scholarly journals Bone Mineralization in Celiac Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Tiziana Larussa ◽  
Evelina Suraci ◽  
Immacolata Nazionale ◽  
Ludovico Abenavoli ◽  
Maria Imeneo ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Bone Mineralization ◽  
Nuclear Factor ◽  
Mineral Density ◽  
Factor B ◽  
Additional Information ◽  
Bone Injury ◽  
Parathyroid Function ◽  
Receptor Activator ◽  
Calcium Malabsorption

Evidence indicates a well-established relationship between low bone mineral density (BMD) and celiac disease (CD), but data on the pathogenesis of bone derangement in this setting are still inconclusive. In patients with symptomatic CD, low BMD appears to be directly related to the intestinal malabsorption. Adherence to a strict gluten-free diet (GFD) will reverse the histological changes in the intestine and also the biochemical evidence of calcium malabsorption, resulting in rapid increase of BMD. Nevertheless, GFD improves BMD but does not normalize it in all patients, even after the recovery of intestinal mucosa. Other mechanisms of bone injury than calcium and vitamin D malabsorption are thought to be involved, such as proinflammatory cytokines, parathyroid function abnormalities, and misbalanced bone remodeling factors, most of all represented by the receptor activator of nuclear factor B/receptor activator of nuclear factor B-ligand/osteoprotegerin system. By means of dual-energy X-ray absorptiometry (DXA), it is now rapid and easy to obtain semiquantitative values of BMD. However, the question is still open about who and when submit to DXA evaluation in CD, in order to estimate risk of fractures. Furthermore, additional information on the role of nutritional supplements and alternative therapies is needed.

scholarly journals Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/β-Catenin/ATF4 Signaling Pathways

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 506 ◽  
Author(s):  
Hyeon Choi ◽  
Gyeong-Ji Kim ◽  
Han-Seok Yoo ◽  
Da Song ◽  
Kang-Hyun Chung ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Vitamin C ◽  
Signaling Pathways ◽  
Nuclear Factor Kappa B ◽  
Type I ◽  
Nuclear Factor ◽  
Mineral Density ◽  
Nuclear Factor Kappa ◽  
Ovx Rats ◽  
Receptor Activator

This study evaluated the effects of vitamin C on osteogenic differentiation and osteoclast formation, and the effects of vitamin C concentration on bone microstructure in ovariectomized (OVX) Wistar rats. Micro-computed tomography analysis revealed the recovery of bone mineral density and bone separation in OVX rats treated with vitamin C. Histomorphometrical analysis revealed improvements in the number of osteoblasts, osteoclasts, and osteocytes; the osteoblast and osteoclast surface per bone surface; and bone volume in vitamin C-treated OVX rats. The vitamin C-treated group additionally displayed an increase in the expression of osteoblast differentiation genes, including bone morphogenetic protein-2, small mothers against decapentaplegic 1/5/8, runt-related transcription factor 2, osteocalcin, and type I collagen. Vitamin C reduced the expression of osteoclast differentiation genes, such as receptor activator of nuclear factor kappa-B, receptor activator of nuclear factor kappa-B ligand, tartrate-resistant acid phosphatase, and cathepsin K. This study is the first to show that vitamin C can inhibit osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through the activation of wingless-type MMTV integration site family/β-catenin/activating transcription factor 4 signaling, which is achieved through the serine/threonine kinase and mitogen-activated protein kinase signaling pathways. Therefore, our results suggest that vitamin C improves bone regeneration.

Normal parathyroid function with decreased bone mineral density measurements in treated celiac disease

2000 ◽  
Vol 118 (4) ◽  
pp. A364
Author(s):  
Michel Boivin ◽  
Bernard Lemieux ◽  
Victor Plourde ◽  
Pierre Poitras ◽  
Raymond G. Lahaie ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Celiac Disease ◽  
Bone Mineral ◽  
Mineral Density ◽  
Density Measurements ◽  
Parathyroid Function

scholarly journals The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor κB legend with bone mineral density in older adults: the Rancho Bernardo Study

2007 ◽  
Vol 156 (5) ◽  
pp. 555-562 ◽  
Author(s):  
Anna Stern ◽  
Gail A Laughlin ◽  
Jaclyn Bergstrom ◽  
Elizabeth Barrett-Connor
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Mineral Density ◽  
Cross Sectional ◽  
Total Hip ◽  
Receptor Activator

Objective: The role of osteoprotegerin (OPG) and its receptor activator of nuclear factor κB legend (RANKL) in the regulation of bone in humans remain unclear. We examined the sex-specific associations of serum OPG, RANKL, and their ratio with bone mineral density (BMD) in older adults. Design: Participants were 681 community-dwelling adults, ages 45–90 years, who had serum OPG and RANKL measured and bone density scans in 1988–1991, with follow-up scans 5 and/or 10 years later. Methods: Analyses were sex-specific; women using and not using estrogen were evaluated separately. Cross-sectional analyses used multivariable regression models; longitudinal analyses used repeated measures mixed effects models. Results: In cross-sectional analyses, age- and weight-adjusted serum OPG levels were significantly positively associated with BMD at the lumbar spine in men, and at the femoral neck, total hip, and lumbar spine in women using estrogen, but not in non-users of estrogen. RANKL concentrations were significantly and inversely associated with BMD in men only, and at the total hip. Neither OPG nor RANKL was significantly associated with bone loss. Results for the RANKL/OPG ratio were the same as those for RANKL alone. Conclusions: These results suggest a modulatory effect of both endogenous and exogenous sex hormones on the biologic interaction of OPG, RANKL, and bone.

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