scholarly journals Small-for-Gestational-Age Births in Pregnant Women with HIV, due to Severity of HIV Disease, Not Antiretroviral Therapy

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Erika Aaron ◽  
Alexa Bonacquisti ◽  
Leny Mathew ◽  
Gregg Alleyne ◽  
Laura P. Bamford ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Bivariate Analysis ◽  
Hiv Disease ◽  
Prospective Data ◽  
Record Data ◽  
Chi Squared ◽  
Women With Hiv ◽  
Birth Weight Distribution

Objectives. To determine rate and factors associated with small-for-gestational-age (SGA) births to women with HIV.Methods. Prospective data were collected from 183 pregnant women with HIV in an urban HIV prenatal clinic, 2000–2011. An SGA birth was defined as less than the 10th or 3rd percentile of birth weight distribution based upon cut points developed using national vital record data. Bivariate analysis utilized chi-squared andt-tests, and multiple logistic regression analyses were used.Results. The prevalence of SGA was 31.2% at the 10th and 12.6% at the 3rd percentile. SGA at the 10th (OR 2.77; 95% CI, 1.28–5.97) and 3rd (OR 3.64; 95% CI, 1.12–11.76) percentiles was associated with cigarette smoking. Women with CD4 count >200 cells/mm3at the first prenatal visit were less likely to have an SGA birth at the 3rd percentile (OR 0.29; 95% CI, 0.10–0.86). Women taking NNRTI were less likely to have an SGA infant at the 10th (OR 0.28; 95% CI, 0.10–0.75) and 3rd (OR 0.16; 95% CI, 0.03–0.91) percentiles compared to those women on PIs.Conclusions. In this cohort with high rates of SGA, severity of HIV disease, not ART, was associated with SGA births after adjusting for sociodemographic, medication, and disease severity.

Performance of a local reference curve for predicting small for gestational age fetuses in pregnant women with HIV / AIDS

2020 ◽  
Author(s):  
Daniel Massamatsu Pianovski Kato ◽  
Liziane Lorusso ◽  
Rafael Frederico Bruns ◽  
Elisa Chicareli Pinhat ◽  
Natália Roberta Andrade Dalla Costa ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Reference Curve ◽  
Local Reference ◽  
Women With Hiv ◽  
Hiv Aids

scholarly journals Risk of Dysglycemia in Pregnancy amongst Kenyan Women with HIV Infection: A Nested Case-Control Analysis from the STRiDE Study

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Sonak D. Pastakia ◽  
Wycliffe K. Kosgei ◽  
Astrid Christoffersen-Deb ◽  
Benson Kiragu ◽  
John N. Hector ◽  
...  
Keyword(s):  
Family History ◽  
Pregnant Women ◽  
Gestational Age ◽  
Fasting Glucose ◽  
Case Control ◽  
Oral Glucose ◽  
Control Analysis ◽  
History Of ◽  
Women With Hiv ◽  
Nested Case Control

Introduction. Gestational diabetes is a common complication, whose incidence is growing globally. There is a pressing need to obtain more data on GDM in low- and middle-income countries, especially amongst high-risk populations, as most of the data on GDM comes from high-income countries. With the growing awareness of the role HIV plays in the progression of noncommunicable diseases and the disproportionate HIV burden African countries like Kenya face, investigating the potential role HIV plays in increasing dysglycemia amongst pregnant women with HIV is an important area of study. Methods. The STRiDE study is one of the largest ever conducted studies of GDM in Kenya. This study enrolled pregnant women aged between 16 and 50 who were receiving care from public and private sector facilities in Eldoret, Kenya. Within this study, women received venous testing for glycosylated hemoglobin (HbA1c) and fasting glucose between 8- and 20-week gestational age. At their 24-32-week visit, they received a venous 75 g oral glucose tolerance test (OGTT). Because of the pressing need to assess the burden of GDM within the population of pregnant women with HIV, a nested case-control study design was used. Pregnant women with HIV within the larger STRiDE cohort were matched to non-HIV-infected women within the STRiDE cohort at a 1 : 3 ratio based on body mass index, parity, family history of GDM, gestational age, and family history of hypertension. The measurements of glucose from the initial visit (fasting glucose and HbA1c) and follow-up visit (OGTT) were compared between the two groups of HIV+ cases and matched HIV- controls. Results. A total of 83 pregnant women with HIV were well matched to 249 non-HIV-infected women from the STRiDE cohort with marital status being the only characteristic that was statistically significantly different between the two groups. Statistically significant differences were not observed in the proportion of women who developed GDM, the fasting glucose values, the HbA1c, or OGTT measurements between the two groups. Discussion. Significant associations were not seen between the different measures of glycemic status between pregnant women with and without HIV. While significant differences were not seen in this cohort, additional investigation is needed to better describe the association of dysglycemia with HIV, especially in Kenyan populations with a higher prevalence of GDM.

scholarly journals FACTORS RELATED TO ANEMIA IN PREGNANT WOMEN EVENTS IN GENERAL HOSPITAL REGIONAL dr. ZAINOEL ABIDIN

2017 ◽  
Vol 1 (2) ◽  
Author(s):  
Faradilla Safitri ◽  
Mizan Jalinan
Keyword(s):  
At Risk ◽  
Pregnant Women ◽  
General Hospital ◽  
Gestational Age ◽  
Univariate Analysis ◽  
The Body ◽  
Bivariate Analysis ◽  
Blood Disorder ◽  
The Relationship ◽  
Education Work

Anemia is a common blood disorder that occurs when levels of red bloodcells in the body becomes too low. Data from Riskesdas the year 2013 thenumber of pregnant women suffer from anemia as much as 37.1%, this isvery different to the incidence of anemia among pregnant women in theDistrict General Hospital dr. Zainoel Abidin with a very low percentage of2.9% to 3.4%. To analyze the relationship between age, parity, education,occupation, gestational age, origin of a referral, and health servicesResearch methodsThis type of research is analytic survey using casecontrol design. Univariate analysis found women with anemia 33.3% andanemia not as much as 66.7%. Bivariate analysis between age <20 yearswith anemia (p = 0.001, OR = 9.549), parity (p = 0.001, OR = 1.955),gestational age (p = 0.027, OR = 1.608), education (p = 0.002, OR =2.338), occupation (p = 0.006, OR = 2.167). Results of multivariateanalysis the dominant variable is the age of the OR (age> 35 years =9.009 and aged <20 years = 6.994). No correlation between age, parity,gestational age, education, work with anemia among pregnant women. allpregnant women at risk for anemia, pregnant women should routinely visitantenatal care, because the mother will get information about thenutritional needs during pregnancy and other factors that can lead toanemia during pregnancy.Keywords: Anemia, age, education, gestational age, parity

scholarly journals Preconception use of cART by HIV-positive pregnant women increases the risk of infants being born small for gestational age

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0191389 ◽  
Author(s):  
Ingrid J. M. Snijdewind ◽  
Colette Smit ◽  
Mieke H. Godfried ◽  
Rachel Bakker ◽  
Jeannine F. J. B. Nellen ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Hiv Positive

scholarly journals P0150APREECLAMPSIA ABOUT 252 PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Boubchir Akli ◽  
Boubchir Akli ◽  
Brahim Kichou ◽  
MADIOU ALI
Keyword(s):  
Risk Factors ◽  
Adverse Events ◽  
Pregnant Women ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Fetal Death ◽  
Gestational Hypertension ◽  
Adverse Outcomes ◽  
Previous Pregnancy ◽  
Fetal Complications

Abstract Background and Aims The main objective was to estimate the prevalence of pre-eclampsia (PE) in pregnant women in Tizi-ouzou (Algeria). Secondary objectives were to estimate the frequency of PE risk factors, and the incidence of maternal and fetal complications. Methods Our study was observational, prospective and descriptive, including all pregnant women at the prenatal appointment in the 2 maternity units of Tizi-ouzou, between January 2012 and June 2013. PE was diagnosed if gestational hypertension was associated with proteinuria &gt; 300mg/24h, after 20 weeks of gestation. Results We had 252 cases of PE on 3225 pregnant women. The prevalence of PE was 7.8% (CI 95%: 6.9%–8.7%). The most frequent PE risk factors were nulliparity (56%), age &gt;40 years (27%), obesity (26%) and PE in any previous pregnancy (21%). The incidence of maternal adverse events was 28.7% (CI 95%: 23.1%–34.3%), including 5 deaths. The rates of prematurity, small for gestational age infant and fetal death were 58.2%, 49.7% and 6.7%, respectively. Conclusion The prevalence of PE in pregnant women in Tizi-ouzou is around 8%. The incidence of maternal and fetal adverse outcomes remains high. Only earlier diagnosis and closer monitoring could improve the prognosis of our patients, since the treatment of PE remains currently childbirth.

scholarly journals Examining the predictive accuracy of metabolomics for small-for-gestational-age babies: a systematic review

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e031238 ◽  
Author(s):  
Debora Farias Batista Leite ◽  
Aude-Claire Morillon ◽  
Elias F Melo Júnior ◽  
Renato T Souza ◽  
Fergus P McCarthy ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Predictive Accuracy ◽  
Grey Literature ◽  
Synthesis Methods ◽  
Significant Heterogeneity ◽  
Second Trimester ◽  
Case Control Studies ◽  
Eligibility Criteria

IntroductionTo date, there is no robust enough test to predict small-for-gestational-age (SGA) infants, who are at increased lifelong risk of morbidity and mortality.ObjectiveTo determine the accuracy of metabolomics in predicting SGA babies and elucidate which metabolites are predictive of this condition.Data sourcesTwo independent researchers explored 11 electronic databases and grey literature in February 2018 and November 2018, covering publications from 1998 to 2018. Both researchers performed data extraction and quality assessment independently. A third researcher resolved discrepancies.Study eligibility criteriaCohort or nested case–control studies were included which investigated pregnant women and performed metabolomics analysis to evaluate SGA infants. The primary outcome was birth weight <10th centile—as a surrogate for fetal growth restriction—by population-based or customised charts.Study appraisal and synthesis methodsTwo independent researchers extracted data on study design, obstetric variables and sampling, metabolomics technique, chemical class of metabolites, and prediction accuracy measures. Authors were contacted to provide additional data when necessary.ResultsA total of 9181 references were retrieved. Of these, 273 were duplicate, 8760 were removed by title or abstract, and 133 were excluded by full-text content. Thus, 15 studies were included. Only two studies used the fifth centile as a cut-off, and most reports sampled second-trimester pregnant women. Liquid chromatography coupled to mass spectrometry was the most common metabolomics approach. Untargeted studies in the second trimester provided the largest number of predictive metabolites, using maternal blood or hair. Fatty acids, phosphosphingolipids and amino acids were the most prevalent predictive chemical subclasses.Conclusions and implicationsSignificant heterogeneity of participant characteristics and methods employed among studies precluded a meta-analysis. Compounds related to lipid metabolism should be validated up to the second trimester in different settings.PROSPERO registration numberCRD42018089985.

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