scholarly journals PET Imaging in Recurrent Medullary Thyroid Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Giorgio Treglia ◽  
Vittoria Rufini ◽  
Massimo Salvatori ◽  
Alessandro Giordano ◽  
Luca Giovanella
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fdg Pet ◽  
Medullary Thyroid ◽  
Primary Surgery ◽  
Pet Tracer ◽  
Positron Emission ◽  
Pet Ct ◽  
Pet Radiopharmaceuticals

Purpose. To perform an overview about the role of positron emission tomography (PET) or PET/computed tomography (PET/CT) using different radiopharmaceuticals in recurrent medullary thyroid carcinoma (MTC) based on biochemical findings (increased tumor marker levels after primary surgery). Methods. A comprehensive literature search of studies published in PubMed/MEDLINE, Scopus, and Embase databases through February 2012 regarding PET or PET/CT in patients with recurrent MTC was performed. Results. Twenty-nine studies comprising 714 patients with suspected recurrent MTC were retrieved. Twenty-seven articles evaluated the role of fluorine-18-fluorodeoxyglucose (FDG) PET or PET/CT in recurrent MTC with conflicting results. Diagnostic accuracy of FDG-PET and PET/CT increased in MTC patients with higher calcitonin and carcinoembryonic antigen values, suggesting that these imaging methods could be very useful in patients with more advanced and aggressive disease. Eight articles evaluated the role of fluorine-18-dihydroxyphenylalanine (FDOPA) PET or PET/CT in recurrent MTC reporting promising results. Overall, FDOPA seems to be superior but complementary compared to FDG in detecting recurrent MTC. Few studies evaluating other PET tracers are also discussed. Conclusions. PET radiopharmaceuticals reflect different metabolic pathways in MTC. FDOPA seems to be the most useful PET tracer in detecting recurrent MTC based on rising levels of tumor markers. FDG may complement FDOPA in patients with more aggressive MTC.

Localization of Medullary Thyroid Carcinoma after Surgery Using11C-Methionine PET/CT: Comparison with18F-FDG PET/CT.

2010 ◽  
pp. P1-577-P1-577
Author(s):  
Hye Won Jang ◽  
Ji In Lee ◽  
Hee Kyung Kim ◽  
Seo Young Sohn ◽  
Sun Wook Kim ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fdg Pet ◽  
Medullary Thyroid ◽  
Pet Ct ◽  
Fdg Pet Ct

Comparison of 68Ga-DOTATATE PET-CT, 18F-FDG PET-CT and 99mTc-(V)DMSA scintigraphy in the detection of recurrent or metastatic medullary thyroid carcinoma

2015 ◽  
Vol 36 (3) ◽  
pp. 242-250 ◽  
Author(s):  
Zeynep G. Ozkan ◽  
Serkan Kuyumcu ◽  
Ayse Kubat Uzum ◽  
Mehmet F. Gecer ◽  
Sevda Ozel ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fdg Pet ◽  
Medullary Thyroid ◽  
Dmsa Scintigraphy ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

The value of 18F-DOPA PET-CT in patients with medullary thyroid carcinoma: comparison with 18F-FDG PET-CT

2009 ◽  
Vol 19 (6) ◽  
pp. 1425-1434 ◽  
Author(s):  
Mohsen Beheshti ◽  
Sigrid Pöcher ◽  
Reza Vali ◽  
Peter Waldenberger ◽  
Gabriele Broinger ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fdg Pet ◽  
Medullary Thyroid ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals F-18 FDG-PET-CT in the Diagnostic of a Late Medullary Thyroid Carcinoma Recurrence in a Patient with Follicular-Papillary Thyroid Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Doina Piciu ◽  
Andra Piciu
Keyword(s):  
Thyroid Carcinoma ◽  
Papillary Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fdg Pet ◽  
Whole Body ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Superior Mediastinum ◽  
Pet Ct ◽  
Fdg Pet Ct

Mixed medullary and follicular or papillary carcinoma of thyroid is an extremely rare tumor, characterized by coexistence of morphological and immunohistochemical features of both medullary carcinoma and follicular (or papillary) carcinoma. This case report describes for the first time in the indexed database a late recurrence of a medullary thyroid carcinoma initially diagnosed as follicular-papillary form, treated and monitored accordingly. After 14 years, a superior mediastinum tumor was discovered incidentally at a thorax computer tomography. The whole-body I-131 scan was negative and F-18 FDG-PET-CT showed glucose avidity of the tumor. The patient was operated on and the histology revealed medullary thyroid carcinoma. If there are no possibilities to have routinely extensive immunohistologic profiles, it is recommended to check the serum calcitonin, at least in any patient with confirmed thyroid carcinoma.

scholarly journals Carcinoembryonic Antigen Increase in a Patient with Colon Cancer Who Have Achieved Complete Remission and Negative 18F-FDG PET/CT: Don’t Forget the Thyroid!

2021 ◽  
Vol 28 (4) ◽  
pp. 2987-2992
Author(s):  
Alexandre Lugat ◽  
Pauline Hulo ◽  
Catherine Ansquer ◽  
Yann Touchefeu ◽  
Eric Mirallié ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Carcinoembryonic Antigen ◽  
Medullary Thyroid Carcinoma ◽  
Fdg Pet ◽  
Colon Adenocarcinoma ◽  
Medullary Thyroid ◽  
Pet Ct ◽  
Serum Carcinoembryonic Antigen ◽  
18F Fdg ◽  
Fdg Pet Ct

Serum carcinoembryonic antigen (CEA) is a tumor marker especially used to follow a patient with colorectal cancer. However, it is non-specific and could be increased in several cancers and some benign conditions. We report the case of a 70-year-old man followed since 2014 for a left colon adenocarcinoma with the persistence of an increased CEA. There was no evidence of recurrence, but a right lobar thyroid nodule without a significantly increased uptake was incidentally discovered on the CT scan of 18F-fluorodeoxyglucose (18F-FDG) PET/CT. We suspected a medullary thyroid carcinoma (MTC) explaining the persistent elevation of CEA. Plasma calcitonin levels were 47 ng/L (N < 10). Fine needle aspiration cytology found atypia of undetermined significance and the patient was reluctant to undergo surgery without any further exploration. We performed a 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET/CT preoperatively which revealed a punctiform focus of the right thyroid lobe corresponding to a pT1aN1aMxR0 medullary thyroid carcinoma, histopathologically confirmed. This case highlights that despite the potential usefulness of 18F-FDG PET/CT in case of an unknown source of elevated CEA this imaging may be falsely negative as in the case of MTC and should lead to further explorations.

68Ga-DOTANOC and 18F-FDG PET/CT in metastatic medullary thyroid carcinoma: novel correlations with tumoral biomarkers

Endocrine ◽  
2019 ◽  
Vol 64 (2) ◽  
pp. 322-329 ◽  
Author(s):  
Pedro Souteiro ◽  
Patrícia Gouveia ◽  
Gonçalo Ferreira ◽  
Sandra Belo ◽  
Cláudia Costa ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fdg Pet ◽  
Medullary Thyroid ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct
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