scholarly journals Melanocyte Colonization and Pigmentation of Breast Carcinoma: Pathological and Clinical Aspects

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Marco Mele ◽  
Tinne Laurberg ◽  
Tine Engberg Damsgaard ◽  
Jonas Funder ◽  
Vibeke Jensen
Keyword(s):  
Breast Cancer ◽  
Malignant Melanoma ◽  
Breast Carcinoma ◽  
Basement Membrane ◽  
Histological Examination ◽  
Clinical Aspects ◽  
Pathological Features ◽  
Clinical And Pathological Features

Introduction. Melanocyte colonization of breast carcinoma by nonneoplastic melanocytes of epidermal origin is a rare and serious condition first described in 1977. We report on the exceptional clinical and pathological features of this migration phenomenon in a 74-year-old patient.Discussion. The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential.Conclusion. Histological examination and additional staining of skin are essential to differentiate breast cancer melanosis from malignant melanoma.

scholarly journals Histology of Luminal Breast Cancer

Breast Care ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. 327-336
Author(s):  
Ramona Erber ◽  
Arndt Hartmann
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Breast Carcinoma ◽  
Expression Profiling ◽  
Molecular Subtypes ◽  
Luminal Breast Cancer ◽  
Pathological Features ◽  
Histological Subtypes ◽  
Ki 67 ◽  
Clinical And Pathological Features

Background: Invasive breast cancer (IBC) can be categorized into prognostic and predictive molecular subtypes (including luminal breast cancer) using gene expression profiling. Luminal IBC comprises a variety of histological subtypes with varying clinical and pathological features. Summary: IBC of no special subtype is the most common histological subtype in general and likewise within luminal IBC. Classical invasive lobular breast cancer, typically clustering into luminal subgroup, is characterized by discohesive growth and loss of E-cadherin expression. Infrequent, morphologically distinct luminal IBC subtypes are tubular, invasive cribriform, mucinous, and invasive micropapillary carcinomas. Breast carcinoma with apocrine differentiation, with characteristic expression of androgen receptor (AR), often clusters into the luminal AR category. Rarely, neuroendocrine neoplasms of the breast can be seen. IBC of the male breast usually matches with the luminal subtype. Key Messages: Independently from histological subtypes, invasive breast cancer (IBC) can be divided into molecular subtypes based on mRNA gene expression levels. Using this molecular subtyping, risk scores based on gene expression profiling (established for hormone receptor-positive, HER2-negative IBC), grading, and Ki-67 index, prognosis of patients with luminal breast cancer and response to chemotherapy can be predicted. In routine diagnostics, the expression of estrogen receptor (ER) and progesterone receptor (PR), HER2 status, and the proliferation rate (Ki-67) are used to determine a surrogate (molecular-like) subtype. Within luminal(-like) IBC, no special subtype and invasive lobular breast carcinoma are the most common histological subtypes. Other rare histological subtypes (e.g., tubular carcinoma) should be recognized due to their distinct clinical and pathological features.

scholarly journals Melanocyte Colonization and Pigmentation of Breast Carcinoma: Description of Two Pathological Cases and Review of Literature

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 709
Author(s):  
Angela Santoro ◽  
Giuseppe Angelico ◽  
Vincenzo Fiorentino ◽  
Qianqian Zhang ◽  
Saveria Spadola ◽  
...  
Keyword(s):  
Growth Factors ◽  
Breast Carcinoma ◽  
Basement Membrane ◽  
Pathological Features ◽  
Review Of Literature ◽  
Old Patients ◽  
Clinical And Pathological Features

Colonization of breast carcinoma by non-neoplastic melanocytes of epidermal origin was first described by Azzopardi and Eusebi in 1977. We herein report two cases on the exceptional clinical and pathological features of this phenomenon in a 66-year-old and a 51-year-old patients. The pathogenesis is not fully understood, but a disrupted basement membrane and the role of tumoral growth factors are considered essential.

scholarly journals Clinical and Pathological Features of Early-Onset Breast Cancer

2014 ◽  
Vol 25 ◽  
pp. v69
Author(s):  
Hiroko Bando ◽  
Mai Furuya ◽  
Aya Sawa ◽  
Emika Ichioka ◽  
Takeshi Saitou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Onset ◽  
Pathological Features ◽  
Early Onset Breast Cancer ◽  
Clinical And Pathological Features

Estrogen and Progesterone Receptors in Breast Cancer: Correlation with Clinical and Pathological Features and with Prognosis

Oncology ◽  
1992 ◽  
Vol 49 (2) ◽  
pp. 82-88 ◽  
Author(s):  
Annamaria Molino ◽  
Monica Turazza ◽  
Andrea Bonetti ◽  
Pasqualina Biondani ◽  
Claudia Griso ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptors ◽  
Pathological Features ◽  
Estrogen And Progesterone Receptors ◽  
Clinical And Pathological Features

scholarly journals Enhanced targeting of triple-negative breast carcinoma and malignant melanoma by photochemical internalization of CSPG4-targeting immunotoxins

2018 ◽  
Vol 17 (5) ◽  
pp. 539-551 ◽  
Author(s):  
M. S. Eng ◽  
J. Kaur ◽  
L. Prasmickaite ◽  
B. Ø. Engesæter ◽  
A. Weyergang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Malignant Melanoma ◽  
Breast Carcinoma ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Photochemical Internalization ◽  
Triple Negative Breast Carcinoma

Light-controlled immunotargeting of CSPG4+ triple negative breast cancer and malignant melanoma.

PET avidity and tumor clinical and pathological features in breast cancer.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e12623-e12623
Author(s):  
Ahmed Gamal Elsayed ◽  
Emnet Wassie ◽  
Heather Katz ◽  
Roma Srivastava ◽  
Maria R. B. Tria Tirona
Keyword(s):  
Breast Cancer ◽  
Pathological Features ◽  
Clinical And Pathological Features
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