scholarly journals Sertraline May Improve Language Developmental Trajectory in Young Children with Fragile X Syndrome: A Retrospective Chart Review

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Tri Indah Winarni ◽  
Weerasak Chonchaiya ◽  
Evan Adams ◽  
Jacky Au ◽  
Yi Mu ◽  
...  
Keyword(s):  
Young Children ◽  
Fragile X Syndrome ◽  
Chart Review ◽  
Fragile X ◽  
Retrospective Chart Review ◽  
Developmental Trajectory

scholarly journals Developmental trajectory of communication repair in children with Fragile X Syndrome

2020 ◽  
Vol 5 ◽  
pp. 239694152090901 ◽  
Author(s):  
Heather Fielding-Gebhardt ◽  
Steven F Warren ◽  
Nancy C Brady
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X ◽  
Developmental Trajectory

scholarly journals Early Intervention Combined with Targeted Treatment Promotes Cognitive and Behavioral Improvements in Young Children with Fragile X Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Tri Indah Winarni ◽  
Andrea Schneider ◽  
Mariya Borodyanskara ◽  
Randi J. Hagerman
Keyword(s):  
Young Children ◽  
Fragile X Syndrome ◽  
Dendritic Spine ◽  
Environmental Enrichment ◽  
Fragile X ◽  
Educational Interventions ◽  
Targeted Treatment ◽  
Pharmacological Intervention ◽  
Cgg Repeats ◽  
And Behavior

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability due to an expansion in the full mutation range (>200 CGG repeats) of the promoter region of theFMR1gene leading to gene silencing. Lack of FMRP, a critical protein for dendritic spine formation and maturation, will cause FXS. Early environmental enrichment combined with pharmacological intervention has been proven to rescue dendritic spine abnormalities in the animal model of FXS. Here we report on 2 young children with FXS who were treated early with a combination of targeted treatment and intensive educational interventions leading to improvement in their cognition and behavior and a normal IQ.

scholarly journals Metformin treatment in young children with fragile X syndrome

2019 ◽  
Vol 7 (11) ◽  
Author(s):  
Hazel Maridith B. Biag ◽  
Laura A. Potter ◽  
Victoria Wilkins ◽  
Sumra Afzal ◽  
Alexis Rosvall ◽  
...  
Keyword(s):  
Young Children ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Metformin Treatment

scholarly journals Joint Engagement and Early Language in Young Children With Fragile X Syndrome

2016 ◽  
Vol 59 (5) ◽  
pp. 1087-1098 ◽  
Author(s):  
Laura J. Hahn ◽  
Nancy C. Brady ◽  
Kandace K. Fleming ◽  
Steven F. Warren
Keyword(s):  
Young Children ◽  
Fragile X Syndrome ◽  
Rating Scale ◽  
Fragile X ◽  
Language Skills ◽  
Expressive Language ◽  
Autism Spectrum ◽  
Language Abilities ◽  
Joint Engagement ◽  
Autism Symptomatology

PurposeIn this study, we examine joint engagement (JE) in young children with fragile X syndrome (FXS) and its relationship to language abilities and autism spectrum disorder symptomatology at 24 to 36 months (toddler period) and 59 to 68 months (child period).MethodParticipants were 28 children with FXS (24 boys, four girls) and their mothers. Videotaped home observations were conducted during the toddler period and coded for JE. Language abilities were measured at both ages from a developmental assessment, a functional measure, and from a language sample. The Childhood Autism Rating Scale (Schopler, Reichler, & Renner, 1988) was completed at both ages.ResultsChildren with FXS spent more time in supported JE than in coordinated JE. Using a weighted JE variable, we found that children with FXS who had higher weighted JE scores also had more advanced expressive language skills at both the toddler and child periods. Weighted JE was negatively related to autism symptomatology in the toddler period.ConclusionThis study provides evidence that children with FXS who use more JE also have more advanced expressive language skills in early development. Therefore, existing early interventions that target JE behaviors may be effective for promoting language, social communication, and social interaction in this population.

scholarly journals Communication in Young Children With Fragile X Syndrome: A Qualitative Study of Mothers' Perspectives

2006 ◽  
Vol 15 (4) ◽  
pp. 353-364 ◽  
Author(s):  
Nancy Brady ◽  
Debra Skinner ◽  
Joanne Roberts ◽  
Elizabeth Hennon
Keyword(s):  
Qualitative Study ◽  
Young Children ◽  
Fragile X Syndrome ◽  
Fragile X

scholarly journals A Randomized, Double-Blind, Placebo-Controlled Trial of Low-Dose Sertraline in Young Children With Fragile X Syndrome

2016 ◽  
Vol 37 (8) ◽  
pp. 619-628 ◽  
Author(s):  
Laura Greiss Hess ◽  
Sarah E. Fitzpatrick ◽  
Danh V. Nguyen ◽  
Yanjun Chen ◽  
Kimberly N. Gaul ◽  
...  
Keyword(s):  
Young Children ◽  
Fragile X Syndrome ◽  
Low Dose ◽  
Fragile X ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Biobehavioral Indicators of Social Fear in Young Children With Fragile X Syndrome

2013 ◽  
Vol 118 (6) ◽  
pp. 447-459 ◽  
Author(s):  
Bridgette L. Tonnsen ◽  
Svetlana V. Shinkareva ◽  
Sara C. Deal ◽  
Deborah D. Hatton ◽  
Jane E. Roberts
Keyword(s):  
Young Children ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Theoretical Models ◽  
Control Group ◽  
Heart Activity ◽  
Cross Sectional ◽  
Age Dependent ◽  
Distress Vocalizations ◽  
And Behavior

Abstract Anxiety is among the most impairing conditions associated with Fragile X syndrome (FXS) and is putatively linked to atypical physiological arousal. However, few studies have examined this association in young children with FXS. The authors examined whether patterns of arousal and behavior during an experimental stranger approach paradigm differ between a cross-sectional sample of 21 young children with FXS and 19 controls (12–58 months old). Groups did not differ in mean levels of behavioral fear. Unlike the control group, however, the FXS group demonstrated increased facial fear at older ages, as well as age-dependent changes in associations between heart activity and distress vocalizations. These findings may inform theoretical models of anxiety etiology in FXS and early detection efforts.

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