scholarly journals Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Hao Qian ◽  
Na Luo ◽  
Yuling Chi
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Molecular Mechanism ◽  
Major Risk Factor ◽  
Cardiovascular Disorders ◽  
Endothelium Dysfunction ◽  
Age Related ◽  
Endothelium Function ◽  
Available Information ◽  
Age Related Changes

Age-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence indicates that the age-related changes in endothelial eicosanoids contribute to decline in endothelium function and are associated with pathological dysfunction. In this review we summarize currently available information on aging-shifted prostaglandin profiles in endothelium and how these shifts are associated with cardiovascular disorders, providing one molecular mechanism of age-associated endothelium dysfunction and cardiovascular diseases.

Subclinical Hypothyroidism as a Risk Factor for Cardiovascular Disease

2021 ◽  
Vol 15 (9) ◽  
pp. 2748-2752
Author(s):  
Roman Evgenyevich Tokmachev ◽  
Andrey Valerievich Budnevsky ◽  
Andrey Yakovlevich Kravchenko ◽  
Tatiana Alexandrovna Chernik ◽  
Sudakov Oleg Valerievich ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Cause Of Death ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Epidemiological Studies ◽  
Cardiovascular Disorders ◽  
The World

Nowadays, more than 485 million people in the world suffer from cardiovascular diseases (CVD). According to large epidemiological studies, the group of CVD is the leading cause of death in the world. One of the neurohumoral mechanisms that appears to be a risk factor for CVD is thyroid dysfunction. In this regard, in recent years, more and more attention is paid to the study the influence of subclinical hypothyroidism on the occurrence and development of cardiovascular disorders. MeSH words: cardiovascular diseases, subclinical hypothyroidism

Abstract T P136: Potential Contributors to the Declining Impact of Stroke Risk Factors with Age: Implications for Stroke Epidemiology in the Elderly

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
George Howard ◽  
Mary Cushman ◽  
Maciej Banach ◽  
Brett M Kissela ◽  
David C Goff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Stroke Risk ◽  
Multivariable Analysis ◽  
The Elderly ◽  
Stroke Risk Factors ◽  
Age Related ◽  
Increased Risk ◽  
The Impact ◽  
Age Related Changes

Purpose: The importance of stroke research in the elderly is increasing as America is “graying.” For most risk factors for most diseases (including stroke), the magnitude of association with incident events decreases at older ages. Potential changes in the impact of risk factors could be a “true” effect, or could be due to methodological issues such as age-related changes in residual confounding. Methods: REGARDS followed 27,748 stroke-free participants age 45 and over for an average of 5.3 years, during which 715 incident strokes occurred. The association of the “Framingham” risk factors (hypertension [HTN], diabetes, smoking, AFib, LVH and heart disease) with incident stroke risk was assessed in age strata of 45-64 (Young), 65-74 (Middle), and 75+ (Old). For those with and without an “index” risk factor (e.g., HTN), the average number of “other” risk factors was calculated. Results: With the exception of AFib, there was a monotonic decrease in the magnitude of the impact across the age strata, with HTN, diabetes, smoking and LVH even becoming non-significant in the elderly (Figure 1). However, for most factors, the increasing prevalence of other risk factors with age impacts primarily those with the index risk factor absent (Figure 2, example HTN as the “index” risk factor). Discussion: The impact of stroke risk factors substantially declined at older ages. However, this decrease is partially attributable to increases in the prevalence of other risk factors among those without the index risk factor, as there was little change in the prevalence of other risk factors in those with the index risk factor. Hence, the impact of the index risk factor is attenuated by increased risk in the comparison group. If this phenomenon is active with latent risk factors, estimates from multivariable analysis will also decrease with age. A deeper understanding of age-related changes in the impact of risk factors is needed.

scholarly journals A CASE STUDY ON ESSENTIAL HYPERTENSION MANAGING THROUGH AYURVEDA W.S.R. RAKTAGATA VYAN VAISHAMYA

2021 ◽  
Vol p5 (4) ◽  
pp. 2965-2968
Author(s):  
Ruhi Zahir ◽  
Iqbal Khan
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Risk Factor ◽  
Essential Hypertension ◽  
Cardiovascular Diseases ◽  
High Blood Pressure ◽  
Direct Reference ◽  
Major Risk Factor ◽  
End Stage

Essential hypertension is high blood pressure that doesn't have any known etiopathology. Most of sufferers (85%) are asymptomatic and as per available reports, in more than 95% cases of hypertension under lying cause is not found. It is estimated that 600 million people are affected worldwide. Hypertension is a major risk factor for the development of cardiovascular diseases (CVD). Its impact is greatest on stroke, MI and end stage is renal failure as it’s known as a Silent Killer. Hence there is no direct reference of hypertension in Ayurvedic classics by name as well as by its path physiological views. Many works have been carried out on hypertension to evaluate the perfect diagnosis and mode of treatment on the basis of Different nomenclatures also have been adopted by Ayurveda experts like Raktagata Vata, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Raktavrita Vata, Siragata Vata etc. Keywords: Essential hypertension, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Cardiovascular diseases, Silent Killer.

scholarly journals Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3

2020 ◽  
Vol 245 (15) ◽  
pp. 1326-1334
Author(s):  
Mohamed M Elseweidy ◽  
Sousou I Aly ◽  
Sally K Hammad ◽  
Noura I Shershir
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Rat Model ◽  
Myocardial Injury ◽  
Major Risk Factor ◽  
Albino Rats ◽  
Fatty Acid Binding ◽  
Reactive Protein ◽  
Hypercholesterolemic Diet

Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury. The present study aimed to illustrate the myocardial injury induced in a diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-DHGD intake either individually or in combination form. Male albino rats were selected for the study, received alloxan, hypercholesterolemic diet, and categorized into four groups. The first one (DHC), received hypercholesterolemic diet only and referred to as control. The remaining groups (2, 3, 4) received vitamin D3, 10-DHGD, and combination of both, respectively. Certain biomarkers that were selected for MI evaluation included blood glucose, lipogram pattern, Copeptin, C-reactive protein, myeloperoxidase, heart fatty acid-binding protein, and histopathological changes in myocardium and aorta. Vitamin D3 and 10-DHGD intake induced significant hypoglycemic, hypolipidemic effects, decreased inflammation, and MI biomarkers. Decreased myocardial vacuoles, foam cells, and intimal lesions were also observed compared to DHC. Their combination intake induced more marked reduction in all biomarkers and showed a histopathological pattern similar to normal features of myocardium and aorta. Our findings suggest the therapeutic roles of vitamin D3, 10-DHGD, and their combination against myocardial injury in diabetic hyperlipidemic rats. Impact statement Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury (MI). The present study aimed to illustrate the pattern of myocardial injury induced in diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-dehydrogingerdione (10-DHGD) intake either individually or in combination form.

A focus on inflammation as a major risk factor for atherosclerotic cardiovascular diseases

2015 ◽  
Vol 14 (3) ◽  
pp. 391-403 ◽  
Author(s):  
Ida Gregersen ◽  
Sverre Holm ◽  
Tuva B Dahl ◽  
Bente Halvorsen ◽  
Pål Aukrust
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Major Risk Factor ◽  
Atherosclerotic Cardiovascular Diseases

scholarly journals Age-Associated Epigenetic Alterations, Somatic Mutations, and Their Crosstalk in Alzheimer’s Disease

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 636-637
Author(s):  
Yaroslav Markov ◽  
Kyra Thrush ◽  
Morgan Levine
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Somatic Mutations ◽  
Brain Regions ◽  
Major Risk Factor ◽  
Postmortem Brain ◽  
Biological Aging ◽  
Learning Approaches ◽  
Age Related

Abstract Aging is the major risk factor for Alzheimer’s Disease (AD), and as life expectancy increases, neurodegeneration will continue to afflict an ever-increasing proportion of the population. While numerous theories are attempting to explain the drivers behind AD pathology, what unites them is the observation that AD is reliably associated with a progressive buildup of age-related molecular changes. Because of the varying clinical presentations of AD in patients with similar genetic backgrounds, it has been postulated that epigenetics may be implicated in its etiology. Building on our prior work showing that AD pathology is linked to alterations in age-related DNA CpG methylation (DNAme) across various brain regions, we use state-of-the-art machine learning approaches to identify patterns of molecular damage in postmortem brain samples. We show that alterations in DNAme are associated with accelerated biological aging, AD, and the APOE e4 genotype, which is a major risk factor for AD. We also demonstrate that these associations are present in the PFC but not cerebellum -- in line with the current understanding of AD progression in the brain. Finally, we perform whole-exome sequencing and protein mass spectrometry on the same brain samples to test our hypothesis as to whether AD-associated alterations of DNAme are linked with the accumulation of somatic mutations that affect the structural and binding properties of protein epigenetic regulators.

scholarly journals Which One to Endorse Among the Multitude of Lipid Guidelines?

2015 ◽  
Vol 11 (1) ◽  
pp. 32
Author(s):  
Alper Sonmez ◽  
Keyword(s):  
Risk Assessment ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Major Risk Factor ◽  
Treatment Target ◽  
Advantages And Disadvantages ◽  
Lipid Guidelines ◽  
Atherosclerotic Cardiovascular Diseases

Dyslipidemia is the major risk factor for atherosclerotic cardiovascular diseases. A multitude of lipid guidelines exist, with several controversies, and the best approach in dyslipidemia management is not clear. The tools and lipoproteins used for risk assessment, whether to use a treatment target and implementing drugs other than statins are all controversial points. Until the time for the publication of an agreeable lipid guideline, physicians should choose their way by considering the advantages and disadvantages of the existing guidelines.

Age-Related Changes in Risk Factor Effects on the Incidence of Coronary Heart Disease

2002 ◽  
Vol 12 (3) ◽  
pp. 173-181 ◽  
Author(s):  
Robert D Abbott ◽  
J.David Curb ◽  
Beatriz L Rodriguez ◽  
Kamal H Masaki ◽  
Katsuhiko Yano ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Age Related ◽  
Changes In Risk ◽  
Age Related Changes

scholarly journals REVIEW ON UNDERSTANDING DYSLIPIDEMIA AND ITS MANAGEMENT IN AYURVEDA: A CONCEPTUAL PERSPECTIVE

2021 ◽  
Vol 12 (1) ◽  
pp. 150-153
Author(s):  
Lolashri S J ◽  
Kiran M Goud
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Lipid Level ◽  
Lifestyle Changes ◽  
Treatment Modalities ◽  
Cardiovascular Disorders ◽  
Metabolic Derangement

Lifestyle changes and alteration in diet brings about metabolic derangement eventually leading to conditions like Dyslipidemia. Raise in lipid level is the major cause and risk factor for Cardiovascular disorders, Diabetes mellitus etc. Globally one-third of incidence of Cardiovascular diseases are attributing by Dyslipidemia. In Ayurveda, this condition falls under the category of Santarpanotthavikara, which starts its pathology from the vitiation of kapha dosha, rasa and Medo dhatu. The prime Nidanas involved in this pathogenesis are Shleshmala ahara sevana, Adhyashana, avyayama and divaswapna. Considering these Nidana s and dosha-dushya vivechana our Acharya s mentioned about the administration of Guru-Atarpana dravyas, Vataghna annapana, Katu, Tikta, Kashaya rasa pradhana, Ruksha Ushna guna lines, treatment modalities like Vamana karma, Ruksha ushna Basti, Lekhana Basti, Ruksha Udvartana to tackle this condition.

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