scholarly journals Efficacy and Tolerability of Malartin and Sulphadoxine-Pyrimethamine Combination against Uncomplicated Falciparum Malaria in Dibanda, Southwest Cameroon

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Helen Kuokuo Kimbi ◽  
Mesame Ntoko ◽  
Nelson N. Ntonifor ◽  
Emmaculate Lum ◽  
Anna L. Njunda ◽  
...  

Artemisinin derivatives are now the most potent and rapidly acting antimalarials. The aim of this study was to assess thein vivoefficacy and tolerability of a combination of Malartin (an artesunate) and sulphadoxine-pyrimethamine (SP) in the treatment of uncomplicated falciparum malaria in Dibanda, Cameroon. A total of 197 subjects were recruited into the study and administered Malartin for 3 days and SP as a single dose on day 0. Only 174 of the subjects were successfully followed up on days 3, 7, and 14. The overall success rate of the drug combination was 92.53%. Parasite density decreased during the follow-up period in different age groups, sexes, and social classes. The prevalence of anaemia decreased from 22.99% at enrolment to 9.77% on day 14, and the difference was significant (P<0.05) on all days of followup. The drug combination did not give rise to any serious side effects.

1977 ◽  
Vol 232 (6) ◽  
pp. E580
Author(s):  
M P Zabinski ◽  
P Biancani

Longitudinal force-length relationship of the rat esophagus was studied in vitro in three age groups: 1 mo, 3 mo, and 12 mo. The length of maximum force development (MFD) occurs at 1.4-1.5 times the in vivo length for all age groups. The active force developed at MFD increases markedly with age. The difference in the active forces in the 3-mo and 12-mo age groups is due to differences in cross section because the active stress of the esophagus in the longitudinal direction is approximately equal for the two age groups. The active stress in the 1-mo-old rats is lower than in the 3-mo-old rats, suggesting an increased contractility of the esophagus with age in this period of development.


2018 ◽  
Vol 3 (3) ◽  
pp. 2473011418S0019
Author(s):  
David Ciufo ◽  
Michelle Lawson ◽  
Benjamin Strong ◽  
Benedict DiGiovanni

Category: Midfoot/Forefoot Introduction/Purpose: Hallux rigidus, or 1st metatarsophalangeal (MTP) joint degeneration, is commonly encountered in foot and ankle practice. Operative management can include a dorsal cheilectomy, a motion sparing procedure to reduce impingement. Hallux rigidus affects patients across all age groups, and etiologies may include trauma, first ray hypermobility, pes planus, or hallux valgus. First MTP joint trauma may result in an osteochondral defect (OCD). Literature is sparse regarding OCD management in the 1st MTPJ, as is follow-up data on cheilectomy using validated outcome measures. We hypothesize that the presence of an OCD is associated with symptomatic hallux rigidus at a lower Coughlin and Shurnas grade. We also hypothesize that OCD treatment concurrent with cheilectomy leads to outcomes equivalent to patients treated with isolated hallux rigidus. Methods: A retrospective review of prospectively collected data was performed. All patients of a single surgeon were reviewed based on the CPT code (28289) for cheilectomy from 1/1/2011 to 12/31/2015. Demographic data, presence/drilling of an OCD on operative reports, and Coughlin grading were recorded. All patients had taken the FAAM and SF-36 preoperatively per the surgeon’s routine preoperative data collection. After approval by the institutional review board, all patients were contacted by telephone for follow-up and answered the FAAM, SF-36 and Patient Acceptable Symptom State (PASS) questionnaires. Visual analog scores (VAS), patient satisfaction, complications, and whether they would opt for surgery again were recorded.Paired T-tests were performed to evaluate improvement in FAAM activity of daily living (ADL), FAAM sport, SF-36 physical component scores (PCS), and SF-36 mental component scores (MCS). Two-tailed T-tests were performed to evaluate the difference in groups with and without OCDs. Results: Seventy-one patients met inclusion criteria. Follow-up was obtained from 28 patients (29 feet) for analysis, 10 with OCDs. Mean responder age was 53.1 years (32.6-70.9), with average 4 year follow-up (minimum 2 years). Patients with OCDs had lower Coughlin grade (p<0.01) and trended towards lower age (p=0.07), but similar improvement in FAAM sport (p=0.43), SF-36 PCS (p=0.33), and MCS (p=0.46). Patients with OCDs trended towards greater improvement in FAAM ADL (p=0.07). The entire cohort demonstrated significant improvements (p<0.01) in ADL, Sport, PCS, and MCS after cheilectomy. ADL and Sport scores met the MCID of 8 and 9 points, respectively. MCID is not well-defined for SF-36. One patient required subsequent fusion. Conclusion: Cheilectomy is an effective surgical option for improving function and pain in the setting of hallux rigidus, as measured at intermediate-term follow-up with validated patient outcome measures. Patients with a 1st MTP joint OCD become symptomatic at a younger age and with a lower radiographic grade of hallux rigidus. These patients demonstrate equivalent improvements in the FAAM sport, SF-36 PCS and MCS while trending towards greater improvement in the FAAM ADL score as those without OCDs. The presence and treatment of a 1st MTP joint OCD should be considered in younger patients with symptomatic hallux rigidus and lower radiographic severity.


2004 ◽  
Vol 9 (2) ◽  
pp. 222-229 ◽  
Author(s):  
Ambrose O. Talisuna ◽  
Anne Nalunkuma-Kazibwe ◽  
Nathan Bakyaita ◽  
Peter Langi ◽  
Theonest K. Mutabingwa ◽  
...  

2015 ◽  
Vol 85 (3) ◽  
pp. 374-380 ◽  
Author(s):  
Amely Eckstein ◽  
Hans-Joachim Helms ◽  
Michael Knösel

ABSTRACT Objective:  To assess camouflage effects by concealment of postorthodontic white-spot lesions (WSLs) to sound adjacent enamel (SAE) achieved over 12 months with resin infiltration (Icon, DMG, Hamburg, Germany). Methods:   Twenty subjects (trial teeth nteeth = 111) who had received resin infiltration treatment of noncavitated postorthodontic WSLs were contacted for a 1-year follow-up assessment of CIE-L*a*b* colors (T12). Color and lightness (CIE-L*a*b*) data for WSLs and SAE were compared to baseline data assessed before infiltration (T0) and those assessed after 6 months (T6), using a spectrophotometer. The target parameter was the difference between the summarized color and lightness values (ΔEWSL/SAE). Intergroup (WSL, SAE) and intertime comparisons (T0 vs T6, T12) were performed using paired t-tests at a significance level of α = 5%. Results:  Nine subjects (trial teeth nteeth = 49; male/female ratio 5/4; age range 13–19 years) were available at T12. After the highly significant reduction of ΔEWSL/SAE discrepancies between T0 and T6, analysis of 12-month records revealed color and lightness discrepancy of WSL vs SAE that was significantly decreased compared with baseline, indicating an assimilation of WSL color to SAE appearance after infiltration, while an additional reduction of discrepancies between T6 and T12 was not significant. Conclusion:  As color and lightness characteristics of the Icon infiltrant as well as the esthetic camouflage effects achieved by WSL infiltration were not altered significantly or clinically relevant after 12 months, the method of resin infiltration can be recommended for an enduring esthetic improvement of postorthodontic WSL. (Angle Orthod. 2015;85:374–380.)


1973 ◽  
Vol 5 (3) ◽  
pp. 377-391 ◽  
Author(s):  
K. Sadashivaiah ◽  
M. S. Subba Rao

SummaryIntra-uterine contraception is a useful method of fertility control, because of its applicability at all levels of socio-economic development and it has been the mainstay of the fertility control programme in many countries.The present evaluation is based on the hospital follow-up records of 4067 IUD cases from randomly selected mission hospitals for the years 1967 and 1968. Of the insertions, 97·7% were non-post-partum, and 60% of the acceptors were from the age group 25–34 years with a median age of 29·8 years; nearly 70% had fewer than four living children. The pattern of distribution by religion is similar to that of the 1961 census figures.The average number of women months (6·7) of IUD use is very low in a follow-up study of 24 months but is more or less consistent, both by age and parity.The incidence of expulsion, removal and pregnancy was 8·2, 12·9 and 0·6 respectively for all ages and although these rates were higher with the 27½-mm loop than the 30-mm loop the differences are not statistically significant.The rates of expulsion, removals and complaints were greatest during the first 6 months of use and decreased gradually with increase in duration of use.Bleeding, or other symptoms associated with bleeding, were the main reasons for the removals.Incidence of re-insertion was higher among those aged <25 years than among those aged ≥25 years and the difference in the proportion of re-insertions between the two age groups is statistically significant.The size of the loop seems to have no bearing on the incidence of re-insertions.Total termination rates at the end of 6, 12, 18 and 24 months were 9·9, 15·2, 25·0 and 55·9 per 100 first insertions respectively.


1981 ◽  
Author(s):  
F C Chao ◽  
D M Kenney ◽  
J L Tullis ◽  
C A Alper ◽  
J E Silbert

Changes in blood coagulation and platelet functions in vivo in healthy smoking and non-smoking individuals of different age groups were studied. Blood samples were obtained on four different occasions (6 months apart during 1978-1980) from each of the 21 smokers and 42 non-smokers (age range 35-79), and analyzed. Statistically significant changes (p < 0.03) associated with cigarette smoking are: 1) increases in platelet count and fibrinogen in plasma; 2) elevation in a platelet procoagulant, platelet factor-3 (PF-3) activity in platelet-poor plasma (PPP); 3) increases in serum levels of α1-antitrypsin, orosomucoid, haptoglobin and properdin factor B; and 4) shortening of the lag period of collagen-induced platelet aggregation. Filtration through Millipore filters removed membrane vesicles which are enriched with PF-3 activity from the PPP. The difference in PF-3 activity in filtered plasma between the smoking and non-smoking groups were no longer statistically significant. The results are consistent with the interpretation that enhanced PF-3 activity in plasma occurs in association with cigarette smoking and results from the liberation into plasma of platelet membranes enriched in PF-3 activity.


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