTI due to ESBL-positive organisms is a risk factor for bacteraemia among patients with type 2 diabetes mellitus. Methods: This was a cross-sectional analytical study, done in BIRDEM General Hospital, Dhaka, Bangladesh from January to April 2016. Adult (e”18 years) type 2 diabetic subjects of either sex with culture proven UTI were included in this study. All study participants were subjected to undergo blood cultures as well. ESBL-positivity of the infective organisms for UTI was evaluated as possible risk factor for bacteraemia. Results: Total patients were 145 including 119 (82%) females. Eshcerichia coli (112, 77.2%) was the most common aetiological agents followed by Klebsiella pneumoniae (28, 19.3%). In 54 (37.2%) patients UTI was due to ESBL-positive organisms. Ten (6.9%) patients were complicated by bacteraemia [7 (7/ 54, 13%) among patients with UTI due to ESBL-positive organisms and 3 (3/91, 3.3%) among patients with UTI due to non-ESBL organisms]. UTI due to ESBL-positive organisms appeared as a significant risk factor for bacteraemia (OR 4.37, 95% CI 1.08-17.38, p 0.03). Conclusion: Nearly two-fifths of UTI cases were due to ESBL-positive organisms in this study. ESBLpositivity of the causative organisms was a significant risk factor for bacteraemia among type 2 diabetic subjects. Bangladesh J Medicine Jan 2020; 31(1) : 9-12

scholarly journals Incidence and Risk Factors of Contrast Induced Nephropathy in Patients Following Coronary Angiography

2018 ◽  
Vol 15 (1) ◽  
pp. 20-25
Author(s):  
Mohammed Rashed Anwar ◽  
Abu Noim Md Abdul Hai ◽  
Dilip Kumar Debnath ◽  
Md Anwarul Hoque Faraji ◽  
KAM Mahbub Hasan
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Regression Analysis ◽  
Risk Factor ◽  
Coronary Angiography ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Estimated Gfr ◽  
Contrast Induced Nephropathy ◽  
Contrast Volume

Background: Contrast induced nephropathy (CIN) is a common complication after administration of contrast medium. As the third leading cause of hospital acquired acute kidney injury, CIN occurs in half of the patients undergoing coronary angiography (CAG).Objective: The purpose of the present study was to see the frequency of contrast induced nephropathy in patients after coronary angiography and its risk factors.Methodology: This comparative cross sectional study was performed at National Institute of Kidney Diseases and Urology, Dhaka and Department of Cardiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July, 2016 to December 2016 for a period of six (06) months. All patients 18 years and above who underwent coronary angiography with or without percutaneuous Transluminal coronary angioplasty with normal or impaired renal function, with or without Diabetes Mellitus or hypertension were included in the study. The patients were divided into two groups named as group A who did not develop CIN and group B developed CIN. Pre- and Post procedure serum creatinine was estimated at 48 hours after coronary angiogram. Independent characteristics associated with CIN were identified.Results: A total number of 250 patients were recruited for this study. Older age ≥70 years, diabetes mellitus were significant risk factor for CIN whereas hypertension was not statistically significant. Logistic regression analysis of risk factors were identified 05 (five) risk factors in this study which were baseline estimated GFR <60mi/min/1.73m2 BSA, diabetes mellitus, contrast volume >100ml, PTCA and LVEF < 40%). Effect of drugs used in the development of CIN by logistic regression analysis. None of the drugs showed significant relationship on development of CIN.Conclusion: Older age, baseline estimated GFR <60mi/min/1.73m2 BSA, diabetes mellitus, contrast volume >100ml, PTCA and LVEF < 40%) were significant risk factor to developed CIN. Journal of Science Foundation 2017;15(1):20-25

scholarly journals Diabetes Mellitus Increases the Risk of Hepatocellular Carcinoma After Direct-Acting Antiviral Therapy: Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Szilárd Váncsa ◽  
Dávid Németh ◽  
Péter Hegyi ◽  
Zsolt Szakács ◽  
Ádám Farkas ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Risk Factor ◽  
De Novo ◽  
Meta Analysis ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Predictive Risk Factor ◽  
Direct Acting

Background: Hepatitis C virus (HCV)-infected patients treated with direct-acting antivirals (DAAs) are still at risk of developing hepatocellular carcinoma (HCC) after sustained virologic response (SVR). This study aimed to investigate the role of diabetes mellitus (DM) as a potential predictive risk factor in developing de novo HCC in HCV-infected patients after DAA treatment.Methods: This study was registered on PROSPERO under registration number CRD42021230457. We performed a systematic search in four medical databases from inception through November 3rd, 2020. Studies were eligible if they reported on HCV-infected patients treated with DAAs and compared the frequency of de novo HCC in patients with and without DM. We calculated pooled odds ratios, unadjusted (UHR), and adjusted hazard ratios (AHR) with 95% confidence intervals (CIs) in meta-analysis.Results: We included 30 articles in our systematic review and meta-analysis. DM proved to be a significant risk factor of HCC in DAA-treated HCV patients in unadjusted (UHR = 1.44, CI: 1.15–1.79) and adjusted analyses (AHR = 1.31, CI: 1.06–1.62). In the group of patients achieving SVR after DAA therapy, DM increased the risk of HCC in unadjusted (UHR = 1.3, CI: 1.09–1.51) analysis; however, in adjusted results, the risk was non-significant (AHR = 1.07, CI: 0.89–1.28). In patients with advanced liver fibrosis, DM was a risk factor for HCC in adjusted (AHR = 1.36, CI: 1.03–1.8), but not in unadjusted analysis (UHR = 1.11, CI: 0.8–1.42).Conclusions: DM is an independent risk factor of de novo HCC after DAA treatment in HCV-infected patients.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=230457, identifier: CRD42021230457.

scholarly journals Pro12Ala gene polymorphism in the peroxisome proliferator-activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the Serbian population

2010 ◽  
Vol 62 (2) ◽  
pp. 263-270 ◽  
Author(s):  
Sanja Soskic ◽  
Aleksandra Stankovic ◽  
Tamara Djuric ◽  
Maja Zivkovic ◽  
P. Ristic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Study Population

The peroxisome proliferator-activated receptor gamma (PPAR?) is a gene candidate for the onset of type 2 diabetes mellitus (T2DM). We investigated the association of the PPAR? Pro12Ala gene with the onset of T2DM for the first time in the Serbian population. The study population consisted of 197 controls and 163 T2DM patients. The 12Ala allele tended to be more frequent in the group of T2DM patients (0.11) compared to the control subjects (0.09). The results from this study indicate that the PPAR?2 12Ala allele presents a non-significant risk factor for T2DM development in the Serbian population.

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