scholarly journals Chitosan-Grafted Copolymers and Chitosan-Ligand Conjugates as Matrices for Pulmonary Drug Delivery

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Fernanda Andrade ◽  
Francisco Goycoolea ◽  
Diego A. Chiappetta ◽  
José das Neves ◽  
Alejandro Sosnik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chemical Structure ◽  
Pulmonary Delivery ◽  
Pulmonary Drug Delivery ◽  
Systemic Diseases ◽  
Pulmonary Administration ◽  
Materials Used ◽  
Chemical Groups ◽  
Chitosan Molecule ◽  
Nanosized Systems

Recently, much attention has been given to pulmonary drug delivery by means of nanosized systems to treat both local and systemic diseases. Among the different materials used for the production of nanocarriers, chitosan enjoys high popularity due to its inherent characteristics such as biocompatibility, biodegradability, and mucoadhesion, among others. Through the modification of chitosan chemical structure, either by the addition of new chemical groups or by the functionalization with ligands, it is possible to obtain derivatives with advantageous and specific characteristics for pulmonary administration. In this paper, we discuss the advantages of using chitosan for nanotechnology-based pulmonary delivery of drugs and summarize the most recent and promising modifications performed to the chitosan molecule in order to improve its characteristics.

Crystal Engineering: Upcoming Paradigm for Efficacious Pulmonary Drug Delivery

2018 ◽  
Vol 24 (21) ◽  
pp. 2438-2455 ◽  
Author(s):  
Preshita P. Desai ◽  
Sanyat S. Mapara ◽  
Vandana B. Patravale
Keyword(s):  
Drug Delivery ◽  
Crystal Engineering ◽  
Pulmonary Delivery ◽  
Delivery Systems ◽  
Pulmonary Drug Delivery ◽  
Particle Engineering ◽  
Particle Properties ◽  
Drug Deposition ◽  
Systemic Drug Delivery

Background and objective: Pulmonary drug delivery has transformed over a past few decades from being a platform for local pulmonary disease treatment to systemic drug delivery opportunities. In case of pulmonary delivery systems, particle properties are critical as they affect inhalation efficacy, pulmonary deposition, drug delivery and overall performance. With this in view, particle engineering has emerged as an advanced science that helps in designing of efficacious pulmonary delivery systems. Among various particle engineering branches, crystal engineering is being extensively explored as it provides an opportunity to optimize particles at morphological, physicochemical and molecular levels which are essential to understand the role of crystal engineering in pulmonary drug delivery. Methods: A thorough literature survey in the field of crystal engineering approaches explored for pulmonary drug delivery was conducted and the collected data was meticulously studied and summarized. Results: In the review, pulmonary system is discussed with respect to various sites for drug deposition in respiratory tract, mechanism of drug deposition and clearance. Further, critical crystal parameters are discussed in-depth and various crystal engineering methods are summarized with emphasis on their impact on pulmonary delivery. Also, inhalation devices are overviewed to understand their performance in relation to crystal based pulmonary formulations. Conclusion: The review enabled a detailed insight on crystal engineering approaches for design of pulmonary delivery systems.

scholarly journals Advances in Pulmonary Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 911
Author(s):  
Ayca Yıldız-Peköz ◽  
Carsten Ehrhardt
Keyword(s):  
Drug Delivery ◽  
Drug Disposition ◽  
Pulmonary Delivery ◽  
Pulmonary Drug Delivery ◽  
Formulation Development ◽  
Inhaler Device ◽  
Non Invasive ◽  
Sufficient Stability ◽  
In Silico Models

Pulmonary drug delivery represents an attractive, non-invasive administration option. In addition to locally acting drugs, molecules that are intended to produce systemic effects can be delivered via the pulmonary route. Several factors need to be considered in the context of delivering drugs to or via the lungs—in addition to the drug itself, its formulation into an appropriate inhalable dosage form of sufficient stability is critical. It is also essential that this formulation is paired with a suitable inhaler device, which generates an aerosol of a particle/droplet size that ensures deposition in the desired region of the respiratory tract. Lastly, the patient’s (patho-) physiology and inhalation manoeuvre are of importance. This Special Issue brings together recent advances in the areas of inhalation device testing, aerosol formulation development, use of in vitro and in silico models in pulmonary drug deposition and drug disposition studies, and pulmonary delivery of complex drugs, such as vaccines, antibiotics and peptides, to or via the lungs.

Application of Chitosan and its Derivatives in Nanocarrier Based Pulmonary Drug Delivery Systems

2018 ◽  
Vol 5 (4) ◽  
Author(s):  
Kamal Dua ◽  
Mary Bebawy ◽  
Rajendra Awasthi ◽  
Rakesh K. Tekade ◽  
Muktika Tekade ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Pulmonary Drug Delivery

scholarly journals Polyhydroxyalkanoate Nanoparticles for Pulmonary Drug Delivery: Interaction with Lung Surfactant

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1482
Author(s):  
Olga Cañadas ◽  
Andrea García-García ◽  
M. Auxiliadora Prieto ◽  
Jesús Pérez-Gil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Bacterial Species ◽  
High Surface ◽  
Lung Surfactant ◽  
Delivery Systems ◽  
Pulmonary Drug Delivery ◽  
Epifluorescence Microscopy ◽  
Energy Storage Materials ◽  
The Stability

Polyhydroxyalkanoates (PHA) are polyesters produced intracellularly by many bacterial species as energy storage materials, which are used in biomedical applications, including drug delivery systems, due to their biocompatibility and biodegradability. In this study, we evaluated the potential application of this nanomaterial as a basis of inhaled drug delivery systems. To that end, we assessed the possible interaction between PHA nanoparticles (NPs) and pulmonary surfactant using dynamic light scattering, Langmuir balances, and epifluorescence microscopy. Our results demonstrate that NPs deposited onto preformed monolayers of DPPC or DPPC/POPG bind these surfactant lipids. This interaction facilitated the translocation of the nanomaterial towards the aqueous subphase, with the subsequent loss of lipid from the interface. NPs that remained at the interface associated with liquid expanded (LE)/tilted condensed (TC) phase boundaries, decreasing the size of condensed domains and promoting the intermixing of TC and LE phases at submicroscopic scale. This provided the stability necessary for attaining high surface pressures upon compression, countering the destabilization induced by lipid loss. These effects were observed only for high NP loads, suggesting a limit for the use of these NPs in pulmonary drug delivery.

scholarly journals Biopolymeric Materials Used as Nonviral Vectors: A Review

2021 ◽  
Vol 2 (1) ◽  
pp. 100-109
Author(s):  
Jailson de Araújo Santos ◽  
Daniel Barbosa Liarte ◽  
Alessandra Braga Ribeiro ◽  
Marcia dos Santos Rizzo ◽  
Marcília Pinheiro da Costa ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Web Of Science ◽  
Gene Transfection ◽  
Genetic Material ◽  
Nonviral Vectors ◽  
Cationic Polymers ◽  
Genetic Trait ◽  
Low Diversity ◽  
Different Types ◽  
Materials Used

Bacterial transformation and gene transfection can be understood as being the results of introducing specific genetic material into cells, resulting in gene expression, and adding a new genetic trait to the host cell. Many studies have been carried out to investigate different types of lipids and cationic polymers as promising nonviral vectors for DNA transfer. The present study aimed to carry out a systematic review on the use of biopolymeric materials as nonviral vectors. The methodology was carried out based on searches of scientific articles and applications for patents published or deposited from 2006 to 2020 in different databases for patents (EPO, USPTO, and INPI) and articles (Scopus, Web of Science, and Scielo). The results showed that there are some deposits of patents regarding the use of chitosan as a gene carrier. The 16 analyzed articles allowed us to infer that the use of biopolymers as nonviral vectors is limited due to the low diversity of biopolymers used for these purposes. It was also observed that the use of different materials as nonviral vectors is based on chemical structure modifications of the material, mainly by the addition of cationic groups. Thus, the use of biopolymers as nonviral vectors is still limited to only a few polysaccharide types, emphasizing the need for further studies involving the use of different biopolymers in processes of gene transfer.

Pulmonary drug delivery with aerogels: engineering of alginate and alginate–hyaluronic acid microspheres

2021 ◽  
Vol 26 (5) ◽  
pp. 509-521
Author(s):  
Tamara Athamneh ◽  
Adil Amin ◽  
Edit Benke ◽  
Rita Ambrus ◽  
Pavel Gurikov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Pulmonary Drug Delivery

Superparamagnetic electrospun microrods for magnetically-guided pulmonary drug delivery with magnetic heating

2021 ◽  
Vol 126 ◽  
pp. 112117
Author(s):  
Maria Nikolaou ◽  
Kyriakos Avraam ◽  
Argiris Kolokithas-Ntoukas ◽  
Aristides Bakandritsos ◽  
Frantisek Lizal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pulmonary Drug Delivery ◽  
Magnetic Heating

Alginate and hybrid alginate-hyaluronic acid aerogel microspheres as potential carrier for pulmonary drug delivery

2019 ◽  
Vol 150 ◽  
pp. 49-55 ◽  
Author(s):  
Tamara Athamneh ◽  
Adil Amin ◽  
Edit Benke ◽  
Rita Ambrus ◽  
Claudia S. Leopold ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Pulmonary Drug Delivery
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