scholarly journals Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
E. Vandeix ◽  
F. Favard ◽  
N. Pichon ◽  
M. Delage-Corre ◽  
B. Melloni ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Acute Respiratory Distress Syndrome ◽  
Proteasome Inhibitor ◽  
Bronchiolitis Obliterans ◽  
Respiratory Symptoms ◽  
Distress Syndrome ◽  
Pulmonary Complications ◽  
Organizing Pneumonia ◽  
Rapid Improvement ◽  
Bronchiolitis Obliterans Organizing Pneumonia

Introduction. Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients. The most frequent side effects are gastrointestinal and neurological. Serious pulmonary complications have been described rarely.Observation. This case involves a 74-year-old man suffering from IgG Kappa myeloma treated with bortezomib, melphalan, and dexamethasone. After administering chemotherapy, the patient developed an acute respiratory distress syndrome (ARDS). A surgical pulmonary biopsy proved the existence of bronchiolitis obliterans organizing pneumonia (BOOP) lesions. Systemic corticotherapy led to a rapid improvement in the patient’s condition.Conclusion. This is the first reported histologically confirmed case of bortezomid-induced BOOP. Faced with severe respiratory symptoms in the absence of other etiologies, complications due to bortezomid treatment should be evoked and corticotherapy considered.

scholarly journals Rituximab-Induced Bronchiolitis Obliterans Organizing Pneumonia

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Ahmet B. Ergin ◽  
Nancy Fong ◽  
Hamed A. Daw
Keyword(s):  
Bronchiolitis Obliterans ◽  
Hypersensitivity Pneumonitis ◽  
Distress Syndrome ◽  
Marginal Zone ◽  
Relevant Literature ◽  
Single Agent ◽  
Organizing Pneumonia ◽  
Computed Tomography Imaging ◽  
Bronchiolitis Obliterans Organizing Pneumonia ◽  
Prompt Diagnosis

Rituximab-induced lung disease (R-ILD) is a rare entity that should be considered in patients treated with rituximab who present with dyspnea, fever, and cough, but no clear evidence of infection. A variety of pathologic findings have been described in this setting. Bronchiolitis obliterans organizing pneumonia (BOOP) is the most common clinicopathologic diagnosis, followed by interstitial pneumonitis, acute respiratory distress syndrome (ARDS), and hypersensitivity pneumonitis. Prompt diagnosis and treatment with corticosteroids are essential as discussed by Wagner et al. (2007). Here we present a case of an 82-year-old man who was treated with rituximab for recurrent marginal zone lymphoma. After the first infusion of rituximab, he reported fever, chills, and dyspnea. On computed tomography imaging, he was found to have bilateral patchy infiltrates, consistent with BOOP on biopsy. In our patient, BOOP was caused by single-agent rituximab, in the first week after the first infusion of rituximab. We reviewed the relevant literature to clarify the different presentations and characteristics of R-ILD and raise awareness of this relatively overlooked entity.

Unusual Complication after Radiotherapy for Breast Cancer Bronchiolitis Obliterans Organizing Pneumonia Case Report and Review of the Literature

2005 ◽  
Vol 91 (5) ◽  
pp. 421-423 ◽  
Author(s):  
Gabriella Guerriero ◽  
Cleonice Battista ◽  
Marilena Montesano ◽  
Rita Carino ◽  
Angelo Primavera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bronchiolitis Obliterans ◽  
Postoperative Radiotherapy ◽  
Corticosteroid Treatment ◽  
Breast Conserving Surgery ◽  
Left Breast ◽  
Unusual Complication ◽  
Organizing Pneumonia ◽  
Rapid Improvement ◽  
Bronchiolitis Obliterans Organizing Pneumonia

Breast-conserving surgery and postoperative radiotherapy play an important role in the treatment of early breast cancer. Bronchiolitis obliterans with organizing pneumonia (BOOP) is an uncommon syndrome reported to be one of the complications of adjuvant radiotherapy. We report the case of a 71-year-old woman who developed cough, dyspnea and fever three weeks after radiation therapy to the left breast for breast carcinoma. Chest X-ray and computed tomography scan demonstrated alveolar opacities within both lungs. Antibiotic therapy against any probable septic pathology did not improve the symptoms, while corticosteroid treatment resulted in rapid clinical improvement together with regression of the pulmonary opacities. Irradiation was thought to be the cause of the migratory pneumonitis, hence this case was clinically diagnosed as radiation-induced migratory pneumonitis similar to BOOP, without lung biopsy. The present case suggests that one should be mindful of this disease when treating patients with a history of irradiation to the breast. BOOP promptly responds to systemic corticosteroid therapy with rapid improvement of symptoms and regression of the pulmonary opacities.

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