scholarly journals Renal Pelviceal Keratinizing Squamous Metaplasia with Sparing of Pyramidal Zones

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Richard H. Siderits ◽  
Jared Fingerman ◽  
Anup Hazra ◽  
Cheryl Rimmer ◽  
Marc Colaco ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Renal Disease ◽  
Renal Pelvis ◽  
Chronic Renal Disease ◽  
Squamous Metaplasia ◽  
Upper Urinary Tract ◽  
Muscularis Mucosa ◽  
Chronic Infections ◽  
History Of

Metaplastic changes in the urothelium of the upper urinary tract are relatively infrequent. Metaplasia may present as either squamous or less often glandular differentiation. The process may be associated with chronic inflammation or associated chronic infections. There may be malignant transformation to either squamous cell carcinoma or adenocarcinoma. The demarcation of the metaplastic process in the minor calyces has not been well documented to date. We report the case of a 74-year-old female patient who presented with a history of chronic renal disease and acute pyohydronephrosis. The patient underwent a nephroureterectomy which revealed keratinizing desquamative squamous metaplasia throughout the renal pelvis and upper urinary tract with abrupt termination of metaplasia at the junction of the renal pelvis and the minor calyx (pyramidal zone). Immunohistochemical evaluation documents metaplastic urothelium stained positive for CK5, before converting sharply to simple cuboidal epithelium in the minor calyx (pyramidal zones) which stained positive CK7. At the junction of the metaplastic components and low cuboidal lined minor calyceal surfaces, the underlying stroma showed loss of ureteral muscularis mucosa with transition to renal parenchymal type stroma. We believe that this observation is unique and potentially relevant to the etiology and pathophysiology of pelviceal metaplasia.

Villous Adenoma Arising in the Native Bladder Mucosa and the Upper Urinary Tract With Coexisting Neuroendocrine Carcinoma Following Augmentation Cystoplasty

2019 ◽  
Vol 27 (4) ◽  
pp. 450-456
Author(s):  
Anupma Nayak ◽  
Brittany Depasquale ◽  
Norge Vergara ◽  
Thomas A. Guzzo ◽  
Priti Lal
Keyword(s):  
Urinary Tract ◽  
Neuroendocrine Carcinoma ◽  
Renal Pelvis ◽  
Villous Adenoma ◽  
Upper Urinary Tract ◽  
Augmentation Cystoplasty ◽  
Bladder Mucosa ◽  
Unique Case ◽  
History Of ◽  
Villous Adenomas

Villous adenomas arising in the bladder following augmentation cystoplasty procedures are exceedingly rare. Even rarer is their occurrence in the native bladder mucosa and the upper urinary tract. In this article, we present a unique case of multifocal recurrent villous adenoma involving native bladder mucosa of an augmented bladder, bilateral ureters, and renal pelvis, with coexistent foci of adenocarcinoma and neuroendocrine carcinoma, in a patient with history of augmentation colocystoplasty. We additionally discuss the pathogenesis of development of carcinoma in the setting of augmentation cystoplasty.

The patient with urinary tract obstruction

2015 ◽  
Author(s):  
Muhammad M. Yaqoob ◽  
Katherine Bennett-Richards ◽  
Islam Junaid
Keyword(s):  
Urinary Tract ◽  
Renal Impairment ◽  
Renal Disease ◽  
Renal Pelvis ◽  
Chronic Renal Disease ◽  
Urinary Tract Obstruction ◽  
Renal Scarring ◽  
Obstructive Uropathy ◽  
Diagnosis And Treatment ◽  
Obstructive Nephropathy

Several terms usually describe obstruction of the urinary tract and its consequences such as hydronephrosis, obstructive uropathy, and obstructive nephropathy. Obstruction can be due to anatomical or functional abnormalities of the urethra, bladder, ureter, or renal pelvis. These abnormalities can be congenital or acquired. Obstructive uropathy also can occur during the course of diseases extrinsic to the urinary tract. This is a reversible cause of renal impairment and calls for urgent diagnosis and treatment to prevent chronic irreversible renal scarring and consequent progressive chronic renal disease.

scholarly journals Ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation: a case report

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shangqing Ren ◽  
Hualin Feng ◽  
Yige Bao ◽  
Yi Wei ◽  
Yong Ou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Standard Treatment ◽  
Clinical Manifestations ◽  
Sarcomatoid Carcinoma ◽  
Upper Urinary Tract ◽  
Malignant Tumours

Abstract Background Upper urinary tract urothelial carcinoma (UTUC) with multiple pathological types is extremely rare in the clinic, but the recurrence rate and mortality these patients are high. At present, there is no standard treatment for such cases. Case presentation We reported a case of ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation and rapid ileal metastasis and reviewed the literature related to different pathological types of upper urinary tract tumours to explore the diagnosis, treatment and prognosis characteristics of the disease, enhance our understanding of its clinical manifestations and history of evolution and provide guidance for avoiding missed diagnosis and misdiagnosis. Conclusion There is no standard treatment for urinary malignant tumours with multiple pathological types; radical surgery is considered a suitable choice. Chemotherapy, targeted drug therapy and immunotherapy may be beneficial to the survival of patients. In short, these patients have a high risk of recurrence and metastasis and a poor prognosis.

Hereditary Nonpolyposis Colorectal Cancer Syndrome in a Patient With Urothelial Carcinoma of the Upper Urothelial Tract

2003 ◽  
Vol 127 (2) ◽  
pp. e60-e63
Author(s):  
Arndt Hartmann ◽  
John C. Cheville ◽  
Wolfgang Dietmaier ◽  
Ferdinand Hofstädter ◽  
Lawrence J. Burgart ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Upper Urinary Tract ◽  
Cancer Syndrome ◽  
Tract Cancer ◽  
Hereditary Nonpolyposis ◽  
History Of ◽  
History Of Cancer

Abstract Urothelial carcinoma of the upper urinary tract is relatively uncommon but may develop as a manifestation of the hereditary nonpolyposis colorectal cancer syndrome (HNPCC), which is characterized by mutations in a number of DNA mismatch repair genes and detectable as microsatellite instability or loss of the respective protein by immunostaining. No well-established screening test is available for urothelial carcinomas of the upper urinary tract, and little is known of the clinical impact of screening for HNPCC in patients with upper urinary tract cancer. We describe herein a patient with a urothelial carcinoma of the ureter and a strongly positive history of cancer, who was subsequently found to have HNPCC. Our findings reinforce the importance of obtaining a comprehensive history of cancer in patients with urothelial carcinoma of the renal pelvis and ureter. Subsequent identification of individuals with HNPCC enables the patient and at-risk relatives to benefit from targeted surveillance and management programs.

Squamous Cell Carcinoma Arising in Keratinizing Desquamative Squamous Metaplasia (KDSM) of the Renal Pelvis

2013 ◽  
Vol 06 (04) ◽  
Author(s):  
Mohammed S. Al-Marhoon ◽  
P. A. M. Saparamadu ◽  
Krishna P. Venkiteswaran ◽  
Omar Shareef ◽  
Joseph Mathewkunju
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Renal Pelvis ◽  
Squamous Metaplasia

Is baseline routine renal ultrasound indicated for all MS patients?

2019 ◽  
Vol 96 (1134) ◽  
pp. 194-196
Author(s):  
Igor B Títoff ◽  
Victoria Titoff ◽  
Thomas F Scott
Keyword(s):  
Urinary Tract ◽  
Upper Urinary Tract ◽  
Renal Ultrasound ◽  
Red Flags ◽  
Inclusion Criteria ◽  
Detrusor Sphincter Dyssynergia ◽  
History Of ◽  
Bladder Symptoms ◽  
Tract Infections

BackgroundMost patients with multiple sclerosis (MS) develop multiple urological complaints due to hyperactive or hypoactive bladder, and may have detrusor-sphincter dyssynergia. Routine renal ultrasound (RUS) screening has been recommended for both symptomatic and asymptomatic MS patients; however, there is little data to support this practice.MethodsProspectively screened consecutive MS clinic patients in 2016–2017 with functional systems scores (FSS) indicating moderate to severe neurogenic bladder symptoms (FSS bladder ≥2) were sent for RUS. We also screened for history of urinary tract infections.Results872 patients were screened between 3 September 2016 and 13 April 2017. 58 patients met inclusion criteria for RUS. 6 were excluded due to non-compliance with testing or unavailability of results; 52 patients were imaged. Only 3/52 patients were found to have renal pathology requiring follow-up. Of those three, one had known symptomatic nephrolithiasis, and one had subsequently normal findings, leaving one patient newly found to have valid abnormal upper urinary tract (UUT) findings. Multiple incidental findings were also discovered.ConclusionThe minimal yield for significant UUT pathology found in this enriched group of symptomatic MS patients indicates that RUS screening for asymptomatic MS patients without clear risk factors is not indicated. Red flags for high risk of UUT complications should be used as triggers for baseline RUS screening in MS patients.

Absence of Epstein-Barr virus infection in squamous cell carcinoma of upper urinary tract and urinary bladder

Urology ◽  
2006 ◽  
Vol 68 (4) ◽  
pp. 775-777 ◽  
Author(s):  
Kwai-Fong Ng ◽  
Cheng-Keng Chuang ◽  
Phei-Lang Chang ◽  
Sheng-Hsien Chu ◽  
Christopher Glenn Wallace ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Urinary Bladder ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Upper Urinary Tract ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection
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