scholarly journals A Therapeutic and Diagnostic Dilemma: Granular Cell Tumor of the Breast

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Ahmet Pergel ◽  
Ahmet Fikret Yucel ◽  
A. Serdar Karaca ◽  
Ibrahim Aydin ◽  
Dursun Ali Sahin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Granular Cell Tumor ◽  
Histopathological Examination ◽  
Granular Cell ◽  
Excisional Biopsy ◽  
Final Diagnosis ◽  
Cell Tumor ◽  
Immunohistochemical Examination ◽  
Diagnostic Dilemma

Six to eight percent of granular cell tumors are seen in the breast. Although mostly benign, they rarely have malignant features clinically and radiologically reminding of breast cancer. This may lead to a potential misdiagnosis of breast carcinoma and overtreatment of patients. The final diagnosis is made by immunohistochemical examination. We performed excisional biopsy on a patient who was diagnosed to have a breast mass. The histopathological examination of the mass revealed granular cell tumor.

scholarly journals Difficulties of Differential Diagnosis of Abrikosov’s Tumor and Breast Cancer in the Outpatient Polyclinic Practice

2021 ◽  
pp. 113-120
Author(s):  
E. V. Shivilov ◽  
Kh. S. Arslanov ◽  
G. E. Kvetenadze ◽  
A. L. Miftakhova ◽  
M. V. Rusakova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Differential Diagnosis ◽  
Biological Material ◽  
Core Biopsy ◽  
Granular Cell Tumor ◽  
Malignant Neoplasm ◽  
Granular Cell ◽  
Final Diagnosis ◽  
Cell Tumor ◽  
Immunohistochemical Studies

The clinical example shows the difficulties of differential diagnosis at the outpatient policlinic stage of the granular cell tumor (Abrikosov’s tumor) and malignant neoplasm of the breast, which have similar semiotic signs. The final diagnosis of «granular cell tumor» is established only on the basis of pathomorphological and immunohistochemical studies obtained during core-biopsy of biological material.

scholarly journals Granular Cell Tumor: A Mimicker of Breast Carcinoma

2021 ◽  
Vol 105 (1) ◽  
Author(s):  
Frederik Bosmans ◽  
Sofie Dekeyzer ◽  
Filip Vanhoenacker
Keyword(s):  
Breast Carcinoma ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor

scholarly journals Granular Cell Tumor Breast Masquerading as a Malignancy Cytologically: a Rare Case Presenting a Diagnostic Dilemma

2020 ◽  
Vol 11 (2) ◽  
pp. 321-324
Author(s):  
Mukta Pujani ◽  
Kanika Singh ◽  
Sujata Raychaudhuri ◽  
Charu Agarwal ◽  
Aparna Khandelwal ◽  
...  
Keyword(s):  
Rare Case ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Diagnostic Dilemma

scholarly journals Coexistence of Granular Cell Tumor and Invasive Ductal Breast Cancer in Contralateral Breasts: A Case Report

2014 ◽  
Vol 15 (8) ◽  
pp. 13166-13171
Author(s):  
Maurizio Di Bonito ◽  
Monica Cantile ◽  
Francesca Collina ◽  
Rossella De Cecio ◽  
Teresa Petrosino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Invasive Ductal Breast Cancer ◽  
Ductal Breast Cancer

scholarly journals Pediatric Granular Cell Tumor of the Breast: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Nathan P. Heinzerling ◽  
Shannon M. Koehler ◽  
Sara Szabo ◽  
Amy J. Wagner
Keyword(s):  
Granular Cell Tumor ◽  
Granular Cell ◽  
Excisional Biopsy ◽  
Cell Tumor ◽  
The Body ◽  
Positive Staining ◽  
Review Of The Literature ◽  
Rare Presentation ◽  
Breast Masses

Objective. Granular cell tumors arise from neurogenic mesenchymal stem cells and can occur anywhere throughout the body. They rarely present as breast masses and should be included in the differential diagnosis of pediatric breast neoplasms. We report a rare presentation of a pediatric breast granular cell tumor and a review of the literature.Participant. A 15-year-old female presented with an enlarging breast mass. She underwent ultrasound imaging and excisional biopsy, which revealed a granular cell tumor. Granular cell tumors of the breast are difficult to diagnose using ultrasound and mammography due to numerous similarities to other breast masses. Histopathologic staining best differentiates breast granular cell tumors from other breast masses with their positive staining for S100, CD68, and neurospecific enolase.Conclusion. Although rare, granular cell tumors of the breast should be considered as a possible diagnosis for pediatric breast masses to allow for proper management and follow-up for these patients. Although rare, these tumors do have malignant potential necessitating a correct and timely diagnosis.

scholarly journals Granular Cell Tumor of the Breast Coexisting with Ductal Carcinoma in situ: Case Report

2021 ◽  
pp. 303-308
Author(s):  
Yuko Ueki ◽  
Yoshiya Horimoto ◽  
Akihiko Shiraishi ◽  
Atsushi Arakawa ◽  
Hyonmi Sai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carcinoma In Situ ◽  
Granular Cell Tumor ◽  
Ductal Carcinoma ◽  
Granular Cell ◽  
Cell Tumor ◽  
Lower Mass ◽  
Contrast Enhanced ◽  
The Right

Granular cell tumor (GCT) is a benign tumor arising from Schwann cells. GCT of the breast is rare and while predominantly benign, it can be difficult to differentiate from breast cancer by imaging. While it is not generally associated with breast cancer, we here report a rare case of GCT coexisting with ductal carcinoma in situ (DCIS). A 38-year-old Japanese woman had microcalcification suggestive of malignancy in the right upper breast and a 6-cm well-defined mass in the right lower breast. Ultrasonography showed that the lower mass was circular in shape with a clear border, and internal echo level was slightly uneven. Contrast-enhanced magnetic resonance imaging found that the inside was unevenly contrast-enhanced and showed fast/washout enhanced pattern. Hence, imaging could not exclude malignancy. Pathological diagnosis from biopsies taken from the upper calcification and lower mass was DCIS and GCT, respectively. Imaging showed no evidence of continuity between the two, but the patient elected for mastectomy. Final pathological diagnosis confirmed an S-100-positive and keratin-negative GCT for the lower lesion and no histological evidence of continuity. Although GCT is a rare disease, greater awareness of the disease and its imaging findings is needed to avoid overdiagnosis, particularly when it coexists with breast cancer.

Metastatic breast carcinoma mimicking granular cell tumor

1989 ◽  
Vol 16 (4) ◽  
pp. 218-222 ◽  
Author(s):  
M. J. Franzblau ◽  
M. Manwaring ◽  
C. Plumhof ◽  
M. B. Listrom ◽  
W. H. C. Burgdorf
Keyword(s):  
Breast Carcinoma ◽  
Granular Cell Tumor ◽  
Metastatic Breast ◽  
Granular Cell ◽  
Cell Tumor ◽  
Metastatic Breast Carcinoma

scholarly journals Infrascapular granular cell tumor: an unusual entity

2017 ◽  
Vol 4 (1) ◽  
pp. 293
Author(s):  
Sabina Khan ◽  
Sujata Jetley
Keyword(s):  
Soft Tissue ◽  
Granular Cell Tumor ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Granular Cell ◽  
Cell Tumor ◽  
Cutaneous Lesions ◽  
Clinical Appearance ◽  
Common Location ◽  
Schwannian Origin

Granular cell tumor (GCT) is an uncommon soft tissue tumor of schwannian origin frequent among women and blacks between the second and sixth decades of life. The common location of GCT is the oral cavity, but it can also occur at other sites. Cutaneous lesions constitute about 30% of cases and are characterized by a gradually developing nodular lesion. Due to their subtle clinical appearance and symptomatology, GCTs are often misdiagnosed. We report a case of subcutaneous GCT in the infrascapular region in a 40 year old female which mimicked granular cell dermatofibroma on histopathology. Although a rare entity, Granular cell tumor should be considered in the differential diagnosis of the subcutaneous soft tissue tumours and require histopathological examination along with immunohistochemistry to confirm the diagnosis and differentiate them from other benign and malignant tumors showing granular cell change.

scholarly journals Malignant granular cell tumor of the arm – case report

2021 ◽  
Vol 4 (1) ◽  
pp. 3-8
Author(s):  
Mihai Mehedinţu ◽  
Răzvan Danciu ◽  
Anca I. Toma ◽  
Corina Ştefan ◽  
Cristian R. Jecan
Keyword(s):  
Granular Cell Tumor ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Granular Cell ◽  
Surgical Excision ◽  
Female Gender ◽  
Cell Tumor ◽  
Malignant Granular Cell Tumor ◽  
Tissue Cancer

Abstract Granular cell tumor (GCT) is a rare form of soft tissue cancer that is usually benign. Its malignant evolution is encountered in less than 2% of cases, having a more rapid and unfavorable evolution. Clinical presentation betraying malignant features could be increased tumor size, rapid growth, deep localization, and female gender. This paper presents the case of a 52-year-old patient with a hard, rapidly evolving tumor in the left arm. The diagnosis of granular cell tumor was made based on histopathological examination using the Fanburg and Smith criteria to differentiate the formation as malignant, but with certainty this was subsequently confirmed by the existence of a metastasis. Surgical excision was performed and the evolution was favorable. Evolution and treatment differ depending on the benign or malignant form, but surgical treatment with wide local excision is recommended. This may be followed by chemotherapy or radiotherapy, and follow-up of patients for the rest of their lives is mandatory.

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