scholarly journals Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics: Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Shin Akakura ◽  
Irwin H. Gelman
Keyword(s):  
Protein Kinase ◽  
Actin Cytoskeleton ◽  
Cell Cycle Progression ◽  
Cellular Adhesion ◽  
Null Mouse ◽  
Oncogenic Signaling ◽  
Cycle Progression ◽  
Cytoskeleton Reorganization ◽  
Dependent Protein

Cellular dynamics are controlled by key signaling molecules such as cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). AKAP12/SSeCKS/Gravin (AKAP12) is a scaffold protein for PKA and PKC which controls actin-cytoskeleton reorganization in a spatiotemporal manner. AKAP12 also acts as a tumor suppressor which regulates cell-cycle progression and inhibits Src-mediated oncogenic signaling and cytoskeletal pathways. Reexpression of AKAP12 causes cell flattening, reorganization of the actin cytoskeleton, and the production of normalized focal adhesion structures. Downregulation of AKAP12 induces the formation of thickened, longitudinal stress fibers and the proliferation of adhesion complexes. AKAP12-null mouse embryonic fibroblasts exhibit hyperactivation of PKC, premature cellular senescence, and defects in cytokinesis, relating to the loss of PKC scaffolding activity by AKAP12. AKAP12-null mice exhibit increased cell senescence and increased susceptibility to carcinogen-induced oncogenesis. The paper describes the regulatory and scaffolding functions of AKAP12 and how it regulates cell adhesion, signaling, and oncogenic suppression.

scholarly journals Involvement of DNA-dependent Protein Kinase in Normal Cell Cycle Progression through Mitosis

2011 ◽  
Vol 286 (14) ◽  
pp. 12796-12802 ◽  
Author(s):  
Kyung-Jong Lee ◽  
Yu-Fen Lin ◽  
Han-Yi Chou ◽  
Hirohiko Yajima ◽  
Kazi R. Fattah ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Normal Cell ◽  
Cell Cycle Progression ◽  
Dependent Protein Kinase ◽  
Cycle Progression ◽  
Dependent Protein ◽  
Normal Cell Cycle

scholarly journals The role of profilin-1 in cardiovascular diseases

2021 ◽  
Vol 134 (9) ◽  
Author(s):  
Abigail Allen ◽  
David Gau ◽  
Partha Roy
Keyword(s):  
Cardiovascular Diseases ◽  
Actin Cytoskeleton ◽  
Cell Cycle Progression ◽  
Neurological Diseases ◽  
Essential Feature ◽  
Actin Binding ◽  
Cycle Progression ◽  
Cellular Processes ◽  
Damage Response

ABSTRACT Dynamic remodeling of the actin cytoskeleton is an essential feature for virtually all actin-dependent cellular processes, including cell migration, cell cycle progression, chromatin remodeling and gene expression, and even the DNA damage response. An altered actin cytoskeleton is a structural hallmark associated with numerous pathologies ranging from cardiovascular diseases to immune disorders, neurological diseases and cancer. The actin cytoskeleton in cells is regulated through the orchestrated actions of a myriad of actin-binding proteins. In this Review, we provide a brief overview of the structure and functions of the actin-monomer-binding protein profilin-1 (Pfn1) and then discuss how dysregulated expression of Pfn1 contributes to diseases associated with the cardiovascular system.

scholarly journals The Localization and Activity of cAMP-dependent Protein Kinase Affect Cell Cycle Progression in Thyroid Cells

2000 ◽  
Vol 275 (1) ◽  
pp. 303-311 ◽  
Author(s):  
Antonio Feliciello ◽  
Adriana Gallo ◽  
Evelina Mele ◽  
Antonio Porcellini ◽  
Giancarlo Troncone ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Cell Cycle Progression ◽  
Dependent Protein Kinase ◽  
Thyroid Cells ◽  
Cycle Progression ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Affect Cell Cycle Progression

Involvement of DNA-dependent protein kinase in down-regulation of cell cycle progression

2003 ◽  
Vol 35 (4) ◽  
pp. 432-440 ◽  
Author(s):  
Fumiaki Watanabe ◽  
Ken-ichi Shinohara ◽  
Hirobumi Teraoka ◽  
Kenshi Komatsu ◽  
Kouichi Tatsumi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Cell Cycle Progression ◽  
Down Regulation ◽  
Dependent Protein Kinase ◽  
Cycle Progression ◽  
Dependent Protein ◽  
Regulation Of Cell Cycle

Calmodulin-dependent protein kinase II is required for G1/S progression in HeLa cells

1995 ◽  
Vol 73 (3-4) ◽  
pp. 201-207 ◽  
Author(s):  
Grace Rasmussen ◽  
Colin Rasmussen
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Dna Synthesis ◽  
Hela Cells ◽  
Cell Cycle Progression ◽  
Dependent Protein Kinase ◽  
Cycle Progression ◽  
Cycle Arrest ◽  
Calmodulin Kinase ◽  
Dependent Protein

Calmodulin (CaM) has been previously shown to be essential for cell cycle progression in eukaryotic cells, being required at the G1/S,G2/M, and metaphase–anaphase transitions. Little is known about the specific CaM-dependent enzymes that mediate Ca2+/CaM signaling to affect cell proliferation. In this study we show that inhibition of calmodulin kinase II (CaMKII) in HeLa cells using the CaMKII inhibitor KN-93 causes cell cycle arrest, demonstrating that CaMKII is required for cell cycle progression. Detailed analysis of arrest cells suggests that CaMKII is required for the initiation of DNA synthesis. Cells treated with KN-93 arrest with a G1 DNA content, but with elevated cyclin-dependent histone H1 kinase activity, suggesting that CaMKII may act at a point very close to the onset of DNA synthesis in mammalian cells.Key words: calmodulin, protein kinase, cell cycle, HeLa.

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