scholarly journals Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Nanoparticles: AnIn VitroStudy

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Asahi Tomitaka ◽  
Tsutomu Yamada ◽  
Yasushi Takemura
Keyword(s):  
Magnetic Field ◽  
Temperature Rise ◽  
Hela Cells ◽  
Cytotoxic Effect ◽  
Magnetic Nanoparticle ◽  
Hyperthermia Treatment ◽  
Coated Nanoparticles ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Induced Apoptosis

Magnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, andin vitrohyperthermia effect of nanoparticles coated with Pluronic f-127 were evaluated in this paper. The Pluronic-coated nanoparticles exhibited no cytotoxic effect on HeLa cells. The optimal magnetic field of Pluronic-coated nanoparticles was 16 kA/m (200 Oe) at the field strength of 210 kHz. Appropriate temperature rise significantly reduced the viability of HeLa cells and induced apoptosis.

scholarly journals Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia

Sensors ◽  
2021 ◽  
Vol 21 (16) ◽  
pp. 5545 ◽  
Author(s):  
Izaz Raouf ◽  
Piotr Gas ◽  
Heung Soo Kim
Keyword(s):  
Numerical Model ◽  
Cancer Therapy ◽  
Magnetic Nanoparticle ◽  
Research Work ◽  
Thermal Response ◽  
Linear Response Theory ◽  
Novel Approach ◽  
Magnetic Nanoparticle Hyperthermia

Recently, in-vitro studies of magnetic nanoparticle (MNP) hyperthermia have attracted significant attention because of the severity of this cancer therapy for in-vivo culture. Accurate temperature evaluation is one of the key challenges of MNP hyperthermia. Hence, numerical studies play a crucial role in evaluating the thermal behavior of ferrofluids. As a result, the optimum therapeutic conditions can be achieved. The presented research work aims to develop a comprehensive numerical model that directly correlates the MNP hyperthermia parameters to the thermal response of the in-vitro model using optimization through linear response theory (LRT). For that purpose, the ferrofluid solution is evaluated based on various parameters, and the temperature distribution of the system is estimated in space and time. Consequently, the optimum conditions for the ferrofluid preparation are estimated based on experimental and mathematical findings. The reliability of the presented model is evaluated via the correlation analysis between magnetic and calorimetric methods for the specific loss power (SLP) and intrinsic loss power (ILP) calculations. Besides, the presented numerical model is verified with our experimental setup. In summary, the proposed model offers a novel approach to investigate the thermal diffusion of a non-adiabatic ferrofluid sample intended for MNP hyperthermia in cancer treatment.

Fabrication of a pH responsive DOX conjugated PEGylated palladium nanoparticle mediated drug delivery system: an in vitro and in vivo evaluation

RSC Advances ◽  
2015 ◽  
Vol 5 (56) ◽  
pp. 44998-45014 ◽  
Author(s):  
Krishnamurthy Shanthi ◽  
Karuppaiya Vimala ◽  
Dhanaraj Gopi ◽  
Soundarapandian Kannan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hela Cells ◽  
Ph Responsive ◽  
Palladium Nanoparticle ◽  
In Vivo Evaluation ◽  
Induced Apoptosis

Schematic illustration of the possible mechanism of pH based drug delivery system of DOX conjugated PEGylated PdNPs induced apoptosis in HeLa cells.

scholarly journals THE CYTOTOXIC EFFECT OF CHELIDONIUM MAJUS IN VITRO

2015 ◽  
Vol 8 (2) ◽  
Author(s):  
Vladimíra Tomečková ◽  
Veronika Tkáčová ◽  
Peter Urban ◽  
Marek Stupák
Keyword(s):  
Tumor Cells ◽  
Hela Cells ◽  
Antiproliferative Activity ◽  
Cytotoxic Effect ◽  
Lymphoblastic Leukemia ◽  
Mammary Adenocarcinoma ◽  
Chelidonium Majus ◽  
Mcf 7 ◽  
Lipophilic Substances

The effect of aqueous and ether Chelidonium majus haulms extract on cervical HeLa tumor cells, mammary adenocarcinoma MCF 7 tumor cells and acute lymphoblastic leukemia CEM tumor cells in vitro have been studied. The purpose of this research was to compare the effect of aqueous and ether Chelidonium majus haulms extract on selected tumor cells. Colorimetric MTT assay have been used for the study of the antiproliferative effect of aqueous and ether haulms extract of Chelidonium majus on cell viability in vitro. The results of the experiments have shown the cytotoxic effect of the aqueous and the ether Chelidonium majus haulms extract on the individual tumor cells. The aqueous Chelidonium majus haulms extract was the most effective on CEM cells, it was less effective on MCF 7 cells and it was the least effective on HeLa cells. The ether haulms extract of Chelidonium majus was the most effective at all of studied concentrations on CEM cells and MCF 7 cells in comparison with HeLa cells, where it was significantly effective only at the highest concentration. Aqueous and ether haulms extract of Chelidonium majus tested in vitro indicated their cytotoxic activity. Both haulms extract of Chelidonium majus were more efficient on CEM cells. It is assumed that higher antiproliferative activity of ether haulms extract of Chelidonium majus is the result of higher antiproliferative activity of lipophilic substances. The lipophilic substances pass through membrane and bind to various proteins and change their biological activity.

scholarly journals Magnetically Modified Electrospun Nanofibers for Hyperthermia Treatment

2020 ◽  
Vol 65 (8) ◽  
pp. 655
Author(s):  
M. Molcan ◽  
I. Safarik ◽  
K. Pospiskova ◽  
K. Paulovicova ◽  
M. Timko ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Temperature Rise ◽  
Magnetic Particle ◽  
Electrospun Nanofibers ◽  
Polyvinyl Butyral ◽  
Magnetic Hyperthermia ◽  
Linear Increase ◽  
Field Application ◽  
Hyperthermia Treatment ◽  
Magnetic Nanofibers

Several methodologies for the preparation of nanofibrous materials exist. Electrospinning is currently the most popular technique due to its versatility and simplicity. Nanofibrous materials prepared in such a way are widely studied in medicine and material engineering. Polyvinyl butyral (PVB) nanofibers were generated by a rod-shaped spinning-electrode. Nanofibers were modified by a magnetic fluid (MF) added into the PVB solution. These magnetic nanofibers can be considered as a material for magnetic hyperthermia applications, either as implants or for the surface heating. The samples with various magnetic particle concentrations were tested in the alternating magnetic field. An immediate increase in the temperature after the field application was observed. The nature of the temperature rise is interesting: a non-linear increase could be seen, which is in contrast to the rising temperature for pure magnetic fluids.

Lignans from Schisandra hernyi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro

Fitoterapia ◽  
2005 ◽  
Vol 76 (3-4) ◽  
pp. 370-373 ◽  
Author(s):  
Ye-Gao Chen ◽  
Zheng-Cai Wu ◽  
Shi-Hong Gui ◽  
Yu-Ping Lv ◽  
Xin-Rong Liao ◽  
...  
Keyword(s):  
Hela Cells ◽  
Cytotoxic Effect ◽  
Dna Cleaving

Enhancement in Treatment Planning for Magnetic Nanoparticle Hyperthermia: Optimization of the Heat Absorption Pattern

2009 ◽  
Author(s):  
Maher Salloum ◽  
Ronghui Ma ◽  
Liang Zhu
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticle ◽  
Relaxation Mechanism ◽  
Field Frequency ◽  
Nanoparticle Distribution ◽  
Injection Parameters ◽  
Absorption Pattern ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Heating Pattern ◽  
Low Magnetic Field

Magnetic nanoparticle hyperthermia has potential to achieve optimal therapeutic results due to its ability to deliver adequate heating power to irregular and/or deep-seated tumor at low magnetic field frequency and amplitude [1]. The heat generated by the particles under the application of an external alternating magnetic field is mainly due to the Néel relaxation mechanism and/or Brownian motion of the particles [2]. In clinical applications, it is very important to ensure a maximum damage to the tumor while protecting the normal tissue. The resulted heating pattern by the nanoparticle distribution in tumor is closely related to the injection parameters [3, 4].

Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia

2015 ◽  
Vol 60 (5) ◽  
Author(s):  
Frederik Soetaert ◽  
Luc Dupré ◽  
Robert Ivkov ◽  
Guillaume Crevecoeur
Keyword(s):  
Amplitude Modulation ◽  
Magnetic Nanoparticle ◽  
Three Dimensional ◽  
Cancer Tissue ◽  
Bioheat Equation ◽  
Hyperthermia Treatment ◽  
Survival Fraction ◽  
Computational Evaluation ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Complex Relationships

AbstractMagnetic nanoparticles (MNPs) can interact with alternating magnetic fields (AMFs) to deposit localized energy for hyperthermia treatment of cancer. Hyperthermia is useful in the context of multimodality treatments with radiation or chemotherapy to enhance disease control without increased toxicity. The unique attributes of heat deposition and transfer with MNPs have generated considerable attention and have been the focus of extensive investigations to elucidate mechanisms and optimize performance. Three-dimensional (3D) simulations are often conducted with the finite element method (FEM) using the Pennes’ bioheat equation. In the current study, the Pennes’ equation was modified to include a thermal damage-dependent perfusion profile to improve model predictions with respect to known physiological responses to tissue heating. A normal distribution of MNPs in a model liver tumor was combined with empirical nanoparticle heating data to calculate tumor temperature distributions and resulting survival fraction of cancer cells. In addition, calculated spatiotemporal temperature changes were compared among magnetic field amplitude modulations of a base 150-kHz sinusoidal waveform, specifically, no modulation, sinusoidal, rectangular, and triangular modulation. Complex relationships were observed between nanoparticle heating and cancer tissue damage when amplitude modulation and damage-related perfusion profiles were varied. These results are tantalizing and motivate further exploration of amplitude modulation as a means to enhance efficiency of and overcome technical challenges associated with magnetic nanoparticle hyperthermia (MNH).

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