scholarly journals Beyond Cat Scratch Disease: A Case Report ofBartonellaInfection Mimicking Vasculitic Disorder

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Amelia Spinella ◽  
Federica Lumetti ◽  
Gilda Sandri ◽  
Valentina Cestelli ◽  
Maria Teresa Mascia
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Skin Lesions ◽  
Bacterial Disease ◽  
Cat Scratch Disease ◽  
History Of ◽  
Vasculitic Disorder

Cat scratch disease (CSD) is a bacterial disease caused byBartonella henselaeand it is mainly characterized by self-limiting lymphadenopathy in the draining site of a cat scratch or bite. We report a patient with history of fever, swelling lymph nodes, vasculitic-like skin lesions, and positivity ofBartonellaserology initially considered as expression of a disimmune disease.

scholarly journals Cat Scratch Disease: The First Case Report in Republic of North Macedonia

PRILOZI ◽  
2020 ◽  
Vol 41 (3) ◽  
pp. 71-75
Author(s):  
Kostadin Poposki ◽  
Zaklina Sopova ◽  
Marija Dimzova ◽  
Elena Denkovska ◽  
Tatjana Stoleska ◽  
...  
Keyword(s):  
Case Report ◽  
Day Treatment ◽  
Bartonella Henselae ◽  
Complete Recovery ◽  
Cat Scratch Disease ◽  
First Case ◽  
History Of ◽  
Disease Specialist ◽  
Adult Female Patient ◽  
Main Clinical Manifestation

AbstractCat scratch disease (CSD) is the main clinical manifestation caused by Bartonella henselae in immuno-competent patients. The bacterium is transmitted to humans from cats via scratches or bites. In this case report, we are presenting to our knowledge the first etiologically confirmed case of CSD in our country. Here we describe the case of a previously healthy adult female patient presenting with fever and axillar lymphadenopathy over 1-month period. She underwent numerous clinical and paraclinical investigations for potential etiologies associated with lymphadenopathy and fever. Finally, serological testing for B.henselae was performed with titers for IgG 1:1024 and 1:160 for IgM, which confirmed the diagnosis. Five-day treatment with azithromycin resulted with good clinical response and complete recovery. We proved that CSD is a reality in our country and this report should raise awareness in medical doctors, especially infectious disease specialist. Also, CSD should be included in differential diagnosis in patients with fever of unkown origin (FUO), who are presenting with regional lymphadenopathy, with or without history of cat contact.

scholarly journals Muir-Torre Syndrome: case report and molecular characterization

2014 ◽  
Vol 132 (1) ◽  
pp. 61-64 ◽  
Author(s):  
Carolina Alejandra Rios ◽  
Ricardo Villalon ◽  
Jorge Munoz ◽  
Monica Acuna ◽  
Lucia Cifuentes
Keyword(s):  
Case Report ◽  
Autosomal Dominant ◽  
Treatment Options ◽  
Skin Lesions ◽  
Molecular Techniques ◽  
Causative Mutation ◽  
Colorectal Tumors ◽  
History Of ◽  
Repair Genes ◽  
Microsatellite Instability Analysis

CONTEXT: Muir-Torre syndrome is a rare autosomal dominant genodermatosis caused by mutations in the mismatch repair genes. It is characterized by the presence of sebaceous skin tumors and internal malignancies, affecting mainly the colon, rectum and urogenital tract. Awareness of this syndrome among physicians can lead to early diagnosis of these malignancies and a better prognosis. CASE REPORT: We report the case of a Chilean patient who, over the course of several years, had multiple skin lesions, endometrial cancer and colon cancer. The syndrome was diagnosed using molecular techniques such as microsatellite instability analysis, immunohistochemistry and DNA sequencing, which allowed us to find the causative mutation. CONCLUSION: Molecular diagnostics is a highly useful tool, since it allows clinicians to confirm the presence of mutations causing Muir-Torre syndrome. It is complementary to the analysis of the clinical data, such as dermatological presentation, presence of visceral malignancies and family history of colorectal tumors, and it provides important knowledge to help physicians and patients choose between treatment options.

Bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease

2017 ◽  
Vol 36 (11) ◽  
pp. 2207-2213 ◽  
Author(s):  
E. Prudent ◽  
H. Lepidi ◽  
G. Audoly ◽  
B. La Scola ◽  
P.-E. Fournier ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Cat Scratch Disease

scholarly journals Case Report: Mastocytosis: The Long Road to Diagnosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Tiago Azenha Rama ◽  
Diana Martins ◽  
Nuno Gomes ◽  
Jorge Pinheiro ◽  
Ana Nogueira ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Case Report ◽  
Mast Cells ◽  
Allergic Sensitization ◽  
Skin Lesions ◽  
Normal Serum ◽  
Cutaneous Lesions ◽  
History Of ◽  
Exercise Induced ◽  
Low Prevalence

Mastocytosis is a heterogeneous group of disorders characterized by expansion and accumulation of clonal mast cells. Patients mainly present with either cutaneous lesions, anaphylaxis, or both. Its low prevalence and unusual features often hinder its diagnosis for several years. We report the case of an 18-year-old male who was referred to our department with a long-standing history of atypical skin lesions, allergic rhinitis, exercise-induced bronchoconstriction and what was believed to be food-related flushing and anaphylaxis, that was later diagnosed with mastocytosis. This case illustrates the need to consider investigating for mastocytosis when recurrent anaphylaxis is present, especially in the presence of atypical skin lesions, even if normal serum basal tryptase levels and allergic sensitization are present.

scholarly journals Giant lung metastasis of NRAS-mutant melanoma in a 24-year-old patient with a history of BRAF-mutant conventional melanoma harboring Spitzoid morphology: a case report

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Jiri Vachtenheim ◽  
Roman Kodet ◽  
Ondrej Fischer ◽  
Vitezslav Kolek ◽  
Zuzana Strizova ◽  
...  
Keyword(s):  
Case Report ◽  
Skin Lesion ◽  
Molecular Characterization ◽  
Lung Metastasis ◽  
Skin Lesions ◽  
Lung Tumour ◽  
Spitz Nevus ◽  
History Of ◽  
Braf Mutant

Abstract Background Spitzoid melanocytic lesions represent a heterogeneous group of proliferations with ambiguous and overlapping terminology. The exact distinction of a Spitz nevus from a Spitzoid melanoma can be very difficult or, in some cases, impossible. Among the Spitzoid lesions, there is a lesion termed an atypical Spitz tumour (AST) that has intermediate histopathologic features between those of a Spitz nevus and a Spitzoid melanoma and thus uncertain malignant potential. There are several rare cases of patients with a Spitzoid melanoma initially misdiagnosed as a Spitz nevus or an AST with fatal consequences. It is, therefore, advised to perform a molecular characterization in cases where uncertain skin lesions are presented, as it may provide extended set of information with a possible impact on the treatment options. Furthermore, preventive measures, such as regular physical and skin examinations, as well as thorough scheduling of individual follow-up visits, are essential in patients with potentially malignant skin nevi. Case report We report a case of a young adult female with a history of AST excision with a negative sentinel lymph node biopsy (SLNB) and insufficient follow-up. Four years after the primary dermatological diagnosis, she presented with a giant tumour in the right hemithorax. Radical en bloc resection of the tumour with right pneumonectomy and resection of the pericardium with reconstruction of the pericardium using mesh was performed. A definitive histopathological examination revealed a metastatic melanoma. The association of the previously diagnosed AST and subsequent appearance of melanoma metastases led to a retrospective re-evaluation of the initial lesion. The suspected diagnosis of Spitzoid melanoma, however, was not confirmed. Moreover, the molecular examination revealed a major discordance between the initial lesion and the lung tumour, which most likely excluded the possible association of the lung metastasis with the initial skin lesion. The initial skin lesion was a BRAF-mutant melanoma with Spitzoid features and termed as AST, while the giant lung metastasis was NRAS-mutant melanoma. The subsequent postoperative course was complicated by the appearance of brain metastases that were stereotactically irradiated. Nevertheless, despite complex specialised medical care, the patient’s clinical condition rapidly deteriorated. By this time, no active oncological treatment was possible. The patient was delegated to local hospice for palliative care six months after the surgery and died three weeks later. Conclusions Our patient was surgically treated at the age of 20 for AST and died four years later of metastatic NRAS-mutant melanoma most likely of different occult origin. Molecular characterization, as well as the close clinical follow-up should be always precisely performed in patients with uncertain skin lesions, such as AST.

scholarly journals Cystic fibrohistiocytic tumour of the lung presenting with recurrent pneumothoraces: a case report

2020 ◽  
Vol 90 (3) ◽  
Author(s):  
Christos Kakos ◽  
Savvas Lampridis ◽  
Georgios Geropoulos ◽  
Reena Khiroya ◽  
Achilleas Antonopoulos ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Fibrous Histiocytoma ◽  
Skin Lesions ◽  
Natural Course ◽  
Cystic Lesions ◽  
Fibrous Histiocytomas ◽  
Pulmonary Neoplasm ◽  
History Of

Cystic fibrohistiocytic tumour of the lung is a very rare pathological entity that occurs either as a primary pulmonary neoplasm or as a metastasis from skin lesions called cellular fibrous histiocytomas. Herein, we present the case of a 19-year old man with a history of recurrent pneumothoraces who was managed surgically and was eventually diagnosed with cystic fibrohistiocytic tumour of the lung. Clinicians should include this disease in the differential diagnosis of pulmonary cystic lesions and be aware of its association with cellular fibrous histiocytoma. Reporting of more cases is warranted to further elucidate the natural course of the disease and optimise its management.

Atypical gnathostomiasis-confirmed cutaneous larva migrans, Vietnam

2021 ◽  
Vol 14 (7) ◽  
pp. e243276
Author(s):  
Cuong Minh Duong ◽  
Phuc Vinh Dinh Le ◽  
Oanh Kieu Nguyet Pham ◽  
Hong Quang Huynh
Keyword(s):  
Case Report ◽  
Skin Lesion ◽  
Skin Lesions ◽  
Larva Migrans ◽  
Blood Eosinophil ◽  
Serological Testing ◽  
Third Stage ◽  
History Of ◽  
Serology Testing ◽  
Eosinophil Counts

We reported a case of gnathostomiasis in a 42-year-old woman with an unclear history of eating high-risk foods and had a non-migratory skin lesion, negative serological testing and normal blood eosinophil counts. A diagnosis of gnathostomiasis was based on a live, third-stage Gnathostoma spinigerum larva that was randomly taken from the patient’s skin lesion by herself. The presenting case report demonstrates challenges in correctly diagnose cutaneous gnathostomiasis even in endemic countries due to atypical skin lesions, negative serology testing and the absence of eosinophilia and thus, the widely used classic triad of suggestive evidence of gnathostomiasis is not fulfilled.

scholarly journals Right atrial myxosarcoma in a dog : case report

1997 ◽  
Vol 68 (4) ◽  
Author(s):  
O.M. Briggs ◽  
R.M. Kirberger ◽  
N.B. Goldberg
Keyword(s):  
Weight Loss ◽  
Case Report ◽  
Lymph Nodes ◽  
Exercise Intolerance ◽  
Right Atrial ◽  
Secondary Spread ◽  
Cardiac Tumour ◽  
Cardiac Tumours ◽  
History Of

A case of right atrial myxosarcoma is described in a Staffordshire bull terrier with a history of weight loss, exercise intolerance and collapse. The diagnosis of an intracavitary cardiac tumour was made on echocardiography. The dog was euthanased. Secondary spread to the lungs and lymph nodes was present. Myxoma is one of the rare intracavitary cardiac tumours and this case is believed to be the 1st report of its more malignant form in the dog.

Cat Scratch Disease

2019 ◽  
pp. 136-138
Author(s):  
Remide Arkun
Keyword(s):  
Bartonella Henselae ◽  
Systemic Disease ◽  
Granulomatous Inflammation ◽  
Cat Scratch Disease ◽  
Tissue Sampling ◽  
Gram Negative ◽  
Atypical Manifestations ◽  
History Of ◽  
Polymerase Chain ◽  
Severe Systemic Disease

Chapter 94 reviews cat scratch disease, which is an infection caused by Bartonella henselae, a gram-negative intracellular Bacillus, which causes granulomatous inflammation of the tissues. There is usually a history of exposure to cats, and cat scratch, bite or licking. The disease is characterized by chronic lymphadenopathy in children and adolescents. In immunocompromised patients, severe systemic disease or other atypical manifestations may develop, including osteomyelitis together with ipsilateral lymphadenopathy. A history of cat exposure, polymerase chain reaction (PCR), and other serologic tests are helpful in diagnosis and complement imaging findings. Tissue sampling of lymph nodes or bones reveals granulomatous infection.

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