scholarly journals The PIT: SToPP Trial—A Feasibility Randomised Controlled Trial of Home-Based Physiotherapy for People with Parkinson's Disease Using Video-Based Measures to Preserve Assessor Blinding

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Emma Stack ◽  
Helen Roberts ◽  
Ann Ashburn
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Outcome Measurement ◽  
Controlled Trial ◽  
Video Data ◽  
Video Production ◽  
Control Group ◽  
Group Participant ◽  
Home Based ◽  
Randomised Controlled

Purpose. To trial four-week's physiotherapy targeting chair transfers for people with Parkinson's disease (PwPD) and explore the feasibility of reliance on remote outcome measurement to preserve blinding.Scope. We recruited 47 PwPD and randomised 24 to a focused home physiotherapy programme (exercise, movement strategies, and cueing) and 23 to a control group. We evaluated transfers (plus mobility, balance, posture, and quality of life) before and after treatment and at followup (weeks 0, 4, 8, and 12) from video produced by, and questionnaires distributed by, treating physiotherapists. Participants fed back via end-of-study questionnaires. Thirty-five participants (74%) completed the trial. Excluding dropouts, 20% of questionnaire data and 9% of video data were missing or unusable; we had to evaluate balancein situ. We noted trends to improvement in transfers, mobility, and balance in the physiotherapy group not noted in the control group. Participant feedback was largely positive and assessor blinding was maintained in every case.Conclusions. Intense, focused physiotherapy at home appears acceptable and likely to bring positive change in those who can participate. Remote outcome measurement was successful; questionnaire followup and further training in video production would reduce missing data. We advocate a fully powered trial, designed to minimise dropouts and preserve assessor blinding, to evaluate this intervention.

scholarly journals Home-based step training using videogame technology in people with Parkinson’s disease: a single-blinded randomised controlled trial

2017 ◽  
Vol 32 (3) ◽  
pp. 299-311 ◽  
Author(s):  
Jooeun Song ◽  
Serene S Paul ◽  
Maria Joana D Caetano ◽  
Stuart Smith ◽  
Leland E Dibble ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Home Based ◽  
Randomised Controlled

scholarly journals Feasibility of a Cognitive Training Game in Parkinson’s Disease: The Randomized Parkin’Play Study

2020 ◽  
Vol 83 (4) ◽  
pp. 426-432 ◽  
Author(s):  
Sjors C.F. van de Weijer ◽  
Annelien A. Duits ◽  
Bastiaan R. Bloem ◽  
Nienke M. de Vries ◽  
Roy P.C. Kessels ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Training ◽  
Controlled Trial ◽  
Intervention Group ◽  
Waiting List ◽  
Control Group ◽  
Positive Effects ◽  
Home Based ◽  
Global Cognition

Cognitive training (CT) shows modest positive effects on cognitive function in patients with Parkinson’s disease (PD). Gamification may enhance adherence to traditional CT, but this has not been studied yet. Here, we investigated the feasibility of a gamified CT. We performed a randomized controlled trial including PD patients with mild cognitive impairment. Participants were randomly allocated to a 12-week home-based gamified CT intervention or waiting-list control group. Assessments were performed at baseline and at weeks 12 and 24. Forty-one patients were included (21 intervention and 20 waiting-list controls). Sixty-three percent of the intervention group trained >50% of the recommended sessions, while 81% voluntarily continued training after 12 weeks. After 24 weeks, 87.5% graded the game to be satisfactory. Global cognition scores improved after 24 weeks. Home-based gamified CT shows acceptable feasibility in patients with PD, and we observed preliminary indications for efficacy. Larger trials are needed to establish this efficacy.

scholarly journals Effectiveness of home-based and remotely supervised aerobic exercise in Parkinson's disease: a double-blind, randomised controlled trial

2019 ◽  
Vol 18 (11) ◽  
pp. 998-1008 ◽  
Author(s):  
Nicolien M van der Kolk ◽  
Nienke M de Vries ◽  
Roy P C Kessels ◽  
Hilde Joosten ◽  
Aeilko H Zwinderman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomised Controlled Trial ◽  
Aerobic Exercise ◽  
Controlled Trial ◽  
Double Blind ◽  
Home Based ◽  
Randomised Controlled

scholarly journals Efficacy of electroacupuncture for the treatment of constipation in Parkinson’s disease: study protocol for a multicentre randomised controlled trial

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e029841
Author(s):  
Kunshan Li ◽  
Zhaoqin Wang ◽  
Yiyi Chen ◽  
Lirong Shen ◽  
Zhongqiu Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomised Controlled Trial ◽  
Usual Care ◽  
Controlled Trial ◽  
Control Group ◽  
Bowel Movements ◽  
Secondary Outcomes ◽  
Randomised Controlled ◽  
Change In Mean

IntroductionConstipation is one of the most common non-motor symptoms in Parkinson’s disease (PD). Acupuncture can have a positive on chronic functional constipation and PD, but its efficacy for the treatment of constipation in PD has not yet been confirmed by high-quality clinical trials. Therefore, this study aims to evaluate the efficacy and safety of electroacupuncture (EA) in the treatment of constipation in PD.Methods and analysisThis study is a multicentre randomised controlled trial. A total of 124 qualified patients with PD and constipation will be randomly divided into the intervention group (62 participants will receive 12 weeks of EA +usual care) or the waitlist control group (62 participants will receive 12 weeks of usual care). EA will be performed three times per week from weeks 1–8, two times per week during weeks 9 and 10, and once a week during weeks 11 and 12. The primary outcome is the change in mean weekly spontaneous bowel movements from baseline to weeks 8 and 9. The secondary outcomes are the changes from baseline in mean weekly bowel movements, mean weekly stool consistency, and mean weekly straining. Other secondary outcomes include the weekly doses of defecation drugs, Visual Analogue Scale for subjective improvements in stool symptoms, Unified Parkinson’s Disease Rating Scale, and the time and number of steps required to walk 20 m. Outcomes will be assessed at baseline, week 4, 8, 12 (intervention period); as well as at week 16, 24 (follow-up period).Ethics and disseminationEthical approval has been obtained from four local ethics committees. The results of the study will be published in peer-reviewed journals and will be disseminated through national and international conferences.Trial registration numberChiCTR1900021053

scholarly journals Action Imagery and Observation in Neurorehabilitation for Parkinson’s Disease (ACTION-PD): development and pilot randomised controlled trial of a user-informed home training intervention to improve everyday functional actions

2020 ◽  
Author(s):  
Judith Bek ◽  
Paul S. Holmes ◽  
Jordan Webb ◽  
Chesney E. Craig ◽  
Zoё C. Franklin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomised Controlled Trial ◽  
Motor Imagery ◽  
Action Observation ◽  
Controlled Trial ◽  
List Type ◽  
Home Based ◽  
Home Based Intervention ◽  
Randomised Controlled

ABSTRACTBackgroundParkinson’s disease (PD) causes difficulties with everyday manual activities, but few studies have addressed these therapeutically. Training with action observation (AO) and motor imagery (MI) can significantly improve performance in healthy individuals, particularly when these techniques are applied simultaneously (AO+MI). Both AO and MI have shown promising effects in PD, but previous studies have used these separately. This article describes the development and pilot testing of an intervention combining AO+MI and physical practice to improve functional manual actions in PD.MethodsThe home-based intervention, delivered using a tablet computer app, was iteratively designed by an interdisciplinary team including people with PD, and further developed through focus groups and initial testing. The intervention was then tested in a six-week randomised controlled trial (ISRCTN 11184024) of 10 participants with mild to moderate PD (6 intervention; 4 treatment as usual).Results and ConclusionsUsage and qualitative data provided preliminary evidence of acceptability and usability, indicating that a feasibility RCT is warranted. Exploratory analyses suggested potential improvements in manual actions. The importance of personalisation, choice, and motivation was highlighted, as well as the need to facilitate engagement in motor imagery. The findings also have broader relevance for AO+MI interventions in PD and other populations.IMPLICATIONS FOR REHABILITATIONParkinson’s disease affects everyday manual activities and there is a need to address these therapeutically.A home-based intervention based on combined action observation and motor imagery is acceptable and usable for people with Parkinson’s, and may improve everyday hand movements.Important considerations for interventions using observation and imagery include personalisation, choice, and motivation.Some people with Parkinson’s may need additional support to engage in motor imagery, and this should be addressed within future interventions.

scholarly journals A randomised controlled trial on effectiveness and feasibility of sport climbing in Parkinson’s disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Agnes Langer ◽  
Sebastian Hasenauer ◽  
Anna Flotz ◽  
Lucia Gassner ◽  
Rochus Pokan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rating Scale ◽  
Controlled Trial ◽  
Drop Out ◽  
Control Group ◽  
Class Iii ◽  
Yahr Stage ◽  
Sport Climbing ◽  
Randomised Controlled

AbstractPhysical activity is of prime importance in non-pharmacological Parkinson’s disease (PD) treatment. The current study examines the effectiveness and feasibility of sport climbing in PD patients in a single-centre, randomised controlled, semi-blind trial. A total of 48 PD patients without experience in climbing (average age 64 ± 8 years, Hoehn & Yahr stage 2–3) were assigned either to participate in a 12-week sport climbing course (SC) or to attend an unsupervised physical training group (UT). The primary outcome was the improvement of symptoms on the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale part III (MDS-UPDRS-III). Sport climbing was associated with a significant reduction of the MDS-UPDRS-III (−12.9 points; 95% CI −15.9 to −9.8), while no significant improvement was to be found in the UT (−3.0 points; 95% CI −6.0 to 0.1). Bradykinesia, rigidity and tremor subscales significantly improved in SC, but not in the unsupervised control group. In terms of feasibility, the study showed a 99% adherence of participants to climbing sessions and a drop-out rate of only 8%. No adverse events occurred. This trial provides class III evidence that sport climbing is highly effective and feasible in mildly to moderately affected PD patients.

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