scholarly journals Acid-Fast Bacilli Other than Mycobacteria in Tuberculosis Patients Receiving Directly Observed Therapy Short Course in Cross River State, Nigeria

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Benjamin Thumamo Pokam ◽  
Anne E. Asuquo
Keyword(s):  
Laboratory Culture ◽  
Hiv Positive ◽  
Sputum Smear ◽  
Directly Observed Therapy ◽  
Isolation And Identification ◽  
Tuberculosis Patients ◽  
Cross River ◽  
Cross River State ◽  
Antituberculosis Therapy ◽  
Short Course

The information on the contribution of non tuberculous mycobacteria (NTM) to mycobacterial infections in Africa is scarce due to limited laboratory culture for its isolation and identification. One hundred and thirty-seven sputum smear positive patients were recruited into a study on the molecular epidemiology ofMycobacterium tuberculosisin Cross River State. Following sputum culture, 97 pure isolates were obtained and identified using Capilia TB-Neo and further confirmed by the GenoType Mycobacterium CM kit. Of the 97 isolates, 81 (83.5%) isolates were Capilia TB-Neo positive while 16 (16.5%) were Capilia TB-Neo negative. Further confirmation with the GenoType Mycobacterium CM kit revealed that 4 (25%) of the 16 isolates belonged to NTM and includedM. fortuitum I, M. fortuitum II/M magaritense, M. abscessus,andM. aviumssp. The remaining 12 (75%) Capilia TB-Neo negative isolates were not members of the genusMycobacteriumdespite their AFB appearance. Six (33.3%) of the Capilia TB-Neo negative were from HIV positive tuberculosis patients. All subjects in this study were placed on DOTS shortly after the AFB results were obtained. The implication of isolation of 16.5% nontuberculous isolates further emphasizes the need for culture of sputum specimen especially in HIV positive patients prior to administration of antituberculosis therapy.

scholarly journals Prolonged Infectiousness of Tuberculosis Patients in a Directly Observed Therapy Short‐Course Program with Standardized Therapy

2010 ◽  
Vol 51 (4) ◽  
pp. 371-378 ◽  
Author(s):  
Sean P. Fitzwater ◽  
Luz Caviedes ◽  
Robert H. Gilman ◽  
Jorge Coronel ◽  
Doris LaChira ◽  
...  
Keyword(s):  
Directly Observed Therapy ◽  
Tuberculosis Patients ◽  
Short Course

scholarly journals Effect of psychiatric co-morbidity on adherence to anti tubercular treatment: a cross sectional study from North India

2021 ◽  
Vol 8 (3) ◽  
pp. 1325
Author(s):  
Ravdeep Kaur ◽  
Tarundeep Singh ◽  
Shubh Mohan Singh ◽  
Rajesh Kumar
Keyword(s):  
Depressive Disorder ◽  
Cross Sectional Study ◽  
North India ◽  
Directly Observed Therapy ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Short Course ◽  
Co Morbidity ◽  
Mdr Tb ◽  
Tuberculosis Therapy

Background: Study explores relationship between depressive disorder and adherence to DOTS (Directly Observed Therapy Short Course) and whether treatment of depressive disorder according to severity of depressive disorder should be an option to improve adherence to DOTS.Methods: Study included 182 newly diagnosed adult cases of tuberculosis who were on anti- tuberculosis therapy (ATT) as per program guidelines and were in third month under DOTS category I and category II therapy. Patients were screened for depressive and anxiety disorder using PHQ-9 and GAD-7. Modified ACTG baseline questionnaire was used to collect data about adherence and reasons for partial adherence.Results: Overall prevalence of depressive disorder amongst participants was found to be 37.9% and that of partial adherence (missed two or more than two doses) was 12.1%. Partial adherence was mostly seen in the first month, followed by third and second month of DOTS. Twenty- two percent patients with depressive disorder were partially adherent to ATT. Odds ratio suggests higher risk being partially adherent to ATT were greater in the participants who had depressive disorder.Conclusions: This study highlights the benefit of screening patients while diagnosing tuberculosis patients for depressive disorder, to improve disease outcome and reduce likelihood of MDR-TB.

scholarly journals Prevalence of Treatment Failure among Pulmonary Tuberculosis Patients in Federal Medical Centre, Gombe, Northeastern Nigeria

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Y. B. Jibrin ◽  
A. B. Ali ◽  
S. T. Saad ◽  
P. M. Kolo
Keyword(s):  
Pulmonary Tuberculosis ◽  
Treatment Failure ◽  
Medical Centre ◽  
Healthcare Personnel ◽  
Sputum Smear ◽  
Directly Observed Therapy ◽  
Tuberculosis Patients ◽  
Treatment Failure Rate ◽  
High Treatment ◽  
Great Danger

Treatment failure in patients with pulmonary tuberculosis poses a great danger to the global effort in control of tuberculosis. This study evaluated prevalence of treatment failure among pulmonary tuberculosis patients at Federal Medical Centre (FMC) Gombe, Nigeria. Consecutive patients managed between August 2008 and August 2009 at the Directly Observed Therapy (Tuberculosis) Unit of our hospital were enrolled for the study. Sputum specimens were collected from each patient at entry for Acid Fast Bacilli and repeated at the end of 2nd, 5th and 7th month of treatment. Of the 247 patients recruited, 200 patients consisting of 118 (59%) males and 82 (41%) females aged 15–78 years with a mean of 36.8 ± 12.4 years completed the study. One hundred and fifteen (57.5%) of the patients were sputum smear positive at entry while 85 (42%) were negative. Among 115 smear positive patients at baseline, 80 patients (69.6%), 26 (22.6%) and 24 (20.9%) remained positive after 2nd, 5th and 7th month of treatment respectively. In conclusion, there is a high treatment failure rate (22.6%) among our TB patients; and this poses a great danger to healthcare personnel and close contacts in the community.

scholarly journals Multidrug resistance and demography of newly diagnosed tuberculosis patients in Cross River State, Nigeria

2013 ◽  
Vol 2 (2) ◽  
pp. 89-93 ◽  
Author(s):  
Benjamin Thumamo Pokam ◽  
Anne E. Asuquo ◽  
Lydia N. Abia-Bassey ◽  
Mandor B. Idasa ◽  
Nse O. Umoh ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Newly Diagnosed ◽  
Tuberculosis Patients ◽  
Cross River ◽  
Cross River State

scholarly journals Factors at first diagnosis of tuberculosis associated with compliance with the Directly Observed Therapy (DOT) in the Limpopo Province, South Africa

Curationis ◽  
2002 ◽  
Vol 25 (3) ◽  
Author(s):  
K. Peltzer ◽  
H. Onya ◽  
P. Seoka ◽  
F.M. Tladi
Keyword(s):  
South Africa ◽  
Health Beliefs ◽  
Limpopo Province ◽  
Sputum Smear ◽  
Health Practitioner ◽  
Directly Observed Therapy ◽  
Health Seeking ◽  
Tuberculosis Patients ◽  
Patient Interaction ◽  
First Diagnosis

The aim of this study is to compare and contrast health beliefs, demographic and socio-economic variables, causative beliefs, knowledge, health-seeking behaviour and health provider-patient interaction of compliant and non-compliant tuberculosis patients. The sample included 219 consecutive new sputum-smear and/or culture positive pulmonary tuberculosis patients registered between October 1999 and March 2000 in three hospitals in the Limpopo Province of South Africa. The patients were 144 (65.8%) men and 75 (34.2%) women in the age range of 18 to 79 years (M age 35.9 yr., SD= 12.6). The consultation at first diagnosis was observed and tape-recorded. Thereafter an interview was conducted and a questionnaire was face-to-face administered with the patient including knowledge, causative beliefs, health seeking, and Health Belief Model items. Discriminant analysis between compliant and non-compliant groups after six months follow-up showed that the quality of the health practitioner-patient interaction and causative belief were associated with compliance behaviour whereas knowledge, onset of TB, sociodemographic variables, health care seeking, and health beliefs were not associated.

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