scholarly journals Focal Laser Ablation of Prostate Cancer: Definition, Needs, and Future

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Pierre Colin ◽  
Serge Mordon ◽  
Pierre Nevoux ◽  
Mohammed Feras Marqa ◽  
Adil Ouzzane ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Laser Ablation ◽  
Low Cost ◽  
Relevant Literature ◽  
Focal Therapy ◽  
Integrated System ◽  
Therapeutic Modality ◽  
Potential Candidate ◽  
Cancer Management

Current challenges and innovations in prostate cancer management concern the development of focal therapies that allow the treatment of only the cancer areas sparing the rest of the gland to minimize the potential morbidity. Among these techniques, focal laser ablation (FLA) appears as a potential candidate to reach the goal of focusing energy delivery on the identified targets. The aim of this study is to perform an up-to-date review of this new therapeutic modality. Relevant literature was identified using MEDLINE database with no language restrictions (entries: focal therapy, laser interstitial thermotherapy, prostate cancer, FLA) and by cross-referencing from previously identified studies. Precision, real-time monitoring, MRI compatibility, and low cost of integrated system are principal advantages of FLA. Feasibility and safety of this technique have been reported in phase I assays. FLA might eventually prove to be amiddle groundbetween active surveillance and radical treatment. In conclusion, FLA may have found a role in the management of prostate cancer. However, further trials are required to demonstrate the oncologic effectiveness in the long term.

scholarly journals Current Challenges in Prostate Cancer Management and the Rationale behind Targeted Focal Therapy

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Al B. Barqawi ◽  
Kevin J. Krughoff ◽  
Khadijah Eid
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Focal Therapy ◽  
Current Treatment ◽  
Cancer Awareness ◽  
Cancer Statistics ◽  
Cancer Management ◽  
Treatment Techniques ◽  
High Prevalence

Among men, prostate cancer has a high prevalence, with relatively lower cancer-specific mortality risk compared to lung and colon cancer. Prostate-specific antigen (PSA) screening has increased prostate cancer awareness since its implementation as a screening tool almost 25 years ago, but, due to the largely indolent course of this disease and the unspecific nature of the PSA test, increased incidence has largely been associated with cancers that would not go on to cause death (clinically insignificant), leading to an overdiagnosis challenge and an ensuing overtreatment consequences. The overtreatment problem is exacerbated by the high risk of side effects that current treatment techniques have, putting patients’ quality of life at risk with little or no survival benefit. The goals of this paper are to evaluate the rise, prevalence, and impact of the overdiagnosis and ensuing overtreatment problems, as well as highlight potential solutions. In this effort, a review of major epidemiological and screening studies, cancer statistics from the advent of prostate-specific antigen screening to the present, and reports on patient concerns and treatment outcomes was conducted to present the dominant factors that underlie current challenges in prostate cancer treatment and illuminate potential solutions.

scholarly journals Prostate cancer management: long-term beliefs, epidemic developments in the early twenty-first century and 3PM dimensional solutions

2020 ◽  
Vol 11 (3) ◽  
pp. 399-418 ◽  
Author(s):  
Radek Kucera ◽  
Ladislav Pecen ◽  
Ondrej Topolcan ◽  
Anshu Raj Dahal ◽  
Vincenzo Costigliola ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
First Century ◽  
Cancer Management ◽  
Early Twenty ◽  
Twenty First Century ◽  
Prostate Cancer Management

scholarly journals Unfavorable Outcomes in Solid and Spongiform Thyroid Nodules Treated with Laser Ablation. A 5-Year Follow-up Retrospective Study

2019 ◽  
Vol 19 (7) ◽  
pp. 1041-1045 ◽  
Author(s):  
Roberto Negro ◽  
Gabriele Greco
Keyword(s):  
Retrospective Study ◽  
Laser Ablation ◽  
Thyroid Nodules ◽  
False Negative ◽  
Thyroid Function Test ◽  
Final Diagnosis ◽  
Therapeutic Modality ◽  
Nodule Volume

Objective: Laser Ablation (LA) is a therapeutic modality for reducing the volume of large benign thyroid nodules. This retrospective study was aimed at assessing the outcome of LA in patients with benign nonfunctioning thyroid nodules in a 5-years follow-up. Methods: Sixty-two patients (47 females; mean age 54.7±12 yr) with benign cold thyroid nodules underwent LA from July 2009 to March 2012. Nodule volume, thyroid function test, and ultrasound were monitored at baseline, and at 3, 6 and 12 months after the procedure, then annually. After dividing nodules in solid and spongiform, we evaluated unfavourable outcomes: 1) nodule’s volume reduction <50%; 2) need for surgery; 3) need for additive LA session (due to nodule re-growth with persistence of cosmetic concern or compressive symptoms). Results: Baseline volume did not differ between solid and spongiform nodules as well as energy delivered and the number of needles used. Unfavourable outcomes occurred in 24 patients (38.7%). Nineteen/ 24 (79.2%) patients who experienced unfavourable outcomes belonged to the solid nodules group (P<0.01). When considering only those who benefited from LA, the 5-years reduction was 59.7% for solid and 78.6% for spongiform nodules (P<0.05). One/6 patients who underwent surgery (solid nodules group) had a final diagnosis of Follicular Variant of Papillary Thyroid Cancer (FVPTC). Conclusion: Large solid nodules, unlike spongiform, submitted to LA are characterized by a long-term unfavourable outcome and entail a potential risk of false negative cytologic results.

scholarly journals A Robust EMD-Based RVFL Network Fusion Algorithm for Low-Cost GPS/INS Integrated System

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
Da Liu ◽  
Shufang Zhang ◽  
Jingbo Zhang
Keyword(s):  
Inertial Sensors ◽  
Low Cost ◽  
Integrated System ◽  
Fusion Algorithm ◽  
Functional Link ◽  
Mode Decomposition ◽  
Error Accumulation ◽  
Lower Complexity ◽  
High Level

Global positioning system (GPS) and inertial navigation system (INS) are commonly combined to overcome disadvantages of each and constitute an integrated system that realizes long-term precision. However, the performance of the integrated system deteriorates on which GPS is unavailable. Especially when low-cost inertial sensors based on the microelectromechanical system (MEMS) are used, performance of the integrated system degrades severely over time. In this study, in order to minimize the adverse impact of high-level stochastic noise from low-cost MEMS sensors, denoising technology based on empirical mode decomposition (EMD) is employed to improve signal quality before navigation solution by which significant improvement of removing noise is achieved. Moreover, a random vector functional link (RVFL) network-based fusion algorithm is presented to estimate and compensate position error during GPS outage such that error accumulation is suppressed quickly when INS is working standalone. Performance of the proposed approach is evaluated by experimental results. It is indicated from comparison that the proposed algorithm takes advantages such as better accuracy and lower complexity and is more robust than the commonly reported methods and is more appropriate for real-time and low-cost application.

464 FOCAL LASER ABLATION FOR PROSTATE CANCER FOLLOWED BY RADICAL PROSTATECTOMY –VALIDATION OF FOCAL THERAPY AND IMAGING ACCURACY

2010 ◽  
Vol 183 (4S) ◽  
Author(s):  
Uri Lindner ◽  
Nathan Lawrentschuk ◽  
Robert A. Weersink ◽  
Sean R.H. Davidson ◽  
Orit Raz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Laser Ablation ◽  
Radical Prostatectomy ◽  
Focal Therapy

A novel, nanocrystal (nc) based non-volatile memory device

2000 ◽  
Vol 638 ◽  
Author(s):  
Jan W. De Blauwe ◽  
Marty L. Green ◽  
Tom W. Sorsch ◽  
Garry R. Weber ◽  
Jeff D. Bude ◽  
...  
Keyword(s):  
Low Cost ◽  
Electrical Characterization ◽  
Memory Device ◽  
Fabrication Process ◽  
Floating Gate ◽  
Potential Candidate ◽  
Non Volatile Memory ◽  
Volatile Memory

AbstractThis paper describes the fabrication, and structural and electrical characterization of a new, aerosol-nanocrystal floating-gate FET, aimed at non-volatile memory (NVM) applications. This aerosol- nanocrystal NVM device features program/erase characteristics comparable to conventional stacked gate NVM devices, excellent endurance (>105 P/E cycles), and long-term non-volatility in spite of a thin bottom oxide (55-60Å). In addition, a very simple fabrication process makes this aerosol-nanocrystal NVM device a potential candidate for low cost NVM applications.

Focal therapy for prostate cancer: Attitude and practice patterns.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. e541-e541
Author(s):  
Amit L Jain ◽  
Abhinav Sidana ◽  
Mahir Maruf ◽  
Dordaneh Sugano ◽  
Brian P. Calio ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Independent Predictor ◽  
Multivariate Logistic Regression Analysis ◽  
Cost Effective ◽  
Focal Therapy ◽  
High Intensity Focused Ultrasound ◽  
Localized Prostate Cancer ◽  
Intermediate Risk ◽  
Online Questionnaire ◽  
Cancer Management

e541 Background: Focal therapy (FT) for localized prostate cancer (PCa) has been shown to have encouraging short term oncological outcomes, excellent preservation of functional outcomes and is increasing in popularity in Urologic community. We aim to evaluate the preferences and practice trends among urologists regarding this upcoming treatment strategy. Methods: An anonymous online questionnaire was designed to collect information on urologists’ views and use of focal therapy. The survey was sent to members of the Endourological Society (ES) and American Urological Association (AUA). Multivariate logistic regression analysis was done to determine predictors for utilization of FT for localized prostate cancer. Results: A total of 383 responses were received [AUA: 342, ES: 41]. Mean age of respondents was 43(±11.2) years. Although about half of the respondents (51.4%) believed FT to be moderate to extremely beneficial in the treatment of PCa, only 23% (89) of the respondents currently utilize FT in their practice. While the most common setting for utilization of FT was in patients with unilateral intermediate risk (75.2%) PCa, a small percentage of respondents also used FT for patients with bilateral intermediate risk and unilateral high risk PCa (9% and 7% respectively). The most common FT modality was Cryoablation in 62% followed by High Intensity Focused Ultrasound in 44%. Most common reasons for not using focal therapy were the lack of belief in ‘index lesion theory’ (186) (63.2%) followed by the lack of experience (121) (41.1%). About 58.2% respondents would use FT often in an office or outpatient setting if they had access to reliable and cost effective options. Surgeon’s experience (practice for more than 15 years) (p = 0.035) was the only independent predictor for utilizing FT in localized PCa. Conclusions: Only a quarter of our respondents utilize FT in their practice with surgeon’s experience being the only independent predictor for utilizing FT. Majority of respondents though consider FT to be beneficial in prostate cancer management would use it more often if they provided more reliable and cost effective options. Over time experience and accessibility to reliable methods to perform FT may lead to further use of this novel treatment.

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