scholarly journals Donor Smoking Negatively Affects Donor and Recipient Renal Function following Living Donor Nephrectomy

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Jonathan Heldt ◽  
Robert Torrey ◽  
Daniel Han ◽  
Pedro Baron ◽  
Christopher Tenggardjaja ◽  
...  
Keyword(s):  
Renal Function ◽  
Patient Survival ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Tobacco Exposure ◽  
Kidney Donor ◽  
Chi Square ◽  
Living Donor Nephrectomy ◽  
Percent Increase ◽  
Percent Decrease

Background.While tobacco use by a renal transplant recipient has been shown to negatively affect graft and patient survival, the effect of smoking on the part of the kidney donor remains unknown.Methods.29 smoking donors (SD) and their recipients (SD-R) as well as 71 non-smoking donors (ND) and their recipients (ND-R) were retrospectively reviewed. Preoperative demographics and perioperative variables including serum creatinine (Cr) and glomerular filtration rate (GFR) were calculated and stratified by amount of tobacco exposure in pack-years. Clinical outcomes were analyzed with a Student'st-test, chi-square, and multiple linear regression analysis ().Results.At most recent followup, SD-R's had a significantly smaller percent decrease in postoperative Cr than ND-R's (−57% versus −81%; ) and lower calculated GFR's (37.0 versus 53.0 mL/min per 1.73 m2; . SD's had a larger percent increase in Cr than ND's at most recent followup (57% versus 40%; ), with active smokers having a larger increase than those who quit, although this difference was not statistically significant (68% versus 52%; ).Conclusions.Use of tobacco by kidney donors is associated with decreased posttransplant renal function, although smoking cessation can improve outcomes. Kidneys from donors who smoke should be used with caution.

scholarly journals Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime

2021 ◽  
Author(s):  
Kentaro Takezawa ◽  
Sohei Kuribayashi ◽  
Koichi Okada ◽  
Yosuke Sekii ◽  
Yusuke Inagaki ◽  
...  
Keyword(s):  
Renal Function ◽  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Excretion Rate ◽  
Linear Regression Analysis ◽  
Urine Volume ◽  
Multiple Linear Regression Analysis ◽  
Volume Rate ◽  
Salt Excretion

Abstract Purpose: To determine the pathophysiology of nocturnal polyuria associated with renal dysfunction.Methods: Patients who underwent laparoscopic nephrectomy were studied prospectively. The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day two and postoperative day seven. The factors associated with an increase in the nighttime urine volume rate with decreased renal function were evaluated by multiple linear regression analysis.Results: Forty-nine patients were included. The eGFR decreased from 73.3 ± 2.0 to 47.2 ± 1.6 mL/min/1.73 m2 (P < 0.01) and the nighttime urine volume rate increased from 40.6% ± 2.0% to 45.3% ± 1.5% (P = 0.04) with nephrectomy. The nighttime urine osmolality decreased from 273 ± 15 to 212 ± 10 mOsm/kg (P < 0.01) and the nighttime salt excretion rate increased from 38.7% ± 2.1% to 48.8% ± 1.7% (P < 0.01) with nephrectomy. Multiple linear regression analysis revealed that the increase in the nighttime urine volume rate was strongly affected by the increase in the nighttime salt excretion rate.Conclusion: A decrease in renal function causes an increase in the nighttime urine volume rate, mainly due to an increase in nighttime salt excretion.Trial registration number: UMIN000036760 (University Hospital Medical Information Network Clinical Trials Registry)Date of registration: From June 1st, 2019 to October 31th 2020

scholarly journals Associations Between Day-by-Day Home Blood Pressure Variability and Renal Function and Albuminuria in Patients With and Without Diabetes

2020 ◽  
Vol 33 (9) ◽  
pp. 860-868
Author(s):  
Daisuke Suzuki ◽  
Satoshi Hoshide ◽  
Kazuomi Kario
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Home Blood Pressure ◽  
Diabetes Group ◽  
Urine Albumin ◽  
Blood Pressure Study ◽  
Average Real Variability ◽  
Day By Day

Abstract BACKGROUND The phenotype of diabetic kidney disease represents a lower estimated glomerular filtration rate (eGFR) and albuminuria. We investigated the association between day-by-day home blood pressure (BP) variability and the eGFR in subjects with diabetes and compared this association with that in subjects without diabetes. We then attempted to determine whether the association is present in albuminuria. METHODS We analyzed 4,231 patients with risk factors of cardiovascular disease (24.4% with diabetes) from the J-HOP (Japan Morning Surge-Home Blood Pressure) study. Home BP was measured in the morning and evening for 14 days. We calculated the SD, coefficient of variation, average real variability (ARV), and variation independent of the mean of the subjects’ morning and evening home systolic BP (SBP) as the indexes of day-by-day home BP variability. RESULTS A multiple linear regression analysis adjusted for covariates showed both average morning and evening SBP were associated with the log-transformed urine albumin-to-creatinine ratio (UACR) with and without diabetes (all P &lt; 0.05), but not with the eGFR except for an association of average evening SBP in the no-diabetes group. None of the indexes of day-by-day morning and evening home SBP variability were associated with the log-transformed UACR except for the association between the ARV of home morning SBP in the diabetes group. All of the indexes of day-by-day morning and evening home SBP variability were associated with the eGFR only in the diabetes group (all P &lt; 0.05). CONCLUSIONS The association between increased day-by-day home BP variability and impaired renal function was unique in diabetes.

scholarly journals Analisis Determinan Lingkungan Kerja Terhadap Kinerja Tenaga Perawat Di Rumah Sakit Umum Bahteramas Provinsi Sulawesi Tenggara

2021 ◽  
Vol 4 (2) ◽  
pp. 8-21
Author(s):  
Rania Fatrizza Pritami ◽  
Marheni Fadillah Harun ◽  
Fitri Kurniawati ◽  
Irman Idrus
Keyword(s):  
Job Satisfaction ◽  
Work Environment ◽  
Quantitative Research ◽  
Linear Regression Analysis ◽  
Sampling Technique ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Nurse Job Satisfaction

Hospitals must continue to develop in order to improve the quality of hospital services. The purpose of the study was to determine the relationship between the work environment and job satisfaction of nurses at Bahteramas Hospital, Kendari City. Quantitative research method with cross sectional study approach with relative random sampling technique. Data analysis using Chi-Square test and multiple linear regression analysis. The results showed that there was a relationship between transformational leadership and nurse job satisfaction (p=0.001), structural empowerment and nurse job satisfaction (p=0.001); ideal professional practice with nurse job satisfaction (p = 0.001); innovation with nurse job satisfaction (p=0.013); and empirical quality with nurse job satisfaction (p = 0.017). The conclusion is that the determinant analysis states that there is a relationship between the work environment and job satisfaction of nurses.

scholarly journals Identifikasi Kekeliruan Penggunaan Metode Statistika pada Artikel yang Dimuat di Jurnal OJS Unud

2019 ◽  
Vol 9 (1) ◽  
pp. 26
Author(s):  
Ni Luh Putu Suciptawati
Keyword(s):  
Statistical Methods ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Ordinal Scale ◽  
Small Samples ◽  
Research Use ◽  
Chi Square ◽  
Inappropriate Use ◽  
Two Samples ◽  
Chi Square Test

Abstract:  The statistical method plays a role in scientific research. Use of appropriate statistical methods in analyzing  data influences research conclusions. Misuse  statistical methods will lead to incorrect conclusions. This study aims to identify the misuse of statistical methods in articles published in the OJS UNUD Journals. We reviewed 97 articles from OJS UNUD Journals published in 2017. This study  found several  misuse statistical methods these included: misuse multiple linear regression analysis, generalize conclusions based on descriptive statistics, inappropriate use of  ANOVA, misinterpretation of negative correlation values, use of Chi square test for small samples, use of t-test two samples for observations with ordinal scale Keywords: statistical methods, misuse statistical, OJS UNUD Journal

The probability of indicating Osteoprotegrin as a biomarker for osteoporosis in patient with thalassemia major

2020 ◽  
Author(s):  
Shahin Koohmanaee ◽  
Bahram Dabandi ◽  
Adel Baghersalimi ◽  
Roghayeh Zare ◽  
Mohammad Aghaeizadeh Zoroufi ◽  
...  
Keyword(s):  
Linear Regression Analysis ◽  
Thalassemia Major ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Z Score ◽  
Chi Square ◽  
Cross Sectional ◽  
Calcium Phosphorus ◽  
Bone Mineral Densitometry ◽  
Chi Square Test

Background: Osteoporosis is one of the main causes of morbidity in patients with thalassemia major. Osteoprotegerin (OPG) is secreted by osteoblasts and osteogenic stromal stem cells and protects the skeleton from excessive bone reabsorption. In this study, the authors aimed to assess the relationship between OPG with osteoporosis and osteopenia in patients with thalassemia major. Materials and Methods: In this analytic cross-sectional study, 37 patients aged 8-18 years, with thalassemia major were enrolled. Biochemical markers including hemoglobin, ferritin, calcium, phosphorus levels, and MRI T2* heart and liver were assessed. A bone mineral densitometry (BMD) was performed as well. Statistical analysis was performed by the independent T-test and Chi-Square test using the SPSS 20. The Multiple linear regression analysis was used to investigate the association between the BMD Z-score and OPG by the effect modification. Results: The mean age of patients was 14.86±3.72 years. Normal bone density, osteopenia, and osteoporosis were noted in 2 (5.4%), 21 (56.8%), and 14 (37.08%) patients, respectively. The number of girls (P=0.042), mean age (P=0.045), and MRI T2* heart (P=0.033) in patients with osteopenia was significantly higher than patients with osteoporosis. The BMD Z-score was not significantly associated with OPG regarding the total number of participants, whereas in patients with osteoporosis, this association was significant (P=0.001). In all effect modified models, BMD remained statistically non-significant except for body mass index modification (P=0.046). Conclusion: Based on the results, it seems that further complicated studies are needed to be performed on this issue.

scholarly journals Urinary Leukotriene E4Is Associated with Renal Function but Not with Endothelial Function in Type 2 Diabetes

2013 ◽  
Vol 35 ◽  
pp. 475-480 ◽  
Author(s):  
Arnar Rafnsson ◽  
Magnus Bäck
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Endothelial Function ◽  
Independent Predictor ◽  
Reactive Hyperemia ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Disease Marker ◽  
Vasoactive Mediators

Leukotrienes are inflammatory and vasoactive mediators implicated in endothelium-dependent relaxations and atherosclerosis. Urinary leukotriene E4(U-LTE4) is a validated disease marker of asthma and increases also in diabetes and acute coronary syndromes. The aim of the present study was to evaluate the association of U-LTE4and CRP with endothelial function. Urine samples were obtained from 30 subjects (80% males; median age 65) with type 2 diabetes of at least two years duration and a median glomerular filtration rate (eGFR) of 71 (14–129) mL/min. Reactive hyperemia index (RHI) was used as a measure of microvascular endothelial function, whereas macrovascular endothelial function was determined be means of flow-mediated dilatation of the brachial artery (FMD). Decreased renal function was associated with lower concentrations of U-LTE4. In addition, U-LTE4was correlated with serum creatinine (R=−0.572;P=0.001) and eGFR (R=0.517;P=0.0036). A stepwise multiple linear regression analysis identified eGFR as an independent predictor of U-LTE4concentrations. In conclusion, the present results did not establish an association of U-LTE4with endothelial dysfunction. However, eGFR was an independent predictor of U-LTE4, but not CRP, in this cohort, suggesting that GFR should be considered in biomarker studies of U-LTE4.

scholarly journals Influence of initial occlusal severity on time and efficiency of Class I malocclusion treatment carried out with and without premolar extractions

2014 ◽  
Vol 19 (4) ◽  
pp. 38-49 ◽  
Author(s):  
Ruben Leon-Salazar ◽  
Guilherme Janson ◽  
José Fernando Castanha Henriques ◽  
Vladimir Leon-Salazar
Keyword(s):  
Treatment Duration ◽  
Linear Regression Analysis ◽  
Negative Relationship ◽  
Multiple Linear Regression Analysis ◽  
Efficiency Index ◽  
Class I ◽  
Chi Square ◽  
Extraction Protocol ◽  
Group 2 ◽  
Group 1

INTRODUCTION: The aim of this retrospective study was to compare the occlusal outcomes, duration and efficiency of Class I malocclusion treatment carried out with and without premolar extractions in patients with different degrees of initial malocclusion severity. METHODS: Complete records of 111 patients were obtained and divided into two groups: Group 1 consisted of 65 patients at an initial mean age of 13.82 years old treated with four premolar extractions; whereas Group 2 consisted of 46 patients at an initial mean age of 14.01 years old treated without extractions. Two subgroups were obtained from each group (1A, 1B, 2A and 2B) with different degrees of malocclusion severity according to the initial values of PAR index. Compatibility was assessed using chi-square and t-tests. The subgroups were compared by means of Analysis of Variance (ANOVA).The variables that might be related to treatment duration and efficiency were assessed using the multiple linear regression analysis. RESULTS: Initial malocclusion severity was positively related to the amount of occlusal correction and consequently to a higher efficiency index. Moreover, extraction protocol showed a positive relationship with treatment duration and a negative relationship with treatment efficiency. CONCLUSION: Extraction and non-extraction protocols for correction of Class I malocclusion provide similar satisfactory results; however, the extraction protocol increases the overall treatment duration. Orthodontic treatment is more efficient in cases with high initial malocclusion severity treated with a non-extraction protocol.

scholarly journals Fibroblast growth factor (FGF)-23 in patients with primary hyperparathyroidism

2004 ◽  
pp. 55-60 ◽  
Author(s):  
H Yamashita ◽  
T Yamashita ◽  
M Miyamoto ◽  
T Shigematsu ◽  
JJ Kazama ◽  
...  
Keyword(s):  
Renal Function ◽  
Regression Analysis ◽  
Growth Factor ◽  
Serum Calcium ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Serum Phosphate ◽  
Healthy Controls ◽  
Fibroblast Growth ◽  
Fgf 23

OBJECTIVE: We aimed to determine the serum level of fibroblast growth factor-23 (FGF-23) in patients with primary hyperparathyroidism (pHPT) to understand its physiological role in the disorder. PATIENTS AND METHODS: Ninety-eight patients with pHPT who underwent parathyroidectomy formed the study group. We also measured serum FGF-23 in 11 of these patients on postoperative day 6. RESULTS: Serum FGF-23 levels was significantly higher in pHPT patients than in healthy controls (35.6+/-17.8 ng/l vs 28.9+/-11.2 ng/l (mean+/-s.d.); P<0.001 (Pearson's correlation coefficient)), but there was no significant difference in the serum FGF-23 level between pHPT patients with normal renal function (creatinine clearance (Ccr) of >or=70 ml/min) and healthy controls. Serum FGF-23 correlated positively with serum calcium (P<0.0001) and intact parathyroid hormone (PTH) (P<0.01), and negatively with Ccr (P<0.001), serum phosphate (P<0.05), and serum 1,25-dihydroxyvitamin D (1,25(OH)(2)D) (P<0.05). Multiple linear regression analysis of factors potentially determining serum FGF-23 levels in pHPT patients showed serum calcium (P<0.01) and Ccr (P<0.001) to be significant predictors. The serum levels of FGF-23 did not change after parathyroidectomy despite the normalization of serum calcium values. Multiple linear regression analysis revealed that serum FGF-23 was not a significant predictor of serum phosphate or 1,25(OH)(2)D in pHPT patients. CONCLUSIONS: FGF-23 may not play a significant role in regulating phosphate or 1,25(OH)(2)D in pHPT patients, especially in those with normal renal function. Further studies are warranted to determine the role of FGF-23 in renal insufficiency or failure.

scholarly journals Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kentaro Takezawa ◽  
Sohei Kuribayashi ◽  
Koichi Okada ◽  
Yosuke Sekii ◽  
Yusuke Inagaki ◽  
...  
Keyword(s):  
Renal Function ◽  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Excretion Rate ◽  
Linear Regression Analysis ◽  
Urine Volume ◽  
Multiple Linear Regression Analysis ◽  
Volume Rate ◽  
Salt Excretion

AbstractTo determine the pathophysiology of nocturnal polyuria associated with renal dysfunction, patients who underwent laparoscopic nephrectomy were prospectively studied. The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day 2 and postoperative day 7. The factors associated with an increase in the nighttime urine volume rate with decreased renal function were evaluated using multiple linear regression analysis. Forty-nine patients were included. The estimated glomerular filtration rate decreased from 73.3 ± 2.0 to 47.2 ± 1.6 mL/min/1.73 m2 (P < 0.01) and the nighttime urine volume rate increased from 40.6% ± 2.0% to 45.3% ± 1.5% (P = 0.04) with nephrectomy. The nighttime urine osmolality decreased from 273 ± 15 to 212 ± 10 mOsm/kg and the nighttime salt excretion rate increased from 38.7% ± 2.1% to 48.8% ± 1.7% (both P < 0.01) with nephrectomy. Multiple linear regression analysis showed that the increase in the nighttime urine volume rate was strongly affected by the increase in the nighttime salt excretion rate. A decrease in renal function causes an increase in the nighttime urine volume rate, mainly because of an increase in nighttime salt excretion.Trial registration number: UMIN000036760 (University Hospital Medical Information Network Clinical Trials Registry).Date of registration: From 1 June 2019 to 31 October 2020.

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