scholarly journals Validation of a New Animal Model of Vulnerable Plaques by Intravascular Optical Coherence TomographyIn Vivo

2012 ◽  
Vol 2012 ◽  
pp. 1-9
Author(s):  
Yan Fang ◽  
Sining Hu ◽  
Jingbo Hou ◽  
Lingbo Meng ◽  
Shaosong Zhang ◽  
...  
Keyword(s):  
Animal Model ◽  
Optical Coherence ◽  
Vulnerable Plaques

scholarly journals Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

2020 ◽  
Vol 13 (2) ◽  
pp. 106-112 ◽  
Author(s):  
Se-Joon Oh ◽  
Il-Woo Lee ◽  
Soo-Geun Wang ◽  
Soo-Keun Kong ◽  
Hong-Ki Kim ◽  
...  
Keyword(s):  
Animal Model ◽  
Optical Coherence Tomography ◽  
Inner Ear ◽  
Oval Window ◽  
Diagnostic Information ◽  
Optical Coherence ◽  
Swept Source ◽  
Diagnostic Technology ◽  
Swept Source Oct ◽  
Rats And Mice

Objectives. This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic technology in ear imaging.Methods. Five rats and mice were included, and the swept-source OCT system was applied to confirm the extent of visibility of the middle and inner ear and measure the length or thickness of the microstructures in the ear. The cochlea was subsequently dissected following OCT and histologically evaluated to compare with the OCT images.Results. The middle ear microstructures such as ossicles, stapedial artery and oval window through the tympanic membrane with the OCT could be confirmed in both rats and mice. It was also possible to obtain the inner ear images such as each compartment of the cochlea in the mice, but the bone covering bulla needed to be removed to visualize the inner ear structures in the rats which had thicker bulla. The bony thickness covering the cochlea could be measured, which showed no significant differences between OCT and histologic image at all turns of cochlea.Conclusion. OCT has been shown a promising technology to assess real-time middle and inner ear microstructures noninvasively with a high-resolution in the animal model. Therefore, OCT could be utilized to provide additional diagnostic information about the diseases of the middle and inner ear.

scholarly journals Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Rui Lv ◽  
Akiko Maehara ◽  
Mitsuaki Matsumura ◽  
Liang Wang ◽  
Qingyu Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intravascular Ultrasound ◽  
Coronary Plaque ◽  
Mean Value ◽  
Optical Coherence ◽  
Plaque Vulnerability ◽  
Fibrous Cap ◽  
Vulnerable Plaques ◽  
The Mean ◽  
Thickness Measurements

Abstract Background Detecting coronary vulnerable plaques in vivo and assessing their vulnerability have been great challenges for clinicians and the research community. Intravascular ultrasound (IVUS) is commonly used in clinical practice for diagnosis and treatment decisions. However, due to IVUS limited resolution (about 150–200 µm), it is not sufficient to detect vulnerable plaques with a threshold cap thickness of 65 µm. Optical Coherence Tomography (OCT) has a resolution of 15–20 µm and can measure fibrous cap thickness more accurately. The aim of this study was to use OCT as the benchmark to obtain patient-specific coronary plaque cap thickness and evaluate the differences between OCT and IVUS fibrous cap quantifications. A cap index with integer values 0–4 was also introduced as a quantitative measure of plaque vulnerability to study plaque vulnerability. Methods Data from 10 patients (mean age: 70.4; m: 6; f: 4) with coronary heart disease who underwent IVUS, OCT, and angiography were collected at Cardiovascular Research Foundation (CRF) using approved protocol with informed consent obtained. 348 slices with lipid core and fibrous caps were selected for study. Convolutional Neural Network (CNN)-based and expert-based data segmentation were performed using established methods previously published. Cap thickness data were extracted to quantify differences between IVUS and OCT measurements. Results For the 348 slices analyzed, the mean value difference between OCT and IVUS cap thickness measurements was 1.83% (p = 0.031). However, mean value of point-to-point differences was 35.76%. Comparing minimum cap thickness for each plaque, the mean value of the 20 plaque IVUS-OCT differences was 44.46%, ranging from 2.36% to 91.15%. For cap index values assigned to the 348 slices, the disagreement between OCT and IVUS assignments was 25%. However, for the OCT cap index = 2 and 3 groups, the disagreement rates were 91% and 80%, respectively. Furthermore, the observation of cap index changes from baseline to follow-up indicated that IVUS results differed from OCT by 80%. Conclusions These preliminary results demonstrated that there were significant differences between IVUS and OCT plaque cap thickness measurements. Large-scale patient studies are needed to confirm our findings.

scholarly journals Novel application of In Vivo Micro-Optical Coherence Tomography to assess Cornea scarring in an Animal Model

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Marcus Ang ◽  
Kavya Devarajan ◽  
Suchandrima Das ◽  
Gary H. F. Yam ◽  
Hla Mynt Htoon ◽  
...  
Keyword(s):  
Animal Model ◽  
Optical Coherence Tomography ◽  
Optical Coherence

NONINVASIVE DETECTION OF AIRWAY EDEMA USING OPTICAL COHERENCE TOMOGRAPHY IN A SMOKE INHALATION ANIMAL MODEL

CHEST Journal ◽  
2006 ◽  
Vol 130 (4) ◽  
pp. 154S
Author(s):  
Kelly Kreuter ◽  
David Mukai ◽  
Jangwoen Lee ◽  
Shuguang Guo ◽  
Lillian Tseng ◽  
...  
Keyword(s):  
Animal Model ◽  
Optical Coherence Tomography ◽  
Smoke Inhalation ◽  
Noninvasive Detection ◽  
Optical Coherence ◽  
Airway Edema

scholarly journals Cholesterol crystal as a new feature of coronary vulnerable plaques: An optical coherence tomography study

2017 ◽  
Vol 69 (1) ◽  
pp. 253-259 ◽  
Author(s):  
Satoshi Nishimura ◽  
Shoichi Ehara ◽  
Takao Hasegawa ◽  
Kenji Matsumoto ◽  
Junichi Yoshikawa ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Cholesterol Crystal ◽  
Vulnerable Plaques ◽  
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