scholarly journals Potential Infectious Etiology of Behçet's Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Massimiliano Galeone ◽  
Roberta Colucci ◽  
Angelo Massimiliano D'Erme ◽  
Silvia Moretti ◽  
Torello Lotti
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Molecular Mimicry ◽  
Behçet's Disease ◽  
Parvovirus B19 ◽  
Infectious Agent ◽  
Skin Lesions ◽  
Inflammatory Disorder ◽  
Behcet's Disease ◽  
Varicella Zoster

Behçet's disease is a multisystem inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. The cause of Behçet's disease remains unknown, but epidemiologic findings suggest that an autoimmune process is triggered by an environmental agent in a genetically predisposed individual. An infectious agent could operate through molecular mimicry, and subsequently the disease could be perpetuated by an abnormal immune response to an autoantigen in the absence of ongoing infection. Potentia bacterial are Saccharomyces cerevisiae, mycobacteria, Borrelia burgdorferi, Helicobacter pylori, Escherichia coli, Staphylococcus aureus, and Mycoplasma fermentans, but the most commonly investigated microorganism is Streptococcus sanguinis. The relationship between streptococcal infections and Behçet's disease is suggested by clinical observations that an unhygienic oral condition is frequently noted in the oral cavity of Behçet's disease patients. Several viral agents, including herpes simplex virus-1, hepatitis C virus, parvovirus B19, cytomegalovirus, Epstein-Barr virus and varicella zoster virus, may also have some role.

scholarly journals Immunopathogenesis of Ocular Behçet’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Un Chul Park ◽  
Tae Wan Kim ◽  
Hyeong Gon Yu
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Retinal Vasculitis ◽  
Skin Lesions ◽  
Unknown Etiology ◽  
Ocular Involvement ◽  
Inflammatory Disorder ◽  
General Hypothesis ◽  
Behcet's Disease

Behçet’s disease (BD) is a chronic recurrent systemic inflammatory disorder of unknown etiology characterized by oral and genital ulcerations, skin lesions, and uveitis. The ocular involvement of BD, or Behçet’s uveitis (BU), is characterized by panuveitis or posterior uveitis with occlusive retinal vasculitis and tends to be more recurrent and sight threatening than other endogenous autoimmune uveitides, despite aggressive immunosuppression. Although pathogenesis of BD is unclear, researches have revealed that immunological aberrations may be the cornerstone of BD development. General hypothesis of BD pathogenesis is that inflammatory response is initiated by infectious agents or autoantigens in patients with predisposing genetic factors and perpetuated by both innate and acquired immunity. In addition, a network of immune mediators plays a substantial role in the inflammatory cascade. Recently, we found that the immunopathogenesis of BU is distinct from other autoimmune uveitides regarding intraocular effector cell profiles, maturation markers of dendritic cells, and the cytokine/chemokine environment. In addition, accumulating evidence indicates the involvement of Th17 cells in BD and BU. Recent studies on genetics and biologics therapies in refractory BU also support the immunological association with the pathogenesis of BU. In this review, we provide an overview of novel findings regarding the immunopathogenesis of BU.

Behçet’s Disease: A Review

2005 ◽  
Vol 84 (3) ◽  
pp. 209-222 ◽  
Author(s):  
L.M. Al-Otaibi ◽  
S.R. Porter ◽  
T.W.J. Poate
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Infectious Agent ◽  
Inflammatory Disorder ◽  
Autoimmune Reaction ◽  
Behcet's Disease ◽  
Worldwide Distribution ◽  
Life Threatening ◽  
Silk Route

Behçet’s disease (BD) is a multi-system inflammatory disorder dominated clinically by recurrent oral and genital ulceration, uveitis, and erythema nodosum. Behçet’s disease runs a chronic course, with unpredictable exacerbations and remissions whose frequency and severity may diminish with time. Behçet’s disease typically arises in young adults, although childhood-onset BD has also been reported. The disease can affect both genders and has a worldwide distribution, although it is more prevalent in countries of the ancient Silk Route. The cause of BD remains unknown, although an autoimmune reaction triggered by an infectious agent in a genetically predisposed individual has been suggested. The treatment of BD is symptomatic and empirical, but generally specific to the clinical features of each patient. The majority of affected individuals do not have life-threatening disease, although mortality can be associated with vascular-thrombotic and neurological disease.

scholarly journals Histopathological Evaluation of Behçet's Disease and Identification of New Skin Lesions

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Özgür Gündüz
Keyword(s):  
Differential Diagnosis ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Skin Lesions ◽  
Direct Immunofluorescence ◽  
Inflammatory Disorder ◽  
Behcet's Disease ◽  
Histopathological Evaluation ◽  
New Skin

Behçet's disease (BD) is a multisystemic, relapsing inflammatory disorder with an obscure etiology and pathogenesis. Diagnosis depends on the clinician's ability to identify a group of nonspecific mucocutaneous lesions, which also manifest in a number of other diseases. In recent years, there has been an increase in the studies focusing on the histopathological aspects of Behçet's disease diagnostic mucocutaneous lesions. Their results emphasize the value of histopathology and direct immunofluorescence (DIF) in the differential diagnosis of Behçet's disease.

scholarly journals Behcet’s Disease in Southeast Asia. Clinical Features, Genetic Study, and Review of Recent Treatment

2021 ◽  
pp. 1-15
Author(s):  
Worawit Louthrenoo
Keyword(s):  
Southeast Asia ◽  
Behçet’S Disease ◽  
Genetic Study ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Clinical Manifestations ◽  
Case Series ◽  
Skin Lesions ◽  
Inflammatory Disorder ◽  
Behcet's Disease

Behçet’s disease (BD) is a chronic systemic inflammatory disorder characterized by recurrent oral and genital ulcers, skin lesions, and ocular inflammations. It also can affect other organs such as blood vessels, nervous, gastrointestinal, and articular systems. The disease has a worldwide distribution, but is more prevalent in countries along the Silk Road. Genetic study has shown that the disease is associated with the presence of human leukocyte antigen (HLA)-B*51/B%51:01. BD is considered an uncommon disease in Southeast Asia, and only a few case series have been reported. This article reviews the clinical manifestations and genetic association of BD in Southeast Asian countries and compares them with those in East Asia, South Asia, and the Middle East. It also updated the treatment of BD, particularly the use of biologic agents.

scholarly journals Detection of Herpes Virus Genomes in Skin Lesions from Patients with Behçet's Disease and Other Related Inflammatory Diseases

2003 ◽  
Vol 83 (2) ◽  
pp. 124-127 ◽  
Author(s):  
MICHIKO TOJO ◽  
XUEYI ZHENG ◽  
HIROKATSU YANAGIHORI ◽  
NORITAKA OYAMA ◽  
KAZUO TAKAHASHI ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Herpes Virus ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Inflammatory Diseases ◽  
Skin Lesions ◽  
Behcet's Disease ◽  
Herpès Virus ◽  
Virus Genomes

Characteristics of T cell lines established from skin lesions of Behcet's disease

1997 ◽  
Vol 15 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Mitsuru Mochizuki ◽  
Eishin Morita ◽  
Shoso Yamamoto ◽  
Seizo Yamana
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Skin Lesions ◽  
Behcet's Disease ◽  
T Cell Lines

scholarly journals A Darwinian view of Behçet's disease

2021 ◽  
Vol 2 (2) ◽  
pp. 91-99
Author(s):  
Rhodri Smith ◽  
Robert J. Moots ◽  
Mariam Murad ◽  
Graham R. Wallace
Keyword(s):  
Behçet’S Disease ◽  
Complex Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Clinical Findings ◽  
Unknown Etiology ◽  
Inflammatory Disorder ◽  
Protective Mechanisms ◽  
Behcet's Disease ◽  
Cns Lesions

Abstract Behçet’s disease (BD) is a multisystem inflammatory disorder of unknown etiology, characterized by oral and genital ulceration, with other complications including eye, skin, joint, and central nervous system (CNS) lesions. Diagnosis is based on clinical findings, which may differ between patients. There is a strong genetic basis for BD; however, only a few genes have been associated with the disease across the geographical spread of BD. In this article, we discuss the history and combination of genes involved in this complex disease in relation to the geographical range and present our view that the disease has developed from a Darwinian perspective, with different gene polymorphisms that affect the same biological pathway. Moreover, these mutations individually are protective mechanisms against the disease relevant to each region, which affected both archaic and modern humans.

scholarly journals Neuro-Behçet’s Disease – Clinical Features, Diagnosis and Differential Diagnosis

2018 ◽  
Vol 13 (2) ◽  
pp. 93
Author(s):  
Selen Ozyurt ◽  
Petros Sfikakis ◽  
Aksel Siva ◽  
Cris S Constantinescu ◽  
◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Case Reports ◽  
Illustrative Case ◽  
Inflammatory Disorder ◽  
Behcet's Disease ◽  
Multisystem Involvement ◽  
The Central Nervous System

Background:Behçet’s disease is a relatively uncommon, inflammatory disorder with characteristic mucocutaneous lesions and multisystem involvement, of unknown aetiology; presumably a vascular autoinflammatory syndrome that develops under combined environmental and genetic influences. As neuro-Behçet’s disease affects the central nervous system in about 10% of cases and in ways that can mimic other neuroinflammatory conditions, awareness of its manifestations, significance, and management is important for neurologists. In March 2017, a mini-symposium at the 11th Congress of Controversies in Neurology in Athens, Greece, was dedicated to specific aspects of Behçet’s and neuro-Behçet’s disease. These included an introduction to Behçet’s disease, pathogenesis and treatment, an overview of its neurological manifestations (neuro-Behçet’s disease) and the differential diagnosis from other neuroinflammatory conditions. Illustrative case reports were used.Objectives:To provide a brief overview of neuro-Behçet’s disease that is informative for clinical neurological practice and that follows the structure of the 2017 mini-symposium.Data sources:Relevant recent comprehensive reviews of the subject and relevant original articles and case reports were provided by each speaker at the mini-symposium. This article contains some of these sources and some additions where necessary to emphasise specific points. References are also provided for more comprehensive recent reviews.Limitations:The mini-symposium was an opportunity for providing a brief update and overview of neuro-Behçet’s disease and to exchange ideas and experience among neurologists. As such, it was found to be helpful, but also limited in scope. This resultant article refers to comprehensive reviews on the topic but is not in itself a comprehensive systematic review.Conclusions:Neuro-Bechet’s disease comprises largely two forms, parenchymal and a non-parenchymal. These manifestations seldom overlap in the same individual and may reflect different pathogenetic mechanisms. The principles of treatment largely follow the principles of treating Bechet’s disease in general, with the mainstay being corticosteroids for exacerbations and immunosuppressive treatments for prevention of exacerbations. One notable exception is cyclosporine, which is typically avoided in neuro-Bechet’s disease. Anti-tumour necrosis factor biologicals play an increasing role in treatment. Distinguishing neuro-Behçet’s disease from other neuroinflammatory conditions, such as multiple sclerosis, is essential for both management and prognostic reasons.

scholarly journals Behcet’s Disease in an Adult Male From Nepal: A Case Report

2021 ◽  
Author(s):  
Madan Basnet ◽  
Abisha Phudong ◽  
Kamal Gautam ◽  
Bishnu Pathak ◽  
Suman Gaire ◽  
...  
Keyword(s):  
Case Report ◽  
Blood Vessels ◽  
Behçet’S Disease ◽  
Adult Male ◽  
Acute Inflammation ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Systemic Vasculitis ◽  
Skin Lesions ◽  
Behcet's Disease

Behcet’s Disease is a rare systemic vasculitis characterized by recurrent episodes of acute inflammation affecting blood vessels of all sizes. Symptoms include orogenital apthosis, cutaneous skin lesions, and uveitis. We present the case of a 38-year-old Nepalese man with Behcet’s Disease. In Nepal, Behcet’s Disease may still be under-reported.

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