scholarly journals Prevention of Preeclampsia

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Sammya Bezerra Maia e Holanda Moura ◽  
Laudelino Marques Lopes ◽  
Padma Murthi ◽  
Fabricio da Silva Costa

Preeclampsia (PE) affects around 2–5% of pregnant women. It is a major cause of maternal and perinatal morbidity and mortality. In an attempt to prevent preeclampsia, many strategies based on antenatal care, change in lifestyle, nutritional supplementation, and drugs have been studied. The aim of this paper is to review recent evidence about primary and secondary prevention of preeclampsia.

2021 ◽  
Vol 10 (16) ◽  
pp. 3631
Author(s):  
Yolanda Cuñarro-López ◽  
Santiago García-Tizón Larroca ◽  
Pilar Pintado-Recarte ◽  
Concepción Hernández-Martín ◽  
Pilar Prats-Rodríguez ◽  
...  

Coronavirus disease-19 (COVID-19) is perhaps the most worrisome pandemic in the 21st century, having entailed devastating consequences for the whole society during the last year. Different studies have displayed an existing association between pregnancy and COVID-19 severity due to the various physiological changes that occur during gestation. Recent data identified maternal country of origin as an important determinant of COVID-19 presentation in pregnant women. However, the explanation of this fact remains to be fully elucidated. Therefore, the purpose of this work is to analyze the possible relationship between Human Development Index (HDI) of maternal country of origin with the morbimortality of pregnant women and their newborns. Here, we conducted a multicentric, ambispective, observational case-control study (1:1 ratio) and compare with the HDI of each country (group 1—very high HDI, group 2—high HDI, group 3—medium HDI, and group 4—low HDI). In total, 1347 pregnant women with confirmed SARV-CoV-2 infection (cases) were enrolled, and each was paired with one control to give a total number of 2694 participants from 81 tertiary care centers. Among the women with SARS-CoV-2 infection, more cases were produced of perinatal mortality, overall maternal morbidity, COVID-19 maternal morbidity, C-sections, hypertensive maternal morbidity, and perinatal morbidity. Our results described an inverse association between HDI and maternofetal morbidity and mortality. Moreover, the countries with an HDI lower than 1 showed higher rates of patients with maternal COVID-19-related morbidity (6.0% vs. 2.4%, p < 0.001), a need for oxygen therapy (4.7% vs. 1.8%, p < 0.001), and maternal ICU admission (2.6% vs. 1.0%, p = 0.007). Compared to other risk factors such as overweight, obesity, preexisting and obstetric comorbidities, HDI emerged as an independent risk factor explaining much of the increased maternal–perinatal morbidity and mortality detected in our group of cases. Further research is needed to establish to confirm the real impact of this factor and its components on pregnancy outcomes.


1999 ◽  
Vol 48 (2) ◽  
pp. 22-26
Author(s):  
M. A. Repina ◽  
N. V. Kulagina ◽  
Ya. A. Kornilova

In modern obstetrics there is an urgent problem of treatment of threat of premature labor being one of the basic reasons for perinatal losses. In the article the prospects of Gynipral application in pregnant women, and also the results of practical application of a drug in clinic are considered. It is proved, that the application of beta-adrenomimetic Gynipral allows effectively and without development of complications on the part of the mother to carry out the treatment of premature labor threat, hypoxia a fetus, discoordination in labor, that provides the perinatal morbidity and mortality reduction.


Author(s):  
Nyasiro S Gibore ◽  
Agatha F Ngowi ◽  
Mariam J Munyogwa ◽  
Mwanaisha M Ali

Abstract Background Anemia is a major cause of morbidity and mortality of pregnant women and increases the risks of fetal and neonatal morbidity and mortality. Approximately 50% of all anemia is estimated to be caused by low dietary intake of iron, poor absorption of dietary iron, or blood loss. The objective of the present study was to determine the prevalence and assess the dietary habits associated with anemia among pregnant women receiving antenatal care in Unguja Island, Tanzania. A cross-sectional study was conducted to select 338 pregnant women at Kivunge, Mwembeladu and Mnazimmoja hospitals from March to June, 2018. Hemoglobin concentration was measured using a HemoCue photometer on capillary blood. Sociodemographic data and dietary habits were collected using a structured questionnaire. The data were analysed using the SPSS version 21.0. Multivariate logistic regression analysis was carried out to determine the predictors of anemia among pregnant women. The overall prevalence of anemia was 80.8%. Of these 68.64% had mild anemia, 11.24% had moderate anemia and 0.89% had severe anemia. Anemia was significantly associated with inadequate dietary diversity (Adjusted Odds Ratio (AOR) = 1.16, 95%CI = 0.57–2.36, p &lt; 0.05), drinking tea or coffee with meal (AOR = 0.06, 95%CI = 0.03–0.13, p &lt; 0.001), consuming less than three meals per day (AOR = 2.92, 95%CI = 1.60–5.84, p &lt; 0.001), higher education level (AOR = 3.4, 95%CI = 1.6–7.2, p &lt; 0.0001), birth interval of less than two years (AOR = 3.6, 95%CI = 1.1–11.9, p &lt; 0.05) and multigravida (AOR = 1.2, 95% = 0.3–4.4, p &lt; 0.0001). The prevalence of anemia in this study demonstrates a severe public health problem among pregnant women. Inadequate dietary diversity coupled with inadequate daily meal intake and consumption of tea or coffee were the dietary habits predictors of anemia among pregnant women. Other predictors of anemia were higher education level, multigravida and birth interval of less than two years. Nutrition policy interventions are needed in order to complement antenatal care services by providing important information on healthy eating habits during pregnancy.


2021 ◽  
Vol 3 (1) ◽  
pp. 001-011
Author(s):  
Peter Chibuzor Oriji ◽  
Dennis Oju Allagoa ◽  
Datonye Christopher Briggs ◽  
Judith Isioma Adhuze ◽  
Tornubari Romeo Mbooh ◽  
...  

Background: Multiple gestation occurs when the gravid uterus harbours more than one foetus. It is a high-risk pregnancy, because of the associated adverse pregnancy outcomes culminating in some cases, in a high rate of maternal and perinatal morbidity and mortality. Objective: To determine the incidence of multiple gestation, and maternal and perinatal outcomes associated with it at the Federal Medical Centre, Yenagoa, South-South, Nigeria, over a five-year period. Materials and Methods: This retrospective study was carried out between 1st January, 2016 and 31st December, 2020. Data were retrieved and entered into a pre-designed proforma, and analysed using IBM SPSS version 25.0. Results were presented in frequencies and percentages for categorical variables, and mean and standard deviation for continuous variables. Results: One hundred and sixty-three women had multiple gestation in the period under review, out of a total of 4,571 pregnancies, which represented a case incidence rate of 35.6 multiple gestations per 1,000 deliveries in the Centre. Incidence rates for twins and triplets were 32.5 and 3.5 per 1,000 deliveries, respectively. About 51.5% were unbooked for antenatal care in the index pregnancy. The most common (47.2%) complication was preterm delivery. There were 342 neonates from 163 multiple gestations. There was death of 20 (5.8%) babies. Conclusion: The significant maternal and perinatal morbidity and mortality associated with multiple gestation can be reduced by early diagnosis, specialized antenatal care, skilled intrapartum, postpartum and neonatal care in centres with a full complement of skilled obstetricians, anaesthetists and neonatologists.


1986 ◽  
Vol 67 (1) ◽  
pp. 71-72
Author(s):  
Z. Sh. Gilyazutdinova

The plenary session was devoted to the topical issue of reducing maternal and perinatal morbidity and mortality in late toxicosis of pregnant women. Attention was drawn to the risk factors in the development of this pathology and, first of all, to extragenital diseases of the mother: kidney disease (G. M. Savelyeva, V. N. Serov), chronic tonsillitis, high infectious index in childhood, tonsillectomy during menarche.


2009 ◽  
Vol 1 (3) ◽  
pp. 25-28 ◽  
Author(s):  
Anshu LNU ◽  
Deepika LNU

ABSTRACT Background Pre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide. Present study was planned to find the maternal and perinatal outcome in patients of severe pre-eclampsia and eclampsia. Methodology It is a prospective study, carried out on 100 pregnant women admitted with severe pre-eclampsia and eclampsia at a tertiary care referral unit. Detailed history and examination was carried out. Investigations like complete hemogram, liver function tests, renal function tests, coagulation profile, fundus and 24 hours urine for protein were done. Obstetric management was done as per existing protocol in the department, magnesium sulphate was the drug of choice for controlling convulsions, and blood pressure was controlled either by oral nefidipene or methyl dopa. Maternal and perinatal complications were noted down. Results The majority of the patients was unbooked (82%), belonged to lower socioeconomic status (84%) and had rural background (84%). Headache was the most common antecedent symptom (44%) followed by epigastric pain (20%), oliguria (9%), blurring of vision (8%) and ascitis (5%). There was high incidence of maternal complications like PPH (31%), abruption placentae (11%), renal dysfunction (8%), pulmonary edema (8%), pulmonary embolism (4%), HELLP syndrome (2%) and DIC (2%). Maternal mortality was 8% and the causes were pulmonary embolism in four women, DIC in two, HELLP and pulmonary edema in one each. Perinatal complications were also high 71.43% were low birth weight, 66% had preterm delivery, 52.4% babies had birth asphyxia and 28.57% were still born. Maternal and perinatal outcome was much poorer in eclampsia as compared to severe pre-eclampsia. Conclusion There is a very high maternal and perinatal morbidity and mortality and 82% patients had no antenatal care. Good antenatal care could have been prevented severe pre-eclampsia and eclampsia to some extent. Thus it is suggested that developing countries have to go a long way to create awareness about importance of antenatal check ups and take measures for implementation.


Author(s):  
Mareko Ramotsababa ◽  
Vincent Setlhare

Background: Despite good access to antenatal care (ANC) services for most women, and regular training of healthcare workers in obstetrics and gynaecology, many pregnant women with a previous history of caesarean section (C/S) still presented late for ANC services at Letsholathebe II Memorial Hospital (LIIMH) in Maun, Botswana. This may increase morbidity and mortality in women with previous C/S delivery and neonates. Knowing why women with previous C/S present late for ANC may help in the formulation of interventions that decrease morbidity and mortality amongst these women and neonates.Aim: The aim of this study was to explore the reasons why pregnant women with a previous history of C/S registered late for ANC, at LIIMH.Setting: This study was performed at LIIMH, a district hospital situated in Maun, Botswana.Methods: This was a descriptive qualitative study. Consenting pregnant women with previous C/S who presented at LIIMH after the 20 weeks of pregnancy were interviewed until data saturation. The data was analysed for themes.Results: The reasons for late registration at LIIMH include lack of information, misconception on the appropriate booking time and venue, dissatisfaction with the quality of ANC clinic services, use of alternative ANC providers, delayed referral, and pregnancy experience.Conclusion: Lack of knowledge of ANC delivery venue, using alternative ANC providers, and dissatisfaction with ANC clinic services, contributed to late registration. Pregnant women with previous history of C/S should be informed about ANC, delivery plans, and the assistance of alternative ANC providers should be explored.


2020 ◽  
Vol 25 (3) ◽  
pp. 42-47
Author(s):  
Mihaela Corina Radu ◽  
Anca Irina Dumitrescu ◽  
Adrian Calin Boeru ◽  
Loredana Sabina Cornelia Manolescu ◽  
Oana Roxana Dumitrescu ◽  
...  

AbstractIn the last two decades, group B streptococcus (GBS) infection has established itself as a major cause of perinatal morbidity and mortality. The purpose of this study is to identify if the electively induced labor with oxytocin in women with positive cultures of Streptococcus agalactiae, namely the group B streptococcus (GBS), helps the mother and fetus and decreases the risk associated with perinatal transmission of GBS compared with the spontaneous labor. Results associated with induction of labor with oxytocin compared with spontaneous labor in pregnant women who have GBS - positive cervical cultures, are also used to determine whether induction of labor decreases the risk of complications from GBS infection.


2013 ◽  
Vol 66 (7-8) ◽  
pp. 292-296
Author(s):  
Branka Cancarevic-Djajic ◽  
Rade Vilendecic

Introduction. Perinatal morbidity and mortality are the ultimate indicators of antenatal care today, whose responsible task is to assess the respiratory function of the placenta, fetal growth and placental maturation in order to provide conditions for the delivery of a living and viable newborn. The diagnostic procedures of antenatal care tested within this study were the biophysical tests of cardiotocography and the fetal biophysical profile, along with the colour doppler evaluation of the cerebral-umbilical ratio. The objective of this study was to determine the most effective diagnostic procedure when assessing fetal oxygenation. Materials and Methods. The prospective study included 119 pregnant women. They all underwent cardiotocography, biophysical profile and colour doppler evaluation of the cerebral-umbilical ratio. The babies? umbilical artery blood pH was determined in the first minute upon birth, along with the Apgar score. Results. The results were processed statistically and the most effective diagnostic procedure for the evaluation of fetal oxygenation was selected, after which the rates of perinatal morbidity and mortality were calculated. The findings revealed that cardiotocography was the most sensitive antepartal predictor of fetal acidosis, while the fetal biophysical profile proved the most specific. The rates of perinatal morbidity and of perinatal mortality were 24.37% and 1.68%, respectively. Conclusion. The findings analysis revealed a high statistical significance of both biophysical tests and the cerebral-umbilical ratio evaluation as predictors of the fetal distress syndrome. The analysis of the cerebral-umbilical ratio and biophysical tests showed that the cerebral-umbilical ratio evaluation not only was more sensitive as a parameter compared to biophysical tests but it was also more specific than cardiotocography. Cardiotocography is the most sensitive antepartal predictor of fetal acidosis, followed by the cerebral-umbilical ratio, and the biophysical profile as the least sensitive. The biophysical profile proved to be the most specific, followed by the cerebral-umbilical ratio, and cardiotocography as the least specific.


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