scholarly journals Reversal of Jaundice in Two Patients with Inoperable Cholangiocarcinoma Treated with Cisplatin and Gemcitabine Combination

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Maarten Criel ◽  
Filip Geurs ◽  
Siegfried Ponette ◽  
Katrien Bulte ◽  
Johan Ponette
Keyword(s):  
Liver Function ◽  
Combination Chemotherapy ◽  
Serum Bilirubin ◽  
Liver Function Tests ◽  
Normal Serum ◽  
Tumor Type ◽  
Chemotherapeutic Approach ◽  
Function Tests ◽  
Severe Jaundice

Two patients are presented with severe jaundice, due to inoperable cholangiocarcinoma. The chemotherapeutic approach in patients with severe jaundice is discussed. Many schedules of chemotherapy were developed in this tumor type with normal serum bilirubin. We report here the first successful use of cisplatin and gemcitabine combination chemotherapy in these patients. Tolerability was good and liver function tests gradually improved.

scholarly journals Comparative study of anthropometric measurements, liver function tests, hemoglobin and plasma glucose levels between individuals with alcohol abuse and controls

2019 ◽  
Vol 6 (4) ◽  
pp. 1064
Author(s):  
P. C. Lalramenga ◽  
Honey Satish Savla ◽  
Naveen P.
Keyword(s):  
Alcohol Abuse ◽  
Liver Function ◽  
Plasma Glucose ◽  
Serum Bilirubin ◽  
Liver Function Tests ◽  
Anthropometric Measurements ◽  
Years Of Life Lost ◽  
Glucose Levels ◽  
Function Tests ◽  
The Mean

Background: Alcohol abuse is global burden to families as well as society. On the ‘years of life lost scale’, which is based on alcohol attributable years of life lost, India has been rated 4 on a scale of 1 to 5. This implies that the alcohol consuming population of our country loses most of the years of their life because of drinking and its consequences. The aim of this research is to compare anthropometric measurements, liver function tests, haemoglobin and plasma glucose levels in individuals with alcohol abuse and normal population.Methods: The study was conducted in the Department of General Medicine, Civil Hospital, Aizawl. 84 cases of individuals with alcohol abuse (as per DSM-IV criteria) within the age group of 18-70 years and 70 age, sex, height and weight matched lifetime abstainers, healthy individuals were taken as controls from medicine department. They underwent a detailed clinical examination, anthropometric measurements, liver function tests, haemoglobin and plasma glucose levels.Results: 15.5% of the individuals with alcohol abuse had hypertension. The mean post prandial glucose among the individuals with alcohol abuse was 116.8±12.3 mg/dl and among the controls was 121.1±11.0 mg/dl. Mean serum bilirubin 1.1 mg/dl, AST 79 IU/l & ALT was 79.6 in alcoholics. The mean serum bilirubin 0.8 mg/dl, AST 27.2 IU/l and ALT was 29.4 in non-alcoholics.Conclusions: The individuals with alcohol abuse have raised serum bilirubin, AST and ALT levels compared to the non-alcoholics. Prevalence of hypertension is higher in the individuals with alcohol abuse compared to normal population.

scholarly journals COMPARISON OF LIVER FUNCTION TESTS OF NORMALAND PRE-ECLAMPTIC PREGNANT FEMALES: A HOSPITAL BASED STUDY

2020 ◽  
pp. 8-9
Author(s):  
Shayista Gull
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Total Protein ◽  
Serum Bilirubin ◽  
Complete Blood Count ◽  
Liver Function Tests ◽  
Unknown Etiology ◽  
Serum Total Protein ◽  
Function Tests ◽  
Function Test

Background: Pre-eclampsia is a multi-system disorder of unknown etiology involving almost every organ of body including kidney, liver, brain, heart, stomach and adrenals. In liver periportal hemorrhagic necrosis, ischemic lesions and fibrin deposition occurs due to thrombosis of arterioles. Objective: To compare the liver function tests in normal pregnancy and preeclampsia Methodology: This study was conducted in the Department of Obstetrics and Gynaecology, SKIMS, Soura, Kashmir for 18 months. Participants were divided into two groups: Cases: Comprised of 200 patients with toxemia of pregnancy, Controls: comprised of 500 normal, healthy normotensive pregnant women. This group was studied to get the normal values of liver enzymes and served as controls. A complete blood count, microscopic examination of urine, liver function test, kidney function test , 24 hour urinary protein estimation was done on all participants. Results: Among the cases, 49(24.5%) patients while 76 (15.2%) controls had deranged serum bilirubin. Ninety-nine(49.5%) cases had deranged ALT while 16(3.2%) controls had so. Among the cases, 103(51.5%) had deranged AST level while it was deranged in 64(12.8%) controls. ALP and serum total protein followed similar pattern (more deranged in cases than controls). Conclusion: Liver function test impairment occurs in preeclampsia which is characterized by rise in mean level of serum transaminase levels and serum bilirubin level and fall in serum total protein and albumin level.

scholarly journals Biochemical Evaluation of Serum Bilirubin Fractions and Liver Function Tests in Sepsis Neonates with Hyperbilirubinemia

2016 ◽  
Vol 7 (1) ◽  
pp. 38
Author(s):  
Biswajit Das ◽  
Suma H. R. ◽  
Kavitha P. Rasalkar ◽  
Abdul Nasar S. ◽  
Suvarna Devi C. ◽  
...  
Keyword(s):  
Liver Function ◽  
Serum Bilirubin ◽  
Liver Function Tests ◽  
Function Tests ◽  
Biochemical Evaluation

scholarly journals Study of liver function tests and spontaneous bacterial peritonitis in a patients of liver cirrhosis

2020 ◽  
Vol 7 (3) ◽  
pp. 421
Author(s):  
Sangram S. Mangudkar ◽  
Sachin K. Shivnitwar ◽  
Vijayashree S. Gokhale ◽  
Ameya A. Ithape
Keyword(s):  
Liver Cirrhosis ◽  
Liver Function ◽  
Bacterial Infections ◽  
Spontaneous Bacterial Peritonitis ◽  
Defense Mechanism ◽  
Serum Bilirubin ◽  
Tertiary Care ◽  
Liver Function Tests ◽  
Bacterial Peritonitis ◽  
Function Tests

Background: Liver cirrhosis patients are highly susceptible to bacterial infections specially Spontaneous bacterial peritonitis (SBP) which is commonest infection. this study undertaken to understand liver function tests and Spontaneous bacterial peritonitis in patients of liver cirrhosis admitted to tertiary care hospital.Methods: A descriptive cross-sectional study conducted among Liver cirrhosis patients in tertiary care center. Total 100 liver cirrhotic patients were included in present study. All the patients were subjected for biochemical evaluation of Serum albumin and globulin level, Serum bilirubin, SGOT (Serum glutamic oxaloacetic transaminase), SGPT (Serum glutamic pyruvate transaminase) and Ascitic fluid polymorph nuclear neutrophil (PMN) count to diagnose SBP.Results: Spontaneous bacterial peritonitis was present in 12% patients. Relation of Serum bilirubin level and SBP was statistically significant. Relation of serum SGOT, SGPT level and serum globulin between SBP and non-SBP group was statistically non-significant.Conclusions: Liver cirrhosis patients are susceptible for bacterial infections because of defects in various host defense mechanism and hence patients of liver cirrhosis must be screened for spontaneous bacterial peritonitis along with liver function tests.

scholarly journals Comparison of Sensitivity of TLC and Liver Assay in Diagnosing Appendicitis and Complicated Appendicitis at a Rural Medical Institution

2020 ◽  
Vol 7 (46) ◽  
pp. 2710-2713
Author(s):  
Sandeep Kumar Goyal ◽  
Vilkram Saini ◽  
Minaxi Saini ◽  
Gopal Singhal ◽  
Kanishak Mehta ◽  
...  
Keyword(s):  
Liver Function ◽  
Acute Appendicitis ◽  
Serum Bilirubin ◽  
Clinical Signs ◽  
Liver Function Tests ◽  
Complicated Appendicitis ◽  
Total Serum Bilirubin ◽  
Total Leukocyte Count ◽  
Total Serum ◽  
Function Tests

BACKGROUND Diagnosis of acute appendicitis is always a challenging task in emergency ward which can most of the time be diagnosed with thorough history and physical examination by surgeon, various clinical signs and laboratory investigations like total leukocyte count (TLC), neutrophils shift to left. Unnecessary surgical interventions of appendix can be reduced by precise diagnosis of levels of TLC and total serum bilirubin values. We wanted to evaluate the sensitivity of laboratory marker like TLC and liver function tests in diagnosing a case of appendicitis and complicated appendicitis. METHODS 100 patients who were admitted in the Department of General Surgery, Maharaja Agrasen Medical Collage, Agroha (Hisar), with clinical diagnosis of acute appendicitis were included in the study. Data was statistically analysed and sensitivity of TLC and liver function test in diagnosing acute appendicitis was compared. RESULTS Sensitivity of TLC was found to be 47 %; that of total serum bilirubin was 72 % which is significant; that of SGOT was 26 %; that of SGPT was 21 % and that of ALP was 8 % in diagnosing acute appendicitis. While comparing sensitivity of this marker to diagnose complicated appendicitis (gangrenous and perforated appendix) it was 56.3 % for TLC, 100 % for total serum bilirubin, 31.3 % for SGOT, 37.5 % for SGPT and 12.5 % for ALP. CONCLUSIONS Raised total serum bilirubin has potential to detect complications of appendicitis and the need for early intervention by surgeon. KEYWORDS Appendicitis; Liver Function Tests; Serum Bilirubin

scholarly journals DETERMINATION OF REFERENCE INTERVAL OF LIVER FUNCTION TESTS DURING PREGNANCY IN URBAN AREA OF DISTRICT RAWALPINDI PAKISTAN

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S250-54
Author(s):  
Alveena Younas ◽  
Mehwish Gilani ◽  
Qurat Ul Ain ◽  
Naveed Asif ◽  
Muhammad Aamir ◽  
...  
Keyword(s):  
Liver Function ◽  
Serum Bilirubin ◽  
Armed Forces ◽  
Reference Interval ◽  
Liver Function Tests ◽  
Second Trimester ◽  
Serum Samples ◽  
Intrauterine Pregnancy ◽  
Cross Sectional ◽  
Function Tests

Objective: To determine the reference Interval of liver function tests during uncomplicated pregnancy inpopulation of Rawalpindi and assess their correlation over first and second trimesters of pregnancy. Study Design: Cross sectional study. Place and Duration of Study: Department of Chemical Pathology & Endocrinology Armed Forces Institute ofPathology Rawalpindi from Feb 2017 to Jun 2018. Methodology: Seven hundred and fifty four pregnant women with uncomplicated, single intrauterine pregnancy were recruited from Rawalpindi. Thirteen patients with known history of Diabetes Mellitus, hypertension, liver disease, renal disorders and those on anti-epileptics, non-steroidal anti-inflammatory drugs and steroids were excluded from the study. Blood sample was taken from each subject to analyze serum bilirubin, albumin, total alkaline phosphates and alanine aminotransferase on random access discrete auto analyser, ADVIA 1800 Chemistry system manufactured in Japan for Siemens Healthcare Diagnostics Inc. Data for serum bilirubin, albumin, ALP and ALT were expressed as mean ± standard deviation. As the reference data followed the Gaussian distribution, therefore the 2.5th and 97.5th percentiles were estimated by values approximately 2SD on each side of mean. Results: After analysis of serum samples of 754 subjects, the reference intervals for bilirubin, albumin, ALP andALT during first trimester were; bilirubin 3-9 µmol/l, albumin 31-45 g/L, ALP 122-224 U/l and ALT 3-35 U/l, while of second trimester were: bilirubin 2- 7µmol/l, albumin 28-45 g/L, ALP131-300U/l and ALT 1-33U/l. Conclusion: First and second trimester wise reference values of Liver Function Tests have been determined inpregnancy in this study. This would not only........

scholarly journals Liver function tests in patients of pre-eclampsia in Bhilai, Chhattisgarh, India: a clinical study

2018 ◽  
Vol 7 (12) ◽  
pp. 5102
Author(s):  
Rashid Lodhi ◽  
Navanil Roy
Keyword(s):  
Blood Pressure ◽  
Liver Function ◽  
Pregnant Women ◽  
Total Protein ◽  
Liver Enzymes ◽  
Serum Bilirubin ◽  
Liver Function Tests ◽  
Mean Value ◽  
Function Tests ◽  
The Mean

Background: Pre-eclampsia is a multisystem disorder, which occurs only in pregnant women during the second and third trimesters of pregnancy and is associated with raised blood pressure and proteinuria. Liver function Test (LFT) abnormalities occur in 3% of the pregnancies and probably the lesion that causes elevated serum liver enzymes. This study was conducted to compare the liver function tests in pre-eclampsia with normal pregnancy.Methods: This study was carried out on 60 pregnant women after 20 weeks of gestation admitted in Obstetrics and Gynaecology units of Shri Shankaracharya Institute of Medical Sciences, Bhilai, and Chhattisgarh. The subjects were divided into two groups. Group A comprised of 30 cases of pre-eclampsia having blood pressure ≥ 140/90mm Hg, proteinuria in 24 hours ≥ 300 mg and edema.  Group B had 30 normal pregnant women after 20 weeks of gestation. The data including parity, period of gestation, blood pressure and presenting complaints of all subjects were recorded. Serum bilirubin, total protein, albumin and plasma levels of liver enzymes ALT and AST were measured.Results: The mean value of serum bilirubin in cases was 3.45 and in controls it was 0.50. The mean value of enzymes ALT in cases was 92.7 while in the controls it was 22.37. Mean serum AST in the cases was 85.43 and in the controls,  it was 21.96. Total protein in cases was 7.77 and controls it was 7.26. Albumin level in cases was 4.62 and controls were 4.17.Conclusions: Increased concentrations of serum bilirubin, total protein, albumin and liver enzymes ALT, AST were found in pre-eclampsia cases.

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