scholarly journals Restless Legs Syndrome Presenting as an Acute Exacerbation of Multiple Sclerosis

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
James H. Bernheimer
Keyword(s):  
Multiple Sclerosis ◽  
Iron Deficiency ◽  
Acute Exacerbation ◽  
Restless Legs Syndrome ◽  
Axonal Degeneration ◽  
Acute Attack ◽  
Brain Iron ◽  
Restless Legs ◽  
Abnormal Accumulation ◽  
Underlying Pathophysiology

Restless legs syndrome is common in patients with multiple sclerosis but has not been reported as occurring due to an acute, inflammatory, demyelinating attack. Restless legs syndrome is known to be related to low brain iron levels. Multiple sclerosis has been associated with the abnormal accumulation of iron in the chronic, progressive phase of axonal degeneration. Iron deficiency may play a role in demyelination. This suggests that restless legs syndrome may be caused by the inflammatory, demyelinating component of multiple sclerosis rather than axonal degeneration. The author presents a case of self-limited restless legs syndrome occurring as an acute attack of multiple sclerosis, supporting the notion that inflammatory demyelination is the underlying pathophysiology of restless legs syndrome in multiple sclerosis.

Multiregional brain iron deficiency in restless legs syndrome

2008 ◽  
Vol 23 (8) ◽  
pp. 1184-1187 ◽  
Author(s):  
Jana Godau ◽  
Uwe Klose ◽  
Adriana Di Santo ◽  
Katherine Schweitzer ◽  
Daniela Berg
Keyword(s):  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Brain Iron ◽  
Restless Legs

scholarly journals Brain iron deficiency in idiopathic restless legs syndrome measured by quantitative magnetic susceptibility at 7 tesla

2016 ◽  
Vol 22 ◽  
pp. 75-82 ◽  
Author(s):  
Xu Li ◽  
Richard P. Allen ◽  
Christopher J. Earley ◽  
Hongjun Liu ◽  
Tiana E. Cruz ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
7 Tesla ◽  
Brain Iron ◽  
Restless Legs

scholarly journals Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome

2016 ◽  
Vol 111 ◽  
pp. 160-168 ◽  
Author(s):  
César Quiroz ◽  
Seema Gulyani ◽  
Wan Ruiqian ◽  
Jordi Bonaventura ◽  
Roy Cutler ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Adenosine Receptors ◽  
Brain Iron ◽  
Restless Legs

Transcreal sonography as a novel neuroimaging tool to determine brain iron deficiency in restless legs syndrome: results in a chilean sample

2019 ◽  
Vol 64 ◽  
pp. S413
Author(s):  
V. Wanner ◽  
C. Garcia-Malo ◽  
C. Miranda ◽  
M.J. Krakowiak ◽  
I. Cano-Pumarega ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Restless Legs Syndrome ◽  
Brain Iron ◽  
Restless Legs

scholarly journals Restless Legs Syndrome as the Initial Presentation of Multiple Sclerosis

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Ceyla Irkec ◽  
Doga Vurallı ◽  
Sebnem Karacay Ozkalaycı
Keyword(s):  
Multiple Sclerosis ◽  
Restless Legs Syndrome ◽  
Axonal Degeneration ◽  
Dopaminergic System ◽  
Sudden Onset ◽  
Initial Presentation ◽  
Central Nervous System Disorder ◽  
Physiological Conditions ◽  
Restless Legs ◽  
System Disorder

The restless legs syndrome (RLS) is a common central nervous system disorder. It is characterized by complaints of unpleasant sensation in the legs occurring during periods of leg inactivity which worsen or only occur in the evening or at night and relieved partially or totally by movement. The RLS may be idiopathic or due to secondary causes. It is associated with several pathological or physiological conditions. Iron metabolism and dysfunctions of the dopaminergic system are the most important factors in the pathophysiology. There are several studies suggesting multiple sclerosis as one of the causes of symptomatic RLS. Here, we report a case of RLS as the initial presentation of MS. The sudden onset of RLS symptoms in our patient suggested the possibility of an underlying cause. His diagnostic evaluation excluded other causes of RLS and his clinical course suggested that RLS was due to MS. MS with the spinal cord involvement is mostly associated with RLS, but any lesion in the hypothalamic-spinal connection may cause disinhibition of lower spinal levels, resulting in RLS. RLS as the initial presentation of MS reflects that the pathophysiology of RLS in MS is related to inflammatory demyelination rather than axonal degeneration.

Restless legs syndrome heralding an acute exacerbation of multiple sclerosis

2014 ◽  
Vol 36 (1) ◽  
pp. 173-174
Author(s):  
Takamichi Kanbayashi ◽  
Hisao Kamiya ◽  
Keiichi Hokkoku ◽  
Yuki Hatanaka ◽  
Masahiro Sonoo
Keyword(s):  
Multiple Sclerosis ◽  
Acute Exacerbation ◽  
Restless Legs Syndrome ◽  
Restless Legs

Validity and reliability of the Suggested Immobilization Test for measurement of restless legs syndrome severity in adults with multiple sclerosis

2021 ◽  
Author(s):  
Katie L.J. Cederberg ◽  
Arthur S. Walters ◽  
Amy W. Amara ◽  
Tiffany J. Braley ◽  
Morgan L. Schuetz ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Restless Legs Syndrome ◽  
Validity And Reliability ◽  
Restless Legs

Prevalence of restless legs syndrome and REM sleep behavior disorder in multiple sclerosis

2007 ◽  
Vol 13 (6) ◽  
pp. 805-808 ◽  
Author(s):  
M.J. Gómez-Choco ◽  
A. Iranzo ◽  
Y. Blanco ◽  
F. Graus ◽  
J. Santamaria ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Restless Legs Syndrome ◽  
Rem Sleep ◽  
Neurological Disease ◽  
Age Distribution ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Healthy Controls ◽  
Sleep Behavior ◽  
Restless Legs

A total of 135 consecutive, unrelated, multiple sclerosis (MS) patients were interviewed for symptoms suggestive of restless legs syndrome (RLS) and REM sleep behavior disorder (RBD), using semi-structured questionnaires. Some 118 unrelated healthy controls of similar sex and age distribution were included for comparison. Patients and controls with equivocal symptoms were re-evaluated by a sleep disorders specialist and video-polisomnography in those who fulfilled the criteria for RBD. We did not find significant differences in frequency (13.3 versus 9.3%), proportion of females (66.7 versus 58.5%), and mean age (42.1±12.6 versus 43±7.8 years) among MS patients and controls with RLS. RBD was found in three patients (1.4%), one associated with antidepressant intake, but in none of the controls. Our study shows that RLS in MS is not more frequent than in the general population, and that RBD, although uncommon, may occur in the setting of this neurological disease. Multiple Sclerosis 2007; 13: 805-808. http://msj.sagepub.com

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