scholarly journals Trends of Components of the Metabolic Syndrome in German First Graders Throughout 10 Years: The PEP Family Heart Study

Cholesterol ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Gerda-Maria Haas ◽  
Thomas Bertsch ◽  
Peter Schwandt
Keyword(s):  
Metabolic Syndrome ◽  
First Graders ◽  
Hdl Cholesterol ◽  
Overweight And Obesity ◽  
Mean Values ◽  
The Metabolic Syndrome ◽  
Childhood Overweight And Obesity ◽  
Family Heart Study ◽  
Heart Study ◽  
Low Hdl

Although childhood overweight and obesity are increasing worldwide, some countries report trends for stabilization. However, the trend for the potentially atherogenic components of the metabolic syndrome (MetS) in children and adolescents is not well understood. Therefore, the purpose of this study was to analyze the trend of the five components of over 10 years in 2228 first graders aged 6 years. Waist circumference (WC) remained mainly unchanged between 1994 and 2003 whereas the other four components continuously decreased. In boys and girls mean values of triglycerides (−25.9% and −28.6%, resp.), HDL cholesterol (−19.8% and −23.4%, resp.), fasting glucose (−7.3% and −9%, resp.), systolic (−3.8% and −4.1%, resp.), and diastolic (−10.2% and −9.7%, resp.) blood pressure significantly decreased. Whereas the prevalence of abdominal adiposity was stable at baseline and after 10 years (−1% in boys and +2% in girls), the prevalence of hypertension, hypertriglyceridemia, low HDL-C, and glucose was very low without any trend.

scholarly journals Age- and Gender-Specific Components of the Metabolic Syndrome in 2228 First Graders: The PEP Family Heart Study

Scientifica ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Peter Schwandt ◽  
Thomas Bertsch ◽  
Evelyn Liepold ◽  
Gerda-Maria Haas
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
First Graders ◽  
Growth Curves ◽  
Age And Gender ◽  
The Metabolic Syndrome ◽  
Family Heart Study ◽  
Heart Study ◽  
And Gender ◽  
Gender Specific

Because first graders are critical for excess weight gain, we assessed components of the metabolic syndrome (MetS) using the pediatric definition of the International Diabetes Federation (IDF). We compared four MetS components as defined by the IDF with age- and gender-specific components in 2228 first graders at the age of 6. The growth curves were derived from 22113 children and adolescents who participated in the PEP Family Heart Study. The aim was to determine in first graders precise values of waist circumference (WC), blood pressure (BP), triglycerides (TG), and HDL-Cholesterol (HDL-C) based on growth curves that were developed for a large German population of youths and to assess the prevalence in terms of both definitions at this critical age. The prevalence of high blood pressure for age was 13% compared with only 2% according to IDF. Because of this considerable divergence, we propose to define MetS components based on national growth curves.

scholarly journals Association between the Mediterranean lifestyle, metabolic syndrome and mortality: a whole-country cohort in Spain

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Mercedes Sotos-Prieto ◽  
Rosario Ortolá ◽  
Miguel Ruiz-Canela ◽  
Esther Garcia-Esquinas ◽  
David Martínez-Gómez ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Mortality ◽  
Cardiovascular Health ◽  
Total Mortality ◽  
Hdl Cholesterol ◽  
Cardiometabolic Health ◽  
The Metabolic Syndrome ◽  
Mediterranean Countries ◽  
Low Hdl ◽  
The Mediterranean

Abstract Background Evidence is limited about the joint health effects of the Mediterranean lifestyle on cardiometabolic health and mortality. The aim of this study was to evaluate the association of the Mediterranean lifestyle with the frequency of the metabolic syndrome (MS) and the risk of all-cause and cardiovascular mortality in Spain. Methods Data were taken from ENRICA study, a prospective cohort of 11,090 individuals aged 18+ years, representative of the population of Spain, who were free of cardiovascular disease (CVD) and diabetes at 2008–2010 and were followed-up to 2017. The Mediterranean lifestyle was assessed at baseline with the 27-item MEDLIFE index (with higher score representing better adherence). Results Compared to participants in the lowest quartile of MEDLIFE, those in the highest quartile had a multivariable-adjusted odds ratio 0.73 (95% confidence interval (CI) 0.5, 0.93) for MS, 0.63. (0.51, 0.80) for abdominal obesity, and 0.76 (0.63, 0.90) for low HDL-cholesterol. Similarly, a higher MELDIFE score was associated with lower HOMA-IR and highly-sensitivity C-reactive protein (P-trend < 0.001). During a mean follow-up of 8.7 years, 330 total deaths (74 CVD deaths) were ascertained. When comparing those in highest vs. lowest quartile of MEDLIFE, the multivariable-adjusted hazard ratio (95% CI) was 0.58 (0.37, 0.90) for total mortality and 0.33 (0.11, 1.02) for cardiovascular mortality. Conclusions The Mediterranean lifestyle was associated with lower frequency of MS and reduced all-cause mortality in Spain. Future studies should determine if this also applies to other Mediterranean countries, and also improve cardiovascular health outside the Mediterranean basin.

scholarly journals Heritability of the metabolic syndrome and its components in the Tehran Lipid and Glucose Study (TLGS)

2012 ◽  
Vol 94 (6) ◽  
pp. 331-337 ◽  
Author(s):  
MARYAM ZARKESH ◽  
MARYAM SADAT DANESHPOUR ◽  
BITA FAAM ◽  
MOHAMMAD SADEGH FALLAH ◽  
NIMA HOSSEINZADEH ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Hdl Cholesterol ◽  
Age And Gender ◽  
The Metabolic Syndrome ◽  
Biological Parents ◽  
Heritability Estimation ◽  
Low Hdl ◽  
And Gender ◽  
Continuous Traits

SummaryGrowing evidence suggests that metabolic syndrome (MetS) has both genetic and environmental bases. We estimated the heritability of the MetS and its components in the families from the Tehran Lipid and Glucose Study (TLGS). We investigated 904 nuclear families in TLGS with two biological parents and at least one offspring (1565 parents and 2448 children), aged 3–90 years, for whom MetS information was available and had at least two members of family with MetS. Variance component methods were used to estimate age and sex adjusted heritability of metabolic syndrome score (MSS) and MetS components using SOLAR software. The heritability of waist circumference (WC), HDL-cholesterol (HDL-C), triglycerides (TGs), fasting blood sugar (FBS), systolic blood pressure (SBP) and diastolic blood pressure (DBP) as continuous traits after adjusting for age and gender were 27, 46, 36, 29, 25, 26 and 15%, respectively, and MSS had a heritability of 15%. When MetS components were analysed as discrete traits, the estimates of age and gender adjusted heritability for MetS, abdominal obesity, low HDL-C, high TG, high FBS and high blood pressure (BP) were 22, 40, 34, 38 and 23%, respectively (P < 0·05). Three factors were extracted from the six continuous traits of the MetS including factor I (BP), factor II (lipids) and factor III (obesity and FBS). Heritability estimation for these three factors were 7, 13 (P < 0·05) and 2%, respectively. The highest heritability was for HDL-C and TG. The results strongly encourage efforts to identify the underlying susceptibility genes.

Abstract MP19: Higher Parity is Associated With Components of the Metabolic Syndrome Among U.S. Hispanic/Latina Women: Results From the HCHS/SOL Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Catherine J Vladutiu ◽  
Anna Maria Siega-Riz ◽  
Alison M Stuebe ◽  
Daniela Sotres-Alvarez ◽  
Andy Ni ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Hispanic Women ◽  
Hdl Cholesterol ◽  
Latina Women ◽  
Live Births ◽  
The Metabolic Syndrome ◽  
Elevated Glucose ◽  
Low Hdl

Background: Physiologic adaptations occurring across successive pregnancies may increase the risk of adverse cardiovascular health outcomes in later life. Previous studies have found an association between higher parity and the metabolic syndrome (MetS). However, no studies have examined this association in a Hispanic/Latina population. Hispanic women have a higher prevalence of the MetS and higher birth rates than non-Hispanic women. Hypothesis: We assessed the hypothesis that higher parity is associated with the prevalence of components of the MetS in a cohort of Hispanic/Latina women. Methods: There were 9,482 Hispanic/Latina women of diverse backgrounds, aged 18-74 years, who participated in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) from 2008-2011. Components of the MetS were defined according to the AHA/NHLBI criteria and included abdominal obesity (waist circumference ≥88cm), elevated triglycerides (≥150 mg/dL), low HDL cholesterol (<50mg/dL), high blood pressure (systolic ≥130mmHg or diastolic ≥85mmHg or on medication), and elevated fasting glucose (≥100mg/dL or on medication). Logistic regression models were used to estimate odds ratios for the association between parity and components of the MetS, adjusting for sociodemographic, behavioral, and reproductive characteristics, and accounting for the complex survey design and sampling weights. Results: At HCHS/SOL baseline, women reported none (19.2%), one (18.9%), two (25.3%), three (19.7%), four (9.3%), and five or more (7.6%) prior live births. Compared to women with only one live birth, women with four live births had the highest odds of abdominal obesity (OR=2.5, 95% CI 1.8, 3.3) and those with five or more live births had the highest odds of low HDL cholesterol (OR=1.5, 95% CI 1.2, 1.9), elevated glucose (OR=1.8, 95% CI 1.3, 2.3), elevated triglycerides (OR=1.4, 95% CI 1.01, 1.8), and high blood pressure (OR=1.5, 95% CI 1.1, 2.0), after adjusting for age, Hispanic background, education, marital status, income, nativity, smoking, physical activity, menopause status, oral contraceptive use, hormone replacement therapy, and field center. Further adjustment for body mass index attenuated these associations for all MetS components, including abdominal obesity (OR=1.5, 95% CI 1.1, 2.2), low HDL cholesterol (OR=1.3, 95% CI 1.03, 1.7), and elevated glucose (OR=1.6, 95% CI 1.2, 2.1), but the associations for triglycerides and blood pressure were no longer statistically significant. Conclusion: Higher parity is associated with the prevalence of selected components of the MetS among U.S. Hispanic/Latina women. High parity among Latinas with a high prevalence of abdominal obesity suggests a context of high risk for metabolic dysregulation. A better characterization of the links between pregnancy, adiposity, and body fat distribution is needed.

scholarly journals Dietary intake of manganese and the risk of the metabolic syndrome in a Chinese population

2016 ◽  
Vol 116 (5) ◽  
pp. 853-863 ◽  
Author(s):  
Biao Zhou ◽  
Xuefen Su ◽  
Danting Su ◽  
Fangfang Zeng ◽  
Maggie Haitian Wang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Animal Studies ◽  
Hdl Cholesterol ◽  
Epidemiological Studies ◽  
Inverse Association ◽  
Chinese Adults ◽  
Related Data ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Low Hdl

AbstractAnimal studies have suggested that Mn might be associated with some components of the metabolic syndrome (MetS). A few epidemiological studies have assessed dietary Mn intake and its association with the risk of the MetS and its components among Chinese adults. In this study, we assessed daily dietary Mn intake and its relationship with MetS risk among Chinese adults in Zhejiang Province using data from the 5th Chinese National Nutrition and Health Survey (2010–2012). A total of 2111 adults were included. Dietary Mn intake was assessed using 3-d 24-h dietary recalls; health-related data were obtained by questionnaire surveys, physical examinations and laboratory assessments. The mean intake of Mn was 6·07 (sd 2·94) mg/d for men (n 998) and 5·13 (sd 2·65) mg/d for women (n 1113). Rice (>42 %) was the main food source of Mn. The prevalence of the MetS was 28·0 % (590/2111). Higher Mn intake was associated with a decreased risk of the MetS in men (Q4 v. Q1 OR 0·62; 95 % CI 0·42, 0·92; Ptrend=0·043) but an increased risk in women (Q4 v. Q1 OR 1·56; 95 % CI 1·02, 2·45; Ptrend=0·078). In addition, Mn intake was inversely associated with abdominal obesity (Ptrend=0·016) and hypertriacylglycerolaemia (Ptrend=0·029) in men, but positively associated with low HDL-cholesterol in both men (Ptrend=0·003) and women (Ptrend<0·001). Our results suggest that higher Mn intakes may be protective against the MetS in men. The inverse association between Mn intake and the MetS in women might be due to the increased risk for low HDL-cholesterol.

scholarly journals Living in the Southern Hemisphere: Metabolic Syndrome and Its Components in Amazonian Riverine Populations

2021 ◽  
Vol 10 (16) ◽  
pp. 3630
Author(s):  
Gabriela P. Arrifano ◽  
Jacqueline I. Alvarez-Leite ◽  
Barbarella M. Macchi ◽  
Núbia F. S. S. Campos ◽  
Marcus Augusto-Oliveira ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Southern Hemisphere ◽  
Vulnerable Populations ◽  
Low Income ◽  
Hdl Cholesterol ◽  
Developed Countries ◽  
Atherogenic Dyslipidemia ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Low Hdl

The metabolic syndrome (MetS) epidemic is a global challenge. Although developing countries (including Brazil, India, and South Africa) present a higher proportion of deaths by cardiovascular diseases than developed countries, most of our knowledge is from these developed countries. Amazonian riverine populations (ARP), as well as other vulnerable populations of the Southern Hemisphere, share low-income and traditional practices, among other features. This large cross-sectional study of ARP (n = 818) shows high prevalence of hypertension (51%) and obesity (23%). MetS was diagnosed in 38% of participants (especially in women and 60–69 years-old individuals) without the influence of ancestry. Only 7–8% of adults had no cardio-metabolic abnormalities related to MetS. Atherogenic dyslipidemia (low HDL-cholesterol) was generally observed, including in individuals without MetS. Still, slight differences were detected between settings with a clear predominance of hypertension in Tucuruí. Hypotheses on possible genetic influence and factors (nutrition transition and environmental pollutants -mercury) are proposed for future studies. Moreover, a roadmap to MetS progression based on the most prevalent components is provided for the development of tailored interventions in the Amazon (initially, individuals would present low HDL-cholesterol levels, later progressing to increased blood pressure characterizing hypertension, and ultimately reaching MetS with obesity). Our alarming results support the need to improve our knowledge on these vulnerable populations.

Dietary Approaches to Stop Hypertension (DASH): potential mechanisms of action against risk factors of the metabolic syndrome

2019 ◽  
Vol 33 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Masoumeh Akhlaghi
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Saturated Fat ◽  
Hdl Cholesterol ◽  
Reduce Blood Pressure ◽  
Overweight And Obesity ◽  
Cross Sectional ◽  
Dash Diet ◽  
The Metabolic Syndrome

AbstractThe metabolic syndrome is a cluster of disorders dominated by abdominal obesity, hypertriacylglycerolaemia, low HDL-cholesterol, high blood pressure and high fasting glucose. Diet modification is a safe and effective way to treat the metabolic syndrome. Dietary Approaches to Stop Hypertension (DASH) is a dietary pattern rich in fruits, vegetables and low-fat dairy products, and low in meats and sweets. DASH provides good amounts of fibre, K, Ca and Mg, and limited quantities of total fat, saturated fat, cholesterol and Na. Although DASH was initially designed for the prevention or control of hypertension, using a DASH diet has other metabolic benefits. In the present review, the effect of each dietary component of DASH on the risk factors of the metabolic syndrome is discussed. Due to limited fat and high fibre and Ca content, individuals on the DASH diet are less prone to overweight and obesity and possess lower concentrations of total and LDL-cholesterol although changes in TAG and HDL-cholesterol have been less significant and available evidence in this regard is still inconclusive. Moreover, high amounts of fruit and vegetables in DASH provide great quantities of K, Mg and fibre, all of which have been shown to reduce blood pressure. K, Mg, fibre and antioxidants have also been effective in correcting glucose and insulin abnormalities. Evidence is provided from cross-sectional investigations, cohort studies and randomised controlled trials, and, where available, from published meta-analyses. Mechanisms are described according to human studies and, in the case of a lack of evidence, from animal and cell culture investigations.

Metabolic Syndrome and Cardiovascular Disease

2005 ◽  
Vol 19 (6_suppl) ◽  
pp. 84-93 ◽  
Author(s):  
Leslie Citrome
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Hdl Cholesterol ◽  
Cardiovascular Disorder ◽  
Clinical Findings ◽  
Blood Cholesterol ◽  
World Health ◽  
Abnormal Glucose Regulation ◽  
The Metabolic Syndrome ◽  
Low Hdl

Metabolic syndrome is a constellation of clinical findings that identify individuals at higher than normal risk of developing diabetes mellitus or cardiovascular disease. There are two principal definitions, one emerging from the American National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, and the other from the World Health Organization. Both definitions share the common elements of abdominal obesity, hypertriglyceridaemia, low HDL-cholesterol, hypertension and abnormal glucose regulation. The syndrome is relatively common across continents, and also among those without marked obesity. It is even more common among patients with major mental health disorders such as schizophrenia. Metabolic syndrome can be used to assess risk for cardiovascular disorder and death, and is an alternative to Framingham Risk Calculations. C-reactive protein may play an additional role in risk prediction. Ongoing monitoring for all components of the metabolic syndrome is necessary. Individuals at high risk require multimodal interventions, including lifestyle interventions and targeted medications as appropriate.

scholarly journals Occurrence of the metabolic syndrome in newly diagnosed hypertensive adult Gujarati patients in G. K. General Hospital, Bhuj

2020 ◽  
Vol 8 (12) ◽  
pp. 4460
Author(s):  
Aalisha U. Dodhiya ◽  
Darshan Patel
Keyword(s):  
Metabolic Syndrome ◽  
General Hospital ◽  
Hdl Cholesterol ◽  
Newly Diagnosed ◽  
The Metabolic Syndrome ◽  
Prior Consent ◽  
Low Hdl ◽  
Risk Patients ◽  
Laboratory Investigations ◽  
Larger Sample

Background: A study of 30 newly diagnosed hypertensive Gujarati patients visiting the OPD of G. K. General Hospital, Bhuj, Gujarat, India was carried out. The main aim of the study was to estimate the occurrence of metabolic syndrome in newly diagnosed hypertensive patientsMethods: The study was carried out in a period of 2 months and data was collected after obtaining prior consent of patients and IEC approval. Blood pressure, waist circumference and BMI (body mass index) of the selected patients were measured while blood sample was collected for the laboratory investigations. The data collected was analysed using appropriate softwareResults: On observation, out of 30 hypertensive patients 22 (73.33%) patients suffered from metabolic syndrome. Also in patients suffering from metabolic syndrome, along with hypertension 63.63% (n=14) patients suffered from hypertriglyceridemia, 68.18% (n=15) patients had low HDL cholesterol, 77.27% (n=17) patients had high FBS, 72.72% (n=16) patients had abnormal BMI and 63.63% (n=14) patients had abnormal waist circumference.Conclusions: This very high occurrence values signifies the need of study with larger sample size based on region for further evaluation to treat the high risk patients on early diagnosis.

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