scholarly journals Pulmonary Mucormycosis: An Emerging Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Mohammed Muqeetadnan ◽  
Ambreen Rahman ◽  
Syed Amer ◽  
Salman Nusrat ◽  
Syed Hassan ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Fungal Infection ◽  
Diabetic Patient ◽  
Patient Survival ◽  
Early Recognition ◽  
Immunocompromised Patients ◽  
Delay In Diagnosis ◽  
Pulmonary Mucormycosis ◽  
Aggressive Management ◽  
Life Threatening

Mucormycosis is a rare, but emerging, life-threatening, rapidly progressive, angioinvasive fungal infection that usually occurs in immunocompromised patients. We present a case of pulmonary mucormycosis in a diabetic patient who was on chronic steroid therapy for ulcerative colitis. Early recognition of this diagnosis, along with aggressive management, is critical to effective therapy and patient survival. The delay in diagnosis of this rapidly progressive infection can result in mortality.

scholarly journals A Rare Case of Fatal Endobronchial Mucormycosis Masquerading as Endobronchial Tuberculosis

Medicina ◽  
2020 ◽  
Vol 56 (2) ◽  
pp. 64
Author(s):  
Minjeong Kim ◽  
Jun Hyeok Lim ◽  
Mihwa Park ◽  
Hyung Keun Cha ◽  
Lucia Kim ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Diabetic Patient ◽  
Airway Obstruction ◽  
Rare Case ◽  
Immunocompromised Patients ◽  
Clinical Form ◽  
Pulmonary Mucormycosis ◽  
Endobronchial Tuberculosis

Pulmonary mucormycosis is a relatively rare but often fatal opportunistic fungal infection that occurs mostly in immunocompromised patients. Endobronchial mucormycosis, a distinct clinical form of pulmonary mucormycosis, is very rare, and only a few cases have been reported. The most common bronchoscopic findings in patients with endobronchial mucormycosis are stenosis, erythematous mucosa and airway obstruction. Here, we present a case of fatal endobronchial mucormycosis mimicking actively caseating endobronchial tuberculosis in a young diabetic patient living in a country with an intermediate tuberculosis burden.

scholarly journals Efficacy of Liposomal Amphotericin B and Posaconazole in Intratracheal Models of Murine Mucormycosis

2013 ◽  
Vol 57 (7) ◽  
pp. 3340-3347 ◽  
Author(s):  
Guanpingsheng Luo ◽  
Teclegiorgis Gebremariam ◽  
Hongkyu Lee ◽  
Samuel W. French ◽  
Nathan P. Wiederhold ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Intratracheal Instillation ◽  
Cortisone Acetate ◽  
Liposomal Amphotericin B ◽  
Immunocompromised Patients ◽  
Content Type ◽  
Pulmonary Mucormycosis ◽  
Life Threatening

ABSTRACTMucormycosis is a life-threatening fungal infection almost uniformly affecting diabetics in ketoacidosis or other forms of acidosis and/or immunocompromised patients. Inhalation ofMucoralesspores provides the most common natural route of entry into the host. In this study, we developed an intratracheal instillation model of pulmonary mucormycosis that hematogenously disseminates into other organs using diabetic ketoacidotic (DKA) or cyclophosphamide-cortisone acetate-treated mice. Various degrees of lethality were achieved for the DKA or cyclophosphamide-cortisone acetate-treated mice when infected with different clinical isolates ofMucorales. In both DKA and cyclophosphamide-cortisone acetate models, liposomal amphotericin B (LAmB) or posaconazole (POS) treatments were effective in improving survival, reducing lungs and brain fungal burdens, and histologically resolving the infection compared with placebo. These models can be used to study mechanisms of infection, develop immunotherapeutic strategies, and evaluate drug efficacies against life-threateningMucoralesinfections.

scholarly journals Pulmonary Mucormycosis with Diabetes Mellitus: A Case Report

2018 ◽  
Vol 2 (2) ◽  
pp. 33-34
Author(s):  
Shikha Jain ◽  
Bharat Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Case Report ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Immunocompromised Patients ◽  
Pulmonary Mucormycosis ◽  
Life Threatening

Mucormycosis is an uncommon but life threatening fungal infection that generally occurs mostly in immunocompromised patients. Patients do not respond to the antibiotics and so the condition may prove to be fatal if not timely detected. In this report, we summarize a case of pulmonary mucormycosis in a patient with diabetes mellitus who was cured using Amphotericin B.

scholarly journals COVID-19 Associated Rhino-Orbital Mucormycosis Complicated by Gangrenous and Bone Necrosis—A Case Report from Honduras

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 826
Author(s):  
Elsa Yolanda Palou ◽  
María Auxiliadora Ramos ◽  
Emec Cherenfant ◽  
Adoni Duarte ◽  
Itzel Carolina Fuentes-Barahona ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Early Diagnosis ◽  
Fungal Infection ◽  
Invasive Fungal Infection ◽  
Immunocompromised Patients ◽  
Bone Necrosis ◽  
Inappropriate Use ◽  
Prompt Treatment ◽  
Life Threatening

Background: Mucormycosis is a life-threatening invasive fungal infection most commonly observed in immunocompromised patients. Throughout the COVID-19 pandemic, a growing number of Mucorales associated infections, now termed COVID-19 associated mucormycosis (CAM), have been reported. Despite an increase in fatality reports, no cases of rhino-orbital CAM complicated with gangrenous bone necrosis have been described in the literature to date. Case: A 56-year-old male with a recent COVID-19 diagnosis developed rhino-orbital mucormycosis after 22 days of treatment with dexamethasone. Cultures and histopathological assessment of tissue biopsy confirmed the diagnosis. The patient survived after treatment with amphotericin B. Conclusions: Mucormycosis is an invasive fungal infection affecting mostly immunocompromised patients. Along with the COVID-19 pandemic, the inappropriate use of steroids, in addition to concurrent risk factors, such as diabetes, has led to an increase in the occurrence of these devastating mycoses, leading to the development of severe presentations and complications, as observed in many cases. Early diagnosis and prompt treatment are crucial in order to avoid dissemination and fatal outcomes.

scholarly journals Pulmonary Mucormycosis in Chronic Lymphocytic Leukemia and Neutropenia

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Izza Mir ◽  
Sijan Basnet ◽  
David Ellsworth ◽  
Elan Mohanty
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Thoracoscopic Surgery ◽  
Left Lung ◽  
Lymphocytic Leukemia ◽  
Pulmonary Mucormycosis ◽  
Life Threatening ◽  
History Of ◽  
Video Assisted Thoracoscopic Surgery

Pulmonary mucormycosis is a rare life-threatening fungal infection associated with high mortality. We present the case of a 61-year-old man with history of chronic lymphocytic leukemia who presented with fever and cough, eventually diagnosed with pulmonary mucormycosis after right lung video-assisted thoracoscopic surgery. The patient was successfully treated with amphotericin B and right lung pneumonectomy; however, he later died from left lung pneumonia.

scholarly journals Interactions of Both Pathogenic and Nonpathogenic CUG Clade Candida Species with Macrophages Share a Conserved Transcriptional Landscape

mBio ◽  
2021 ◽  
Author(s):  
Andrew W. Pountain ◽  
John R. Collette ◽  
William M. Farrell ◽  
Michael C. Lorenz
Keyword(s):  
Fungal Infection ◽  
Candida Species ◽  
Invasive Disease ◽  
Immunocompromised Patients ◽  
Common Cause ◽  
Content Type ◽  
Life Threatening ◽  
Transcriptional Landscape

Candidiasis is a major fungal infection by Candida species, causing life-threatening invasive disease in immunocompromised patients. C. albicans , which is adapted to commensalism of human mucosae, is the most common cause. While several other species cause infection, most are less prevalent or less virulent.

scholarly journals Considering the Impacts of Health Disparities, Inequalities, and Inequities on Early Diagnosis of Pulmonary Arterial Hypertension

2012 ◽  
Vol 11 (2) ◽  
pp. 73-77 ◽  
Author(s):  
Laura Hoyt D'Anna
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Early Recognition ◽  
Delayed Diagnosis ◽  
Delay In Diagnosis ◽  
The Past ◽  
Optimal Health ◽  
Life Threatening ◽  
Pulmonary Arterial ◽  
Martin Luther King

“Of all the forms of inequality, injustice in health care is the most shocking and inhumane.” – Dr. Martin Luther King, Jr. Early recognition, diagnosis, and treatment of pulmonary arterial hypertension (PAH) is a worthwhile endeavor in that it remains underdiagnosed in an era where 9 FDA-approved treatments are available, which have shown to provide clinical improvements and prolonged survival.1 Furthermore, despite the significant advances in understanding the etiology of PAH, the time from onset of symptoms to recognition of the disease has not improved over the past 2 decades, the delay of which results in progression of pathologic changes that are life threatening and irreversible when left untreated. This is particularly concerning in that the potential for optimal clinical outcomes and survival is diminished even after a 2-year delay in diagnosis.2 The aim of this article is to evaluate the current public health framework to highlight social determinants that influence and may result in barriers in achieving optimal health outcomes, with a focus on factors that may contribute to delayed diagnosis of PAH.3

Endemic Fungal Infection

Chest Imaging ◽  
2019 ◽  
pp. 203-207
Author(s):  
Sonia L. Betancourt
Keyword(s):  
Lung Cancer ◽  
Fungal Infection ◽  
Superior Vena ◽  
Vena Cava ◽  
Immunocompromised Patients ◽  
Healthy Individuals ◽  
Cavitary Disease ◽  
Life Threatening ◽  
Vena Cava Syndrome ◽  
Endemic Fungi

Endemic fungi (EF) live in soil as saprophytes, infect humans when their spores are inhaled, and often affect healthy individuals that live in or have visited certain areas. EF infection should be suspected in patients from endemic areas who present with pulmonary opacities and/or cavitary disease on imaging. However, disseminated life-threatening disease may affect also immunocompromised patients (e.g. AIDS). Consider EF infection in patients with bronchopneumonia associated with lymphadenopathy that does not respond to antibiotics. Fungal infection may mimic tuberculosis, metastatic disease, lung cancer. Immunosupression is frequently associated with disseminated EF infection. Chronic mediastinal histoplasmosis is a common benign etiology of superior vena cava syndrome.

scholarly journals A challenging complication following SARS-CoV-2 infection: a case of pulmonary mucormycosis

Infection ◽  
2020 ◽  
Author(s):  
Daniela Pasero ◽  
Silvana Sanna ◽  
Corrado Liperi ◽  
Davide Piredda ◽  
Gian Pietro Branca ◽  
...  
Keyword(s):  
Immune Response ◽  
Severe Acute Respiratory Syndrome ◽  
Fungal Infection ◽  
Invasive Fungal Infection ◽  
Opportunistic Infections ◽  
Immunocompromised Patients ◽  
Pulmonary Mucormycosis ◽  
First Case

AbstractSevere acute respiratory syndrome coronavirus 2 infection might induce a significant and sustained lymphopenia, increasing the risk of developing opportunistic infections. Mucormycosis is a rare but severe invasive fungal infection, mainly described in immunocompromised patients. The first case of a patient diagnosed with coronavirus disease (COVID-19) who developed a pulmonary mucormycosis with extensive cavitary lesions is here reported. This case highlights how this new coronavirus might impair the immune response, exposing patients to higher risk of developing opportunistic infections and leading to worse outcomes.

scholarly journals Pulmonary mucormycosis – diagnostic dilemma and uphill battle in treatment: A case report on life threatening fungal infection

2021 ◽  
Vol 8 (1) ◽  
pp. 130
Author(s):  
Sanchayan Thanancheyan ◽  
Aathavan Muthulingam ◽  
Nisanthan Selvaratnam ◽  
L. S. M. Sigera ◽  
Primali Irosha Jayasekera
Keyword(s):  
Case Report ◽  
Fungal Infection ◽  
Diagnostic Dilemma ◽  
Pulmonary Mucormycosis ◽  
Life Threatening
Sign in / Sign up

Export Citation Format

Share Document