scholarly journals Abnormalities of the Ventilatory Equivalent for Carbon Dioxide in Patients with Chronic Heart Failure

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Lee Ingle ◽  
Rebecca Sloan ◽  
Sean Carroll ◽  
Kevin Goode ◽  
John G. Cleland ◽  
...  
Keyword(s):  
Heart Failure ◽  
Carbon Dioxide ◽  
Chronic Heart Failure ◽  
Oxygen Uptake ◽  
Minute Ventilation ◽  
Carbon Dioxide Production ◽  
Peak Oxygen Uptake ◽  
Healthy Controls ◽  
Ventilatory Equivalent ◽  
All Cause Mortality

Introduction. The relation between minute ventilation (VE) and carbon dioxide production (VCO2) can be characterised by the instantaneous ratio of ventilation to carbon dioxide production, the ventilatory equivalent for CO2(VEqCO2). We hypothesised that the time taken to achieve the lowest VEqCO2(time to VEqCO2 nadir) may be a prognostic marker in patients with chronic heart failure (CHF).Methods. Patients and healthy controls underwent a symptom-limited, cardiopulmonary exercise test (CPET) on a treadmill to volitional exhaustion.Results. 423 patients with CHF (mean age years; 80% males) and 78 healthy controls (62% males; age years) were recruited. Time to VEqCO2 nadir was shorter in patients than controls ( s versus  s; ). Univariable predictors of all-cause mortality included peak oxygen uptake (), VEqCO2nadir (), and time to VEqCO2nadir (). In an adjusted Cox multivariable proportional hazards model, peak oxygen uptake () and VEqCO2nadir () were the most significant independent predictors of all-cause mortality.Conclusion. The time to VEqCO2nadir was shorter in patients with CHF than in normal subjects and was a predictor of subsequent mortality.

scholarly journals Minute ventilation/carbon dioxide production in chronic heart failure

2021 ◽  
Vol 30 (159) ◽  
pp. 200141
Author(s):  
Piergiuseppe Agostoni ◽  
Susanna Sciomer ◽  
Pietro Palermo ◽  
Mauro Contini ◽  
Beatrice Pezzuto ◽  
...  
Keyword(s):  
Heart Failure ◽  
Carbon Dioxide ◽  
Chronic Heart Failure ◽  
Dead Space ◽  
Minute Ventilation ◽  
Carbon Dioxide Production ◽  
Absolute Number ◽  
Prognostic Scores ◽  
And Gender ◽  
End Tidal

In chronic heart failure, minute ventilation (V′E) for a given carbon dioxide production (V′CO2) might be abnormally high during exercise due to increased dead space ventilation, lung stiffness, chemo- and metaboreflex sensitivity, early metabolic acidosis and abnormal pulmonary haemodynamics. The V′Eversus V′CO2 relationship, analysed either as ratio or as slope, enables us to evaluate the causes and entity of the V′E/perfusion mismatch. Moreover, the V′E axis intercept, i.e. when V′CO2 is extrapolated to 0, embeds information on exercise-induced dead space changes, while the analysis of end-tidal and arterial CO2 pressures provides knowledge about reflex activities. The V′Eversus V′CO2 relationship has a relevant prognostic power either alone or, better, when included within prognostic scores. The V′Eversus V′CO2 slope is reported as an absolute number with a recognised cut-off prognostic value of 35, except for specific diseases such as hypertrophic cardiomyopathy and idiopathic cardiomyopathy, where a lower cut-off has been suggested. However, nowadays, it is more appropriate to report V′Eversus V′CO2 slope as percentage of the predicted value, due to age and gender interferences. Relevant attention is needed in V′Eversus V′CO2 analysis in the presence of heart failure comorbidities. Finally, V′Eversus V′CO2 abnormalities are relevant targets for treatment in heart failure.

The Minute Ventilation/Carbon Dioxide Production Slope is Prognostically Superior to the Oxygen Uptake Efficiency Slope

2007 ◽  
Vol 13 (6) ◽  
pp. 462-469 ◽  
Author(s):  
Ross Arena ◽  
Jonathan Myers ◽  
Leon Hsu ◽  
Mary Ann Peberdy ◽  
Sherry Pinkstaff ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Oxygen Uptake ◽  
Minute Ventilation ◽  
Carbon Dioxide Production ◽  
Uptake Efficiency ◽  
Oxygen Uptake Efficiency Slope

Prognostic Comparison of the Minute Ventilation/Carbon Dioxide Production Ratio and Slope in Patients with Heart Failure

Heart Drug ◽  
2004 ◽  
Vol 4 (3) ◽  
pp. 133-139 ◽  
Author(s):  
Ross Arena ◽  
Jonathan Myers ◽  
Syed Salman Aslam ◽  
Elsa B. Varughese ◽  
Mary Ann Peberdy
Keyword(s):  
Heart Failure ◽  
Carbon Dioxide ◽  
Minute Ventilation ◽  
Carbon Dioxide Production ◽  
Production Ratio ◽  
Patients With Heart Failure

Intratest reliability and test–retest reproducibility of the oxygen uptake efficiency slope in healthy participants

2009 ◽  
Vol 16 (4) ◽  
pp. 493-498 ◽  
Author(s):  
Christophe Van Laethem ◽  
Johan De Sutter ◽  
Wim Peersman ◽  
Patrick Calders
Keyword(s):  
Carbon Dioxide ◽  
Oxygen Uptake ◽  
Minute Ventilation ◽  
Exercise Duration ◽  
Peak Oxygen Uptake ◽  
Exercise Tests ◽  
Uptake Efficiency ◽  
Carbon Dioxide Output ◽  
Oxygen Uptake Efficiency Slope ◽  
Healthy Participants

Background The oxygen uptake efficiency slope (OUES) is a newer ventilatory exercise parameter, used in the evaluation of healthy participants and patients with cardiovascular disease. However, few data about the reliability and reproducibility of OUES are available. Our study assessed intratest reliability and test-retest reproducibility of OUES in healthy participants. Design and methods Eighteen participants (age 28 ± 6 years, BMI 22.1 ± 1.9 kg/m2, 10 men) performed two identical maximal exercise tests on a bicycle ergometer. To assess test-retest reproducibility, we performed Bland-Altman analysis and calculated the coefficient of repeatability of the main ventilatory variables. Results OUES remained stable during the second part of the exercise test. Mean values varied 2.4 ± 4.0% between OUES calculated at 70% (OUES70) and at 100% of exercise duration. Mean variation decreased to 1.4 ± 2.3% when OUES was calculated at 90% of exercise duration (OUES90). The Bland-Altman 95% limits of agreement for OUES90 were +3 and –6%, those for OUES70 were +11 and –8%. The coefficient of repeatability for OUES was 597 ml/min or 18.7% of the average value of repeated OUES measurements. These results were similar to those of peak oxygen uptake and minute ventilation/carbon dioxide output. However, the test-retest reproducibility for submaximal-derived values of OUES was lower, as we noted higher coefficients of repeatability for OUES90 and OUES70, increasing up to 27% of the average of repeated values. Conclusion OUES shows excellent intratest reliability and has a test-retest reproducibility that is similar to that of peak oxygen uptake and minute ventilation/carbon dioxide output slope. However, its reproducibility becomes higher when it is calculated from increasing levels of achieved exercise intensity.

scholarly journals Relation between ventilation and carbon dioxide production in patients with chronic heart failure

1992 ◽  
Vol 20 (6) ◽  
pp. 1326-1332 ◽  
Author(s):  
Andrew Lawrence Clark ◽  
Philip Alexander Poole-Wilson ◽  
Andrew Justin Stewart Coats
Keyword(s):  
Heart Failure ◽  
Carbon Dioxide ◽  
Chronic Heart Failure ◽  
Carbon Dioxide Production

scholarly journals Neurohormonal Determinants of Peak Oxygen Uptake in Patients with Chronic Heart Failure

2003 ◽  
Vol 44 (5) ◽  
pp. 725-734 ◽  
Author(s):  
Toru Kinugawa ◽  
Masahiko Kato ◽  
Kazuhide Ogino ◽  
Osamu Igawa ◽  
Ichiro Hisatome ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Oxygen Uptake ◽  
Peak Oxygen Uptake
Sign in / Sign up

Export Citation Format

Share Document