scholarly journals Immunological HCV-Associated Thrombocytopenia: Short Review

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Dimitrios Dimitroulis ◽  
Serena Valsami ◽  
Paraskevas Stamopoulos ◽  
Gregory Kouraklis
Keyword(s):  
Clinical Signs ◽  
Treatment Strategies ◽  
Signs And Symptoms ◽  
Short Review ◽  
Short Paper ◽  
The Usa ◽  
Clinical Signs And Symptoms ◽  
End Stage ◽  
Epidemiological Characteristics ◽  
Symptoms And Signs

Infection with Hepatitis C virus (HCV) is affecting about 3% of the world's population, leading to liver damage, end-stage liver disease, and development of hepatocellular carcinoma, being thus the first indication for liver transplantation in the USA. Apart from the cirrhotic-liver-derived clinical signs and symptoms several conditions with immunological origin can also arise, such as, glomerulonephritis, pulmonary fibrosis, and thrombocytopenia. HCV-related autoimmune thrombocytopenia shows specific pathogenetic characteristics as well as symptoms and signs that differ in severity and frequency from symptoms in patients that are not HCV infected. Aim of this short paper is to estimate the epidemiological characteristics of the disease, to investigate the pathogenesis and clinical manifestation, and to propose treatment strategies according to the pertinent literature.

scholarly journals COVID-19 in End-stage Renal Disease (ESRD) Patients Undergoing Hemodialysis: A Close Follow-up of Clinical Findings and Evolutions in Chest CT Imaging: A Retrospective Study

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Hamid Tayebi khosroshahi ◽  
Armin Zarrintan ◽  
Hesam Manaflouyan ◽  
Dara Rahmanpour ◽  
Ebrahim Farashi ◽  
...  
Keyword(s):  
Retrospective Study ◽  
End Stage Renal Disease ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Chest Ct ◽  
Clinical Signs And Symptoms ◽  
Stage Renal Disease ◽  
End Stage ◽  
Imaging Signs ◽  
Esrd Patients

Background: Coronavirus disease 2019 (COVID-19) has infected millions and caused tens of thousands of casualties. Epidemiologic studies show that specific individuals with pre-existing conditions are prone to severe disease caused by the virus. Thus, it is necessary to determine clinical signs and symptoms and disease progression course in various pre-existing conditions, namely end-stage renal disease (ESRD) patients undergoing hemodialysis. Methods: The present retrospective study was conducted on 17 ESRD patients undergoing chronic hemodialysis. Clinical signs and symptoms were extracted, and laboratory test results and imaging findings were retrieved using the health information systems of the institute where the study was performed. Results: Of 17 patients in the study, six patients were females, and 11 were males. The mean age of the patients was 62.29 ± 15.6 years (22 - 82). The most common pre-existing conditions were hypertension and diabetes. The most common imaging signs were ground-glass opacities. The most common pattern of involvement was peripheral, bilateral, and multifocal involvement, and interestingly, uncommon imaging signs such as crazy-paving, peribronchovascular involvement, and reticulonodular pattern of involvement. The most common laboratory findings were lymphopenia, lymphocytosis, increased erythrocyte sedimentation rate, and positive C reactive protein. Conclusions: ESRD patients undergoing COVID-19 seem to have higher mortalities than the general public and show more significant lung involvement on chest CT imaging. Furthermore, uncommon imaging signs are more common in this group of patients.

Rare neurodegenerative parkinsonism (PSP, MSA, CBD)

2020 ◽  
pp. 133-140
Author(s):  
James B Rowe ◽  
Ian TS Coyle-Gilchrist
Keyword(s):  
Multiple System Atrophy ◽  
Progressive Supranuclear Palsy ◽  
Diagnostic Criteria ◽  
Neurodegenerative Disorders ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Course Of Illness ◽  
The Usa ◽  
Clinical Signs And Symptoms ◽  
Clinical Diagnostic Criteria

Progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA) are three neurodegenerative disorders that lead to parkinsonism amidst a constellation of other distinctive clinical signs and symptoms. In their classical forms they are distinct, and associated with specific neuropathologies. However, non-classical presentations of these pathologies are increasingly recognized, and may even form the majority of presentations, especially for PSP. In addition, phenotypic mimicry, syndromic evolution during the course of illness, and high rates of misdiagnosis and under-diagnosis have all complicated the estimation of the prevalence and incidence of these disorders. Here we review the available data for the epidemiology of these disorders, which arises mainly from Europe, the USA, and Japan. We set these estimates in the context of the changing diagnostic criteria and contemporary knowledge of clinico-pathological correlations. Despite the challenges, and widely varying methods, there is a convergence of estimated prevalence and incidence over the last 20 years, at least for the classical presentations of these three disorders. New studies are required that take into account revised clinical diagnostic criteria, non-classical presentations, and misdiagnosis.

First-use Reactions: A Potential Hazard for Referral Centers

1989 ◽  
Vol 12 (11) ◽  
pp. 688-691 ◽  
Author(s):  
R.J. Caruana
Keyword(s):  
Renal Failure ◽  
Tertiary Care ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Potential Hazard ◽  
End Stage Renal Failure ◽  
Increased Risk ◽  
Dialysis Facility ◽  
Clinical Signs And Symptoms ◽  
End Stage

First-use reactions comprise a spectrum of adverse clinical signs and symptoms occurring in end-stage renal failure patients during hemodialysis treatments. This report describes four patients experiencing first-use reactions in the context of being referred to or from a tertiary care inpatient dialysis facility. Theories on the pathogenesis of first-use reactions are reviewed and recommendations for identifying patients at increased risk for this problem are proposed.

scholarly journals Differential diagnosis between epileptic seizures and psychogenic nonepileptic seizures based on semiology

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Xiaohui Xiang ◽  
Jiajia Fang ◽  
Yi Guo
Keyword(s):  
Differential Diagnosis ◽  
Clinical Signs ◽  
Epileptic Seizures ◽  
Signs And Symptoms ◽  
Standard Test ◽  
Psychogenic Nonepileptic Seizures ◽  
Nonepileptic Seizures ◽  
Clinical Signs And Symptoms ◽  
Symptoms And Signs ◽  
Synchronous Recording

Abstract Psychogenic nonepileptic seizures present as paroxysmal symptoms and signs mimicking epileptic seizures. The gold standard test is the synchronous recording by video, electrocardiogram and electroencephalogram. However, video electroencephalogram is not available at many centers and not entirely independent of semiology. Recent studies have focused on semiological characteristics distinguishing these two circumstances. Clinical signs and symptoms provide important clues when making differential diagnosis. The purpose of this review is to help physicians differentiating psychogenic nonepileptic seizures better from epileptic seizures based on semiology, and improve care for those patients.

Calciphylaxis: A Cause of Necrotic Ulcers in Renal Failure

1998 ◽  
Vol 2 (4) ◽  
pp. 242-244 ◽  
Author(s):  
Amer N. Kalaaji ◽  
Margaret C. Douglass ◽  
Marsha Chaffins ◽  
Lori Lowe
Keyword(s):  
Early Diagnosis ◽  
Early Recognition ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Threatening Condition ◽  
Life Threatening ◽  
Clinical Signs And Symptoms ◽  
Initiation Of Therapy ◽  
Stage Renal Disease ◽  
End Stage

Background: Calciphylaxis is a rare and life-threatening condition occurring in patients with end-stage renal disease on dialysis. The diagnosis is frequently delayed or missed and therapy is often unsuccessful. Objective: The clinical and pathological components of calciphylaxis are emphasized in a patient that may facilitate early diagnosis and initiation of therapy. Results: Early recognition of the clinical signs and symptoms of calciphylaxis is crucial. The tissue diagnosis requires large elliptical biopsies because histological findings are segmental and often missed. Conclusion: Early diagnosis and intervention in calciphylaxis is critical. Parathyroidectomy should be considered in all cases.

scholarly journals Dementia and Major Neurocognitive Disorders: Some Lessons Learned One Century after the first Alois Alzheimer’s Clinical Notes

Geriatrics ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 5
Author(s):  
Donatella Rita Petretto ◽  
Gian Pietro Carrogu ◽  
Luca Gaviano ◽  
Lorenzo Pili ◽  
Roberto Pili
Keyword(s):  
Young Woman ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Neurocognitive Disorders ◽  
Lessons Learned ◽  
Alzheimer Dementia ◽  
Clinical Notes ◽  
Alois Alzheimer ◽  
Clinical Signs And Symptoms

Over 100 years ago, Alois Alzheimer presented the clinical signs and symptoms of what has been later called “Alzheimer Dementia” in a young woman whose name was Augustine Deter [...]

scholarly journals Correction to: Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing’s syndrome

Pituitary ◽  
2020 ◽  
Author(s):  
Eliza B. Geer ◽  
Roberto Salvatori ◽  
Atanaska Elenkova ◽  
Maria Fleseriu ◽  
Rosario Pivonello ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Patient Reported Outcomes ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Cushing's Syndrome ◽  
Original Version ◽  
Patient Reported ◽  
Author Group ◽  
Clinical Signs And Symptoms

The original version of the article unfortunately contained an error in the first name and the surname of one of the authors in the author group. The last author name was incorrectly published as ‘F. Pecori Giraldi’ and the corrected name is ‘Francesca Pecori Giraldi’ (First name: Francesca; Surname: Pecori Giraldi).

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