scholarly journals A Case of Disseminated Histoplasmosis Detected in Peripheral Blood Smear Staining Revealing AIDS at Terminal Phase in a Female Patient from Cameroon

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Christine Mandengue Ebenye
Keyword(s):  
Hiv Infection ◽  
Peripheral Blood ◽  
Blood Smear ◽  
Histoplasma Capsulatum ◽  
Previous History ◽  
Peripheral Blood Smear ◽  
Sub Saharan Africa ◽  
Terminal Phase ◽  
Disseminated Histoplasmosis ◽  
Sub Saharan

Histoplasmosis is endemic in the American continent and also in Sub-Saharan Africa, coexisting with the African histoplasmosis. Immunosuppressed patients, especially those with advanced HIV infection develop a severe disseminated histoplasmosis with fatal prognosis. The definitive diagnosis of disseminated histoplasmosis is based on the detection ofHistoplasma capsulatumfrom patient’ tissues samples or body fluids. Among the diagnostic tests peripheral blood smear staining is not commonly used. Nonetheless a few publications reveal thatHistoplasma capsulatumhas been discovered by chance using this method in HIV infected patients with chronic fever and hence revealed AIDS at the terminal phase. We report a new case detected in a Cameroonian woman without any previous history of HIV infection. Peripheral blood smear staining should be commonly used for the diagnosis of disseminated histoplasmosis in the Sub-Saharan Africa, where facilities for mycology laboratories are unavailable.

scholarly journals Histoplasma capsulatum in peripheral blood smear

2009 ◽  
Vol 2009 (sep27 1) ◽  
pp. bcr0520091877-bcr0520091877
Author(s):  
N. K Singh ◽  
S. Nagendra
Keyword(s):  
Peripheral Blood ◽  
Blood Smear ◽  
Histoplasma Capsulatum ◽  
Peripheral Blood Smear

Disseminated histoplasmosis in peripheral blood smear

2021 ◽  
Author(s):  
Edwin Uriel Suárez ◽  
Carlos José Atencia ◽  
Catalina Quintero-Valencia
Keyword(s):  
Peripheral Blood ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Disseminated Histoplasmosis

scholarly journals Disseminated Histoplasmosis; A Threat in Advanced HIV Disease Population in Sub-Saharan Africa?

2021 ◽  
pp. 115-144
Author(s):  
Christine E. Mandengue ◽  
Bassey Ewa Ekeng ◽  
Rita O. Oladele
Keyword(s):  
Histoplasma Capsulatum ◽  
Clinical Stage ◽  
Sub Saharan Africa ◽  
World Health ◽  
Hiv Disease ◽  
African Countries ◽  
Tb Treatment ◽  
Disseminated Histoplasmosis ◽  
Sub Saharan ◽  
Advanced Hiv Disease

Background: Histoplasmosis is a neglected acquired immune deficiency syndrome (AIDS)-defining disease in sub-Saharan African countries, which is commonly misdiagnosed as tuberculosis (TB) due to similar imagery and clinical features; patients usually receive presumptive anti-TB treatment that is considered as anti-TB treatment failure. Patients with advanced human immunodeficiency virus (HIV) disease (AHD), CD4<200/mm3 or World Health Organisation clinical stage 3 or 4, develop disseminated histoplasmosis (DH) diagnosed at a late stage or at post-mortem, owing to poor clinical suspicion, lack of rapid diagnosis tools to offer rapid and accurate results, and non-availability and accessibility of appropriate antifungal medications. We report 31 cases of DH amongst patients with AHD in sub-Saharan African population from the literature, highlighting the challenging care issue in sub-Saharan Africa. Results: Out of 31 reported cases 64.51% (20/31) were caused by Histoplasma capsulatum var capsulatum, 48.38% (15/31) being immigrants in Europe, Canada and Japan, with 41.93% (13/31) mortality, and 6 cases having no reported outcome. The poor index of suspicion on the part of clinicians; the lack of skilled laboratory personnel and rapid and accurate diagnosis tools of histoplasmosis for a proper detection of either classical or African histoplasmosis coexisting in many sub-Saharan African countries; and the non-availability and accessibility of appropriate antifungal medications were the most challenges in caring DH in advanced HIV disease population in sub-Saharan Africa. Conclusion: there is a need for prompt and routine screening of advanced HIV disease patients in sub-Saharan Africa for histoplasmosis as an AIDS-defining illness.

Disseminated histoplasmosis in peripheral blood smear

Blood ◽  
2014 ◽  
Vol 123 (10) ◽  
pp. 1445-1445 ◽  
Author(s):  
Haeseong Park ◽  
Danielle Shafer
Keyword(s):  
Peripheral Blood ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Disseminated Histoplasmosis

scholarly journals Disseminated histoplasmosis diagnosed in a peripheral blood smear

2017 ◽  
Vol 50 (1) ◽  
pp. 148-148 ◽  
Author(s):  
André Luiz Maltos ◽  
Evaldo Maia ◽  
Cristina da Cunha Hueb Barata de Oliveira
Keyword(s):  
Peripheral Blood ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Disseminated Histoplasmosis
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