scholarly journals Identification of Women for Referral to Colposcopy by Neural Networks: A Preliminary Study Based on LBC and Molecular Biomarkers

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Petros Karakitsos ◽  
Charalampos Chrelias ◽  
Abraham Pouliakis ◽  
George Koliopoulos ◽  
Aris Spathis ◽  
...  
Keyword(s):  
Precancerous Lesions ◽  
Correct Classification ◽  
Test Set ◽  
Dna Test ◽  
Hpv Dna ◽  
Vector Quantizer ◽  
Cervical Precancerous Lesions ◽  
Liquid Based Cytology ◽  
Preliminary Study

Objective of this study is to investigate the potential of the learning vector quantizer neural network (LVQ-NN) classifier on various diagnostic variables used in the modern cytopathology laboratory and to build an algorithm that may facilitate the classification of individual cases. From all women included in the study, a liquid-based cytology sample was obtained; this was tested via HPV DNA test, E6/E7 HPV mRNA test, and p16 immunostaining. The data were classified by the LVQ-NN into two groups: CIN-2 or worse and CIN-1 or less. Half of the cases were used to train the LVQ-NN; the remaining cases (test set) were used for validation. Out of the 1258 cases, cytology identified correctly 72.90% of the CIN-2 or worst cases and 97.37% of the CIN-1 or less cases, with overall accuracy 94.36%. The application of the LVQ-NN on the test set allowed correct classification for 84.62% of the cases with CIN-2 or worse and 97.64% of the cases with CIN-1 or less, with overall accuracy of 96.03%. The use of the LVQ-NN with cytology and the proposed biomarkers improves significantly the correct classification of cervical precancerous lesions and/or cancer and may facilitate diagnosis and patient management.

scholarly journals MobileNetV2 Ensemble for Cervical Precancerous Lesions Classification

Processes ◽  
2020 ◽  
Vol 8 (5) ◽  
pp. 595 ◽  
Author(s):  
Cătălin Buiu ◽  
Vlad-Rareş Dănăilă ◽  
Cristina Nicoleta Răduţă
Keyword(s):  
Uterine Cervix ◽  
Precancerous Lesions ◽  
Binary Classification ◽  
The United States ◽  
Medical Procedure ◽  
Medical Doctors ◽  
Analysis Framework ◽  
Cervical Precancerous Lesions ◽  
Classification Tasks

Women’s cancers remain a major challenge for many health systems. Between 1991 and 2017, the death rate for all major cancers fell continuously in the United States, excluding uterine cervix and uterine corpus cancers. Together with HPV (Human Papillomavirus) testing and cytology, colposcopy has played a central role in cervical cancer screening. This medical procedure allows physicians to view the cervix at a magnification of up to 10%. This paper presents an automated colposcopy image analysis framework for the classification of precancerous and cancerous lesions of the uterine cervix. This framework is based on an ensemble of MobileNetV2 networks. Our experimental results show that this method achieves accuracies of 83.33% and 91.66% on the four-class and binary classification tasks, respectively. These results are promising for the future use of automatic classification methods based on deep learning as tools to support medical doctors.

Population-based cervical cancer screening using high-risk HPV DNA test and liquid-based cytology in Northern Thailand

Pathology ◽  
2014 ◽  
Vol 46 ◽  
pp. S68
Author(s):  
Sumalee Siriaunkgul ◽  
Jongkolnee Settakorn ◽  
Kornkanok Sukpun ◽  
Jatupol Srisomboon ◽  
Prapaporn Suprasert ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Cervical Cancer Screening ◽  
Population Based ◽  
Dna Test ◽  
Hpv Dna ◽  
Liquid Based Cytology ◽  
High Risk Hpv ◽  
Hpv Dna Test

scholarly journals Value of PAP’s Smear with Regard to DNA Testing for Identification of Cervical Precancerous Lesions in VIA Positive Cases

2020 ◽  
Vol 18 (2) ◽  
pp. 27-32
Author(s):  
Bonita Biswas ◽  
Shahanara Chowdhury ◽  
Serajun Noor Rosy ◽  
Rinku Rani Das ◽  
Moshammat Zebunnesa ◽  
...  
Keyword(s):  
Precancerous Lesions ◽  
Screening Strategy ◽  
Dna Testing ◽  
College Hospital ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Hpv Dna ◽  
Hpv Dna Testing ◽  
Gynecology And Obstetrics ◽  
Cervical Precancerous Lesions

Background: Carcinoma cervix is one of the cause of female death in developing country like Bangladesh. Prevention can be done by several screening procedure like VIA, Pap's smear, HPV DNA testing, Colposcopy and colposcopy directed biopsy. We can markedly reduce the mortality and morbidity by these procedures and can be detected carcinoma in precancerous and very early carcinoma stage. This study was conducted to compare HPV DNA testing and pap’s smear for identification of cervical precancerous lesions in VIA positive cases. Materials and methods: It was an analytical type of cross sectional study. Data were obtained in outpatient Department of Gynecology and Obstetrics, Chattogram Medical College Hospital, Chattogram from July 2014 to December 2014. Total 90 subjects were included in the study consecutively after considering inclusion and exclusion criteria and taking written informed consent. Data analysis was done by SPSS (Version 17). Results: Histopathology findings of biopsy materials of colposcopy positive cases where 8(28.6%) were chronic cervicitis, 10(35.7%) were CIN I, 7(25.0%) were CIN II, 3(10.7%) were CIN III. Total 20(71.4%) cases were found positive or precancerous. Regarding validity analysis of different tests that were performed for cervical precancerous conditions taking histopathology results as a gold standard, sensitivity of Pap’s smear was found lower (75.0%) than the HPV DNA whereas specificity of Pap’s Smear was higher (87.5%) then the specificity of HPV DNA (75.0%). Conclusion: HPV DNA testing was both more sensitive and specific near to Pap cytology. So the use of a less invasive and more user friendly primary screening strategy like HPV-DNA testing may be required to achieve the coverage necessary for effective reduction in cervical cancer mortality. Chatt Maa Shi Hosp Med Coll J; Vol.18 (2); July 2019; Page 27-32

scholarly journals The Accuration of LiquidBased Cytology and HPV DNA Test Combination as Precervical Cancer Lesion Screening

2017 ◽  
pp. 241
Author(s):  
Junita Indarti ◽  
Yuven S Pratama
Keyword(s):  
False Negative ◽  
Screening Method ◽  
Cross Sectional Study ◽  
Health Clinic ◽  
Cross Sectional ◽  
Dna Test ◽  
Hpv Dna ◽  
Liquid Based Cytology ◽  
Cancer Lesion ◽  
Hpv Dna Test

Objective: To investigate the accuracy of liquid-based cytology, HPV DNA test, and the combination of liquid-based cytologyband HPV DNA test, compared to histopathology as the gold standard of precervical cancer lesion screening. Methods: This was a cross-sectional study. The medical records of patients who came to the Women’s Health Clinic of Dr. Cipto Mangunkusumo Hospital during the period of July 2013 to December 2015 were evaluated. Results: The high risk type HPV DNA is detected in 76% CIN 1, 88.46% CIN 2, and 84.21 CIN 3 in histopathology results. The accuracy of liquid-based cytology; sensitivity 88.54%, specificity35.71%, PPV 75.89%, and NPV 57.69%. The accuracy of HPV DNA; sensitivity 81.25%, specificity 78.57%, PPV 89.66%, and NPV 64.71%. The accuracy of combination: sensitivity 94.79%, specificity 35.71%, PPV 77.12%, and NPV 75%. Conclusion: The addition of HPV DNA test increased the sensitivity from 88.54% to 94.79% because of decreasing of false negative of liquid-based cytology. This thing has showed that the combination of liquid-based cytology and HPV DNA test could the one of the option of precervical cancer lesion screening method, especially in secondary or tertier health center in Indonesia. Keywords: accuracy test, HPV DNA, liquid-based cytology, precervical cancer lesion, precervical cancer lesion screening

scholarly journals Population-based Cervical Cancer Screening Using High-risk HPV DNA Test and Liquid-based Cytology in Northern Thailand

2014 ◽  
Vol 15 (16) ◽  
pp. 6837-6842 ◽  
Author(s):  
Sumalee Siriaunkgul ◽  
Jongkolnee Settakorn ◽  
Kornkanok Sukpan ◽  
Jatupol Srisomboon ◽  
Prapaporn Suprasert ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Cervical Cancer Screening ◽  
Population Based ◽  
Dna Test ◽  
Hpv Dna ◽  
Liquid Based Cytology ◽  
High Risk Hpv ◽  
Hpv Dna Test

scholarly journals HPV-DNA testing for detecting precancerous lesions of cervix: how effective?

2016 ◽  
Vol 5 (1) ◽  
pp. 280
Author(s):  
Ruchi N. Thakur
Keyword(s):  
Pap Smear ◽  
Histopathological Examination ◽  
Precancerous Lesions ◽  
Cervical Squamous Cell Carcinoma ◽  
Low Grade ◽  
Dna Test ◽  
Hpv Dna ◽  
Large Loop ◽  
Gynecological Examination ◽  
Hybrid Capture 2

Background: Human Papilloma Virus has been found to be associated with cervical squamous cell carcinoma. Studies and reviews indicate that HPV testing is more sensitive than Pap smear for identifying cervical cancer and its precursors in population screening. Hybrid capture 2 assays detect high oncogenic risk viruses and can be used as primary screening tool for women older than 30 years.Methods: A detailed history followed by a thorough clinical and gynecological examination was carried out for women attending the gynecological O.P.D. HPV-DNA (HCT) samples were collected using a cytobrush. Suspicious lesions of the cervix were further subjected to colposcopy directed loop electrosurgical excision procedure (LEEP) and sent for histopathological examination in formalin. The results of HPV-DNA (HCT) and histopatholgical report were then correlated.Results: In this study, one hundred and sixty women were screened for HPV-DNA. Thirty-two women were found to be positive for HPV-DNA. They were further subjected to colposcopy directed large loop electrosurgical procedure. The positive patients were found to have either low-grade or high-grade cervical intraepithelial neoplasia.Conclusions: The use of HPV-DNA test may make it a viable alternative to cytological screening especially as a less frequent screening.

Liquid‐based cytology and HPV DNA test in anal specimens from women with cervical cancer

2021 ◽  
Author(s):  
Jose Eleutério ◽  
Walyson Surimã ◽  
Matheus A. T. Lima ◽  
Joao V. S. Bezerra ◽  
Renata M. N. Eleutério
Keyword(s):  
Cervical Cancer ◽  
Dna Test ◽  
Hpv Dna ◽  
Liquid Based Cytology ◽  
Hpv Dna Test

scholarly journals Clinical evaluation of HPV DNA test combined with liquid-based cytology in the diagnosis of cervical disease

2013 ◽  
Vol 03 (03) ◽  
pp. 371-376
Author(s):  
Raghvendra Thakur ◽  
Jasma Mally ◽  
Rajina Shrestha ◽  
Xuehua Zheng ◽  
Mengli Zhang ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Dna Test ◽  
Hpv Dna ◽  
Cervical Disease ◽  
Liquid Based Cytology ◽  
Hpv Dna Test

scholarly journals Incidence of Positive HPV High Risk in Negative Cytology Result

2019 ◽  
pp. 244-250
Author(s):  
Junita Indarti ◽  
Darrell Fernando ◽  
Finish Fernando ◽  
Ribkhi A. Putri ◽  
Anggara Mahardika ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Dna Test ◽  
Hpv Dna ◽  
Hpv Test ◽  
Significant Difference ◽  
Flow Through ◽  
Liquid Based Cytology ◽  
High Risk Hpv ◽  
Cytology Result

Abstract Objective: This research aim is to report the incidence of positive HPV high risk in negative cytology result. Method: We collected 83 women underwent liquid-based cytology (LBC) and HPV DNA examination at the same time. We were using DiagCor GenoFlow Human Papillomavirus Array Test (GenoFlow), a novel HPV test based on PCR and "Flow-through" hybridization that can identify 33 HPV subtypes: 18 types of High risk HPV such as 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 81 and 82 Result: We grouped the subjects based on age below or equal to 30 years old (n=6) and above 30 years old (n=77). We found a significant difference in HPV DNA result within this group (P = 0.034), with 19.3% had HPV DNA type 16 and 18 in a group of age above 30 years old. Our study showed that 27 women (32.5%) underwent screening for cervical cancer having negative LBC result but showed positive HPV DNA positive. Conclusion: We found a significant difference in HPV DNA test result among women above 30 years old. Co-testing of Pap and HPV DNA is needed, especially if HPV DNA type 16 and 18 were found among negative Pap results. Keywords: Cervical cancer, HPV DNA, incidence, LBC, screening   Abstrak Tujuan: Penelitian ini bertujuan melaporkan insidensi dari HPV risiko tinggi yang positif pada hasil sitologi negatif. Metode: Kami mengumpulkan 83 wanita yang menjalani liquid based cytology (LBV) dan pemeriksaan HPV DNA pada waktu yang bersamaan. Dengan menggunakan DiagCor GenoFlow Human Papilloma Virus Array Test (GenoFlow), yaitu sebuah uji HPV terbaru yang berbasis PCR dan “Flow-throug” hybridization dapat mengidentifikasi 33 subtipe HPV: 18 tipe HPV risiko tinggi seperti 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 81 dan 82. Hasil: Kami mengelompokkan subjek berdasarkan usia dibawah atau setara 30 tahun dan diatas 30 tahun (n=77). Kami menemukan perbedaansignifikan dari hasil HPV DNA dalam kelompok ini (P=0.034), dengan 19.3% memiliki HPV DNA tipe 16 dan 18 dalam kelompok usia diatas 30 tahun. Penelitian ini menunjukkan 27 perempuan (32.5%) menjalani skrining kanker serviks memiliki hasil LBC yang negatif namun menunjukkan HPV DNA positif. Kesimpulan: Terdapat perbedaan signifikan dari uji HPV DNA pada wanita usia diatas 30 tahun. Pemeriksaan bersamaan antara Pap dan HPV DNA dibutuhkan terutama ketika HPV DNA tipe 16 dan 18 ditemuka pada hasil Pap negatif. Kata kunci: HPV DNA, insidensi, kanker serviks, LBC, skrining

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