scholarly journals Atrioventricular Conduction Delay in Fetuses Exposed to Anti-SSA/Ro and Anti-SSB/La Antibodies: A Magnetocardiography Study

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Annette Wacker-Gußmann ◽  
Henrike Paulsen ◽  
Isabelle Kiefer-Schmidt ◽  
Joerg Henes ◽  
Jana Muenssinger ◽  
...  
Keyword(s):  
Heart Block ◽  
Fetal Echocardiography ◽  
Conduction Delay ◽  
Study Group ◽  
Normal Range ◽  
Time Intervals ◽  
Fetal Electrocardiogram ◽  
Fetal Magnetocardiography ◽  
Electrocardiogram Ecg ◽  
Cardiac Conducting System

Background. The presence of anti-SSA/Ro and anti-SSB/La antibodies during pregnancy is associated with fetal congenital heart block (CHB), which is primarily diagnosed through fetal echocardiography. Conclusive information about the complete electrophysiology of the fetal cardiac conducting system is still lacking. In addition to echocardiography, fetal magnetocardiography (fMCG) can be used. fMCG is the magnetic analogue of the fetal electrocardiogram (ECG).Patients and Methods. Forty-eight pregnant women were enrolled in an observational study; 16 of them tested positive for anti-SSA/Ro and anti-SSB/La antibodies. In addition to routine fetal echocardiography, fMCG was used. Fetal cardiac time intervals (fCTIs) were extracted from the magnetic recordings by predefined procedures. ECGs in the neonates of the study group were performed within the first month after delivery.Results. The PQ segment of the fCTI was significantly prolonged in the study group (P=0.007), representing a delay of the electrical impulse in the atrioventricular (AV) node. Other fCTIs were within normal range. None of the anti-SSA/Ro and/or anti-SSB/La fetuses progressed to a more advanced heart block during pregnancy or after birth.Conclusion. The study identified a low-risk population within antibody positive mothers, where PQ segment prolongation is associated with a lack of progression of the disease.

scholarly journals Atrioventricular Conduction Delay in the Second Trimester Measured by Fetal Magnetocardiography

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Annette Wacker-Gussmann ◽  
Henrike Paulsen ◽  
Krunoslav Stingl ◽  
Johanna Braendle ◽  
Rangmar Goelz ◽  
...  
Keyword(s):  
Fetal Echocardiography ◽  
Vascular Diseases ◽  
P Wave ◽  
Conduction Delay ◽  
Study Group ◽  
Conduction Time ◽  
Av Block ◽  
Collagen Vascular Diseases ◽  
Fetal Magnetocardiography ◽  
Av Conduction

Introduction. Fetal AV block in SSA/Ro pregnancies is generally not seen before 18-week gestation and onset is rare after 28-week gestation. If complete AV block appears, it is believed to be irreversible. The purpose of the study was to evaluate precise electrophysiological AV conduction from 18-week gestation onwards.Patients and Methods. 21 fetuses of pregnant women with collagen vascular diseases were included in the study group and 59 healthy fetuses served as controls. In addition to fetal echocardiography, fetal magnetocardiography (fMCG) was used to investigate precise electrophysiological fetal cardiac time intervals (fCTIs).Results. The PR segment (isoelectric segment between the end of the P wave and the start of the QRS complex) was significantly prolonged (P<0.0362nd trimester,P<0.0233rd trimester) in both trimesters within the study group. In fetuses less than 23-week gestational age, a nearly complete separation was found, where a PR segment of 60 ms or greater completely excluded control fetuses. All other fCTIs did not differ significantly. None of the fetuses progressed to a more advanced heart block.Conclusion. Slight antibody effects in pregnancy, leading to PR segment prolongation, can already be seen from 18-week gestation onwards by fMCG. Serial fetal Doppler echocardiography and additional fMCG can be useful methods to measure early and precise AV conduction time, to achieve best surveillance for these high-risk pregnancies.

scholarly journals Early impact of the COVID-19 pandemic and social restrictions on ambulance missions

2021 ◽  
Author(s):  
Lauri Laukkanen ◽  
Sanna Lahtinen ◽  
Janne Liisanantti ◽  
Timo Kaakinen ◽  
Ari Ehrola ◽  
...  
Keyword(s):  
Early Phase ◽  
Health Care Services ◽  
Mental Health Problems ◽  
Significant Decline ◽  
Control Group ◽  
Study Group ◽  
Time Intervals ◽  
Care Services ◽  
Group A ◽  
New Strategies

Abstract Background The SARS-CoV-2 coronavirus disease (COVID-19) has had a major impact on health care services globally. Recent studies report that emergency departments have experienced a significant decline in the number of admitted patients in the early phase of the pandemic. To date, research regarding the influence of COVID-19 on emergency medical services (EMS) is limited. The present study investigates a change in the number and characteristics of EMS missions in the early phase of the pandemic. Methods All EMS missions in the Northern Ostrobothnia region, Finland (population 295 500) between 1 March to 30 June 2020 were screened and analyzed as the study group. A control group was composed from the EMS calls between the corresponding months in the years 2016–2019. Results A total of 74 576 EMS missions were screened for the study. Within the first two months after the first COVID-19 cases in the study area, the decline in the number of EMS missions was 5.7% – 13% compared to the control group average. EMS time intervals (emergency call to dispatch, dispatch, en-route, on-scene and hospital handover) prolonged in the COVID-19 period. Dispatches concerning mental health problems increased most in the study period (+1.2%, p &lt; 0.001). Only eleven confirmed COVID-19 infections were encountered by EMS in the study period. Conclusion Our findings suggest that the present COVID-19 pandemic and social restrictions lead to changes in the EMS usage. These preliminary findings emphasize the importance of developing new strategies and protocols in response to the oncoming pandemic waves.

Circulating Catecholamines and Systolic Time Intervals in Labile and Sustained Hypertension

1978 ◽  
Vol 55 (s4) ◽  
pp. 65s-68s ◽  
Author(s):  
D. Cousineau ◽  
J. de Champlain ◽  
L. Lapointe
Keyword(s):  
Heart Rate ◽  
Essential Hypertension ◽  
Myocardial Contractility ◽  
Systolic Time Intervals ◽  
Normal Range ◽  
Time Intervals ◽  
Hypertensive Patients ◽  
Sustained Hypertension ◽  
Systolic Time ◽  
Hypotensive Response

1. Average supine circulating total catecholamine concentrations were found to be higher than the normal range in about 50% of patients with labile hypertension and in about 30% of patients with sustained essential hypertension. 2. These higher resting concentrations were mainly due to an increase in adrenaline in labile hypertension and to an increase in noradrenaline in sustained hypertension. 3. Patients with elevated catecholamine concentrations were also characterized by a higher heart rate, by an increased myocardial contractility and by greater hypotensive response after treatment with β-adrenoreceptor blocking agents. 4. These studies suggest the existence of subgroups of hypertensive patients with increased sympathetic tone.

Development of a Home-based Fetal Electrocardiogram (ECG) Monitoring System

2021 ◽  
Author(s):  
Sadaf Sarafan ◽  
Tai Le ◽  
Floranne Ellington ◽  
Zhijie Zhang ◽  
Michael P. H. Lau ◽  
...  
Keyword(s):  
Monitoring System ◽  
Ecg Monitoring ◽  
Fetal Electrocardiogram ◽  
Home Based ◽  
Electrocardiogram Ecg

scholarly journals A systematic review of cardiac time intervals utilising non-invasive fetal electrocardiogram in normal fetuses

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Vinayak Smith ◽  
Senthuran Arunthavanathan ◽  
Amrish Nair ◽  
Diane Ansermet ◽  
Fabricio da Silva Costa ◽  
...  
Keyword(s):  
Systematic Review ◽  
Time Intervals ◽  
Fetal Electrocardiogram ◽  
Non Invasive ◽  
Cardiac Time Intervals

scholarly journals Use of medetomidine, midazolam, ketamine and sevoflurane as an anesthetic protocol for domestic chickens

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Yıldırım Çelik ◽  
Gültekin Atalan ◽  
Vehbi Güneş ◽  
Umut Alpman ◽  
Muhammed Kaan Yönez
Keyword(s):  
Biochemical Parameters ◽  
Mean Amplitude ◽  
P Wave ◽  
Reflex Response ◽  
Time Intervals ◽  
Life Threatening ◽  
Baseline Values ◽  
The Mean ◽  
Electrocardiogram Ecg ◽  
Anesthesia Time

Changes in physiological and biochemical parameters after administration of medetomidine (MED), midazolam (MID), ketamine (KET) and a 2% of the inhalation anesthetic sevoflurane (SEVO), were investigated in domestic chickens. The anesthetic protocol began with a simultaneous intrapectoral injection (IP) of MED (50 μg/kg) and MID (0.5 mg/kg), followed by IP administration of 25 mg/kg of KET 10 min later. Anesthesia was then maintained for 30 min by 2% SEVO (with a 500 ml/min oxygen flow), using an Ayres T piece device. Heart and respiratory rates, cloacal temperature, reflex response and electrocardiogram (ECG) parameters were recorded at time cero (T0) before anesthesia (BA, baseline values), at time of MED+MID administration (T1), at time of ketamine injection (T2), 30 min after the start of SEVO inhalation (T3) and at recovery. Blood was also drawn at T0 and T3 to assess albumin, creatinine, glucose and liver enzyme concentrations. Cloacal temperature, heart and respiratory rates differed from baseline values at all time intervals during anesthesia (p<0.05). Heart rate decreased following the MED + MID injection (at T1, T2 and T3), and partially recovered by the reanimation period. Reflex response also differed between time 0 and all anesthesia time points (p<0.05). Mean amplitude of the P wave of the ECG was increased during MED + MID (T1) and KET (T2) anesthesia. The mean ST interval showed a large increase at T1, which was maintained throughout anesthesia (p <0.05). Albumin, glucose and the ALT enzyme decreased between T0 and T3. In conclusion, the use of MED+MID+KET and SEVO as an anesthetic combination altered cardiorespiratory and biochemical parameters of chickens, but no life-threatening effects were observed as a result of these changes. Hence, this drug combination can be adequately used as an anesthesia protocol in chickens.

Fetal cardiac time intervals in healthy pregnancies – an observational study by fetal ECG (Monica Healthcare System)

2018 ◽  
Vol 46 (6) ◽  
pp. 587-592 ◽  
Author(s):  
Annette Wacker-Gussmann ◽  
Cordula Plankl ◽  
Maria Sewald ◽  
Karl-Theo Maria Schneider ◽  
Renate Oberhoffer ◽  
...  
Keyword(s):  
Healthcare System ◽  
P Wave ◽  
Signal Loss ◽  
Qrs Complex ◽  
Time Intervals ◽  
Cardiac Time Intervals ◽  
Fetal Magnetocardiography ◽  
Fetal Ecg ◽  
Global Signal ◽  
Gestational Week

Abstract Background: Fetal electrocardiogram (fECG) can detect QRS signals in fetuses from as early as 17 weeks’ gestation; however, the technique is limited by the minute size of the fetal signal relative to noise ratio. The aim of this study was to evaluate precise fetal cardiac time intervals (fCTIs) with the help of a newly developed fetal ECG device (Monica Healthcare System). Methods: In a prospective manner we included 15–18 healthy fetuses per gestational week from 32 weeks onwards. The small and wearable Monica AN24 monitoring system uses standard ECG electrodes placed on the maternal abdomen to monitor fECG, maternal ECG and uterine electromyogram (EMG). Fetal CTIs were estimated on 1000 averaged fetal heart beats. Detection was deemed successful if there was a global signal loss of less than 30% and an analysis loss of the Monica AN24 signal separation analysis of less than 50%. Fetal CTIs were determined visually by three independent measurements. Results: A total of 149 fECGs were performed. After applying the requirements 117 fECGs remained for CTI analysis. While the onset and termination of P-wave and QRS-complex could be easily identified in most ECG patterns (97% for P-wave, PQ and PR interval and 100% for QRS-complex), the T-wave was detectable in only 41% of the datasets. The CTI results were comparable to other available methods such as fetal magnetocardiography (fMCG). Conclusions: Although limited and preclinical in its use, fECG (Monica Healthcare System) could be an additional useful tool to detect precise fCTIs from 32 weeks’ gestational age onwards.

First-trimester fetal heart block and increased nuchal translucency: an indication for early fetal echocardiography

2005 ◽  
Vol 25 (12) ◽  
pp. 1129-1132 ◽  
Author(s):  
A. Sciarrone ◽  
B. Masturzo ◽  
G. Botta ◽  
S. Bastonero ◽  
M. Campogrande ◽  
...  
Keyword(s):  
Heart Block ◽  
Fetal Heart ◽  
Fetal Echocardiography ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Increased Nuchal Translucency
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