scholarly journals Synergistic Effect of Hyperglycemia and Suppression on Adult Mouse Islet Beta Cell Replication

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Szu-Tah Chen ◽  
Shin-Huei Fu ◽  
Samuel Hsu ◽  
Yu-Yao Huang ◽  
Brend Ray-Sea Hsu
Keyword(s):  
Synergistic Effect ◽  
Beta Cell ◽  
Ex Vivo ◽  
Graft Function ◽  
Cell Replication ◽  
Beta Cell Replication ◽  
Islet Beta Cell ◽  
Adult Mice ◽  
Complementary Role ◽  
Syngeneic Mouse Model

The complementary role of hyperglycemia and suppression on islet beta cell regeneration was investigated in a syngeneic mouse model. gene silencing was performed by infecting islets of C57BL/6 with shRNA lentiviral particles. At 54 hours after viral infection, protein content in cultured targeting islets was 22% of that in freshly isolated islets. Six days after transplantation to diabetic mice, targeting islet graft had considerably more cells with Ki67-staining nuclei than nontargeting islets. The mice in the targeting-islet group had a significantly shorter duration of temporary hyperglycaemia than mice in the non-targeting-islet group. The long-termex vivobeneficial effect of silencing on graft function was also indicated by the significantly higher cumulative cure rate for diabetes in mice receiving 200 targeting islets than that in mice receiving 200 non-targeting islets. Our data suggest that hyperglycemia and persistent suppression have a synergistic effect on islet beta cell replication in adult mice.

Stimulating Beta Cell Replication and Improving Islet Graft Function by a GPR40 and GPR120 Dual Agonist

2012 ◽  
Vol 94 (10S) ◽  
pp. 567
Author(s):  
J. Gao ◽  
G. Weng ◽  
A. Aasarullah ◽  
Y. Lu ◽  
M. Holstein ◽  
...  
Keyword(s):  
Beta Cell ◽  
Graft Function ◽  
Islet Graft ◽  
Cell Replication ◽  
Beta Cell Replication ◽  
Dual Agonist

scholarly journals Stimulation of pancreatic islet beta-cell replication by oncogenes.

1988 ◽  
Vol 85 (1) ◽  
pp. 116-120 ◽  
Author(s):  
M. Welsh ◽  
N. Welsh ◽  
T. Nilsson ◽  
P. Arkhammar ◽  
R. B. Pepinsky ◽  
...  
Keyword(s):  
Beta Cell ◽  
Pancreatic Islet ◽  
Cell Replication ◽  
Beta Cell Replication ◽  
Islet Beta Cell ◽  
Pancreatic Islet Beta Cell ◽  
Stimulation Of

scholarly journals Stimulating beta cell replication and improving islet graft function by GPR119 agonists

2011 ◽  
Vol 24 (11) ◽  
pp. 1124-1134 ◽  
Author(s):  
Jie Gao ◽  
Lei Tian ◽  
Guobin Weng ◽  
Nicholas V. Bhagroo ◽  
Robert L. Sorenson ◽  
...  
Keyword(s):  
Beta Cell ◽  
Graft Function ◽  
Islet Graft ◽  
Cell Replication ◽  
Beta Cell Replication

scholarly journals Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans

Diabetologia ◽  
2006 ◽  
Vol 49 (11) ◽  
pp. 2689-2696 ◽  
Author(s):  
J. J. Meier ◽  
A. E. Butler ◽  
R. Galasso ◽  
R. A. Rizza ◽  
P. C. Butler
Keyword(s):  
Beta Cell ◽  
Cell Replication ◽  
Beta Cell Replication ◽  
Islet Beta Cell

Growth factors and beta cell replication

2006 ◽  
Vol 38 (5-6) ◽  
pp. 931-950 ◽  
Author(s):  
Rupangi C. Vasavada ◽  
Jose A. Gonzalez-Pertusa ◽  
Yuichi Fujinaka ◽  
Nathalie Fiaschi-Taesch ◽  
Irene Cozar-Castellano ◽  
...  
Keyword(s):  
Growth Factors ◽  
Beta Cell ◽  
Cell Replication ◽  
Beta Cell Replication

scholarly journals Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Rebeca Fernandez-Ruiz ◽  
Ainhoa García-Alamán ◽  
Yaiza Esteban ◽  
Joan Mir-Coll ◽  
Berta Serra-Navarro ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Beta Cell Proliferation ◽  
Cell Replication ◽  
Trophic Effect ◽  
Beta Cell Replication

AbstractExpanding the mass of pancreatic insulin-producing beta cells through re-activation of beta cell replication has been proposed as a therapy to prevent or delay the appearance of diabetes. Pancreatic beta cells exhibit an age-dependent decrease in their proliferative activity, partly related to changes in the systemic environment. Here we report the identification of CCN4/Wisp1 as a circulating factor more abundant in pre-weaning than in adult mice. We show that Wisp1 promotes endogenous and transplanted adult beta cell proliferation in vivo. We validate these findings using isolated mouse and human islets and find that the beta cell trophic effect of Wisp1 is dependent on Akt signaling. In summary, our study reveals the role of Wisp1 as an inducer of beta cell replication, supporting the idea that the use of young blood factors may be a useful strategy to expand adult beta cell mass.

scholarly journals IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice

Diabetologia ◽  
2008 ◽  
Vol 51 (10) ◽  
pp. 1862-1872 ◽  
Author(s):  
J. Agudo ◽  
E. Ayuso ◽  
V. Jimenez ◽  
A. Salavert ◽  
A. Casellas ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Beta Cell ◽  
Endocrine Pancreas ◽  
Cell Replication ◽  
Cell Cycle Protein ◽  
Beta Cell Replication ◽  
Igf I

scholarly journals A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

2015 ◽  
Vol 21 (4) ◽  
pp. 383-388 ◽  
Author(s):  
Peng Wang ◽  
Juan-Carlos Alvarez-Perez ◽  
Dan P Felsenfeld ◽  
Hongtao Liu ◽  
Sharmila Sivendran ◽  
...  
Keyword(s):  
Beta Cell ◽  
High Throughput ◽  
Pancreatic Beta Cell ◽  
Cell Replication ◽  
Beta Cell Replication ◽  
Chemical Screen
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