scholarly journals Preparation of Folate-Conjugated Pluronic F127/Chitosan Core-Shell Nanoparticles Encapsulating Doxorubicin for Breast Cancer Treatment

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Chawan Manaspon ◽  
Kwanchanok Viravaidya-Pasuwat ◽  
Nuttaporn Pimpha
Keyword(s):  
Self Assembly ◽  
Sodium Dodecyl ◽  
Pluronic F127 ◽  
Core Shell ◽  
Burst Release ◽  
Shell Nanoparticles ◽  
The Core ◽  
Assembly Method ◽  
Core Shell Nanoparticles

A targeting drug delivery system using folate-conjugated pluronic F127/chitosan core-shell nanoparticles was developed to deliver doxorubicin (DOX) to the target cancer cells. First, DOX was encapsulated in pluronic F127 micelle cores in the presence of sodium dodecyl sulfate (SDS) by a self-assembly method. To form a shell, a layer of either chitosan or folate-conjugated chitosan was deposited onto the pluronic micelles. The encapsulation efficiency was approximately58.1±4.7%. The average size of the core-shell nanoparticles was37.4±2.0 nm, while the zeta potential was12.9±2.3 mV, indicating the presence of a shell layer and more stable particles. In anin vitroDOX release study, an initial burst release, followed by a sustained release, was observed within 24 hours. In addition, the core-shell nanoparticles showed greater cytotoxicity towards MCF-7 cells than free DOX, suggesting a better therapeutic efficacy in treating cancer.

scholarly journals Self-Assembly of Pluronic F127—Silica Spherical Core–Shell Nanoparticles in Cubic Close-Packed Structures

2015 ◽  
Vol 27 (15) ◽  
pp. 5161-5169 ◽  
Author(s):  
Stef Kerkhofs ◽  
Tom Willhammar ◽  
Heleen Van Den Noortgate ◽  
Christine E. A. Kirschhock ◽  
Eric Breynaert ◽  
...  
Keyword(s):  
Self Assembly ◽  
Pluronic F127 ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Spherical Core ◽  
Core Shell Nanoparticles

Facile Synthesis and In Vitro Biological Screening of Pd@SiO2 Core–Shell Nanoparticles

2019 ◽  
Vol 19 (6) ◽  
pp. 3536-3543 ◽  
Author(s):  
K Rajasekar ◽  
A Dinesh ◽  
M Durka ◽  
K Muthukumaravel
Keyword(s):  
Dna Binding ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Core Shell ◽  
Light Illumination ◽  
Shell Nanoparticles ◽  
The Core ◽  
Ft Ir ◽  
Core Shell Nanoparticles

In this study, semiconductor core–shell Pd@SiO2 nanoparticles (NPs) were prepared by Stober’s method. The prepared final products were characterized by XRD, FT-IR, SEM, HR-TEM and EDX techniques. Cell viability of Pd@SiO2 NPs against HeLa cell line was screened by MTT assay. The present study indicates that the core–shell Pd@SiO2 NPs are extremely stable along with very high photodynamic efficiency under LED light illumination. The antibacterial activities of core– shell Pd@SiO2 NPs were determined with Escherichia coli and Staphylococcus aureus by agar diffusion method. DNA binding affinity of the core–shell Pd@SiO2 NPs towards CT-DNA was also investigated. The observed results showed that SiO2 supported on the surface of Pd NPs not only prevented aggregation, but also proved the enhanced antimicrobial and DNA binding propensities than the free Pd NPs.

scholarly journals Synthesis and Characterization of Bio-Active GFP-P4VP Core–Shell Nanoparticles

Catalysts ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 627
Author(s):  
Erik Sarnello ◽  
Yuzi Liu ◽  
Bethany Palen ◽  
Elaine Sun ◽  
Xiaobing Zuo ◽  
...  
Keyword(s):  
Self Assembly ◽  
Core Protein ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Assembly Method ◽  
Synthetic Materials ◽  
Transmission Electron ◽  
Core Shell Nanoparticles ◽  
Enzyme Functionality

Bioactive core–shell nanoparticles (CSNPs) offer the unique ability for protein/enzyme functionality in non-native environments. For many decades, researchers have sought to develop synthetic materials which mimic the efficiency and catalytic power of bioactive macromolecules such as enzymes and proteins. This research studies a self-assembly method in which functionalized, polymer-core/protein-shell nanoparticles are prepared in mild conditions. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) techniques were utilized to analyze the size and distribution of the CSNPs. The methods outlined in this research demonstrate a mild, green chemistry synthesis route for CSNPs which are highly tunable and allow for enzyme/protein functionality in non-native conditions.

Magnetic-field-induced self-assembly of FeCo/CoFe2O4 core/shell nanoparticles with tunable collective magnetic properties

Nanoscale ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 4519-4529
Author(s):  
J. Mohapatra ◽  
J. Elkins ◽  
M. Xing ◽  
D. Guragain ◽  
Sanjay R. Mishra ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
Physical Properties ◽  
Self Assembly ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Novel Approach ◽  
Core Shell Nanoparticles

Self-assembly of nanoparticles into ordered patterns is a novel approach to build up new consolidated materials with desired collective physical properties.

Hybrid Core-Shell Nanoparticles by “Plug and Play” Self-Assembly

2018 ◽  
Vol 24 (67) ◽  
pp. 17672-17676 ◽  
Author(s):  
Benjamin Pacaud ◽  
Loïc Leclercq ◽  
Jean-François Dechézelles ◽  
Véronique Nardello-Rataj
Keyword(s):  
Self Assembly ◽  
Core Shell ◽  
Plug And Play ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles
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