scholarly journals Primary Epithelial Myoepithelial Carcinoma of Lung, Reporting of a Rare Entity, Its Molecular Histogenesis and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Farzana Arif ◽  
Susan Wu ◽  
Shahriyour Andaz ◽  
Stewart Fox
Keyword(s):  
Incidental Finding ◽  
Lower Lobe ◽  
Final Diagnosis ◽  
Myoepithelial Cells ◽  
Myoepithelial Carcinoma ◽  
Rare Entity ◽  
Lobe Bronchus ◽  
Epithelial Myoepithelial Carcinoma ◽  
Bronchial Glands ◽  
The Right

Primary epithelial myoepithelial carcinoma of lung is a rare entity and is thought to arise from the submucosal bronchial glands distributed throughout the lower respiratory tract. Because of the rarity of this tumor, we describe one case of epithelial myoepithelial carcinoma arising in the bronchus intermedius and presenting as an endobronchial mass. A 57-year-old male patient presented with an incidental finding of an endobronchial mass located in the lumen of the right lower lobe bronchus and caused near total luminal occlusion of the bronchus. An endobronchial carcinoid tumor was entertained clinically. Subsequently the patient underwent an uneventful videothoracoscopic lobectomy of lower and middle lobes of the right lung. Morphologically and immunohistochemically the tumor was characterized by two cell populations with epithelial and myoepithelial cells forming duct-like structure. The final diagnosis of epithelial myoepithelial carcinoma of lung was rendered.

Epithelial-Myoepithelial Carcinoma of the Lung

2003 ◽  
Vol 127 (4) ◽  
pp. e177-e180 ◽  
Author(s):  
Latife Doganay ◽  
Selcuk Bilgi ◽  
Asli Ozdil ◽  
Yener Yoruk ◽  
Semsi Altaner ◽  
...  
Keyword(s):  
S100 Protein ◽  
Lower Lobe ◽  
Malignant Neoplasm ◽  
Myoepithelial Cells ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Primary Lung Tumors ◽  
Pulmonary Parenchyma ◽  
Epithelial Myoepithelial Carcinoma ◽  
Bronchial Glands

Abstract Primary lung tumors mimicking the salivary gland–type neoplasms are extremely rare. These types of tumors originate from submucosal bronchial glands. Epithelial-myoepithelial carcinoma is an uncommon tumor in this group, and only 7 cases have been reported. It is considered to be a low-grade malignant neoplasm. We report a case of epithelial-myoepithelial carcinoma of bronchial gland origin in a 73-year-old man who presented with coughing and dyspnea. The bronchus of the left lower lobe contained a tumor mass that had a polypoid growth pattern. The tumor also extended into the pulmonary parenchyma, forming a well-circumscribed mass with a pushing margin. The tumor consisted of epithelial and myoepithelial cells. The epithelial cells were positive for cytokeratins and epithelial membrane antigen, while the myoepithelial cells were positive for S100 protein and muscle-specific actin. According to these findings, we diagnosed epithelial-myoepithelial carcinoma. After undergoing pneumonectomy, the patient has been disease free for 34 months.

scholarly journals Auscultating a pea: the stethoscope may matter in otorhinolaryngology emergency evaluation

2021 ◽  
Vol 7 (3) ◽  
pp. 530
Author(s):  
Francisco Alves De Sousa ◽  
Ana Costa Silva ◽  
Ana Nóbrega Pinto ◽  
Cecília Almeida E. Sousa
Keyword(s):  
Foreign Body ◽  
Lower Lobe ◽  
Signs And Symptoms ◽  
Foreign Body Sensation ◽  
Careful Examination ◽  
Lower Airway ◽  
Lobe Bronchus ◽  
Body Sensation ◽  
The Right

<p>Foreign body sensation is a common complaint in the otorhinolaryngology emergency. Careful examination of the patient’s pharynx is mandatory, but sometimes the object is not visualized. In such scenario, it may be important to explore signs and symptoms indicating lower aerodigestive impaction. This work describes the case of a 73-year-old woman without relevant comorbidities attending to emergency care. She complained of a foreign body sensation on the right side of the throat after ingesting a meal, which motivated referral to otorhinolaryngology. Flexible transnasal nasopharyngoscopy was unremarkable and no foreign bodies were found. Auscultation was performed revealing low-pitch expiratory wheezing on her right hemithorax. The suspicion of bronchial foreign body was then raised, which was ultimately confirmed by imaging and bronchoscopy, showing an impacted pea on the right lower lobe bronchus. The stethoscope was hence determinant for detecting aspiration, by revealing consistent alterations. Its usage should be encouraged in similar scenarios, highlighting the role of this classic but sometimes forgotten tool. Importantly, higher neck/throat sensations should not exclude the possibility of a lower airway foreign body.</p>

Ping-Pong Ball, Tumor or Thrombus in the Right Atrium? A Case Report

2018 ◽  
Vol 9 (3) ◽  
pp. 350-351
Author(s):  
Stephanie Ghaleb ◽  
Bryant Roosevelt ◽  
James Cnota
Keyword(s):  
Clinical Judgment ◽  
Right Atrium ◽  
Frozen Section ◽  
Noninvasive Imaging ◽  
Neoadjuvant Treatment ◽  
Lower Lobe ◽  
Final Diagnosis ◽  
Right Atrial ◽  
Right Atrial Mass ◽  
The Right

Tumors and thrombi are the most common cardiac masses of the right atrium. The use of noninvasive imaging to differentiate between the two can be deceiving, and the clinical judgment of a cardiologist and the emergency of the situation should be partnered to decide on the next step of the management. We present the case of a 29-year-old lady who was receiving neoadjuvant treatment for her rhabdomyosarcoma and was incidentally found to have a very large, very mobile right atrial mass that was protruding in the right ventricle with each cardiac cycle along with findings of a small segmental right lower lobe pulmonary embolism. Along with noninvasive imaging, frozen section analysis procured the wrong diagnosis, and the mass was ultimately found to be a right atrial thrombus on definite pathology review. Exact management of right atrial masses continues to be not well delineated, and when in doubt, final diagnosis might need to be “a posteriori” and based on the treatment response.

scholarly journals Incidental finding of bronchial diverticula in a non-smoker population: evaluation on thin-section CT

2016 ◽  
Vol 81 (1-2) ◽  
Author(s):  
Federica Ciccarese ◽  
Giorgio Garzillo ◽  
Anna Maria Chiesa ◽  
Antonio Poerio ◽  
Serena Baroncini ◽  
...  
Keyword(s):  
Thin Section ◽  
Healthy Subjects ◽  
Respiratory Symptoms ◽  
Incidental Finding ◽  
Radiological Finding ◽  
Chest Ct ◽  
Lobe Bronchus ◽  
Significant Difference ◽  
The Right

<p>Bronchial diverticula have been described as a common radiological finding in smoker patients with COPD, but the specificity of this sign should be further investigated. Thus, the aim of our study was to evaluate the prevalence of diverticula in a cohort of non-smoker subjects. Between February and July 2012, 2438 patients were admitted to our Radiology Unit to undergo a chest CT. Among them, we enrolled 121 non-smoking patients (78/121-64.5% females, 43/121-35.5% males), of different age (57.0±20.7 years-range: 12-88), without any respiratory symptoms, submitted to chest CT for several reasons (oncologic evaluation: 59/121-48.8%; follow up of lung nodules: 27/121-22.3%; screening in connectivitis: 12/121-9.9%; others: 23/121-19.0%). We considered thin-section CT scan on axial, coronal and sagittal plans to evaluate prevalence, numbers and level of bronchial diverticula. Diverticula were found in 41/121-33.9% patients, with a slight major prevalence in males (p=0.048), but no significant difference on age. In 31/41-75.6% the number was &lt;3, whereof 17/31-54.8% with just one diverticulum assessed. Regarding the level, in 30/41-73.2% they were subcarinal, but they were also detected in mainstem (2/41-4.9%) and lobar bronchi (with the right upper lobe bronchus most frequently involved- 12/41-29.3%). Bronchial diverticula can be observed in non-smokers, as well as in smoker patients with COPD. However, their prevalence seems to be lower than in smokers and they tend to be isolated and subcarinal. The age of patients does not influence their finding. More studies should be proposed to better define a cut-off between smokers and healthy subjects.</p>

scholarly journals Pyothorax-associated Lymphoma: a Case Report and Review

2020 ◽  
Author(s):  
Fangyuan Dong ◽  
Yongzhi Wu ◽  
Sufen Wang ◽  
Guomin Sun ◽  
Qinqin Zhang ◽  
...  
Keyword(s):  
Chest Pain ◽  
Rare Disease ◽  
Single Case ◽  
Lower Lobe ◽  
Final Diagnosis ◽  
Patient Treatment ◽  
Ki 67 ◽  
Chronic Empyema ◽  
The Right ◽  
Fdg Pet Ct

Abstract Background: Pyothorax-associated lymphoma is a rare disease with variations in endemic prevalence. PAL arising from a posttraumatic empyema are a rare occurrence.Case presentation: a male patient, 83 years old. Twenty years earlier, the patient fell from a height, sustaining a fracture to the right rib, which improved after conservative treatment. In September 2018, the patient had right chest pain (ribs 9–10). In February 2019, the chest pain became worse during sleep. CT examination showed inflammation of the right lower lobe, chronic empyema on the right with subdiaphragmatic infection, fibrosis of the right lung, atherosclerosis, thickening of the left pleura with rib destruction, and membranous calcification around the lesion. After 5 days of treatment with cefoperazone, sulbactam sodium, and ornidazole, the patient’s chest pain did not improve. The results of 18F-FDG PET/CT showed the following: a solid mass in the lower right thoracic cavity. Immunohistochemistry showed that the tumor cells were negative for CD20 and CD3, positive for background mature T lymphocytes, positive for Pax-5, positive for MUM-1, Ki-67 (70%, +); AE1/AE3, CD138, Bcl-6, CD10, CD5, CD56, MPO (-); CD79α (part +), EMA (part +), CD38 (+), bcl-2 (+). In situ hybridization (CISH): EBER+. Mini-CHOP chemotherapy was implemented on April 11, 2019. The patient stopped taking analgesics on the day of chemotherapy. The pain disappeared one week later, and the EBV-DNA fell to the normal range. In the later stage, the family members of the patient declined further patient treatment and reexamination. The patient’s condition worsened in July 2019 and he died on September 25, 2019.Conclusion: Pathological morphology is vital important to make a final diagnosis and avoid misdiagnosis or miss diagnosis. This case is described by a combination of imaging and pathological examinations that reports the clinical pathological diagnosis and treatment process of a single case of pyothorax-associated lymphoma, and it provides some diagnostic information regarding the rare disease of PAL.

Bronchial Epithelial-Myoepithelial Carcinoma

2004 ◽  
Vol 128 (1) ◽  
pp. 92-94 ◽  
Author(s):  
Kun Ru ◽  
Amitabh Srivastava ◽  
Arthur S. Tischler
Keyword(s):  
Immunohistochemical Staining ◽  
Myoepithelial Cells ◽  
Nodal Metastasis ◽  
Myoepithelial Carcinoma ◽  
Heavy Smoking ◽  
Bronchial Epithelial ◽  
Distal Airway ◽  
Pulmonary Neoplasm ◽  
History Of ◽  
Epithelial Myoepithelial Carcinoma

Abstract Epithelial-myoepithelial tumor is extremely rare as a pulmonary neoplasm. Only 20 cases have been reported to date, of which 14 were malignant. We report a case of intrabronchial epithelial-myoepithelial carcinoma in a 73-year-old man with a history of heavy smoking. The tumor was well-circumscribed and caused distal airway obstruction. Histologically, the tumor showed glandular and solid architecture. The glands were composed of an inner layer of epithelial cells and an outer layer of myoepithelial cells. The solid areas consisted of spindle-shaped myoepithelial cells. Immunohistochemical staining was positive for p53 and c-Kit (CD117). Focal atypia and increased mitotic activity were present, but no vascular invasion or nodal metastasis was identified.

scholarly journals Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Karl Grenier ◽  
Gulbeyaz Altinel ◽  
Zari Dastani ◽  
Atilla Omeroglu
Keyword(s):  
Clear Cell ◽  
Phyllodes Tumor ◽  
Myoepithelial Cells ◽  
Metaplastic Carcinoma ◽  
Myoepithelial Carcinoma ◽  
Diagnostic Challenge ◽  
Carcinoma Of The Breast ◽  
Epithelial Myoepithelial Carcinoma ◽  
Rhabdoid Differentiation ◽  
Rhabdoid Features

Epithelial-myoepithelial carcinoma of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Myoepithelial cells are known to adopt varied morphologies, including spindle, chondroid, clear cell, and rhabdoid morphologies, and can represent a diagnostic challenge when isolated on biopsy. Rhabdomyosarcoma, phyllodes tumor, metaplastic carcinoma, and myoepithelial carcinoma are primary breast tumors that all have been shown to exhibit rhabdoid features, whether representing true differentiation or morphological mimic. We here report an epithelial-myoepithelial carcinoma of the breast with rhabdoid features in a 76-year-old woman. The rhabdoid-appearing myoepithelial cells are negative for myogenin, consistent with a rhabdoid-like morphology rather than a true rhabdoid differentiation, comparably to previously described myoepithelial carcinoma with rhabdoid features. To our knowledge, this is the first reported case of epithelial-myoepithelial carcinoma of the breast with rhabdoid features and thus adds another entity to the differential diagnosis of breast lesions with rhabdoid features.

scholarly journals Congenital Cystic Adenomatoid Malformation Of The Lung: A Case Report And Review Of The Literature

2015 ◽  
Vol 8 (2) ◽  
pp. 160-163
Author(s):  
Doroteya V. Malinova ◽  
Penka L. Kolova ◽  
Radoslav S. Radev
Keyword(s):  
Lung Development ◽  
Incidental Finding ◽  
Ct Scanning ◽  
Final Diagnosis ◽  
Congenital Cystic Adenomatoid Malformation ◽  
Pulmonary Infections ◽  
Cystic Adenomatoid Malformation ◽  
Clinical Presentations ◽  
The Right

Summary Congenital cystic adenomatoid malformation (CCAM) is a rare abnormality of lung development. It was classified into 5 types by Stocker in 2002 and is also known under the name of congenital pulmonary airway malformation (CPAM). Cases are typically identified prenatally by routine ultrasonography screening. CCAM may present in the older child and adult as an incidental finding. The case presented is of a 21-year-old male patient who suffered from pulmonary infections with a recurrent productive cough 3-4 times the last 4 years. CT scanning of the thorax showed multiple cystic lesions in the right middle and lower lobes. The areas with the lesions were resected. The macroscopic and histological findings were typical for congenital cystic adenomatoid malformation type 2, which was the final diagnosis. Clinical presentations and prognosis depend on the type of lesion and its sequelae. The diagnosis is confirmed histologically.

Epithelial-Myoepithelial Carcinoma of Salivary Glands

1992 ◽  
Vol 101 (6) ◽  
pp. 540-542 ◽  
Author(s):  
John G. Batsakis ◽  
Adel K. El-Naggar ◽  
Mario A. Luna
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Cell Population ◽  
Phenotypic Expression ◽  
Myoepithelial Cells ◽  
Salivary Gland Neoplasms ◽  
Myoepithelial Carcinoma ◽  
Parotid Glands ◽  
Ductal Cells ◽  
Epithelial Myoepithelial Carcinoma

Epithelial-myoepithelial carcinomas comprise approximately 1 % of all salivary gland neoplasms. They are preponderantly tumors of the parotid glands with a relatively low mortality but a decided locoregional aggressiveness. Histopathologically, the carcinomas are characterized by a dual cell population of epithelial (ductal) cells and myoepithelial cells. These cells vary in their dominance and phenotypic expression

scholarly journals LONG-TERM STAY OF METALLIC FOREIGN BODIES IN THE BRONCHI

2018 ◽  
Vol 22 (5) ◽  
pp. 275-276
Author(s):  
Aitbay A. Gumerov ◽  
V. A. Paramonov ◽  
R. R. Zainullin ◽  
R. A. Gumerov ◽  
E. S. Semenova ◽  
...  
Keyword(s):  
Foreign Bodies ◽  
Lower Lobe ◽  
The Other ◽  
Preoperative Preparation ◽  
Lobe Bronchus ◽  
Clinical Observations ◽  
First Child ◽  
Lobar Bronchus ◽  
The Right

The article presents two clinical observations of the stay of metallic foreign bodies in the bronchi. In the first child, a needle pushpin with a plastic casing was for 2 years in the lumen of the lower lobe bronchus on the right, while in the other case the screw stayed also in the right lower lobe bronchus for two weeks. Removal of foreign bodies of bronchi is performed urgently after the appropriate preoperative preparation in the operating room. Removal of the foreign body was carried out with pronounced technical difficulties, after repeated attempts for an hour. There were no complications during and after manipulation. Bronchoscopy revealed narrowing of the lumen of the lower lobar bronchus, edema, and hyperemia of the mucous membrane, as well as granulation tissue, partially overlapping the clearance of the bronchus.

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