scholarly journals Intractable Chronic Vulval Ulceration Presenting as Immune Reconstitution Inflammatory Syndrome in a Treatment-Failure Patient: A Case Observation

2011 ◽  
Vol 2011 ◽  
pp. 1-2
Author(s):  
Christine Katusiime ◽  
Ponsiano Ocama ◽  
Andrew Kambugu
Keyword(s):  
Treatment Failure ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Antiretroviral Treatment ◽  
Viral Suppression ◽  
Second Line ◽  
Highly Active ◽  
Inflammatory Syndrome ◽  
Hiv 1 ◽  
Second Line Antiretroviral Therapy

HIV-1 treatment-failure patients are increasingly being initiated on second-line antiretroviral therapy. The case we describe is of a treatment-failure patient who developed intractable chronic vulval ulceration presenting as immune reconstitution inflammatory syndrome (IRIS), following complete viral suppression with second-line highly active antiretroviral treatment (HAART). To the best of our knowledge, this is the first reported case of intractable vulval ulceration IRIS in an HIV-1 treatment-failure patient.

Chronic vulval ulceration — another immune reconstitution inflammatory syndrome?

2005 ◽  
Vol 16 (6) ◽  
pp. 454-455 ◽  
Author(s):  
V Reddy ◽  
G A Luzzi
Keyword(s):  
Differential Diagnosis ◽  
Hiv Infection ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Antiretroviral Treatment ◽  
Highly Active ◽  
Highly Active Antiretroviral Treatment ◽  
Inflammatory Syndrome

We describe a patient who developed intractable chronic vulval ulceration that we believe was related to immune reconstitution following treatment of HIV infection with highly active antiretroviral treatment (HAART). Immune reconstitution inflammatory syndrome should be considered in the differential diagnosis of unexplained vulval ulceration that arises after starting HAART.

scholarly journals Chylous ascites in disseminated Kaposi sarcoma: an unusual manifestation as immune reconstitution inflammatory syndrome

2019 ◽  
Vol 12 (3) ◽  
pp. e228406 ◽  
Author(s):  
Patrícia Cipriano ◽  
Inês Nabais ◽  
Nuno Melo ◽  
Ana Rafaela Alves
Keyword(s):  
Immune Reconstitution Inflammatory Syndrome ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Kaposi Sarcoma ◽  
Chylous Ascites ◽  
Gastrointestinal Involvement ◽  
Unusual Manifestation ◽  
Highly Active ◽  
Inflammatory Syndrome ◽  
Hiv 1

A 29-year-old man with diarrhoea, fever, abdominal pain and multiple purple papular lesions, neither pruriginous nor painful, was diagnosed with HIV-1 infection and disseminated Kaposi sarcoma (KS) with gastrointestinal involvement. He was started on highly active antiretroviral therapy immediately, as well as doxorubicin. Three weeks later, the patient developed bilateral moderate pleural effusion and large-volume ascites compatible with chylothorax and chylous ascites. An immune reconstitution inflammatory syndrome (IRIS) reaction was assumed. KS flare was associated with lymphatic obstruction and infiltration of thoracic duct by the tumour itself with leakage of chylous into pleural and peritoneal cavities. KS is the most common tumour in HIV patients and the existence of related effusions is not uncommon. KS-related chylothorax is an unusual manifestation of KS; there are only four cases described in the literature of chylous ascites related to KS–HIV. Overall survival is improving in KS but explosive and debilitating IRIS reactions can explain cases with poor prognosis.

scholarly journals Acute gouty arthritis as a manifestation of immune reconstitution inflammatory syndrome after initiation of antiretroviral therapy

2012 ◽  
Vol 54 (4) ◽  
pp. 231-233 ◽  
Author(s):  
Walter de Araujo Eyer-Silva ◽  
Maria Cecília da Fonseca Salgado ◽  
Jorge Francisco da Cunha Pinto ◽  
Fernando Raphael de Almeida Ferry ◽  
Rogério Neves-Motta ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Gouty Arthritis ◽  
Infected Male ◽  
Acute Gouty Arthritis ◽  
Highly Active ◽  
History Of ◽  
Inflammatory Syndrome

Immune reconstitution inflammatory syndrome (IRIS) in HIV-infected subjects initiating antiretroviral therapy most commonly involves new or worsening manifestations of previously subclinical or overt infectious diseases. Reports of non-infectious IRIS are much less common but represent important diagnostic and treatment challenges. We report on a 34-year-old HIV-infected male patient with no history of gout who developed acute gouty arthritis in a single joint one month after initiating highly active antiretroviral therapy.

scholarly journals HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome

2015 ◽  
Vol 38 (2) ◽  
pp. 185-198 ◽  
Author(s):  
Rachel P. J. Lai ◽  
Graeme Meintjes ◽  
Robert J. Wilkinson
Keyword(s):  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Inflammatory Syndrome ◽  
Hiv 1

scholarly journals Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Nathalia Beatriz Ramos de Sá ◽  
Marcelo Ribeiro-Alves ◽  
Tatiana Pereira da Silva ◽  
Jose Henrique Pilotto ◽  
Valeria Cavalcanti Rolla ◽  
...  
Keyword(s):  
Genetic Markers ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Inflammatory Syndrome ◽  
Hiv 1

Orbital non-HIV immune reconstitution inflammatory syndrome after cytapheresis

2020 ◽  
pp. 112067212091933
Author(s):  
Jeremy Chiabo ◽  
Sacha Nahon-Esteve ◽  
Mohamed Alketbi ◽  
Sandra Lassalle ◽  
Nathalie Tieulie ◽  
...  
Keyword(s):  
Immune Reconstitution Inflammatory Syndrome ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Highly Active ◽  
First Case ◽  
Neutropenic Patients ◽  
Mantel Cell Lymphoma ◽  
Intravenous Steroids ◽  
Inflammatory Syndrome ◽  
Work Up

The immune reconstitution inflammatory syndrome is a phenomenon typically described in HIV patient during the restoration of CD4 count after highly active antiretroviral therapy. Non-HIV immune reconstitution inflammatory syndrome has also been described after organ transplantation or immune recovery in neutropenic patients. We report the case of a 50-year-old man who presented to our department with left painful proptosis and ophthalmoplegia 2 days after having performed cytapheresis for a mantel cell lymphoma. Systemic work up and biopsy were performed and symptoms were relieved with intravenous steroids therapy. To our knowledge, this is the first case of orbital non-HIV immune reconstitution inflammatory syndrome described in the literature.

A case of immune reconstitution inflammatory syndrome related to a disseminated histoplasmosis in an HIV-1 infected patient

AIDS ◽  
2013 ◽  
Vol 27 (13) ◽  
pp. 2170-2172 ◽  
Author(s):  
Adeline Mambie ◽  
Armelle Pasquet ◽  
Hugues Melliez ◽  
Severine Bonne ◽  
Anne-Laure Blanc ◽  
...  
Keyword(s):  
Immune Reconstitution Inflammatory Syndrome ◽  
Infected Patient ◽  
Immune Reconstitution ◽  
Disseminated Histoplasmosis ◽  
Inflammatory Syndrome ◽  
Hiv 1
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