scholarly journals Nonconvulsive Status Epilepticus on Electroencephalography: An Atypical Presentation of Subacute Sclerosing Panencephalitis in Two Children

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Pratibha Singhi ◽  
Arushi Gahlot Saini ◽  
Jitendra Kumar Sahu
Keyword(s):  
Cerebrospinal Fluid ◽  
Status Epilepticus ◽  
Cognitive Decline ◽  
Neurodegenerative Disease ◽  
Slow Wave ◽  
Subacute Sclerosing Panencephalitis ◽  
Nonconvulsive Status Epilepticus ◽  
Atypical Presentation ◽  
Measles Antibodies

Subacute sclerosing panencephalitis is a neurodegenerative disease secondary to measles infection that usually has a typical presentation with progressive myoclonia, cognitive decline, and periodic slow-wave complexes on electroencephalography. We report two pediatric cases who presented with periodic myoclonic jerks and cognitive decline. In both cases, the electroencephalogram showed continuous nonconvulsive status epilepticus activity. Both had elevated measles antibodies in cerebrospinal fluid and blood. Pediatricians need to be aware of this atypical presentation of subacute sclerosing panencephalitis.

Nonconvulsive Status Epilepticus on Electroencephalography in a Case With Subacute Sclerosing Panencephalitis

2006 ◽  
Vol 21 (3) ◽  
pp. 256-260
Author(s):  
Ömer Faruk Aydin ◽  
Nesrin Şenbil ◽  
Y. K. Yavuz Gürer
Keyword(s):  
Status Epilepticus ◽  
Subacute Sclerosing Panencephalitis ◽  
Closed Head Injury ◽  
High Amplitude ◽  
Nonconvulsive Status Epilepticus ◽  
Computed Tomographic ◽  
Cognitive Difficulties ◽  
Intravenous Diazepam ◽  
Electroencephalogram Eeg ◽  
The Brain

Subacute sclerosing panencephalitis is a neurodegenerative disease with a poor prognosis. We report a case of a 5Z\x-year-old boy who had emotional lability, cognitive difficulties, and myoclonia after a mild closed head injury. The magnetic resonance image of the brain and computed tomographic scan of the head were normal. His electroencephalogram (EEG) showed continuous nonconvulsive status epilepticus activity, which could not be suppressed with intravenous diazepam. After treatment with phenytoin for 2 days, an EEG showed periodic high-amplitude sharp-and-slow-wave complexes, which were also not suppressed with intravenous diazepam. Since the patient had measles at 5 months of age, subacute sclerosing panencephalitis was considered, and the diagnosis was confirmed by the presence of measles antibodies in cerebrospinal fluid. ( J Child Neurol 2006;21:256—260; DOI 10.2310/7010.2006.00056).

Atypical presentation of Costeff syndrome-severe psychomotor involvement and electrical status epilepticus during slow wave sleep

2015 ◽  
Vol 19 (6) ◽  
pp. 733-736 ◽  
Author(s):  
Nirit Carmi ◽  
Dorit Lev ◽  
Esther Leshinsky-Silver ◽  
Yair Anikster ◽  
Lubov Blumkin ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Atypical Presentation

scholarly journals 5-HAYED peptide can protect AD brain by scavenging the redundant iron ions and the catalyzed radicals

2018 ◽  
Author(s):  
Zhenyou Zou ◽  
Shengxi Shao ◽  
Li Li ◽  
Xiaoying Cheng ◽  
Qiqiong Shen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cognitive Decline ◽  
Neurodegenerative Disease ◽  
Iron Ions ◽  
Brain Iron ◽  
Soluble Iron ◽  
The Brain ◽  
Great Burden

AbstractAlzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory and cognitive decline. It is incurable currently and places a great burden on the caregivers of patients. Iron is rich in the brain of AD suffers. It catalyzes radicals which impairs neurons. Therefore, reducing the redundant brain iron is pressing to ease AD. To scavenge the excessive brain iron catalyzed radical, thus protect the brain and decrease the incidence of AD. We synthesized a soluble iron-pro 5-HAYED peptide. By injecting 5-HAYED to the cerebrospinal fluid (CSF) of the AD mouse, we observed that the 5-HAYED is able to decrease the brain iron and radical level, which behaving neurons protection, and can ameliorate the cognition status for AD mouse. Further, 5-HAYED can decreased the AD incidence and can reverse the AD associated anemia and inflammation without hurt kidney and liver.

scholarly journals Subacute Sclerosing Panencephalitis in a Child with Recurrent Febrile Seizures

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Ayşe Kartal ◽  
Ayşegül Neşe Çıtak Kurt ◽  
Tuğba Hirfanoğlu ◽  
Kürşad Aydın ◽  
Ayşe Serdaroğlu
Keyword(s):  
Cerebrospinal Fluid ◽  
Measles Virus ◽  
Unusual Case ◽  
Subacute Sclerosing Panencephalitis ◽  
Febrile Seizures ◽  
Final Diagnosis ◽  
High Amplitude ◽  
Measles Antibodies ◽  
Antibody Titres ◽  
The Central Nervous System

Subacute sclerosing panencephalitis (SSPE) is a devastating disease of the central nervous system (CNS) caused by persistent mutant measles virus infection. The diagnosis of SSPE is based on characteristic clinical and EEG findings and demonstration of elevated antibody titres against measles in cerebrospinal fluid. Subacute sclerosing panencephalitis can have atypical clinical features at the onset. Herein, we report an unusual case of subacute sclerosing panencephalitis in a child with recurrent febrile seizures. The disease progressed with an appearance of myoclonic jerks, periodic high amplitude generalized complexes on EEG, and elevated titers of measles antibodies in cerebrospinal fluid leading to the final diagnosis of subacute sclerosing panencephalitis.

Memory Processes, Aging, Cognitive Decline, and Neurodegenerative Diseases

2006 ◽  
Vol 11 (4) ◽  
pp. 304-311 ◽  
Author(s):  
Lars-Göran Nilsson
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Neurodegenerative Disease ◽  
Genetic Markers ◽  
Brain Activity ◽  
Memory Performance ◽  
Modeling And Simulations ◽  
Aging And Health ◽  
Explained Variance ◽  
Different Levels

This paper presents four domains of markers that have been found to predict later cognitive impairment and neurodegenerative disease. These four domains are (1) data patterns of memory performance, (2) cardiovascular factors, (3) genetic markers, and (4) brain activity. The critical features of each domain are illustrated with data from the longitudinal Betula Study on memory, aging, and health ( Nilsson et al., 1997 ; Nilsson et al., 2004 ). Up to now, early signs regarding these domains have been examined one by one and it has been found that they are associated with later cognitive impairment and neurodegenerative disease. However, it was also found that each marker accounts for only a very small part of the total variance, implying that single markers should not be used as predictors for cognitive decline or neurodegenerative disease. It is discussed whether modeling and simulations should be used as tools to combine markers at different levels to increase the amount of explained variance.

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