scholarly journals QoSS Hierarchical NoC-Based Architecture for MPSoC Dynamic Protection

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Johanna Sepulveda ◽  
Ricardo Pires ◽  
Guy Gogniat ◽  
Wang Jiang Chau ◽  
Marius Strum
Keyword(s):  
Critical Role ◽  
Security Requirements ◽  
Multiprocessor System ◽  
Electronic Systems ◽  
Fast Detection ◽  
Dynamic Security ◽  
Wide System ◽  
Wide Range ◽  
On Chip ◽  
Novel Concept

As electronic systems are pervading our lives, MPSoC (multiprocessor system-on-chip) security is becoming an important requirement. MPSoCs are able to support multiple applications on the same chip. The challenge is to provide MPSoC security that makes possible a trustworthy system that meets the performance and security requirements of all the applications. The network-on-chip (NoC) can be used to efficiently incorporate security. Our work proposes the implementation of QoSS (quality of security service) to overcome present MPSoC vulnerabilities. QoSS is a novel concept for data protection that introduces security as a dimension of QoS. QoSS takes advantage of the NoC wide system visibility and critical role in enabling system operation, exploiting the NoC components to detect and prevent a wide range of attacks. In this paper, we present the implementation of a layered dynamic security NoC architecture that integrates agile and dynamic security firewalls in order to detect attacks based on different security rules. We evaluate the effectiveness of our approach over several MPSoCs scenarios and estimate their impact on the overall performance. We show that our architecture can perform a fast detection of a wide range of attacks and a fast configuration of different security policies for several MPSoC applications.

Shooting a Tiger

2018 ◽  
Author(s):  
Vijaya Ramadas Mandala
Keyword(s):  
Critical Role ◽  
Late Nineteenth Century ◽  
Way Of Life ◽  
Colonial India ◽  
British Raj ◽  
Early Colonial ◽  
Wide Range ◽  
Forest Legislation ◽  
Imperial Governance ◽  
North And South

The main contention of Shooting a Tiger is that hunting during the colonial period was not merely a recreational activity, but a practice intimately connected with imperial governance. The book positions shikar or hunting at the heart of colonial rule by demonstrating that, for the British in India, it served as a political, practical, and symbolic apparatus in the consolidation of power and rule during the nineteenth and early twentieth centuries. The book analyses early colonial hunting during the Company period, and then surveys different aspects of hunting during the high imperial decades in the later nineteenth and early twentieth centuries. The book draws upon an impressive array of archival material and uses a wide range of evidence to support its contentions. It examines hunting at a variety of social and ethnic levels—military, administrative, elite, princely India, Indian professional hunters, and in terms of Indian auxiliaries and (sometimes) resisters. It also deals with different geographical contexts—the plains, the mountains, north and south India. The exclusive privilege of hunting exercised by the ruling classes, following colonial forest legislation, continued to be extended to the Indian princes who played a critical role in sustaining the lavish hunts that became the hallmark of the late nineteenth-century British Raj. Hunting was also a way of life in colonial India, undertaken by officials and soldiers alike alongside their everyday duties, necessary for their mental sustenance and vital for the smooth operation of the colonial administration. There are also two final chapters on conservation, particularly the last chapter focusing on two British hunter-turned-conservationists, Jim Corbett and Colonel Richard Burton.

A high performance scalable fuzzy based modified Asymmetric Heterogene Multiprocessor System on Chip (AHt-MPSOC) reconfigurable architecture

2021 ◽  
pp. 1-12
Author(s):  
Arun Prasath Raveendran ◽  
Jafar A. Alzubi ◽  
Ramesh Sekaran ◽  
Manikandan Ramachandran
Keyword(s):  
High Performance ◽  
Standard Technique ◽  
System On Chip ◽  
Mixed Integer ◽  
Multiprocessor System ◽  
Compound System ◽  
Available Bandwidth ◽  
Mip Model ◽  
Fpga Chip ◽  
On Chip

This Ensuing generation of FPGA circuit tolerates the combination of lot of hard and soft cores as well as devoted accelerators on a chip. The Heterogene Multi-Processor System-on-Chip (Ht-MPSoC) architecture accomplishes the requirement of modern applications. A compound System on Chip (SoC) system designed for single FPGA chip, and that considered for the performance/power consumption ratio. In the existing method, a FPGA based Mixed Integer Programming (MIP) model used to define the Ht-MPSoC configuration by taking into consideration the sharing hardware accelerator between the cores. However, here, the sharing method differs from one processor to another based on FPGA architecture. Hence, high number of hardware resources on a single FPGA chip with low latency and power targeted. For this reason, a fuzzy based MIP and Graph theory based Traffic Estimator (GTE) are proposed system used to define New asymmetric multiprocessor heterogene framework on microprocessor (AHt-MPSoC) architecture. The bandwidths, energy consumption, wait and transmission range are better accomplished in this suggested technique than the standard technique and it is also implemented with a multi-task framework. The new Fuzzy control-based AHt-MPSoC analysis proves significant improvement of 14.7 percent in available bandwidth and 89.8 percent of energy minimized to various traffic scenarios as compared to conventional method.

scholarly journals Proteomic Analysis of Zeb1 Interactome in Breast Carcinoma Cells

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3143
Author(s):  
Sergey E. Parfenyev ◽  
Sergey V. Shabelnikov ◽  
Danila Y. Pozdnyakov ◽  
Olga O. Gnedina ◽  
Leonid S. Adonin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Critical Role ◽  
Malignant Neoplasm ◽  
Malignant Neoplasms ◽  
Breast Cancer Patients ◽  
Survival Prognosis ◽  
Mesenchymal Transition ◽  
Wide Range

Breast cancer is the most frequently diagnosed malignant neoplasm and the second leading cause of cancer death among women. Epithelial-to-mesenchymal Transition (EMT) plays a critical role in the organism development, providing cell migration and tissue formation. However, its erroneous activation in malignancies can serve as the basis for the dissemination of cancer cells and metastasis. The Zeb1 transcription factor, which regulates the EMT activation, has been shown to play an essential role in malignant transformation. This factor is involved in many signaling pathways that influence a wide range of cellular functions via interacting with many proteins that affect its transcriptional functions. Importantly, the interactome of Zeb1 depends on the cellular context. Here, using the inducible expression of Zeb1 in epithelial breast cancer cells, we identified a substantial list of novel potential Zeb1 interaction partners, including proteins involved in the formation of malignant neoplasms, such as ATP-dependent RNA helicase DDX17and a component of the NURD repressor complex, CTBP2. We confirmed the presence of the selected interactors by immunoblotting with specific antibodies. Further, we demonstrated that co-expression of Zeb1 and CTBP2 in breast cancer patients correlated with the poor survival prognosis, thus signifying the functionality of the Zeb1–CTBP2 interaction.

scholarly journals Development of cancer metabolism as a therapeutic target: new pathways, patient studies, stratification and combination therapy

2019 ◽  
Vol 122 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Adrian L. Harris
Keyword(s):  
Metabolic Pathways ◽  
Trial Design ◽  
Cancer Metabolism ◽  
Aerobic Glycolysis ◽  
Critical Role ◽  
Therapeutic Approaches ◽  
Preclinical Models ◽  
Wide Range ◽  
Patient Studies

AbstractCancer metabolism has undergone a resurgence in the last decade, 70 years after Warburg described aerobic glycolysis as a feature of cancer cells. A wide range of techniques have elucidated the complexity and heterogeneity in preclinical models and clinical studies. What emerges are the large differences between tissues, tumour types and intratumour heterogeneity. However, synergies with inhibition of metabolic pathways have been found for many drugs and therapeutic approaches, and a critical role of window studies and translational trial design is key to success.

scholarly journals Determinants of vitamin D status in Kenyan calves

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Rebecca Callaby ◽  
Emma Hurst ◽  
Ian Handel ◽  
Phil Toye ◽  
Barend M. de C. Bronsvoort ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Vitamin D ◽  
Health Outcomes ◽  
Critical Role ◽  
Subsequent Development ◽  
Vitamin D Metabolites ◽  
Vitamin D Status ◽  
Skeletal Health ◽  
A Genome ◽  
Wide Range

AbstractVitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veterinary species. We have previously demonstrated a relationship between vitamin D status, assessed by the measurement of serum concentrations of the major vitamin D metabolite 25 hydroxyvitamin D (25(OH)D), and a wide range of non-skeletal health outcomes in companion and wild animals. The aims of this study were to define the host and environmental factors associated with vitamin D status in a cohort of 527 calves from Western Kenya which were part of the Infectious Disease of East African Livestock (IDEAL) cohort. A secondary aim was to explore the relationship between serum 25(OH)D concentrations measured in 7-day old calves and subsequent health outcomes over the following 12 months. A genome wide association study demonstrated that both dietary and endogenously produced vitamin D metabolites were under polygenic control in African calves. In addition, we found that neonatal vitamin D status was not predictive of the subsequent development of an infectious disease event or mortality over the 12 month follow up period.

scholarly journals Operating System for Runtime Reconfigurable Multiprocessor Systems

2011 ◽  
Vol 2011 ◽  
pp. 1-16 ◽  
Author(s):  
Diana Göhringer ◽  
Michael Hübner ◽  
Etienne Nguepi Zeutebouo ◽  
Jürgen Becker
Keyword(s):  
Operating System ◽  
Resource Management ◽  
Multiprocessor System ◽  
Task Mapping ◽  
Access Port ◽  
Novel Approach ◽  
Hardware Resource ◽  
Hardware Architectures ◽  
On Chip ◽  
Internal Configuration

Operating systems traditionally handle the task scheduling of one or more application instances on processor-like hardware architectures. RAMPSoC, a novel runtime adaptive multiprocessor System-on-Chip, exploits the dynamic reconfiguration on FPGAs to generate, start and terminate hardware and software tasks. The hardware tasks have to be transferred to the reconfigurable hardware via a configuration access port. The software tasks can be loaded into the local memory of the respective IP core either via the configuration access port or via the on-chip communication infrastructure (e.g. a Network-on-Chip). Recent-series of Xilinx FPGAs, such as Virtex-5, provide two Internal Configuration Access Ports, which cannot be accessed simultaneously. To prevent conflicts, the access to these ports as well as the hardware resource management needs to be controlled, e.g. by a special-purpose operating system running on an embedded processor. For that purpose and to handle the relations between temporally and spatially scheduled operations, the novel approach of an operating system is of high importance. This special purpose operating system, called CAP-OS (Configuration Access Port-Operating System), which will be presented in this paper, supports the clients using the configuration port with the services of priority-based access scheduling, hardware task mapping and resource management.

Wildlife management and the debate on the ethics of animal use. II. A challenge for the animal protection movement.

2012 ◽  
Vol 18 (2) ◽  
pp. 81 ◽  
Author(s):  
Daniel Lunney
Keyword(s):  
Wildlife Management ◽  
Critical Role ◽  
Animal Liberation ◽  
Ethical Imperative ◽  
Animal Protection ◽  
Wide Range ◽  
Animal Use

How people coexist and interact with animals has become an intensely debated issue in recent times, particularly with the rise of the animal protection movement following the publication of Peter Singer’s book Animal Liberation in 1975. This paper discusses some shortcomings of the philosophical positions taken in this complex debate. Singer has helped put animals on a new footing as a group that cannot morally be ignored, but his focus is mainly on individual, familiar animals that are used or abused by humans. The argument of this paper is that the ethics of managing wildlife hinges on a broader view of animals, and their contexts, than is apparent from Singer’s text. Wildlife managers aim to conserve populations of a wide range of species, and their habitats, but some mechanisms for achieving these aims, such as research and the control of invasive animals, are frequently opposed by elements of the animal protection movement. We need to adapt our attitude to animals, particularly wildlife, away from the traditional legacy of a few familiar species to embrace an ethic that is more ecological and relevant to Australian contexts. The case argued here has been to see the critical role of context — geographical, ecological, historical, relational — as a basis for a degree of reconciliation between conservation-oriented wildlife managers and the rising interest in the ethics of animal use. There is much to be gained for zoologists, wildlife managers and conservation biologists by framing key elements of their case in ethical arguments. Conversely, the challenge for those in the animal protection movement is to expand their philosophical ideas to include the ethical imperative of the conservation of populations of wildlife.

Abstract 189: Activation of Voltage-Dependent Anion Channel 2 Suppresses Ca 2+ -Induced Cardiac Arrhythmia

2012 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
Jaunian Chen ◽  
Johann Schredelseker ◽  
Hirohito Shimizu ◽  
Jie Huang ◽  
Kui Lu ◽  
...  
Keyword(s):  
Outer Membrane ◽  
Cardiac Arrhythmia ◽  
Critical Role ◽  
Anion Channel ◽  
Cardiac Contraction ◽  
Voltage Dependent Anion Channel ◽  
Rescue Effect ◽  
Cardiac Fibrillation ◽  
Wide Range ◽  
Voltage Dependent

Abnormal Ca2+ handling in cardiac muscle cells is associated with a wide range of human cardiac diseases, including heart failure and cardiac arrhythmias. Zebrafish tremblor (tre) mutant embryos manifest unsynchronized cardiac contractions due to a Ca2+ extrusion defect in cardiomyocytes and thus are used as an animal model for aberrant Ca2+ homeostasis-induced cardiac arrhythmia. To further dissect molecular mechanisms regulating cardiac Ca2+ homeostasis, we conducted a chemical suppressor screen on tre and found that efsevin, a synthetic compound, potently suppresses cardiac fibrillation and restores rhythmic cardiac contractions in tre embryos. In addition, the treatment with efsevin blocks the propagation of arrhythmogenic Ca2+ waves and accelerates the decay phase of Ca2+ sparks in adult murine cardiomyocytes under Ca2+ overload conditions, demonstrating that efsevin modulates Ca2+ handling in both embryonic and adult cardiac tissues. Through a biochemical pulldown assay, we identified a direct interaction between efsevin and VDAC2, a mitochondrial outer membrane voltage dependent anion channel. Overexpression of VDAC2 restores synchronized cardiac contraction in tre and knocking down VDAC2 activity abolishes the rescue effect of efsevin on tre, suggesting that efsevin modulates cardiac Ca2+ homeostasis by potentiating VDAC2 activity. We further showed that enhancing mitochondria Ca2+ uptake by overexpressing MICU or MCU suppresses cardiac fibrillation in tre just like VDAC2 does. Interestingly, this suppressive effect is absent in tre/vdac2 double deficient embryos and co-expression of VDAC2 and MICU or MCU results in synergistic rescue effect on tre, indicating a critical role for mitochondria in regulating cardiac Ca2+ handling and rhythmicity and suggesting that VDAC2 functions as a gate for transporting Ca2+ across the outer membrane. Taken together, our findings identify efsevin as a potent pharmacological tool to modulate cardiac Ca2+ handling, suggest a critical role of mitochondria in the control of cardiac rhythmicity and establish VDAC2 as a modulator of cardiac Ca2+ handling and a potential therapeutic target for the treatment of arrhythmias.

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